KEGG   ENZYME: 4.2.3.49
Entry
EC 4.2.3.49                 Enzyme                                 
Name
(3R,6E)-nerolidol synthase;
terpene synthase 1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3R,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate [RN:R09618]
Reaction(KEGG)
R09618
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3R,6E)-nerolidol [CPD:C19746];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [1]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.49 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15793  acyclic sesquiterpene synthase
Genes
BDI100833760
ATS109780592 109783760
TDC119356231 119356232 119365401 119365402
TAES100873133 123041882 123041883 123054327 123190213 123191849
SBI8072328
ZMA100274033 541974
SITA101771563
SVS117862601
PVIR120640652 120683675
PHAI112898865
Reference
1  [PMID:12481088]
  Authors
Schnee C, Kollner TG, Gershenzon J, Degenhardt J
  Title
The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage.
  Journal
Plant Physiol 130:2049-60 (2002)
DOI:10.1104/pp.008326
  Sequence
[zma:541974]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.49
IUBMB Enzyme Nomenclature: 4.2.3.49
ExPASy - ENZYME nomenclature database: 4.2.3.49
BRENDA, the Enzyme Database: 4.2.3.49

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