KEGG   ENZYME: 4.2.3.204
Entry
EC 4.2.3.204                Enzyme                                 

Name
valerianol synthase;
ChTPS1 (gene name);
CsiTPS8 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (valerianol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = valerianol + diphosphate [RN:R12456]
Reaction(KEGG)
R12456
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
valerianol [CPD:C22174];
diphosphate [CPD:C00013]
Comment
The enzyme was characterized from the trees Camellia hiemalis and Camellia sinensis (black tea). The enzyme from Camellia hiemalis produces (2Z,6E)-hedycaryol as a minor product.
History
EC 4.2.3.204 created 2019
Orthology
K23724  (2E,6E)-hedycaryol/valerianol synthase
Genes
CSIN: 114264357 114282627
Reference
1  [PMID:30127518]
  Authors
Hattan JI, Shindo K, Sasaki T, Ohno F, Tokuda H, Ishikawa K, Misawa N
  Title
Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea.
  Journal
Sci Rep 8:12474 (2018)
DOI:10.1038/s41598-018-30653-w
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.204
IUBMB Enzyme Nomenclature: 4.2.3.204
ExPASy - ENZYME nomenclature database: 4.2.3.204
BRENDA, the Enzyme Database: 4.2.3.204

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