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Entry
EC 4.2.3.25                 Enzyme                                 

Name
S-linalool synthase;
LIS;
Lis;
3S-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3S)-linalool + diphosphate [RN:R07631]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3S)-linalool [CPD:C11389];
diphosphate [CPD:C00013]
Comment
Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed.
History
EC 4.2.3.25 created 2006
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K15086  (3S)-linalool synthase
K22049  S-linalool synthase
Genes
ATH: AT1G61680(TPS14)
ALY: ARALYDRAFT_893341
CSAT: 104705165
BNA: 106393947
BOE: 106314371
THJ: 104809528 104818931 104818943
GMX: 100782471 100789381(NES)
MTR: MTR_2g010960 MTR_6g064980
CSV: 101204552
RCU: 8267425(RcSeTPS13)
SLY: 101244812(TPS37) 101245403(TPS39)
OSA: 4328124
DOSA: Os02t0121700-01(Os02g0121700)
BDI: 100823591
ZMA: 732758(TPS2)
 » show all
Taxonomy
Reference
1  [PMID:7864636]
  Authors
Pichersky E, Lewinsohn E, Croteau R.
  Title
Purification and characterization of S-linalool synthase, an enzyme involved in the production of floral scent in Clarkia breweri.
  Journal
Arch Biochem Biophys 316:803-7 (1995)
DOI:10.1006/abbi.1995.1107
Reference
2  [PMID:11532177]
  Authors
Lucker J, Bouwmeester HJ, Schwab W, Blaas J, van der Plas LH, Verhoeven HA.
  Title
Expression of Clarkia S-linalool synthase in transgenic petunia plants results in the accumulation of S-linalyl-beta-D-glucopyranoside.
  Journal
Plant J 27:315-24 (2001)
DOI:10.1046/j.1365-313x.2001.01097.x
Reference
3  [PMID:8768373]
  Authors
Dudareva N, Cseke L, Blanc VM, Pichersky E.
  Title
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower.
  Journal
Plant Cell 8:1137-48 (1996)
DOI:10.1105/tpc.8.7.1137
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.25
IUBMB Enzyme Nomenclature: 4.2.3.25
ExPASy - ENZYME nomenclature database: 4.2.3.25
BRENDA, the Enzyme Database: 4.2.3.25
CAS: 160477-81-6

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