KEGG   ENZYME: 4.2.3.202
Entry
EC 4.2.3.202                Enzyme                                 

Name
hydropyrenol synthase;
HpS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrenol-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = hydropyrenol + diphosphate [RN:R12364]
Reaction(KEGG)
R12364
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
hydropyrenol [CPD:C22109];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.203, isoelisabethatriene synthase.
History
EC 4.2.3.202 created 2019
Orthology
K23530  hydropyrene/hydropyrenol/isoelisabethatriene synthase
Genes
SCLF: BB341_28045
Reference
1  [PMID:28696553]
  Authors
Rinkel J, Rabe P, Chen X, Kollner TG, Chen F, Dickschat JS
  Title
Mechanisms of the Diterpene Cyclases beta-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus.
  Journal
Chemistry 23:10501-10505 (2017)
DOI:10.1002/chem.201702704
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.202
IUBMB Enzyme Nomenclature: 4.2.3.202
ExPASy - ENZYME nomenclature database: 4.2.3.202
BRENDA, the Enzyme Database: 4.2.3.202

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