KEGG   ENZYME: 4.3.1.12
Entry
EC 4.3.1.12                 Enzyme                                 

Name
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Reaction(IUBMB)
L-ornithine = L-proline + NH3 [RN:R00671]
Reaction(KEGG)
R00671
Substrate
L-ornithine [CPD:C00077]
Product
L-proline [CPD:C00148];
NH3 [CPD:C00014]
Comment
Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].
History
EC 4.3.1.12 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01750  ornithine cyclodeaminase
Genes
DDI: DDB_G0292894
PTI: PHATRDRAFT_35643
FCY: FRACYDRAFT_224163
TPS: THAPSDRAFT_268092
ESA: ESA_01897
CSK: ES15_2054(ocd)
CSJ: CSK29544_03176
CCON: AFK62_09405
CDM: AFK67_09655
CSI: P262_02999
CTU: CTU_20900
YPE: YPO4090
YPK: y4106
YPH: YPC_4611
YPA: YPA_2995
YPN: YPN_3734
YPM: YP_3998
YPZ: YPZ3_3509
YPD: YPD4_3601
YPX: YPD8_3608
YPW: CH59_2046
YPJ: CH55_2771
YPV: BZ15_3613
YPL: CH46_961
YPS: YPTB3900
YPO: BZ17_2681
YPY: YPK_0007
YPB: YPTS_4117
YPQ: DJ40_2467
YPU: BZ21_3257
YPR: BZ20_2164
YPC: BZ23_3571
YPF: BZ19_3409
YEN: YE4168
YEY: Y11_30121
YEW: CH47_3555
YET: CH48_1630
YAL: AT01_2522
YFR: AW19_3299
YIN: CH53_1719
YKR: CH54_2491
YRO: CH64_2545
SPE: Spro_3024
RAA: Q7S_11735
ECA: ECA2039
EAM: EAMY_2207(Crym)
EAY: EAM_2129
EPY: EpC_14320
EPR: EPYR_01529(Crym)
PLU: plu3045
VVY: VV1563
PAE: PA4908
PAEV: N297_5078
PAEI: N296_5078
PAEP: PA1S_26640
PAEM: U769_26905
PAEL: T223_27100
PAEG: AI22_07355
PAEC: M802_5076
PAEO: M801_4943
PCQ: PcP3B5_20880(rapL_2)
PPT: PPS_2421
PPX: T1E_0019(arcB) T1E_1032(y4tK)
PPUH: B479_09255
PPUD: DW66_2681
PMON: X969_07215
PMOT: X970_07190
PFL: PFL_3641(arcB)
PPRC: PFLCHA0_c36820(arcB1)
PPRO: PPC_3781
PFS: PFLU_3970
PFC: PflA506_3344(arcB)
PFB: VO64_1052
PFW: PF1751_v1c34300(arcB)
PEN: PSEEN1859(arcB)
PSEC: CCOS191_1758(arcB2)
PSOS: POS17_3783
PANR: A7J50_3626
PSIL: PMA3_14245
PALI: A3K91_2015
CPS: CPS_2747
PHA: PSHAb0543
PTN: PTRA_b0777(ocd)
PEA: PESP_b0847(ocd)
PNG: PNIG_b0727(ocd)
PAGA: PAGA_b0945(ocd)
MVS: MVIS_1158(arcB)
MYA: MORIYA_4287(ocd)
CBU: CBU_1727(arcB)
CBS: COXBURSA331_A1919(arcB)
CBD: CBUD_0275(arcB)
CBG: CbuG_0108(arcB)
CBC: CbuK_0280(arcB)
CEY: CleRT_01960(arcB)
LPN: lpg2196
LPH: LPV_2448
LPO: LPO_2264
LPM: LP6_2223
LPF: lpl2120
LPP: lpp2145
LPC: LPC_1659
LPA: lpa_03151
LPE: lp12_2188
LLO: LLO_3403
LHA: LHA_2122
LOK: Loa_02512
LCD: clem_04720(rapL)
MAH: MEALZ_0771(arcB)
FTW: FTW_0394
FTL: FTL_0578
FTA: FTA_0612
FTS: F92_03155
FTC: DA46_105
FTV: CH67_891
FTZ: CH68_625
FTN: FTN_1444
FTX: AW25_557
FTD: AS84_1058
FTY: CH70_486
FPH: Fphi_1230
FPT: BZ13_774
FPI: BF30_1477
FPM: LA56_960
FPX: KU46_82
FPZ: LA55_1680
FPJ: LA02_848
FNA: OOM_0787
FRC: KX01_1779
GAI: IMCC3135_33495(rapL)
ADI: B5T_03949(arcB)
AXE: P40_19150
CVI: CV_3249(ocd)
RSL: RPSI07_mp0417(arcB)
RSN: RSPO_m00318(arcB)
RSM: CMR15_mp10460(arcB)
RSE: F504_3884
RSY: RSUY_37340(rapL_3)
REH: H16_A0689(h16_A0689) H16_A3673(h16_A3673) H16_B1881(h16_B1881)
CGD: CR3_2039
BOK: DM82_5356
BOC: BG90_5252
BCJ: BCAM0604
BCEN: DM39_4558
BCEO: I35_4500
BAM: Bamb_5311
BCT: GEM_5158
BCED: DM42_4486
BCON: NL30_22780
BUB: BW23_4328
BTEI: WS51_01570
BSEM: WJ12_23010
BPSL: WS57_10850
BMEC: WJ16_22040
BGP: BGL_1c14730(arcB)
BXB: DR64_8368(eutC)
BFN: OI25_3932(eutC)
PPNO: DA70_02520
PPNM: LV28_03815
PPUL: RO07_22880
PSPU: NA29_14215
PAPI: SG18_22245
CABA: SBC2_38100(ala_1) SBC2_61180(arcB_2) SBC2_69380(ocd_2)
BAV: BAV0458(arcB)
BHZ: ACR54_00645(rapL_1)
BTRM: SAMEA390648701743(arcB)
AXY: AXYL_00273(arcB)
TEA: KUI_0789(arcB)
TEG: KUK_0627(arcB)
TAS: TASI_0895
TAT: KUM_0109(arcB)
AMIM: MIM_c40550(arcB)
BPSI: IX83_00315
AFQ: AFA_18525
RFR: Rfer_3883
PNA: Pnap_3771
AAV: Aave_0121
AJS: Ajs_0613
AAA: Acav_0154
ACRA: BSY15_1884
DAC: Daci_0682
VPD: VAPA_1c48470(arcB)
CTES: O987_24910
LIM: L103DPR2_01265(rapL)
HYR: BSY239_28
HPSE: HPF_05975(rapL)
LCH: Lcho_0279
APET: ToN1_36090
AZA: AZKH_3290(ocd-2)
ALK: ALEK_1697(arcB)
DMS: E8L03_13995(eutC)
DALK: DSCA_61860
MXA: MXAN_7058
CCX: COCOR_00347(ocd1)
SME: SM_b20433(eutC) SM_b21494(ocd) SMa0486
SMD: Smed_3694
RHI: NGR_b18880(ocd1) NGR_b23260(ocd2)
SFH: SFHH103_04916(ocd1) SFHH103_05325(ocd1)
SFD: USDA257_c14360(arcB1) USDA257_c31380(ocd1)
EAD: OV14_a0459(ocd1)
EMX: FKV68_31045(eutC) FKV68_31720(eutC)
ATU: Atu3949(arcB) Atu4758(arcB) Atu6016(ocd)
ARA: Arad_10025(ocdch2) Arad_14151 Arad_7229(ocdch1)
AVI: Avi_5979(ocd) Avi_7398
RET: RHE_CH00058(ocdch1) RHE_CH02594 RHE_PF00181(ocdf)
RLE: RL0060 RL3003(arcB2) RL3095(arcB1) RL4459(ocd) pRL120053(arcB3)
RIR: BN877_II1097(ocd) BN877_II1136(arcB)
RGA: RGR602_PC02176(eutC)
RAD: CO657_26070(eutC)
RHT: NT26_3751(arcB) NT26_3907(ocd)
SHZ: shn_29375
KAI: K32_10430
BME: BMEII0397
BMEL: DK63_2841
BMEE: DK62_2556
BMF: BAB2_0338
BMB: BruAb2_0334(arcB)
BABO: DK55_2329
BABR: DO74_2749
BABT: DK49_2903
BABB: DK48_2362
BABU: DK53_2339
BABS: DK51_2918
BABC: DO78_2721
BMS: BRA0899(arcB)
BSI: BS1330_II0891(arcB)
BSF: BSS2_II0851(arcB)
BSZ: DK67_2852
BSV: BSVBI22_B0890(arcB)
BOV: BOV_A0842(arcB)
BCS: BCAN_B0918(arcB)
BOL: BCOUA_II0899(arcB)
BCAR: DK60_2589
BCAS: DA85_14770
BMR: BMI_II893(arcB)
BPP: BPI_II955(arcB)
BPV: DK65_2752
BCET: V910_200393(arcB)
BCEE: V568_200442(arcB)
BVL: BF3285c2_0422(arcB)
OAN: Oant_1471
OAH: DR92_1038
RPC: RPC_1858
XAU: Xaut_3506
AZC: AZC_2010(ocd2)
MEA: Mex_1p3003(arcB)
MDI: METDI3569(arcB)
MEX: Mext_2802
MCH: Mchl_3030
MPO: Mpop_2926
MET: M446_1826
MNO: Mnod_1216
META: Y590_13520
BBAR: RHAL1_02560(ocd)
MSC: BN69_2878
PLEO: OHA_1_00570(rapL)
AALA: IGS74_01720(eutC)
THD: BHV28_07820(arcb3)
PSF: PSE_0777(arcB) PSE_2943(arcB)
LABT: FIU93_05740(rapL2)
RUT: FIU92_06215(rapL1)
RSP: RSP_0854
RCP: RCAP_rcc02113(arcB1)
JAN: Jann_1530
RDE: RD1_1415(arcB)
RLI: RLO149_c033720(arcB)
PAMN: pAMV3p0337(arcB)
DSH: Dshi_2310
PGA: PGA1_c16390(arcB)
PGL: PGA2_c16220(arcB)
PGD: Gal_01704
PHP: PhaeoP97_01647(arcB)
PPIC: PhaeoP14_01541(arcB)
OAT: OAN307_c23960(arcB2)
OAR: OA238_c21340(arcB)
OTM: OSB_15220(rapL_3)
LAQU: R2C4_08710
PTP: RCA23_c24410(arcB)
CID: P73_4323
MALG: MALG_01627
SPSE: SULPSESMR1_01739(arcB)
ROH: FIU89_08840(rapL3)
LVS: LOKVESSMR4R_01472(arcB)
MARU: FIU81_06900(rapL2)
ROT: FIV09_11025(rapL2)
MALU: KU6B_34350
PAMO: BAR1_08715
GAK: X907_2174
HBA: Hbal_2672
SPHK: SKP52_05960(ocd)
SMAZ: LH19_02825
SPHI: TS85_10390
SECH: B18_11320
GOY: GLS_c16230(arcB)
AMV: ACMV_19460(arcB)
AZL: AZL_b04900(ocd)
ALI: AZOLI_p20520(ocd)
RRU: Rru_A2867
TMO: TMO_a0011
BAN: BA_0902
BAR: GBAA_0902
BAT: BAS0854
BAI: BAA_1005
BANT: A16_09810
BANR: A16R_09930
BANS: BAPAT_0866
BANV: DJ46_5371
BCE: BC0906
BCA: BCE_0995
BCZ: BCE33L0803(arcB)
BCQ: BCQ_0989(arcB)
BCX: BCA_0953
BNC: BCN_0901
BCF: bcf_04635
BCER: BCK_03705
BTK: BT9727_0800(arcB)
BTL: BALH_0814
BTT: HD73_1025
BTHI: BTK_05085
BTM: MC28_0162
BTG: BTB_c09770(ocd)
BTI: BTG_16770
BTW: BF38_2150
BWW: bwei_4101(arcB)
BMYO: BG05_5004
HLI: HLI_08565
PSYO: PB01_01735
SER: SERP0192
SEP: SE0315
SEPP: SEB_00237
SEPS: DP17_1625
SHA: SH2453
SSP: SSP2196
SLN: SLUG_22560(sbnB)
SPAS: STP1_1634
SARL: SAP2_22590
MCAK: MCCS_05590(rapL_2)
LLM: llmg_1149(ocd)
LLW: kw2_1295
STK: STP_0742
LCA: LSEI_0332
LCS: LCBD_0355
LCE: LC2W_0349
LSL: LSL_1273
LSI: HN6_01056
LSJ: LSJ_1259c
EFS: EFS1_0111
EFN: DENG_00120(ocd) DENG_00646(ocd)
ENE: ENT_01680
EFM: M7W_920
EHR: EHR_08120
EMU: EMQU_2065
THL: TEH_10850
CARC: NY10_848
JDA: BW727_101596(arcB_3)
CBO: CBO2575
CBA: CLB_2516
CBH: CLC_2447
CBY: CLM_2882
CBB: CLD_1990
CBI: CLJ_B2805
CBF: CLI_2638
CBM: CBF_2630
CSQ: CSCA_2959
CLD: CLSPO_c08830(arcB1) CLSPO_c26590(ala)
PDC: CDIF630_00657(arcB)
PHX: KGNDJEFE_02117(arcB)
TOC: Toce_0467
CAD: Curi_c05820(ocd)
ERH: ERH_1301(arcB)
CGL: NCgl1520(Cgl1582)
CEF: CE2115(ocd)
CAR: cauri_1343(arcB)
CRD: CRES_0238(arcB)
CCJ: UL81_05640(arcB)
CGV: CGLAU_07290(rapL)
NFA: NFA_48620
SMA: SAVERM_1790(arcB1) SAVERM_3645(arcB2) SAVERM_5617(arcB3)
SGR: SGR_560
SBH: SBI_09087
STRM: M444_14900
SRJ: SRO_1327
ARX: ARZXY2_3448(ocd)
XCE: Xcel_3303
IDO: I598_2651(rapL_2)
PAC: PPA1289
BSD: BLASA_2548(arcB)
AMD: AMED_1481(ocd) AMED_4796(ocd) AMED_6226(ocd)
AMM: AMES_1471(ocd) AMES_4737(ocd)
AMZ: B737_1472(ocd) B737_4737(ocd)
AYM: YM304_01710(ocd)
RCA: Rcas_3909
TDE: TDE2754(arcB)
ABAS: ACPOL_0050
TLI: Tlie_1581
 » show all
Reference
1  [PMID:4399881]
  Authors
Costilow RN, Laycock L.
  Title
Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.
  Journal
J Biol Chem 246:6655-60 (1971)
Reference
2  [PMID:4373469]
  Authors
Muth WL, Costilow RN.
  Title
Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme.
  Journal
J Biol Chem 249:7457-62 (1974)
Reference
3  [PMID:10468639]
  Authors
Espineda CE, Linford AS, Devine D, Brusslan JA.
  Title
The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana.
  Journal
Proc Natl Acad Sci U S A 96:10507-11 (1999)
DOI:10.1073/pnas.96.18.10507
Reference
4  [PMID:15518536]
  Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
  Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
  Journal
Biochemistry 43:13883-91 (2004)
DOI:10.1021/bi048207i
  Sequence
[ppu:PP_3533]
Reference
5  [PMID:15103146]
  Authors
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
  Title
Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida.
  Journal
Acta Crystallogr D Biol Crystallogr 60:941-4 (2004)
DOI:10.1107/S0907444904005256
  Sequence
[ppu:PP_3533]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.12
IUBMB Enzyme Nomenclature: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
BRENDA, the Enzyme Database: 4.3.1.12
CAS: 9054-76-6

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