KEGG   ENZYME: 4.3.1.16
Entry
EC 4.3.1.16                 Enzyme                                 

Name
threo-3-hydroxy-L-aspartate ammonia-lyase;
L-threo-3-hydroxyaspartate dehydratase;
threo-3-hydroxyaspartate ammonia-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)
Reaction(IUBMB)
threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 [RN:R05758]
Reaction(KEGG)
R05758
Substrate
threo-3-hydroxy-L-aspartate [CPD:C11511]
Product
oxaloacetate [CPD:C00036];
NH3 [CPD:C00014]
Comment
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Pseudomonas sp. T62, is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, or Ca2+.
History
EC 4.3.1.16 created 2001, modified 2011
Orthology
K22589  threo-3-hydroxy-L-aspartate ammonia-lyase
Genes
SCE: YKL218C(SRY1)
KPK: A593_26250
KMI: VW41_11195
CFD: CFNIH1_17105
CBRA: A6J81_03435
CYO: CD187_12890
CPOT: FOB25_00645
CFQ: C2U38_12860
CAMA: F384_08610
CAF: AL524_13625
CLAP: NCTC11466_02270(tdcB)
YEN: YE3209
YEY: Y11_21351
YEW: CH47_2578(srr)
YET: CH48_2628
YFR: AW19_2191(srr)
YKR: CH54_3595
SMW: SMWW4_v1c03400(tdcB)
SPE: Spro_1999
SRL: SOD_c18310(tdcB)
SPLY: Q5A_010030(tdcB_2)
SFJ: SAMEA4384070_2070(tdcB_2)
ECA: ECA2040
PATR: EV46_09810
PATO: GZ59_25600
PCT: PC1_2250
PEC: W5S_2531
DDD: Dda3937_02989(tdcB)
PLU: plu0803
PAY: PAU_00758
PMR: PMI1234
PHAU: PH4a_15510
XBO: XBJ1_0484
XBV: XBW1_4268(SRR)
XNE: XNC1_1232
XNM: XNC2_1208
XDO: XDD1_2878(SRR)
PRG: RB151_022360(tdcB)
PHEI: NCTC12003_02053(tdcB)
PRJ: NCTC6933_01926(psdht)
PAE: PA2683
PAEV: N297_2764(srr)
PAEI: N296_2764(srr)
PAEP: PA1S_12175
PAEM: U769_11740
PAEL: T223_12330
PAEG: AI22_21725
PAEC: M802_2761(srr)
PAEO: M801_2630(srr)
PFS: PFLU_2786
PANR: A7J50_2686
ACB: A1S_2394
ABY: ABAYE1083
ABN: AB57_2823
ABB: ABBFA_01033(tdcB_2)
ABAD: ABD1_23880(ilvA)
ABAZ: P795_4955
ABAU: IX87_08715
ABAA: IX88_15260
SPSW: Sps_01248
ILO: IL0222(tdcB)
PAT: Patl_3966
AMAL: I607_16225
AMAE: I876_16530
AMAO: I634_16480
AMAD: I636_16420
AMAI: I635_17165
AMAG: I533_16050
AMAC: MASE_16035
AAUS: EP12_16785
ASP: AOR13_74
GNI: GNIT_0779(ilvA)
GPS: C427_0448
SALH: HMF8227_00499(ilvA)
MMAI: sS8_4909
HCH: HCH_06914
RSO: RSp1516
RSL: RPSI07_mp1534(tdcB)
RSN: RSPO_m00468(tdcB)
RSM: CMR15_mp30162(tdcB)
RSE: F504_4987
RSY: RSUY_36570(tdcB)
RPI: Rpic_4000
REH: H16_B0554(tdcB)
CNC: CNE_2c05020(tdcB)
RME: Rmet_4825(tdcB)
CGD: CR3_0793(tdcB)
BMA: BMA2154
BMAL: DM55_2307
BMAE: DM78_922
BMAQ: DM76_2291
BMAI: DM57_934
BMAF: DM51_1807
BMAZ: BM44_1199
BMAB: BM45_764
BPS: BPSL2633
BPSE: BDL_2814
BPSM: BBQ_681
BPSU: BBN_809
BPSD: BBX_1213(srr)
BPK: BBK_2319(srr)
BPSH: DR55_1887
BPSA: BBU_2933(srr)
BPSO: X996_1533
BUT: X994_3527
BTE: BTH_I1524
BTQ: BTQ_2397(srr)
BTJ: BTJ_3286(srr)
BTZ: BTL_1203
BTD: BTI_991(srr)
BTV: BTHA_1308
BTHE: BTN_189
BTHM: BTRA_1425(srr)
BTHA: DR62_337
BTHL: BG87_1422
BOK: DM82_2266
BOC: BG90_2441
BVE: AK36_3871(sRR)
BCN: Bcen_3918
BCJ: BCAM1591
BCEN: DM39_3405(srr)
BCEW: DM40_4473(srr)
BCEO: I35_5450
BAM: Bamb_3882
BMJ: BMULJ_04328(ilvA)
BMU: Bmul_4177
BMK: DM80_5492(srr)
BMUL: NP80_4438(sRR)
BCT: GEM_4136
BCED: DM42_6369(srr)
BDL: AK34_3933
BCON: NL30_04285
BUB: BW23_3751(sRR)
BLAT: WK25_24805
BTEI: WS51_05600
BSEM: WJ12_27950
BPSL: WS57_06155
BMEC: WJ16_26650
BSTG: WT74_26435
BGU: KS03_5359(sRR)
BGO: BM43_4348(srr)
BUK: MYA_4212
BUL: BW21_1085
BXE: Bxe_A0886
BXB: DR64_3047(srr)
BPH: Bphy_3783
BFN: OI25_2314
PPNO: DA70_13385
PPNM: LV28_17315
PPUL: RO07_11440
PSPU: NA29_07260
PAPI: SG18_11820
CABA: SBC2_10930(thadh)
BPE: BP3420
BPC: BPTD_3372
BPER: BN118_3669
BPET: B1917_3188
BPEU: Q425_6940
BPAR: BN117_1095
BPA: BPP3570
BBR: BB4005
BPT: Bpet0902
BAV: BAV2221(tdcB)
BHO: D560_0040
BHM: D558_0041
BHZ: ACR54_02976(tdcB_2)
BTRM: SAMEA390648703031(tdcB_2)
AXX: ERS451415_01007(tdcB_1) ERS451415_02860(psdht)
PUT: PT7_2006
AMIM: MIM_c06040
AFQ: AFA_14460
POL: Bpro_3215
AAV: Aave_3217
AJS: Ajs_1894
AAA: Acav_2049
ACRA: BSY15_3349
VEI: Veis_0534
CTES: O987_17520
RTA: Rta_21220
LIM: L103DPR2_00777(tdcB)
JAG: GJA_1996(SRY1)
HSE: Hsero_0287(ilvA)
HRB: Hrubri_0269(ilvA)
CFU: CFU_1588
TIN: Tint_1987
URU: DSM104443_01412(thadh)
UPL: DSM104440_01321(thadh)
KCI: CKCE_0693
KCT: CDEE_0304
KBT: BCUE_0303
KDE: CDSE_0297
KGA: ST1E_0333
KON: CONE_0296
KSO: CKSOR_00083(tdcB)
HOH: Hoch_3492
RPO: MA1_02185
RPW: M9W_02185
RPZ: MA3_02210
RPG: MA5_03545
RPS: M9Y_02190
RPV: MA7_02180
RPQ: rpr22_CDS440(tdcB)
RPL: H375_1600
RPN: H374_6210
RTY: RT0436(tdcB)
RCM: A1E_03020
RCC: RCA_02755
RBE: RBE_0798(tdcB) RBE_0800
RAK: A1C_03410
RAU: MC5_04715
RBT: NOVO_03980(tdcB)
MHUA: MCHK_1079
AMIH: CO731_03432(psdht_2) CO731_04444(tdcB) CO731_05559(psdht_3)
EAD: OV14_3447
OAN: Oant_1807
OAH: DR92_1293(srr)
BOS: BSY19_405
MET: M446_4607
MNO: Mnod_0152
MOR: MOC_1213
MAQU: Maq22A_c08635(ilvA)
CAK: Caul_0656
CSE: Cseg_0855
PZU: PHZ_c0405
SECH: B18_25865
AZL: AZL_d04640(tdcB)
ALI: AZOLI_p40060(tdcB2)
TMO: TMO_1883
BFD: NCTC4823_02195(tdcB)
SAY: TPY_2825
MMC: Mmcs_2731
MJL: Mjls_2761
MVA: Mvan_3022
MGI: Mflv_3301
MPHL: MPHLCCUG_02445(tdcB)
MVQ: MYVA_3048
MHAS: MHAS_01878(tdcB)
MAUU: NCTC10437_02916(tdcB)
MMOR: MMOR_33980
MALV: MALV_06850
MARZ: MARA_08930
MGAD: MGAD_08690
MANY: MANY_40480
MPOF: MPOR_34400
SCO: SCO0821(SCF43A.11c)
SALB: XNR_2291
SHY: SHJG_2338
SFA: Sfla_0090
STRP: F750_6936
SALU: DC74_2994
SALL: SAZ_15995
STRE: GZL_05963
SLD: T261_5628
SAMB: SAM23877_6709(tdcB)
SRW: TUE45_01128(tdcB_1)
SLE: sle_06040(sle_06040)
STRD: NI25_02755
SFK: KY5_0977
SGE: DWG14_01035(tdcB_1)
SRJ: SRO_6975
SERJ: SGUI_1568
MPH: MLP_14420
KFL: Kfla_0632
NDA: Ndas_2436
STRR: EKD16_13440(tdcB)
TCU: Tcur_4423
SRO: Sros_4565
NML: Namu_5038
SEN: SACE_3404
AMN: RAM_44045
AMM: AMES_8450(ilvA)
AMZ: B737_8451(ilvA)
AOI: AORI_3409(ilvA) AORI_4006(ilvA) AORI_7367(ilvA)
AMQ: AMETH_0586(ilvA)
AMYY: YIM_00090(tdcB1) YIM_03240(tdcB2) YIM_31790(psdht2)
PDX: Psed_4043
PSEA: WY02_05070
PSEE: FRP1_08285
PSEH: XF36_12355
PAUT: Pdca_26800
SESP: BN6_04490
ACTN: L083_4153
AFS: AFR_18600
PFLA: Pflav_013890 Pflav_073690(ilvA_3)
PSUU: Psuf_003170 Psuf_035990(ilvA_2)
ATL: Athai_00240(ilvA)
PRY: Prubr_22630(ilvA)
LET: O77CONTIG1_00130(tdcB)
GVI: gll3869
GLJ: GKIL_2059(ilvA)
NSH: GXM_02335
AVA: Ava_2749
DOU: BMF77_01709(tdcB_1) BMF77_04408(tdcB_2)
CTHE: Chro_4020
RCA: Rcas_4359
TRA: Trad_0887
TAQ: TO73_0166
MRB: Mrub_0687
PNL: PNK_0512(ilvA)
PIR: VN12_11055(psdht)
ROL: CA51_06870(tdcB)
AHEL: Q31a_59340(tdcB_2)
LCRE: Pla8534_49630(tdcB)
AAGG: ETAA8_22720(tdcB_2) ETAA8_33950(tdcB_3) ETAA8_65240(psdht)
PLH: VT85_05760(psdht_1) VT85_07220(psdht_2)
FMR: Fuma_03572(tdcB_1)
MRI: Mal4_06170(psdht)
SDYN: Mal52_14540(tdcB_2)
IPA: Isop_3461
PBOR: BSF38_01089(tdcB) BSF38_01568(psdht)
AGV: OJF2_20950(tdcB)
ABAC: LuPra_05600(psdht)
GBA: J421_2397
SRU: SRU_1270(ilvA)
SRM: SRM_01459(ilvA)
RMR: Rmar_2122
ZGA: ZOBELLIA_2564(SrrA)
MLT: VC82_522
TLE: Tlet_1811
NMV: NITMOv2_0257(srr)
LOKI: Lokiarch_28720(tdcB_2) Lokiarch_39250(tdcB_4)
 » show all
Reference
1  [PMID:10481099]
  Authors
Wada M, Matsumoto T, Nakamori S, Sakamoto M, Kataoka M, Liu JQ, Itoh N, Yamada H, Shimizu S
  Title
Purification and characterization of a novel enzyme, L-threo-3-hydroxyaspartate dehydratase, from Pseudomonas sp. T62.
  Journal
FEMS Microbiol Lett 179:147-51 (1999)
DOI:10.1111/j.1574-6968.1999.tb08720.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.16
IUBMB Enzyme Nomenclature: 4.3.1.16
ExPASy - ENZYME nomenclature database: 4.3.1.16
BRENDA, the Enzyme Database: 4.3.1.16
CAS: 248270-70-4

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