KEGG   ENZYME: 4.2.3.225
Entry
EC 4.2.3.225                Enzyme                                 
Name
cattleyene synthase;
CyS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, cattleyene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = cattleyene + diphosphate [RN:R13300]
Reaction(KEGG)
R13300
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
cattleyene [CPD:C22901];
diphosphate [CPD:C00013]
Comment
A diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor.
History
EC 4.2.3.225 created 2024
Orthology
K27619  cattleyene synthease
Genes
SCT: SCAT_p0091
SCY: SCATT_p16530
Reference
1  [PMID:31034729]
  Authors
Rinkel J, Steiner ST, Dickschat JS.
  Title
Diterpene Biosynthesis in Actinomycetes: Studies on Cattleyene Synthase and Phomopsene Synthase.
  Journal
Angew Chem Int Ed Engl 58:9230-9233 (2019)
DOI:10.1002/anie.201902950
  Sequence
[sct:SCAT_p0091]
Reference
2  [PMID:35819825]
  Authors
Xing B, Xu H, Li A, Lou T, Xu M, Wang K, Xu Z, Dickschat JS, Yang D, Ma M.
  Title
Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes.
  Journal
Angew Chem Int Ed Engl 61:e202209785 (2022)
DOI:10.1002/anie.202209785
  Sequence
[sct:SCAT_p0091]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.225
IUBMB Enzyme Nomenclature: 4.2.3.225
ExPASy - ENZYME nomenclature database: 4.2.3.225
BRENDA, the Enzyme Database: 4.2.3.225

  All links  
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (2)   

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