KEGG   ENZYME: 4.2.3.48
Entry
EC 4.2.3.48                 Enzyme                                 
Name
(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]
Reaction(KEGG)
R08374
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.48 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14175  (3S,6E)-nerolidol synthase
Genes
CRB17896330
THJ104809526
CIT102617431 102617651 102617908 102620886
CICCICLE_v10004558mg CICLE_v10014632mg CICLE_v10014707mg
PVY116111381 116121150 116145960
MINC123192358 123192360 123192601 123192665 123192702
TCC108662607 18597023 18597024
GRA105777993
GHI107924963 107940942
GAB108452092
DZI111281010 111318783
EGR104445481 104447370 104447372 104447373 104447374 104447375 104447392 104447394 104447396 104447399
GMX100782471(TPS4) 100783015(TPS5) 100814957(TPS6)
GSJ114419462 114419463
PVUPHAVU_002G219100g PHAVU_002G219300g
VRA106765590 106766355 106766356 106766374
VAR108326386 108338184 108338349
VUN114177509 114178712 114178713 114179677
CCAJ109814060 109817871 109817878
APRC113858784
MTRMTR_4g092010 MTR_4g092020
CAM101494917 101495572 101503644
LJALj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2)
ADU107468751 107480611
AIP107623232 107626247
AHF112714726 112728647 112784898 112791359
LANG109334775
FVE101299453 101302321
RCN112165597 112166460 112202907
PPER18778181
PMUM103324596 103343969
PAVI110752892 110768753
PDUL117625092 117626312
MDM103434640 103446596 103446597 103446598(LIS) 114827793
PXB103941370 103941371 103958297
ZJU107421470 107421878
MNT21385024 21408693 21408694
CSV101204794 101215070
CMO103485748 103485753 103485759 103489227
BHJ120080989 120082587 120082664 120082764 120083563
MCHA111010706 111010875 111010876 111010887
CMAX111484385 111490118
CMOS111434067 111434068 111447175 111456834
CPEP111783518 111802148
RCU8259987
JCU105629808 105629819 105629820 105649410
HBR110635396 110644414 110654947 110661963
MESC110603115 110604308 110604309 110605593
POP18102943 7490762 7490764
PEU105107363 105110145
PALZ118031658 118031660 118031663 118042815
JRE108979322 108979323 108989344 109004686 109004723 109007398 109013445
QSU111988830 111989102 111989152
QLO115988645 115991201 115992647 115992733
TWL119990104 119990105
VVI100248531 100266449(LinNer) 100267150 100852561 100852596 100852776 100853562 100853639 100853679 100854717 100854809
VRI117910457 117910459 117910461 117910462 117918890 117923388 117924000 117924001 117924133
SLY101244812(TPS37) 101245403(TPS39)
SPEN107019618 107032586
SOT102580873 102592813
SSTN125852752 125852754 125865371 125865396 125865910 125865911
CANN107845646 124892657
NTA107828192
NTO104117466
NAU109230989
INI109163834 109167275 109167276 109167277 109167278 109167279
ITR116029121 116029228 116029229 116029230 116029231 116029232 116029233 116030387 116030506 116030578
SIND105156792 105175396 105175430 105175469 105175470
OEU111395219 111396005 111396006 111396009 111396013 111396015 111396016
EGT105962255 105962256
SSPL121759727 121783505 121787949 121794424
HAN110884314 110889629 110915780 110916766 110919641
ECAD122597840 122599361 122608148
LSV111884934 111897116 111897141 111897149
CCAV112527638 112527948
DCR108194757 108195481 108195714 108195795 108195952
CSIN114261430 114266222 114282497 114288835 114290333
BVG104883052 104901069 104901071
SOE110789690 110789691
CQI110687149 110687263 110693359 110693461 110693462
NNU104591086 104591099
MING122059466 122059660 122061859 122072008 122072223 122092317 122092318
TSS122638603 122639517 122667458 122667459 122668202
NCOL116246448 116246454 116247351
MUS103973658
AOF109820753
ATR18431529 18440985 18440990
 » show all
Reference
1  [PMID:15522848]
  Authors
Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ
  Title
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.
  Journal
Plant Cell 16:3110-31 (2004)
DOI:10.1105/tpc.104.023895
Reference
2  [PMID:10482672]
  Authors
Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M
  Title
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.
  Journal
Plant Physiol 121:173-80 (1999)
DOI:10.1104/pp.121.1.173
Reference
3  [PMID:10805454]
  Authors
Degenhardt J, Gershenzon J
  Title
Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.
  Journal
Planta 210:815-22 (2000)
DOI:10.1007/s004250050684
Reference
4  [PMID:17924138]
  Authors
Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W
  Title
Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of  jasmonate, ethylene and calcium signaling.
  Journal
Planta 227:453-64 (2008)
DOI:10.1007/s00425-007-0631-y
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.48
IUBMB Enzyme Nomenclature: 4.2.3.48
ExPASy - ENZYME nomenclature database: 4.2.3.48
BRENDA, the Enzyme Database: 4.2.3.48

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