Entry
Name
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
avermitilol hydrolase (cyclizing, avermitilol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate [RN:
R09896 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.
History
EC 4.2.3.96 created 2012
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
Orthology
Genes
Taxonomy
Reference
Authors
Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE
Title
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.96
ExPASy - ENZYME nomenclature database: 4.2.3.96