KEGG ENZYME: 4.2.3.20

ENZYME: 4.2.3.20

Entry

EC 4.2.3.20                 Enzyme

Name

(R)-limonene synthase;
(+)-limonene synthase;
geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming];
geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming]

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranyl-diphosphate diphosphate-lyase [cyclizing, (R)-limonene-forming]

Reaction(IUBMB)

geranyl diphosphate = (R)-limonene + diphosphate [RN:R06120]

Reaction(KEGG)

R06120

Substrate

geranyl diphosphate [CPD:C00341]

Product

(R)-limonene [CPD:C06099];
diphosphate [CPD:C00013]

Comment

Forms the first step of carvone biosynthesis in caraway. The enzyme from Carum carvi (caraway) seeds requires a divalent metal ion (preferably Mn2+) for catalysis. This enzyme occurs in Citrus, Carum (caraway) and Anethum (dill); (-)-limonene, however, is made in the fir, Abies, and mint, Mentha, by EC 4.2.3.16, (4S)-limonene synthase.

History

EC 4.2.3.20 created 2003

Pathway

ec00902

Monoterpenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15096

(R)-limonene synthase

Genes

PVY:	116111384 116117133 116118367 116118374 116120605 116125800 116133856 116133858

MINC:

123205304 123218563 123219687

HSYR:

120138167

Reference

1 [PMID:9662532]

Authors

Bouwmeester HJ, Gershenzon J, Konings MC, Croteau R.

Title

Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration Of enzyme activities and their changes with development

Journal

Plant Physiol 117:901-12 (1998)
DOI:10.1104/pp.117.3.901

Reference

2 [PMID:12084056]

Authors

Lucker J, El Tamer MK, Schwab W, Verstappen FW, van der Plas LH, Bouwmeester HJ, Verhoeven HA

Title

Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases.

Journal

Eur J Biochem 269:3160-71 (2002)
DOI:10.1046/j.1432-1033.2002.02985.x

Sequence

[ag:AAM53944]