KEGG   ENZYME: 4.2.3.37
Entry
EC 4.2.3.37                 Enzyme                                 
Name
epi-isozizaene synthase;
SCO5222 protein
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate [RN:R07830]
Reaction(KEGG)
R07830
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-epi-isozizaene [CPD:C16269];
diphosphate [CPD:C00013]
Comment
Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].
History
EC 4.2.3.37 created 2008
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K10156  epi-isozizaene synthase
Genes
NYALTV02_37160
SCOSCO5222(SC7E4.19)
SALBXNR_1580
SMASAVERM_3032(ezs)
SHYSHJG_6335
SHOSHJGH_6096
SDVBN159_3155(cyc1)
SALSSLNWT_2072
SCIB446_24610
SLVSLIV_12255(cyc1)
SGUSGLAU_22460
SCWTU94_21765
SAMBSAM23877_5010(cyc)
SCXAS200_17635
SRWTUE45_05742(cyc1)
STRFASR50_23820
SLEsle_25180(sle_25180)
SPAVSpa2297_22085
STRTA8713_21090
SGSAVL59_06865
STSIA4E84_26810
SKYD0C37_09635
SALWCP975_23790
SGMGCM10017557_26720(cyc1)
SCADDN051_14275
SPHWNFX46_06115
SLSSLINC_5614
SPLULK06_022335
STRDNI25_13055
SSIAA7J05_12565
SPUNBFF78_14835
SALFSMD44_05799(eizS)
SFKKY5_5348
SNZDC008_23210
SGEDWG14_02917(cyc1)
SRJSRO_2586
SDXC4B68_13430
SGDELQ87_13275
SCYAEJ357_30815
SASTCD934_10770
SNQCP978_22465
SKACP970_14420
SGZC0216_13205
SVNCP980_02640
SHAWCEB94_27435
SGALCP966_24280
SFYGFH48_14925
SAQUEJC51_32135
SGFHEP81_02794
SSEOD0Z67_19535
SSUBCP968_00775
SFUGCNQ36_23695
SPACB1H29_12440
SCHACP983_14570
SCOECP976_28735
SSPBCP982_27720
SBROGQF42_28695
STUIGCM10017668_47520(cyc1)
SCHFIPT68_24085
SCYGS1361_25895(cyc1)
SFEUIM697_37490
SVDCP969_25540
SFBCP974_28095
SPRACP972_23860
SROIIAG44_13195
SXNIAG42_11640
SHKJ2N69_24775
SDDD9753_11945
SACTDMT42_26020
SLFJEQ17_16415
SAOVG3H79_11735
SDURM4V62_15480
 » show all
Reference
1  [PMID:16669656]
  Authors
Lin X, Hopson R, Cane DE
  Title
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.
  Journal
J Am Chem Soc 128:6022-3 (2006)
DOI:10.1021/ja061292s
  Sequence
[sco:SCO5222]
Reference
2  [PMID:18234666]
  Authors
Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE
  Title
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
  Journal
J Biol Chem 283:8183-9 (2008)
DOI:10.1074/jbc.M710421200
  Sequence
[sco:SCO5222]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.37
IUBMB Enzyme Nomenclature: 4.2.3.37
ExPASy - ENZYME nomenclature database: 4.2.3.37
BRENDA, the Enzyme Database: 4.2.3.37

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