KEGG   ENZYME: 4.2.3.77
Entry
EC 4.2.3.77                 Enzyme                                 
Name
(+)-germacrene D synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate [RN:R09558]
Reaction(KEGG)
R09558
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-germacrene D [CPD:C19619];
diphosphate [CPD:C00013]
Comment
Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC 4.2.3.75).
History
EC 4.2.3.77 created 2011
Orthology
K22057  (+)-germacrene D synthase
Genes
ZOF: 122001961
Reference
1  [PMID:16839518]
  Authors
Picaud S, Olsson ME, Brodelius M, Brodelius PE
  Title
Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale.
  Journal
Arch Biochem Biophys 452:17-28 (2006)
DOI:10.1016/j.abb.2006.06.007
  Sequence
[ag:AAX40665]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.77
IUBMB Enzyme Nomenclature: 4.2.3.77
ExPASy - ENZYME nomenclature database: 4.2.3.77
BRENDA, the Enzyme Database: 4.2.3.77

  All links  
Protein sequence (12)   
   UniProt (6)   
   SWISS-PROT (4)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (9)   
   InterPro (9)   
All databases (25)   

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