KEGG   ENZYME: 4.2.3.96Help
Entry
EC 4.2.3.96                 Enzyme                                 

Name
avermitilol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
avermitilol hydrolase (cyclizing, avermitilol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate [RN:R09896]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
avermitilol [CPD:C20181];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.
History
EC 4.2.3.96 created 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18110  avermitilol synthase
Genes
SMA: SAVERM_76(ams)
STRM: M444_02785
Taxonomy
Reference
1  [PMID:20536237]
  Authors
Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
  Journal
J Am Chem Soc 132:8850-1 (2010)
DOI:10.1021/ja103087w
  Sequence
[sma:SAV_76]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.96
IUBMB Enzyme Nomenclature: 4.2.3.96
ExPASy - ENZYME nomenclature database: 4.2.3.96
BRENDA, the Enzyme Database: 4.2.3.96

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
All databases (15)   

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