KEGG ENZYME: 4.2.3.77

ENZYME: 4.2.3.77

Entry

EC 4.2.3.77 Enzyme

Name

(+)-germacrene D synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate [RN:R09558]

Reaction(KEGG)

R09558

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(+)-germacrene D [CPD:C19619];
diphosphate [CPD:C00013]

Comment

Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC 4.2.3.75).

History

EC 4.2.3.77 created 2011

Orthology

K22057

(+)-germacrene D synthase

Reference

1 [PMID:16839518]

Authors

Picaud S, Olsson ME, Brodelius M, Brodelius PE

Title

Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale.

Journal

Arch Biochem Biophys 452:17-28 (2006)
DOI:10.1016/j.abb.2006.06.007

Sequence

[ag:AAX40665]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.77

IUBMB Enzyme Nomenclature:

4.2.3.77

ExPASy - ENZYME nomenclature database:

4.2.3.77

BRENDA, the Enzyme Database:

4.2.3.77

DBGET integrated database retrieval system