KEGG   ENZYME: 4.3.2.5
Entry
EC 4.3.2.5                  Enzyme                                 
Name
peptidylamidoglycolate lyase;
alpha-hydroxyglycine amidating dealkylase;
peptidyl-alpha-hydroxyglycine alpha-amidating lyase;
HGAD;
PGL;
PAL;
peptidylamidoglycolate peptidylamide-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
[peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming)
Reaction(IUBMB)
[peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate [RN:R03874]
Reaction(KEGG)
R03874
Substrate
[peptide]-(2S)-2-hydroxyglycine [CPD:C03303]
Product
[peptide]-amide [CPD:C02179];
glyoxylate [CPD:C00048]
Comment
Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein.
History
EC 4.3.2.5 created 1992, modified 2019
Orthology
K18200  peptidylamidoglycolate lyase
K24006  peptidylglycine monooxygenase / peptidylamidoglycolate lyase
Genes
HSA5066(PAM)
PTR461974(PAM)
PPS100970635(PAM)
GGO101148887(PAM)
PON100449730(PAM)
NLE100603954(PAM)
MCC707733(PAM)
MCF101926659(PAM)
CSAB103244283(PAM)
CATY105576668(PAM)
PANU101026672(PAM)
TGE112626915(PAM)
RRO104669199(PAM)
RBB108527716(PAM)
TFN117064857(PAM)
PTEH111542665(PAM)
CJC100396001(PAM)
SBQ101034151(PAM)
CSYR103263009(PAM)
MMUR105875983(PAM)
OGA100956802(PAM)
MMU18484(Pam)
MCAL110305227(Pam)
MPAH110321660(Pam)
RNO25508(Pam)
MCOC116088825(Pam)
MUN110540758(Pam) 110540935 110543689
CGE100770162(Pam)
PLEU114699806(Pam)
NGI103738185(Pam)
HGL101716909(Pam)
CPOC100713254(Pam)
CCAN109689129(Pam) 109698017
DORD105989825(Pam)
DSP122117119(Pam)
NCAR124986502
OCU100352005(PAM)
OPI101526566(PAM)
TUP102499925(PAM)
CFA479145(PAM)
VVP112915565(PAM)
VLG121489468(PAM)
AML100484534(PAM)
UMR103656467(PAM)
UAH113255028(PAM)
UAR123799268(PAM)
ELK111148403
LLV125101073
MPUF101671790(PAM)
ORO101383156(PAM)
EJU114208638(PAM)
ZCA113929120(PAM)
MLX118017056(PAM)
FCA101084598(PAM)
PYU121012392(PAM)
PBG122491636(PAM)
PTG102961161(PAM)
PPAD109267636(PAM)
AJU106982276(PAM)
HHV120220005(PAM)
BTA280890(PAM)
BOM102271872(PAM)
BIU109562372(PAM)
BBUB102409727(PAM)
CHX102190130(PAM)
OAS101112815(PAM)
ODA120863478(PAM)
CCAD122439492(PAM)
SSC100526040(PAM)
CFR102509591(PAM)
CBAI105082012(PAM)
CDK105103083(PAM)
VPC102529765(PAM)
BACU103008694(PAM)
LVE103088789(PAM)
OOR101274063(PAM)
DLE111183960(PAM)
PCAD102993897(PAM)
PSIU116750498(PAM)
ECB791244(PAM)
EPZ103555847(PAM)
EAI106831159(PAM)
MYB102257709(PAM)
MYD102752613(PAM)
MMYO118655718(PAM)
MLF102422620(PAM)
MNA107544178(PAM)
PKL118703757(PAM)
HAI109394174(PAM)
DRO112307140(PAM)
SHON118977247(PAM)
AJM119047249(PAM)
PDIC114494537(PAM)
PHAS123818032(PAM)
MMF118641919(PAM)
RFQ117024680(PAM)
PALE102894575(PAM)
PGIG120590776(PAM)
PVP105304427(PAM)
RAY107509145(PAM)
MJV108391703(PAM)
TOD119260954(PAM)
SARA101547265(PAM)
LAV100655604(PAM)
TMU101356870
DNM101428897(PAM)
MDO100030601(PAM)
GAS123236274(PAM)
SHR100929728(PAM)
PCW110199219(PAM)
OAA100073355(PAM)
GGA427274(PAM)
PCOC116229802(PAM)
CJO107306340(PAM)
NMEL110389678(PAM)
APLA101795983(PAM)
ACYG106043740(PAM)
AFUL116500419(PAM)
TGU100227923(PAM)
LSR110477851(PAM)
SCAN103822855(PAM)
PMOA120500582(PAM)
OTC121332561(PAM)
PRUF121355586(PAM)
GFR102039677(PAM)
FAB101821831(PAM)
PHI102114573(PAM)
PMAJ107215969(PAM)
CCAE111940620(PAM)
CCW104693194(PAM)
ETL114064047(PAM)
ZAB102069666(PAM)
FPG101920860(PAM)
FCH102052743(PAM)
CLV102087217(PAM)
EGZ104135057(PAM)
NNI104010298(PAM)
ACUN113489698(PAM)
TALA104363524(PAM)
PADL103920863(PAM)
ACHC115336613(PAM)
AROW112970164(PAM)
NPD112951384(PAM)
DNE112988498 112992418
ASN102374229(PAM)
AMJ102559599(PAM)
CPOO109308144(PAM)
GGN109297455(PAM)
PSS102462977(PAM)
CMY102946187(PAM)
CPIC101942761(PAM)
TST117879396(PAM)
CABI116815270(PAM)
MRV120407700(PAM)
ACS100562563(pam)
PVT110079386(PAM)
SUND121924102(PAM)
PBI103055156(PAM)
TSR106548589(PAM)
PGUT117674609(PAM)
VKO123031660(PAM)
PMUA114606841(PAM)
ZVI118076918(PAM)
GJA107121208(PAM)
STOW125436547(PAM)
XLA379207(pam.L) 397736(pam.S)
XTR100170159(pam)
NPR108797815(PAM)
RTEM120931440(PAM)
BBUF120992549(PAM)
BGAR122924652(PAM)
DRE570822(pam)
SRX107715844 107737006
SANH107670040 107702561
SGH107558261(pam) 107560403
CCAR109097266 109098036
CAUA113053993 113109552
PPRM120483160(pam)
MAMB125255806(pam)
IPU108277198(pam)
PHYP113543505(pam)
SMEO124393835(pam)
TFD113639276(pam)
AMEX103031431(pam)
EEE113576732(pam)
TRU101062613(pam)
TNGGSTEN00013653G001
LCO104938829(pam)
CGOB115017065(pam)
ELY117269835(pam)
PLEP121960283(pam)
SLUC116041373(pam)
ECRA117958843(pam)
PFLV114570620(pam)
GAT120831508(pam)
PPUG119226240(pam)
MSAM119914308(pam)
CUD121525000(pam)
MZE101484633(pam)
ONL100700800(pam)
OAU116319154(pam)
OLA101164528(pam)
OML112140341(pam)
XMA102227462(pam)
XCO114149523(pam)
XHE116724732(pam)
PRET103473165(pam)
PFOR103152322
PLAI106947015(pam)
PMEI106922489(pam)
GAF122819675(pam)
CVG107098487(pam)
CTUL119797739(pam)
GMU124872307(pam)
NFU107395057(pam)
KMR108246466(pam)
ALIM106522199(pam)
NWH119424389(pam)
AOCE111579145(pam)
CSEM103389193(pam)
POV109637635(pam)
SSEN122758574(pam)
HHIP117771409(pam)
LCF108877750(pam)
SDU111221118(pam)
SLAL111659622(pam)
XGL120806189(pam)
HCQ109530660(pam)
BPEC110161642(pam)
MALB109960744(pam)
SASA106571984(pam)
OTW112219988(pam)
OMY110523161(pam)
OGO123989512(pam)
ONE115118014(pam)
SALP111961960(pam)
SNH120025478(pam)
ELS105020460(pam)
SFM108929922(pam)
PKI111835769(pam)
AANG118212765(pam)
LOC102682623(pam)
PSPA121302893(pam) 121315078
ARUT117409376 117963343
LCM102348819(PAM)
CMK103178402(pam)
RTP109919477(pam)
BFO118407264 118409685
BBEL109470824 109482227
CIN100186640
SCLV120333720 120334207
SPU579753 587198
APLC110987818
SKO100370314 100373175 102808073
DMEDmel_CG12130(Pal1) Dmel_CG5472(Pal2)
DER6541448 6547868
DSE6608435 6615755
DSIDsimw501_GD10702(Dsim_GD10702) Dsimw501_GD11785(Dsim_GD11785)
DYADyak_GE14315 Dyak_GE19318
DAN6495917 6496404
DSR110177054 110180690
DPODpse_GA11425 Dpse_GA18906
DPE6592784 6593030
DMN108158680 108158961 117185951 117194126
DWI6641076 6652435
DGR6560913 6561212
DMODmoj_GI20014 Dmoj_GI20251
DAZ108616536 108616564
DNV108654373 108654454
DHE111593849 111600629
DVI6625579 6626018
CCAT101455585 101456470
BOD106620753 106624845
MDE101897104 101897772
SCAC106080801 106091732
LCQ111681427 111681954
AGAAgaP_AGAP005784 AgaP_AGAP007606
ACOZ120947392 120952938
AARA120893804 120894091
AAG5571279 5579975
AALB109417982 109622343
CQUCpipJ_CPIJ000256 CpipJ_CPIJ005687
CPII120427439 120428750
CNS116346954 116347859
AME408568
ACER108002175
ALAB122715792
BIM100741817
BBIF117204104
BVK117239857
BVAN117158230
BTER100644430
BPYO122574499
CCAL108630380
OBB114873553
NMEA116426907
CGIG122405238
SOC105193621 105199939
MPHA105839940
AEC105153715 105154160
ACEP105622782 105626661
PBAR105424879 105429536
VEM105562634 105568363
HST105187606 105191264
DQU106741045 106741852
CFO105256161 105256681
FEX115236132 115241061
LHU105669317 105679657
PGC109860270 109862749
OBO105275266 105276820
PCF106788478 106788980
PFUC122520739 122522137
VPS122637433 122637841
NVI100114818 100122955
CSOL105361409 105362823
TPRE106653543
MDL103569578 103570412
CGLO123259187 123268943
FAS105264633
DAM107038240 107043180
AGIF122850645 122853364
CCIN107266516 107275181
TCA657814
DPA109540523
SOY115885428 115890881
ATD109598830
CSET123308297
AGB108907151
LDC111506733
NVL108563948
APLN108737040
PPYR116158659 116164887
OTU111423876
BMOR101742958 105841291
BMAN114242070 114247451
MSEX115444747 115448582 119191969
DPLKGM_202935 KGM_215724
BANY112045179 112050125 112057358
PMAC106714150 106716757
PPOT106099339 106102385
PXU106114412 106124772
PRAP110991508 111001871
ZCE119831604 119838812
HAW110370575 110372930
TNL113501766 113504497
SLIU111349264 111353138
OFU114359644 114366202
PXY105387500 105390219 105395950
API100162090 100166463
DNX107163745 107173682
AGS114128973 114132119
RMD113551314 113560512
BTAB109031371 109035806 109036031
DCI103514212
CLEC106664759 106665330
HHAL106685326
NLU111046785 111049966 120348819
PHUPhum_PHUM262630 Phum_PHUM387350
FOC113213595 113217573
ZNE110830633 110837948
CSEC111862811 111866180
FCD110845914 110846222 110846791
DPXDAPPUDRAFT_327379 DAPPUDRAFT_330720
DMK116919032 116930770 123466817
PVM113800005 113815933 113815942
PJA122253825 122266205
PCHN125041365
HAME121866941 121870797
PCLA123745782 123757522
PTRU123505879 123506128
HAZT108671767
EAF111695161 111695791 111702393
LSM121121168 121129077
ISCIscW_ISCW004436
DSV119433786 119442465
RSAN119405325
RMP119159463 119181443 119185517
TUT107362202 107370625
DPTE113796289 113799508
DFR124492876 124496248
CSCU111617460 111633922
PTEP107452529
SDM118194459 118205964
CELCELE_F21F3.1(pgal-1) CELE_T19B4.1(pamn-1)
CBRCBG_14919(Cbr-pamn-1) CBG_20492(Cbr-pgal-1)
LOALOAG_02126 LOAG_18084
NAINECAME_00981 NECAME_06614
TSPTsp_08245
HROHELRODRAFT_90150 HELRODRAFT_90186
LGILOTGIDRAFT_128636 LOTGIDRAFT_204047
PCAN112553876 112554259
BGT106059574 106074305
GAE121386141
HRF124143750 124146994 124147038
HRJ124288942
CRG105320938
MYI110443164 110453761
PMAX117334163
MMER123565313
OBI106870427 106875056
OSN115218053
LAK106162187
SMMSmp_156530
SHXMS3_0014254
OVIT265_04845 T265_08837
EGLEGR_00446
NVE5505959 5513959
EPA110253509 110253517
ATEN116290559 116306504
ADF107333635
AMIL114961864 114967143
PDAM113668474 113672672
SPIS111322235
DGT114522559 114541151
XEN124452262 124454721
HMG100212200
TADTRIADDRAFT_63754
CRECHLRE_03g152850v5
VCNVOLCADRAFT_120843
CSLCOCSUDRAFT_65252
APROF751_4456
OLUOSTLU_15206(PAM1)
OTAOT_ostta04g04860
BPGBathy08g04470
MISMICPUN_70293
MPPMICPUCDRAFT_60313
EMVHQR01_11890
PNSA9D12_10760
EATEAT1b_2563
EXMU719_07590
STPStrop_2878
CATICS0771_54180
ROOG5S37_12440
PSEGD3H65_32540
PGINFRZ67_14645
FLSGLV81_02430
LACSH4075_12625
PSTYBFS30_16400
PGSCPT03_09935
SHTKO02_09560
SMIZ4412673_03632
MUHHYN43_024645
MRUBDEO27_026125
MGOSDIU38_029515
MMABHQ865_19780
AGDFRZ59_06715
SBXCA265_01595
CMRCycma_2166
CAMUCA2015_2102
ESTDN752_08820
ECHIFKX85_02110
FBCFB2170_01457
ZGAZOBELLIA_2005
PHALH9I45_14220
AALGAREALGSMS7_00469
AQDD1816_07170
FBEFF125_12995
 » show all
Reference
1  [PMID:2207061]
  Authors
Katopodis AG, Ping D, May SW.
  Title
A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation.
  Journal
Biochemistry 29:6115-20 (1990)
DOI:10.1021/bi00478a001
Reference
2  [PMID:9405058]
  Authors
Bell J, Ash DE, Snyder LM, Kulathila R, Blackburn NJ, Merkler DJ
  Title
Structural and functional investigations on the role of zinc in bifunctional rat  peptidylglycine alpha-amidating enzyme.
  Journal
Biochemistry 36:16239-46 (1997)
DOI:10.1021/bi970903d
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.5
IUBMB Enzyme Nomenclature: 4.3.2.5
ExPASy - ENZYME nomenclature database: 4.3.2.5
BRENDA, the Enzyme Database: 4.3.2.5
CAS: 131689-50-4

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