KEGG   ENZYME: 4.3.2.11
Entry
EC 4.3.2.11                 Enzyme                                 
Name
(3R)-3-[(carboxylmethyl)amino]fatty acid synthase;
scoD (gene name);
mmaD (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
(3R)-3-[(carboxylmethyl)amino]fatty acid glycine-lyase ((2E)-unsaturated fatty acyl-[acyl-carrier protein]-forming)
Reaction(IUBMB)
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein] = a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O [RN:R13038]
Reaction(KEGG)
R13038
Substrate
(3R)-3-[(carboxylmethyl)amino]fatty acid [CPD:C22516];
[acyl-carrier protein] [CPD:C00229]
Product
(2E)-unsaturated fatty acyl-[acyl-carrier protein] [CPD:C00693];
glycine [CPD:C00037];
H2O [CPD:C00001]
Comment
The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R)-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein.
History
EC 4.3.2.11 created 2022
Orthology
K26055  (3R)-3-[(carboxylmethyl)amino]fatty acid synthase
Genes
MMAIsS8_4510
HNAHneap_0956
CHROCXB49_14785
BCAIK788_0006365
SURSTAUR_1687
MBDMEBOL_003554
CFUSCYFUS_003180
HOHHoch_6016
MTURv0098(fcoT)
MTVRVBD_0098
MTCMT0107
MRAMRA_0102
MTFTBFG_10099
MTBTBMG_00099
MTKTBSG_00099
MTZTBXG_000099
MTGMRGA327_00630
MTIMRGA423_00630
MTECCDC5079_0086
MTURCFBS_0104
MTLCCDC5180_0087
MTOMTCTRI2_0101
MTDUDA_0098
MTNERDMAN_0115
MTJJ112_00545
MTUBMT7199_0100(fcoT)
MTUCJ113_00665
MTUEJ114_00550
MTXM943_00550
MTUHI917_00705
MTULTBHG_00099
MTUTHKBT1_0104
MTUUHKBT2_0104
MTQHKBS1_0104
MBOBQ2027_MB0101(fcot)
MBBBCG_0131
MBTJTY_0102
MBMBCGMEX_0102
MBKK60_001100
MBXBCGT_3893
MAFMAF_00990
MMICRN08_0115
MCEMCAN_01011
MCQBN44_10121
MCVBN43_10116
MCXBN42_10136
MCZBN45_10114
MLEML1993
MLBMLBr01993
MULMUL_4855
MMIMMAR_0259
MMAEMMARE11_02420
MLIMULP_00231
MPSEMPSD_53400
MSHOMSHO_13060
MYVG155_20085
MHADB586_11340
MSHGMSG_00072 MSG_03153
MLWMJO58_18020
MPAGC0J29_01605
MGORH0P51_07730
MBAIMB901379_00193
MSPGF6B93_01075
MLMMLPF_3234(fcoT)
MFTXA26_41010
MFXMFAL_24240
MIJMINS_08850
MALVMALV_54140
MHEVMHEL_38340 MHEL_38410
MSARMSAR_36850 MSAR_36920
MAUBMAUB_23300 MAUB_23360
MPHUMPHO_47190
MMUCC1S78_023660
MBOKMBOE_32790
MFGK6L26_11645
MBRML2Z93_003585
MSENK3U95_09860
MABMAB_0660
MMVMYCMA_0347
MABBMASS_0631
MABLMMASJCM_0650
MCHEBB28_03150
MIZBAB75_03940
MSTEMSTE_00615
MSAOMYCSP_02840
MSALDSM43276_00571
MMINMMIN_13060
MHERK3U94_21320
MVMMJO54_21215
CPRECsp1_27290
NBRO3I_034370
NTPCRH09_21100
NOZDMB37_13100
NAHF5544_19265
NIEKV110_32410 KV110_33065
GAMGII34_17740
GPDGII33_17150
SMASAVERM_606
SGBWQO_03770
SBHSBI_00520
SGMGCM10017557_04930
SNWBBN63_00230
SGEDWG14_02622
SBYH7H31_00880 H7H31_26460
STSUB7R87_01585
SBROGQF42_33755
SHARHUT13_09605
SMAOCAG99_19770
AMYCCU254_21775
KALKALB_7699
CCAZCOUCH_33500
LEPLepto7376_4249
NSHGXM_09948
NEDHUN01_03910
CSGCylst_3962
RMLFF011L_31820
 » show all
Reference
1  [PMID:28634299]
  Authors
Harris NC, Sato M, Herman NA, Twigg F, Cai W, Liu J, Zhu X, Downey J, Khalaf R, Martin J, Koshino H, Zhang W.
  Title
Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.
  Journal
Proc Natl Acad Sci U S A 114:7025-7030 (2017)
DOI:10.1073/pnas.1705016114
  Sequence
[mtu:Rv0098]
Reference
2  [PMID:29906336]
  Authors
Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W.
  Title
Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.
  Journal
Angew Chem Int Ed Engl 57:9707-9710 (2018)
DOI:10.1002/anie.201804307
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.11
IUBMB Enzyme Nomenclature: 4.3.2.11
ExPASy - ENZYME nomenclature database: 4.3.2.11
BRENDA, the Enzyme Database: 4.3.2.11

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