KEGG   ENZYME: 4.3.1.4Help
Entry
EC 4.3.1.4                  Enzyme                                 

Name
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
Reaction(IUBMB)
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN:R02302]
Reaction(KEGG)
Substrate
5-formimidoyltetrahydrofolate [CPD:C00664]
Product
5,10-methenyltetrahydrofolate [CPD:C00445];
NH3 [CPD:C00014]
Comment
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
History
EC 4.3.1.4 created 1961, modified 2000
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K01746  formiminotetrahydrofolate cyclodeaminase
K13990  glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase
Genes
HSA: 10841(FTCD)
PTR: 107966286(FTCD)
PPS: 100977170(FTCD)
GGO: 101130780(FTCD) 109025493
PON: 100938847(FTCD)
NLE: 100603041(FTCD)
MCC: 721818(FTCD)
MCF: 102134897(FTCD)
CSAB: 103220313(FTCD)
RRO: 104667617(FTCD)
RBB: 108512162(FTCD)
CJC: 100408734(FTCD)
SBQ: 101051019(FTCD)
MMU: 14317(Ftcd)
RNO: 89833(Ftcd)
CGE: 100754097(Ftcd)
NGI: 103739976(Ftcd)
HGL: 101712457(Ftcd)
CCAN: 109695887(Ftcd)
OCU: 100356213(FTCD)
TUP: 102471947(FTCD)
CFA: 607685(FTCD)
AML: 100483097(FTCD)
UMR: 103680733(FTCD)
ORO: 101375831(FTCD)
FCA: 101080907(FTCD)
PTG: 102962298(FTCD)
AJU: 106987518(FTCD)
BTA: 535816(FTCD)
BOM: 102278178(FTCD)
BIU: 109561287(FTCD)
PHD: 102342678(FTCD)
CHX: 102175530(FTCD)
OAS: 101106741(FTCD)
SSC: 397517(FTCD)
CFR: 102517308(FTCD)
CDK: 105090587(FTCD)
BACU: 103009100(FTCD)
LVE: 103077712(FTCD)
OOR: 101288621(FTCD)
ECB: 100049972(FTCD)
EPZ: 103558414(FTCD)
EAI: 106842985(FTCD)
MYB: 102245572(FTCD)
MYD: 102761291(FTCD)
HAI: 109373830(FTCD)
RSS: 109438024(FTCD)
LAV: 100661017(FTCD)
TMU: 101341265
MDO: 100026368(FTCD)
SHR: 100933669(FTCD)
OAA: 100083636(FTCD)
GGA: 395726(FTCD)
MGP: 100547304(FTCD)
CJO: 107316363(FTCD)
APLA: 101789783(FTCD)
ACYG: 106049608(FTCD)
TGU: 100221117(FTCD)
GFR: 102031861(FTCD)
FAB: 101820680(FTCD)
PHI: 102106775(FTCD)
PMAJ: 107207263(FTCD)
CCW: 104694608(FTCD)
FPG: 101910482(FTCD)
FCH: 102051629(FTCD)
CLV: 102087672(FTCD)
EGZ: 104122532(FTCD)
AAM: 106482291(FTCD)
ASN: 102375778(FTCD)
AMJ: 102567824(FTCD)
PSS: 102463032(FTCD)
CMY: 102945805(FTCD)
CPIC: 101930891(FTCD)
ACS: 100558718(ftcd)
PVT: 110090942(FTCD)
PBI: 103060660(FTCD)
GJA: 107110724(FTCD)
XLA: 379483(ftcd.L)
XTR: 448617(ftcd)
NPR: 108793615(FTCD)
DRE: 394052(ftcd)
SRX: 107754243
SANH: 107687873(ftcd)
SGH: 107586964(ftcd)
CCAR: 109046911
IPU: 108259504(ftcd)
AMEX: 103024962(ftcd)
TRU: 101063507(ftcd)
NCC: 104964175(ftcd)
MZE: 101467078(ftcd)
OLA: 101171459(ftcd)
XMA: 102237820(ftcd)
NFU: 107384588(ftcd)
CSEM: 103389813(ftcd)
HCQ: 109510415(ftcd)
BPEC: 110173783(ftcd)
SASA: 100306782(ftcd) 106575213
ELS: 105022525(ftcd)
SFM: 108924266(ftcd)
LCM: 102362862(FTCD)
CMK: 103188928(ftcd)
CIN: 100184708
SPU: 580057
APLC: 110973508
ZNE: 110837014
CRG: 105334085
MYI: 110465531
OBI: 106871263
LAK: 106175096
EPA: 110249093
ADF: 107351438
AQU: 100642146
DDI: DDB_G0287977(ftcd)
DFA: DFA_02269 DFA_10621(ftcd)
DPS: DP2350
DML: Dmul_14970(ftcD2)
DAT: HRM2_43160(ftcD1) HRM2_44060(ftcD2)
DTO: TOL2_C11400(ftcD)
SPY: SPy_2084
SPYA: A20_1816(fchA)
SPS: SPs1772
SPF: SpyM51731
STZ: SPYALAB49_001754(fchA)
SPYH: L897_08815
SSA: SSA_0433
SGO: SGO_1807
SDS: SDEG_2058
SDA: GGS_1890
SDC: SDSE_2158
STK: STP_0393
SCP: HMPREF0833_11150(fchA)
SCF: Spaf_1718
SIK: K710_1367
CTC: CTC_02303
AMT: Amet_4586
OVA: OBV_12240
TOC: Toce_1472
LPIL: LIP_0268
HAU: Haur_0263
ATM: ANT_11210
TTR: Tter_0694
SUS: Acid_5208
GAU: GAU_0899
GBA: J421_2797
BACC: BRDCF_p344(fchA)
PMZ: HMPREF0659_A6723(ftcD)
PDN: HMPREF9137_1323(ftcD)
PIT: PIN17_A1822(ftcD)
PJE: CRM71_10935(ftcD)
AFD: Alfi_3019
ASH: AL1_04570
DORI: FH5T_01095
BLQ: L21SP5_03905(fchA)
MBAS: ALGA_2664
SGN: SGRA_0031
MUC: MuYL_1012
AUE: C5O00_10890(ftcD)
IAL: IALB_1037
MRO: MROS_0055
CACI: CLOAM0177(ftcd)
CABY: Cabys_2265
NDE: NIDE4164
HMA: pNG7381(ftc)
PTO: PTO1243
ABI: Aboo_1135
 » show all
Taxonomy
Reference
1
  Authors
Rabinowitz, J.C. and Pricer, W.E.
  Title
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid.
  Journal
J Am Chem Soc 78:5702-5704 (1956)
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.4
IUBMB Enzyme Nomenclature: 4.3.1.4
ExPASy - ENZYME nomenclature database: 4.3.1.4
BRENDA, the Enzyme Database: 4.3.1.4
CAS: 9032-05-7

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