KEGG   ENZYME: 4.2.99.20
Entry
EC 4.2.99.20                Enzyme                                 
Name
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase;
6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase;
SHCHC synthase;
MenH;
YfbB
Class
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases
Sysname
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming]
Reaction(IUBMB)
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate [RN:R08166]
Reaction(KEGG)
R08166
Substrate
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate [CPD:C16519]
Product
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate [CPD:C05817];
pyruvate [CPD:C00022]
Comment
This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, were carried out by a single enzyme but this has since been disproved [2].
History
EC 4.2.99.20 created 2008 (EC 2.5.1.64 created 2003, part-incorporated 2008)
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08680  2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
K14759  isochorismate synthase / 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / o-succinylbenzoate synthase
Genes
ATHAT1G68890(PHYLLO)
ALY9324753
CRB17894367
CSAT104704752 104750694 104787948
EUSEUTSA_v10017999mg
BRP103852540
BNA106393361 106428528
BOE106327192
RSZ108842359
THJ104821983
CIT102608540
CICCICLE_v100304921m
PVY116119521
MINC123212909
TCC18610138
GRA105794273
GHI107887399 107936532
GAB108465126
DZI111318210
EGR104453859
GMX100798570
GSJ114387540
PVUPHAVU_005G022900g
VRA106761862
VAR108334153
VUN114181785
CCAJ109807754
APRC113858177
MTRMTR_8g069840
CAM101508711
ADU107477124
AIP107628739
AHF112719735 112795954
LANG109332680
FVE101297638
RCN112197898
PPER18791507
PMUM103342087
PAVI110757742
PDUL117614419
MDM103425450
PXB103946661
ZJU107429107
MNT21409174
CSV101217012
CMO103489211
BHJ120082188
MCHA111017565
CMAX111488697
CMOS111458428
CPEP111776726
RCU8264631
JCU105640708
HBR110660726
MESC110599831
POP7482230
PEU105114338
PALZ118047100
JRE108981645
QSU112030165
QLO115981974
TWL119992272
VVI100241089
VRI117913286
SLY101245351
SPEN107017693
SOT102603926
CANN107870618
NTA107794793 107804357
NSY104216590
NTO104112285
NAU109214856
INI109176245
ITR116001545
SIND105161713
OEU111404630
EGT105967597
SSPL121794928
HAN110914946
ECAD122595173
LSV111896435
CCAV112523262
DCR108196102
CSIN114282620
BVG104896273
SOE110791623
CQI110686041 110721096
NNU104597836
TSS122664179
PSOM113275718 113281895
NCOL116250127
OSA4329786
OBR102708030
BDI100843372
ATS109752118
TDC119316956 119321729
TAES123127572 123137052 123144651
SBI8055409
SITA101780975
SVS117859232
PVIR120656211 120706507
PHAI112893416
PDA103706601
EGU105061098
MUS103989974
DCT110109286
PEQ110018366
AOF109840254
ATR18433994
SMOSELMODRAFT_121498 SELMODRAFT_157803
PPP112287061
MNGMNEG_13906
CSLCOCSUDRAFT_11397
CVRCHLNCDRAFT_137782
OTAOT_ostta17g02170
BPGBathy12g00280
MISMICPUN_58883
MPPMICPUCDRAFT_43278
CCPCHC_T00002409001
ECOb2263(menH)
ECJJW2258(yfbB)
ECDECDH10B_2424(yfbB)
EBWBWG_2037(yfbB)
ECOKECMDS42_1834(yfbB)
ECEZ3523(yfbB)
ECSECs_3151(menH)
ECFECH74115_3405
ETWECSP_3141(yfbB)
ELXCDCO157_2915
EOIECO111_3014(yfbB)
EOJECO26_3254(yfbB)
EOHECO103_2730(yfbB)
ECOOECRM13514_3020(yfbB)
ECOHECRM13516_2965(yfbB)
ESLO3K_08170
ESOO3O_17465
ESMO3M_08120
ECKEC55989_2511(yfbB)
ECGE2348C_2408(yfbB)
EOKG2583_2804(yfbB)
ELRECO55CA74_13880
ELHETEC_2398
ECWEcE24377A_2559
EUNUMNK88_2816
ECPECP_2307
ENAECNA114_2357(yfbB)
ECOSEC958_2602(menH)
ECVAPECO1_4298(yfbB)
ECOAAPECO78_15140
ECXEcHS_A2409
ECMEcSMS35_2418
ECYECSE_2523
ECRECIAI1_2341(yfbB)
ECQECED1_2731(yfbB)
EUMECUMN_2606(yfbB)
ECTECIAI39_2411(yfbB)
EOCCE10_2647(menH)
EBRECB_02190(yfbB)
EBLECD_02190(menH)
EBEB21_02149(menH)
EBDECBD_1395
ECIUTI89_C2547(yfbB)
EIHECOK1_2500(menH)
ECZECS88_2414(yfbB)
ECCc2807(yfbB)
ELOEC042_2507
ELNNRG857_11480
ESEECSF_2144
ECLEcolC_1385
EKOEKO11_1500
EKFKO11_11365(yfbB)
EABECABU_c25990(yfbB)
EDHEcDH1_1394
EDJECDH1ME8569_2200(yfbB)
ELUUM146_05480
ELWECW_m2455(yfbB)
ELLWFL_12015(yfbB)
ELCi14_2606(yfbB)
ELDi02_2606(yfbB)
ELPP12B_c2358(yfbB)
ELFLF82_3047(yfbB)
ECOLLY180_11755
ECOIECOPMV1_02425(menH)
ECOJP423_12670
EFEEFER_0905(yfbB)
EALEAKF1_ch3715
EMAC1192_00565
ESZFEM44_01515(menH)
STYSTY2538(yfbB)
STTt0555(yfbB)
SEXSTBHUCCB_5960
SENTTY21A_02825
STMSTM2308(yfbB)
SEOSTM14_2846(yfbB)
SEVSTMMW_23321
SEYSL1344_2277(yfbB)
SEMSTMDT12_C23290
SEJSTMUK_2338(yfbB)
SEBSTM474_2404(yfbB)
SEFUMN798_2490
SETUSTU288_07915
SETCCFSAN001921_05255
SENRSTMDT2_22771(yfbB)
SENDDT104_23661(yfbB)
SENICY43_12365
SEENSE451236_17735
SPTSPA0555(yfbB)
SEKSSPA0519
SPQSPAB_00673
SEISPC_1403(yfbB)
SECSCH_2308(yfbB)
SEHSeHA_C2548
SHBSU5_02903
SENHCFSAN002069_20305
SEEHSEEH1578_20815
SEESNSL254_A2493
SENNSN31241_34130
SEWSeSA_A2536
SEASeAg_B2444
SENSQ786_11380
SEDSeD_A2652
SEGSG2337(yfbB)
SELSPUL_0582
SEGASPUCDC_0582
SETSEN2290(yfbB)
SENAAU38_11575
SENOAU37_11585
SENVAU39_11585
SENQAU40_12965
SENLIY59_11900
SENJCFSAN001992_22035
SEECCFSAN002050_18465
SEEBSEEB0189_008030
SEEPI137_02685
SENBBN855_23890
SENEIA1_11495
SENCSEET0819_18630
SESSARI_00591
SBGSBG_2096(yfbB)
SBZA464_2422
SALZEOS98_07505
SFLSF2342(yfbB)
SFXS2476(yfbB)
SFVSFV_2334(yfbB)
SFESFxv_2586(yfbB)
SFNSFy_3332
SFSSFyv_3407
SFTNCTC1_02576(menH)
SSNSSON_2324(yfbB)
SBOSBO_2300(yfbB)
SBCSbBS512_E2642
SDYSDY_2459(yfbB)
SDZAsd1617_03318
SHQA0259_15140
ENCECL_03613(menH)
ENLA3UG_15950
ECLGEC036_31000
ECLEECNIH2_15915
ECLNECNIH4_07265
ECLIECNIH5_14860
ECLXLI66_15260
ECLYLI62_16760
ECLZLI64_14695
EHMAB284_10160
EXFBFV63_15080
ECLAECNIH3_14955
ECLCECR091_14890
EAUDI57_03825
EKBBFV64_15595
ENOECENHK_15385
EECEcWSU1_03141(menH)
ELGBH714_11755
ECANCWI88_06870
ERNBFV67_15250
ECLSLI67_016505
ECHGFY206_17065(menH)
ESHC1N69_15760
ENTEnt638_2813
EASEntas_2985
ENRH650_07215
ENXNI40_015490
ENFAKI40_1592
LNICWR52_19640
EBGFAI37_13715(menH)
ENDA4308_20055
ENZG0034_16000(menH)
ENSHWQ15_00770(menH)
ENKLOC22_03385(menH)
ESAESA_00950
CSKES15_1204(menH)
CSZCSSP291_04805
CSJCSK29544_02257
CCONAFK62_13335
CDMAFK67_14120
CSIP262_01845
CMJAFK66_006145
CUIAFK65_13615
CMWAFK63_04700
CTUCTU_28950(menH)
KPNKPN_02661(yfbB)
KPUKP1_3902(yfbB)
KPMKPHS_37280
KPPA79E_1441
KPHKPNIH24_10015
KPZKPNIH27_17815
KPVKPNIH29_18610
KPWKPNIH30_18830
KPYKPNIH31_17760
KPGKPNIH32_19160
KPCKPNIH10_18195
KPQKPR0928_18215
KPTVK055_4854(menH)
KPOKPN2242_16405
KPRKPR_2046(menH)
KPID364_13560
KPAKPNJ1_01684
KPSKPNJ2_01652
KPXPMK1_00159(menH)
KPBFH42_09425
KPNEKU54_007765
KPNULI86_07770
KPNKBN49_3878(menH)
KVAKvar_1392
KPEKPK_1488
KPKA593_03170
KVDKR75_00830
KVQSP68_07360
KOXKOX_26275
KOEA225_4155
KOYJ415_11350
KOMHR38_24405
KMIVW41_15530
KOKKONIH1_20485
KOCAB185_15840
KQUAVR78_22600
EAEEAE_24335
EARCCG28951
KQVB8P98_08475
KLLBJF97_20450
KLWDA718_08560
KARLGL98_07475(menH)
KGRJJJ10_08270(menH)
RORRORB6_01210
RONTE10_20175
RPLNB1209_07390
RAODSD31_07590
RTGNCTC13098_02011(menH)
REEelectrica_01486(menH)
CROROD_26701
CKOCKO_00527
CFDCFNIH1_22885
CBRAA6J81_24880
CWECO701_06575
CYOCD187_07820
CPOTFOB25_18945(menH)
CFQC2U38_16840
CSEDJY391_07515(menH)
CAMAF384_12120
CAFAL524_10775
CIFAL515_15790
CFARCI104_17455
CIRC2U53_27305
CIEAN232_12475
CPARCUC49_11840
CTELGBC03_13010(menH)
CITZE4Z61_01415(menH)
CARSE1B03_18275(menH)
EBTEBL_c12860(yfbB)
CNTJT31_19565
CEMLH23_21515
CENLH86_20105
CLAPNCTC11466_01326(menH)
PGELG71_12060
ESCEntcl_1460
KLEAO703_14565
KSAC813_23220
KORAWR26_08170(menH)
KRDA3780_15815
KCOBWI95_20940
KOTEH164_07230
KPSEIP581_15515(menH)
KIENCTC12125_00420(menH)
KASKATP_14150(menH)
LAXAPT61_06925
LEIC2U54_20705
LEHC3F35_19065
LEEDVA44_07060
LERGNG29_15710(menH)
LEAGNG26_15560(menH)
LAZA8A57_14635
LEFLJPFL01_2884
LEWDAI21_12010
BUFD8682_08920
BAGEBADSM9389_29170
SYMK6K13_05865(menH)
METYMRY16398_16350(menH)
AHNNCTC12129_01547(yfbB)
YREHEC60_10695(menH)
SGOEA8O29_007165(menH)
KINAB182_07030
PDZHHA33_10105(menH)
IZHFEM41_22230(menH)
PSHISAMEA2665130_2006(menH)
PSGCG163CM_03900(menH_3)
EBFD782_1401
EBCC2U52_17565
EBUCUC76_23075
YPEYPO2526
YPKy1661
YPHYPC_1595(yfbB)
YPAYPA_2018
YPNYPN_2121
YPMYP_2337(mhpC3)
YPPYPDSF_1936
YPGYpAngola_A1784
YPZYPZ3_2232
YPTA1122_13495
YPDYPD4_2483
YPXYPD8_2178
YPWCH59_62(menH)
YPJCH55_84(menH)
YPVBZ15_1009(menH)
YPLCH46_2587(menH)
YPSYPTB2559
YPOBZ17_4079(menH)
YPIYpsIP31758_1483
YPYYPK_1590
YPBYPTS_2653
YPQDJ40_3984(menH)
YPUBZ21_1855(menH)
YPRBZ20_3650(menH)
YPCBZ23_2139(menH)
YPFBZ19_1921(menH)
YENYE1376
YEPYE105_C2740
YEYY11_02451
YELLC20_03663
YEWCH47_795(menH)
YETCH48_282(menH)
YEFFORC2_1418
YEEYE5303_11601
YSIBF17_22270
YALAT01_1164(menH)
YFRAW19_1834(menH)
YINCH53_356(menH)
YKRCH54_3952(menH)
YROCH64_1176(menH)
YRUBD65_830(menH)
YRBUGYR_04715
YAKACZ76_15640
YMADA391_15190
YHID5F51_05350
YCAF0T03_07790(menH)
YMOHRD69_11990(menH)
SMARSM39_2880
SMACSMDB11_2679
SMWSMWW4_v1c33920(menH)
SPESpro_3282
SRRSerAS9_3478
SRLSOD_c31980(menH)
SRYM621_17410
SPLYQ5A_017360(menH)
SRSSerAS12_3479
SRASerAS13_3480
SMAFD781_3075
SLQM495_16855
SERFL085_11725
SERSSERRSCBI_16460
SFWWN53_25535
SFGAV650_21205
SRZAXX16_1999
SERASer39006_018675
SERQCWC46_18675
SERMCLM71_16265
SQUE4343_24355(menH)
SFJSAMEA4384070_3398(menH)
SOFNCTC11214_03404(menH)
SSURATE40_013605
SURIJ0X03_07070(menH)
SRHZFO014_17965(menH)
SFOZ042_03230
RAHRahaq_1278
RACEJHW33_00900(menH)
RAQRahaq2_1351
RAAQ7S_06140
ROXBV494_01700
RVCJ9880_14210(menH)
GQUAWC35_19835
EAMEGXP68_06775(menH)
ECAECA1212
PATREV46_06095
PATOGZ59_12410
PCTPC1_1112
PCCPCC21_011430
PCVBCS7_05765
PWAPecwa_3202
PECW5S_3200
PWSA7983_14700
PPOABJK05_00800
PBRAB5S52_15960
PPUJE2566_06245(menH)
PARII2D83_16425(menH)
PAQUDMB82_0014820(menH)
PVZOA04_12680(menH)
PPAVLOZ86_15265(menH)
DDDDda3937_01782(yfbB)
DZEDd1591_3013
DDCDd586_1087
DZCW909_05480
DSOA4U42_14820
CEDLH89_06405
DFNCVE23_06300
DDQDDI_0952
DAQDAQ1742_03104(menH)
DICDpoa569_002644(menH)
DDADd703_1046
BRBEH207_05040
BNGEH206_16150
BIZHC231_17055(menH)
LBQCKQ53_10020
LPOPI6N93_05035(menH)
SODSant_1358(menD)
EBIEbC_30510(menH)
EPECI789_03390
ERWIGN242_06460(menH)
ETPLU633_17240(menH)
PANPPSNIH2_04385
PALHB1H58_13755
PGZC2E15_14365
PCDC2E16_14430
MINTC7M51_02078(menH)
MTHIC7M52_00764(menH_1)
PLUplu3072
PLUMA4R40_15355
PAYPAU_01539
PTTVY86_16300
PAKHB0X70_15745
PLUICE143_15740
PMRPMI1744(yfbB)
PMIBBB2000_1852(yfbB)
PVLAOB99_10710
PVGCRN77_10180
PHAUPH4a_00435
PROTBTA34_10380
PCOLF1325_12325(menH)
PCIBF9282_12400(menH)
PPEEI6G31_16140(menH)
XBOXBJ1_0739(yfbB)
XBVXBW1_2774(menH)
XNEXNC1_2846(yfbB)
XNMXNC2_2741(yfbB)
XDOXDD1_2569(menH)
XPOXPG1_1254(menH)
XHOA9255_08420
XBUHGO23_07885(menH)
PSIS70_02315
PSXDR96_3623(menH)
PSTABGK56_05645
PRGRB151_026550(menH)
PALACO695_11860
PHEINCTC12003_01572(menH)
PRQCYG50_02785(menH)
PRJNCTC6933_02322(menH)
PVCG3341_08190(menH)
MMKMU9_2541
ANSArsFIN_26280(menH)
AETLDL57_05425(menH)
MWIMNY66_09780(menH)
EICNT01EI_2649
ETRETAE_2357(yfbB)
ETDETAF_2129
ETEETEE_0380(menH)
ETCETAC_11130
EDWQY76_08570
EHOA9798_05390
HAVAT03_14515
HPARAL518_11700
OPODSM2777_17885
LPVHYN51_15525
PFQQQ39_12005
PRAGEKN56_05660
LRINCTC12151_01276(menH)
HINHI_0282
HITNTHI0391
HIPCGSHiEE_01645
HIQCGSHiGG_04205
HIFHIBPF_02250
HILHICON_11920
HIUHIB_04000
HIER2846_0298(menH)
HIZR2866_0297(menH)
HIKHifGL_001790(menH)
HIAH733_0178
HIHNF38_03970
HIWNTHI477_01327(menH)
HICNTHIC486_00706(menH)
HIXNTHI723_01411(menH)
HPRPARA_00880
HDUHD_1854
HAYC3V42_07015
HPITNCTC13334_01273(menH)
HHZNCTC10839_00884(menH)
HAEGNCTC8502_00939(menH)
HPAAE5Q53_07435(menH)
HSEML3077_04815(menH)
HAPHAPS_1251(yfbB)
HPAZK756_00420
HPASJL26_11125
HPAKJT17_09350
GLECJD39_10740
HSOHS_0616
HSMHSM_0967
PMUPM0055
PMVPMCN06_1253(menH)
PULNT08PM_1337
PMPPmu_12670
PMULDR93_2023(menH)
PDAG4362423_00351(menH)
PSKYA6B44_10680
PATLKGI96_09140(menH)
PCAIK7G93_000109(menH)
MSUMS1793(mhpC)
BSUNA4G13_06635
MHTD648_2920
MHQD650_25220
MHATB824_23770
MHXMHH_c08350(menH)
MHAEF382_09335
MHAOJ451_09555
MHALN220_01415
MHAQWC39_12420
MHAYVK67_12425
MVRX781_22190
MVIX808_1910
MVGX874_1990
MVEX875_18940
MANNGM695_01520(menH)
MGRAA4G16_09005
MBOSICJ55_02930(menH)
MPEGHV560_01595(menH)
APLAPL_1749
APJAPJL_1784
APAAPP7_1834
ASUAsuc_0652
ASIASU2_09815
ASSASU1_09860
AEUACEE_09300
APORDDU33_00885
AIOEXH44_07065(menH)
ADPNCTC12871_00402(menH)
ALIGNCTC10568_02125(menH)
AAPNT05HA_2368
AAZADJ80_04500
AATD11S_2020
AAOANH9381_0205
AAND7S_01921
AAHCF65_00087
AACNAANUM_0039
AACTACT75_03275
ASEGNCTC10977_00866(menH)
GANUMN179_00770
BTOWQG_21340
BTREF542_1250
BTRHF543_1290
BTRAF544_21890
APAGEIA51_03785
AVTNCTC3438_01960(menH)
RPNENCTC8284_01143(menH)
RHEYFEE42_11115(menH)
RHAEIHV77_03460(menH)
OOIA6A10_08110
FCLA4G17_03480
BHUDA6A11_08720
PAETNCTC13378_01484(menH)
VCHVC_1974
VCFIR04_15015
VCSMS6_1731
VCEVch1786_I1466
VCQEN18_12975
VCJVCD_002393
VCIO3Y_09535
VCOVC0395_A1560
VCRVC395_2089
VCMVCM66_1898
VCLVCLMA_A1715
VCXVAA049_905(menH)
VCZVAB027_2610(menH)
VVUVV1_3171
VVYVV1117
VVMVVMO6_02110
VVLVV93_v1c10380(menH)
VPAVP0930
VPBVPBB_0888
VPKM636_17025
VPFM634_06660
VPHVPUCM_1031
VHAVIBHAR_01430
VCAM892_05895
VAGN646_0004
VEXVEA_004031
VDBAL552_13040
VHRAL538_14315
VNAPN96_08905
VOWA9237_03700
VROBSZ04_18575
VSPVS_2190
VEJVEJY3_04270
VFUvfu_A01340
VNIVIBNI_A2413(menH)
VANVAA_03316
LAGN175_06010
VAUVANGNB10_cI1810c(ytxM_menH?)
VCYIX92_04415
VCTJV59_10105
VTUIX91_10005
VEUIXK98_18805(menH)
VFLAL536_10665
VMIAL543_19140
VBRA6E01_03735
VSCVSVS12_01286(menH)
VGABSQ33_03385
VSHBSZ05_11090
VQICCZ37_08595
VTAA1984(yfbB)
VAFD1115_10620
VNLD3H41_04740
VCCFAZ90_10485(menH)
VASGT360_04885(menH)
VAQFIV01_09670(menH)
VSRVspart_01145(menH)
VKABTD91_11005(menH)
VZIG5S32_09705(menH)
VNVIF132_10670(menH)
VFIVF_1670(yfbB)
VFMVFMJ11_1795
VSAVSAL_I1100
AWDAWOD_I_1789
PPRPBPRA2623(STM2308)
PGBH744_2c2764
PDSCAY62_09600
PGHFH974_11075(menH)
GHOAL542_04710
SALYE8E00_03470(menH)
SKSFCN78_09375(menH)
SCOTHBA18_09860(menH)
SONSO_4574(menH)
SFRSfri_0281
SAZSama_3461
SBLSbal_0177
SBMShew185_4158
SBNSbal195_4289
SBPSbal223_0178
SBTSbal678_4322
SBSSbal117_0276
SBBSbal175_4069
SLOShew_3600
SPCSputcn32_0309
SHPSput200_4070
SSESsed_0225
SPLSpea_3972
SHEShewmr4_3768
SHMShewmr7_3841
SHNShewana3_3966
SHWSputw3181_3899
SHLShal_0296
SWDSwoo_0208
SWPswp_4793
SVOSVI_0219
SHFCEQ32_15025(menH)
SJASJ2017_0217
SPSWSps_00298
SBJCF168_19985(menH)
SMAVCFF01_17870(menH)
SHEWCKQ84_06560(menH)
SALGBS332_08570
SLJEGC82_21075(menH)
SMAIEXU30_08530(menH)
SPOLFH971_01295(menH)
SBKSHEWBE_0798(menH)
SKHSTH12_03402(menH)
SAESHBH39_16495(menH)
SLITJQC75_17800(menH)
SDKKHX94_09855(menH)
SCAATUM17387_36810(menH)
SPSHFM037_01230(menH)
SEURFM038_001250(menH)
SYKKDN34_16590(menH)
SCYPJYB88_17485(menH)
SAVIJYB87_00890(menH)
SSEMJYB85_18040(menH)
SGLAFJ709_01110(menH)
SINVK8B83_00485(menH)
AGZM0C34_19570(menH)
PINPing_0351
PSYPCNPT3_11350
FBLFbal_0043
FESHER31_15500(menH)
MVSMVIS_2785(menH)
MYAMORIYA_1408(menH)
MMAAFR932_09760(menH)
TTUTERTU_2727
ALVAlvin_0765
ATEPAtep_04790
TVIThivi_4014
TMBThimo_0879
MPURMARPU_04580
TTPE6P07_11725
THIPN838_08245
THIMKFB96_25285
TBOGLT988_02490
HHAHhal_1128
HHKHH1059_00680(menH)
HHCM911_03115
EBSECTOBSL9_1653
TNITVNIR_1662(menH_[H])
TTITHITH_08380
HAKKO116_00675
HAMHALO0681
HHHCLM76_07755(menH)
HOLHORIV_62680(menH)
HSRHSBAA_59590(menH)
HAXIHAALTHF_15410n
HPIZGYM47_15755(menH)
GSNYC6258_05119
RFOREIFOR_00521(menH)
AHAAHA_0530
AHYAHML_02715
AHDAI20_16740
AHRV428_02860
AHPV429_02860
AHJV469_20460
AHHRY45_03090
AHIVU14_19845
AAJBOQ57_02560
ASAASA_3736
AEOO23A_p4193
AVRB565_0485
AVOAMS64_03880
AMEDB224_4844
ASRWL1483_3250(menH)
ADHCK627_06440
ACAVVI35_18870(menH)
AEMCK911_14180
AEAC2U39_01750(menH)
ARVC7N77_02050(menH)
AESC2U30_11745(menH)
AELNCTC12917_00432(menH)
ASIMFE240_15845(menH)
AALLI6G90_13305(menH)
AJDI6H43_13385(menH)
ARIVKYK33_01680(menH)
TAUTola_0432
CDIZCEDIAZO_00455(menH_1)
RGERGE_06710(menH)
RBNRBXJA2T_16477
DALDalk_1410
MXAMXAN_3529
MSDMYSTI_04445
MYMA176_003382
MFBMFUL124B02_23770
CCXCOCOR_04514(ytxM)
MFULILAB_25615
MMASMYMAC_003470
SURSTAUR_4046
AGEAA314_05027
AVMJQX13_39360(menH)
MBDMEBOL_006859
CFUSCYFUS_004548
CCROCMC5_010840
SAMYDB32_008588
HOHHoch_5610
SATSYN_02621
BSEDDN745_05875
PCAYFRD00_22870
BVRBVIR_916
BLAGBLTE_27380(menH)
SDOSD1155_07510(menH)
GFUKM031_17780
BBABd3483
BBATBdt_3391
BBWBDW_12895
BBACEP01_02580
BDQCIK05_02230
BDCDOE51_17070
BDZDOM22_17965
BEXA11Q_485
SBFJCM31447_318500
BSUBSU30810(ytxM)
BSRI33_3140
BSLA7A1_2153
BSHBSU6051_30810(ytxM)
BSYI653_14770
BSUTBSUB_03271(ytxM)
BSULBSUA_03271(ytxM)
BSUSQ433_16715
BSOBSNT_09504(ytxM)
BSNBSn5_06250
BSQB657_30810(ytxM)
BSXC663_2930(ytxM)
BSPU712_15305
BSSBSUW23_14955(ytxM)
BSTGYO_3335
BLIBL02407(ytxM)
BLDBLi03221(ytxM)
BLHBaLi_c32950(menH2)
BAYRBAM_027790(menH)
BAQBACAU_2791(ytxM)
BYABANAU_2993(ytxM)
BAMPB938_14335
BQYMUS_3368(ytxM)
BAMLBAM5036_2713(menH)
BAMARBAU_2913(menH)
BAMNBASU_2719(menH)
BAMBBAPNAU_2946(ytxM)
BAMTAJ82_15745
BAMYV529_30590(ytxM)
BMPNG74_02922(menH)
BAOBAMF_2861(ytxM)
BAZBAMTA208_15080(ytxM)
BQLLL3_03157(ytxM)
BXHBAXH7_03090(ytxM)
BAMIKSO_005175
BAMCU471_29010
BAMFU722_14995
BSIACWD84_05485(menH)
BAEBATR1942_13215
BVMB9C48_14195
BSONS101395_01270(menH)
BHTDIC78_16195(menH)
BMOJHC660_29450(menH)
BTEQG4P54_15600(menH)
BIQAN935_15430
BANBA_5110(menH)
BARGBAA_5110
BATBAS4749
BAHBAMEG_5144
BAIBAA_5122
BAXH9401_4880
BANTA16_59530
BANRA16R_51690
BANSBAPAT_4902
BANHHYU01_24875
BANVDJ46_3767(menH)
BCEBC4854
BCABCE_5014
BCZBCE33L4609
BCRBCAH187_A4996
BCBBCB4264_A4985(menH)
BCUBCAH820_4967
BCGBCG9842_B0253
BCQBCQ_4672
BCXBCA_4990
BALBACI_c48600
BNCBCN_4772
BCFbcf_24340
BCERBCK_10865
BCYBcer98_3492
BTKBT9727_4587
BTLBALH_4420
BTBBMB171_C4493
BTTHD73_5171
BTHRYBT1520_25625
BTHIBTK_25500
BTCCT43_CH4879
BTFYBT020_23950
BTGBTB_c50150(ytxM)
BTIBTG_24525
BTNBTF1_22900
BTHTH175_ch4962
BTHUYBT1518_26875
BTWBF38_610(menH)
BTHYAQ980_05540
BWEBcerKBAB4_4696
BWWbwei_0027(menH)
BMYOBG05_1169(menH)
BTYBtoyo_2097
BMYCDJ92_1939(menH)
BBYCY96_23435
BWDCT694_25970(menH)
BTROFJR70_18245(menH)
BMOBMLA2C4_25265(menH)
BNTGSN03_23170(menH)
BPACLMD38_02580(menH)
BPUBPUM_2717
BPUMBW16_14650
BPUSUP12_13905
BJSMY9_3085
BACIB1NLA3E_17845
BIFN288_20410
BMETBMMGA3_13695(ytxM)
GSTHW35_06390
BACWQR42_13725
BACPSB24_14845
BACBOY17_17210
BACOOXB_0011
BACYQF06_13590
BACLBS34A_33470(ytxM)
BALMBsLM_3067
BSMBSM4216_2992
BGYBGLY_3638
BWHA9C19_04000
BXIBK049_13445
BALTCFN77_14595(menH)
BACSAUL54_15840
BSAFBSL056_15300
BITBIS30_04795
BACQDOE78_19600(menH)
BFDNCTC4823_01167(menH)
BDAFSZ17_18290(menH)
BBADK7T73_15180(menH)
BHKB4U37_17570
BCOHBC6307_17615
BCIRC2I06_12015(menH)
BMQBMQ_4890
BMDBMD_4876
BMHBMWSH_0356
BMEGBG04_1879(menH)
BEOBEH_21860
BFXBC359_03290
PKSIE339_21050(menH)
BCKBCO26_2089
BAGBcoa_2399
BCOABF29_1161(menH)
BGIBGM20_09360
BONA361_22875
BKOCKF48_15555(menH)
CGOTJ1899_17650(menH)
OIHOB2324
OCNCUC15_13250(menH)
GKAGK2874
GTEGTCCBUS3UF5_32330
GTKGT3570_14055
GTMGT3921_05040
GLIGLN3_07120
GTNGTNG_2772
GWCGWCH70_2798
GYCGYMC61_0569
GYAGYMC52_2986
GCTGC56T3_0613
GMCGY4MC1_0721
GGHGHH_c29490(ytxM)
GJFM493_14890
GEAGARCT_02903
GELIB49_06255
GSEGT50_05950
GSRGS3922_01885
GEJA0V43_12270
GZAIC807_10525(menH)
GTHGeoth_0720
PTLAOT13_18670
PTBDER53_01790(menH)
PCALBV455_02463(menH)
AFLAflv_0382
AGNAFK25_12270
ANMGFC28_3292(menH)
AAMYGFC30_3233(menH)
ANLGFC29_2142(menH)
ANDGRQ40_15145(menH)
ACAIISX45_12660(menH)
LSPBsph_4276
LGYT479_18060
LFUHR49_05780
LYSLBYS11_17590(menH)
LYBC3943_20600(menH)
LYZDCE79_13825(menH)
LYGC1N55_14560(menH)
LPAKGDS87_18590(menH)
LAGRFJQ98_22275(menH)
LMACI6G82_01805(menH)
HHDHBHAL_3862(menH)
HMNHM131_07660
HLIHLI_17485(menH)
TAIDKS242_12180(menH)
VIRX953_13270
VHLBME96_12150
VIGBKP57_03020
VILCFK37_12410(menH)
VNECFK40_07730(menH)
VPNA21D_02870(menH)
VIMGWK91_09140(menH)
VPTKBP50_05740(menH)
LAOAOX59_00685
SJEAAV35_004060
APAKAP3564_09480
BSJUP17_22185
BMURABE28_020805
PBUTDTO10_08630(menH)
PASABAOM_4225(menH)
PPSRI6J18_17805(menH)
AQTFN924_12525(menH)
BTHVCQJ30_04985(menH)
PSYHD0S48_19110(menH)
PSYOPB01_13540(menH)
PRDF7984_15740(menH)
GRCGI584_09610(menH)
POFGS400_15565(menH)
NMKCHR53_21790(menH)
NTMBTDUT50_13760(menH)
MEKUHUW50_02925(menH)
MSEMGMB29_21595(menH)
MDGK8L98_19940(menH)
BLENNCTC4824_03197(menH)
SEDDERJ70_13170(menH)
BVQFHE72_18655(menH)
RMFD5E69_17020(menH)
BVJI5776_06430(menH)
BOUI5818_07630(menH)
CTHUHUR95_10780(menH)
MCUIG8O30_10220(menH)
GAJMY490_03570(menH)
STEAC0679_07655(menH)
SAUSA0897
SAVSAV1044
SAWSAHV_1037
SAHSaurJH1_1126
SAJSaurJH9_1103
SAMMW0928
SASSAS0980
SARSAR1018
SACSACOL1053
SAXUSA300HOU_0992
SAASAUSA300_0947
SAOSAOUHSC_00984
SAENWMN_0914
SADSAAV_1008
SUUM013TW_0974(menH)
SUVSAVC_04390
SUESAOV_0990
SUJSAA6159_00901(yfbB)
SUKSAA6008_00999(yfbB)
SUCECTR2_900
SUTSAT0131_01079
SUQHMPREF0772_12190(menH)
SUZMS7_1002(menH)
SUDST398NM01_1042
SUXSAEMRSA15_08760
SUWSATW20_10410
SUGSAPIG1042
SUFSARLGA251_09590
SAUASAAG_02155
SAUERSAU_000933(menH)
SAUNSAKOR_00965
SAUSSA40_0915
SAUUSA957_0930
SAUGSA268_0932
SAUZSAZ172_0985
SAUTSAI1T1_2007380
SAUJSAI2T2_1007400
SAUKSAI3T3_1007390
SAUQSAI4T8_1007380
SAUVSAI7S6_1007390
SAUWSAI5S5_1007350
SAUXSAI6T6_1007360
SAUYSAI8T7_1007390
SAUFX998_1044(menH)
SABSAB0911
SUYSA2981_0999
SAUBC248_1069
SAUMBN843_9510
SAUCCA347_961(menH)
SAURSABB_03583
SAUIAZ30_04985
SAUDCH52_00660
SAMSNI36_04995
SUHSAMSHR1132_08930
SERSERP0631
SEPSE_0745
SEPPSEB_00721
SEPSDP17_2078(menH)
SHASH1918
SHHShL2_01781(yfbB_2)
SSPSSP1747
SCASCA_0653
SLGSLGD_01828
SLNSLUG_18240
SSDSPSINT_0741
SDTSPSE_1767
SDPNCTC12225_02004(menH)
SWAA284_08595
SPASSTP1_2105
SXYBE24_02545
SXLSXYLSMQ121_1748
SXOSXYL_01891(menH)
SHUSHYC_09130(menH)
SCAPAYP1020_0368(menH)
SSCHLH95_08550
SSCZRN70_09030
SAGQEP23_01295(menH)
SEQOSE1039_08030
SSIFAL483_06680(menH)
SCVA4G25_04665
SPETCEP67_00045(menH)
SLZB5P37_09245
SCOHBZ166_00655
SNLBJD96_09690
SKLC7J89_10495(menH)
SFQC7J90_06975(menH)
SHOMEGX58_01455(menH)
SMUSC7J88_00110(menH)
SCARDWB96_09460(menH)
SCHRDWB92_08605(menH)
SARLSAP2_17820(menH)
SPICSAMEA4384060_1911(menH)
SSHNCTC13712_00990(menH)
SSIMSAMEA4384339_0959(menH)
SDBCNQ82_05000(menH)
SLLOISP08_08780(menH)
SAULI6G39_08080(menH)
SSACI6I31_07445(menH)
SSCUCEP64_08460(menH)
SFFFOB90_10930(menH)
SSTESAMEA4384403_1818(menH)
MLENH3V22_13515(menH)
MVTI6J10_02240(menH)
MCLMCCL_1506
MCAKMCCS_19420(menH)
MACRBHM04_01225
MBOEHT586_09445(menH)
MARYLAU42_08480(menH)
SHVAAT16_08895
SBACBVH56_06225
JEAJEM45_00550(menH)
NAMPKPF49_05275(menH)
LMOlmo1674
LMNLM5578_1821
LMYLM5923_1773
LMTLMRG_01293
LMOCLMOSLCC5850_1737
LMOEBN418_1981
LMOBBN419_1984
LMODLMON_1741
LMOWAX10_02465
LMOQLM6179_2425(menH)
LMRLMR479A_1773(ytxM)
LMOMIJ09_01605
LMFLMOf2365_1698
LMCLm4b_01687
LMOGBN389_17020(ytxM)
LMPMUO_08610
LMOLLMOL312_1681
LMOJLM220_15890
LMOZLM1816_09767(menH)
LMOXAX24_05940
LMHLMHCC_0892
LMQLMM7_1763
LMLlmo4a_1731
LMGLMKG_02963
LMSLMLG_1198
LMJLMOG_00011
LMWLMOSLCC2755_1686
LMXLMOSLCC2372_1739
LMZLMOSLCC2482_1738
LMONLMOSLCC2376_1633
LMOSLMOSLCC7179_1647
LMOOLMOSLCC2378_1695
LMOYLMOSLCC2479_1737
LMOTLMOSLCC2540_1757
LMOALMOATCC19117_1689
LMOKCQ02_08585
LMVY193_07315(menH)
LINlin1782
LWElwe1692
LSGlse_1642
LIVLIV_1649
LIIJL52_08620
LIWAX25_08780
LIAJL58_08765
LIOJL53_09230
LWIUE46_10310
LMARLAX80_008035(menH)
BTHSCNY62_10555(menH)
ESIExig_0626
EATEAT1b_2373
EANEab7_0601
EXUESP131_05695
EAPKB235_13605
EACEKKI46_03465(menH)
AACAaci_1917
AADTC41_2016(menH)
AFXJZ786_15845(menH)
AACOK1I37_13160(menH)
EFFskT53_12940(menH)
SIVSSIL_1097
SSILSOLI23_12790
SOBCSE16_16465(menH)
PLNPlano_0991
PKUAUO94_11100
PRTAUC31_03905
PLLI858_001945
PANABBH88_14975
PDGBCM40_10435
PHCBBI08_01665
PMARB0X71_06375
PPLABBI15_01845
PFAEAJGP001_06120
PLXCW734_07575(menH)
PMATBBI11_06990
PDECH1Q58_06155(menH)
PGQFK545_14295(menH)
JEOJMA_25500
KURASO14_771(menH)
KZONCTC404_02969(menH)
SPSYAZE41_05375
SPORSporoP33_03500
SPOPSporoP37_04200
SURESporoP32a_04060
SPOSDV702_07790(menH)
SPAEE2C16_01655(menH)
RSTATY39_09565
PAEKD3873_08450(menH)
PANCE2636_05435(menH)
PLAYDNR44_014550(menH)
VIJJNUCC6_10265(menH)
NTRB0W44_12855
KPULGXN76_04690(menH)
KEBGXN75_05410(menH)
LLAL0170(menX)
LLKLLKF_0750(menX)
LLTCVCAS_0692(menX)
LLSlilo_0662(menX)
LLDP620_04020(menH)
LLXNCDO2118_0746(menX)
LLJLG36_0712(menX)
LLMllmg_1830(menX)
LLCLACR_0772
LLRllh_9215
LLNLLNZ_09415
LLIuc509_0736(menX)
LLWkw2_0679(menH)
LGRLCGT_0618
LGVLCGL_0637
LACTD7I46_01645(menH)
LTIJW886_04095(menH)
LNGBSQ50_03285
LHWBSQ49_00425
LMALLM596_00620(menH)
LCYLC20004_02970
LPDAYR62_00645
LGNABM34_02200
LBMDS830_07165(menH)
LMELEUM_0753
LMMMI1_03450
LMKLMES_0677
LCILCK_00951
LKILKI_00990
LECLGMK_01695
LCNC270_03685
LGSLEGAS_0914(menH)
LGEC269_04505
LLFBCR17_07735
LGCA9176_07135
LSUA6B45_03640
LPSEFGL85_06675(menH)
WCEWS08_0959
WCTWS74_1025
WCIWS105_1021
WCBAO080_04610
WJOFOL01_1527
WPACO680_01145(menH)
WCFC6P13_02325(menH)
WSOWSWS_01289(menH)
WHEEFA59_07050(menH)
WVRIE337_02135(menH)
EFAEF0449
EFLEF62_0768
EFIOG1RF_10334(menH)
EFDEFD32_0380
EFSEFS1_0329(menH)
EFNDENG_00435(menH)
EFQDR75_2439(menH)
ENEENT_25400
EHREHR_11565 EHR_11570
ECASECBG_02740
EMUEMQU_1437(menH)
EGAAL523_00635(menH)
ESSATZ33_13515
ETHCK496_06795(menH)
ECECNCTC12421_02103(menH)
EIEENLAB_09570(pip)
VTEBHY08_01925
VPIBW732_05290
VACE4Z98_02335(menH)
VAOFA707_02445(menH)
CMLBN424_3100(menH)
CDJBFC22_00600
CPASClopa_1998
CPATCLPA_c25460
CPAECPAST_c25460
ACOLK5I23_05225
TEBT8CH_1568(menH)
DSYDSY0519
DHDDhaf_0471
DDHDesde_1531
DMTDESME_13420
DEDDHBDCA_p1036
DECDCF50_p1092
DRSDEHRE_09650
VGUHYG85_16735(menH)
SAYTPY_3628(menH)
SAPSulac_1291
STHRBXT84_09745
ETMCE91St48_28600
VPRVpar_0375
VATB7L28_01995
VRM44547418_00396(menH)
VDNNCTC11831_00357(menH)
VNKVEIT17_03700
STEDSPTER_12090(menH)
LPILLIP_2424
ACITHPK19_21850(menH)
NCXNocox_20370
ABAIIMCC26256_111892
RXYRxyl_2894
RRDRradSPS_2312
RUBGBA63_16225(menH)
RMARGBA65_16935(menH)
BSOLFSW04_15645
CWOCwoe_3574
AFOAfer_1626
AYMYM304_23990(menH)
ATQGH723_10675
AQZKSP35_02185
IAMHC251_13710
CCUCcur_14030
ELEElen_2975
EYYEGYY_26910(MhpC)
EGDGS424_017055
AEQAEQU_2027
AHATADCFC_23010
RTSCE91St31_31150(menH)
CMPCha6605_3537
AMRAM1_4012
LENLEP3755_61050
LBOLBWT_47620
KOVK9N68_33680(menH)
LSKJ5X98_22820(menH)
PSERABRG53_3325
CHONNIES4102_16500
CYPPCC8801_3284
CYHCyan8802_2839
CYJCyan7822_5848
CYNCyan7425_3399
TERTery_4069
ARPNIES39_L00160
PAGHNIES204_07520
OXYHCG48_16750(menH)
MVAGD0A34_26165(menH)
LFSHFV01_02750(menH)
MICMic7113_6109
OACOscil6304_1887
ONIOsc7112_5498
MPROBJP34_18160
CEPCri9333_3868
ANAall2753
NPUNpun_R0088
NOSNos7107_5170
NOPNos7524_2259
NONNOS3756_37520
NFLCOO91_04925
NOECLI64_25165(menH)
NSHGXM_05680
NEDHUN01_27490(menH)
AVAAva_4319
NAZAazo_3702
ANBANA_C11508
ACYAnacy_0915
AWAAA650_24575
ANNEH233_01835(menH)
CSGCylst_5362
RSINB6N60_01511
CALOCal7507_0974
CALTCal6303_3133
CALHIJ00_14555
RIVRiv7116_6737
FISFIS3754_30350
DOUBMF77_01613(menH)
DFSHGD76_09815(menH)
CCURIAR63_04030(menH)
AFLOHEQ12_19485(menH)
TOQHCG51_20005(menH)
NCNBZZ01_27585
SCSSta7437_1787
STANSTA3757_23930
RRSRoseRS_4115
RCARcas_1310
CAUCaur_0087
CHLChy400_0095
CAGCagg_1168
TROtrd_A0259
STISthe_3023
PBFCFX0092_A0435(ytxM)
KBSEPA93_24685(menH)
TBHTbon_12775(menH)
TTRTter_1232
PCUPC_RS05140
PNLPNK_0813(menH)
PUVPUV_20290
NEYNCS13_1_0812
WCHwcw_1199
SNGSNE_A14240
RPORRHAB15C_0000469
CAACaka_1141
RUFIK0V07_11815
AMUAmuc_1017
AGLPYTT_0708
LUOHHL09_08635
LAMBKBB96_01040
SOAG3M56_005840
UAMUABAM_01397
RBARAWN76_007285
CTECT1845(menH)
CPCCpar_0358
CLZBIU88_10000
CCHCag_1720
CPHCpha266_2090
CPBCphamn1_2076
CLIClim_2049
PVICvib_0395
PLTPlut_0329
PPHPpha_2432
PAAPaes_1879
PROCPtc2401_01967(menH)
PRSB9H02_09445
PROSCHL67_10000(menH)
CTSCtha_1988
IALIALB_1319(menH)
MROMROS_1449
CPRVCYPRO_1678
 » show all
Reference
1  [PMID:18284213]
  Authors
Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z.
  Title
Identification and Characterization of (1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate Synthase in the Menaquinone Biosynthesis of Escherichia coli.
  Journal
Biochemistry 47:3426-34 (2008)
DOI:10.1021/bi7023755
  Sequence
[eco:b2263]
Reference
2  [PMID:17760421]
  Authors
Jiang M, Cao Y, Guo ZF, Chen M, Chen X, Guo Z.
  Title
Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity.
  Journal
Biochemistry 46:10979-89 (2007)
DOI:10.1021/bi700810x
  Sequence
[eco:b2263]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.99.20
IUBMB Enzyme Nomenclature: 4.2.99.20
ExPASy - ENZYME nomenclature database: 4.2.99.20
BRENDA, the Enzyme Database: 4.2.99.20
CAS: 122007-88-9

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