KEGG ENZYME: 4.2.3.40

ENZYME: 4.2.3.40

Entry

EC 4.2.3.40                 Enzyme

Name

(Z)-gamma-bisabolene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate [RN:R09620]

Reaction(KEGG)

R09620

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(Z)-gamma-bisabolene [CPD:C16814];
diphosphate [CPD:C00013]

Comment

This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana. If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E)-nerolidol and alpha-bisabolol are also produced by this enzyme as minor products.

History

EC 4.2.3.40 created 2009

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K15795

(Z)-gamma-bisabolene synthase

Genes

ATH:	AT4G13280(TPS12) AT4G13300(TPS13)

CSAT:

104719135

Reference

1 [PMID:16297850]

Authors

Ro DK, Ehlting J, Keeling CI, Lin R, Mattheus N, Bohlmann J

Title

Microarray expression profiling and functional characterization of AtTPS genes: duplicated Arabidopsis thaliana sesquiterpene synthase genes At4g13280 and At4g13300 encode root-specific and wound-inducible (Z)-gamma-bisabolene synthases.

Journal

Arch Biochem Biophys 448:104-16 (2006)
DOI:10.1016/j.abb.2005.09.019

Sequence

[ath:AT4G13280 AT4G13300]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.40

IUBMB Enzyme Nomenclature:

4.2.3.40

ExPASy - ENZYME nomenclature database:

4.2.3.40

BRENDA, the Enzyme Database:

4.2.3.40

DBGET integrated database retrieval system