KEGG   ENZYME: 4.2.99.24Help
Entry
EC 4.2.99.24                Enzyme                                 

Name
thebaine synthase;
THS
Class
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases
BRITE hierarchy
Sysname
salutaridinol 7-O-acetate acetate-lyase (thebaine forming)
Reaction(IUBMB)
salutaridinol 7-O-acetate = thebaine + acetate [RN:R04769]
Reaction(KEGG)
Substrate
salutaridinol 7-O-acetate [CPD:C05322]
Product
thebaine [CPD:C06173];
acetate [CPD:C00033]
Comment
Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7.
History
EC 4.2.99.24 created 2019
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01742  thebaine synthase
Genes
PSOM: 113322169
Taxonomy
Reference
1  [PMID:29807982]
  Authors
Chen X, Hagel JM, Chang L, Tucker JE, Shiigi SA, Yelpaala Y, Chen HY, Estrada R, Colbeck J, Enquist-Newman M, Ibanez AB, Cottarel G, Vidanes GM, Facchini PJ
  Title
A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis.
  Journal
Nat Chem Biol 14:738-743 (2018)
DOI:10.1038/s41589-018-0059-7
  Sequence
[psom:113322169]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.99.24
IUBMB Enzyme Nomenclature: 4.2.99.24
ExPASy - ENZYME nomenclature database: 4.2.99.24
BRENDA, the Enzyme Database: 4.2.99.24

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