KEGG   ENZYME: 4.3.2.5
Entry
EC 4.3.2.5                  Enzyme                                 
Name
peptidylamidoglycolate lyase;
alpha-hydroxyglycine amidating dealkylase;
peptidyl-alpha-hydroxyglycine alpha-amidating lyase;
HGAD;
PGL;
PAL;
peptidylamidoglycolate peptidylamide-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
[peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming)
Reaction(IUBMB)
[peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate [RN:R03874]
Reaction(KEGG)
R03874
Substrate
[peptide]-(2S)-2-hydroxyglycine [CPD:C03303]
Product
[peptide]-amide [CPD:C02179];
glyoxylate [CPD:C00048]
Comment
Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein.
History
EC 4.3.2.5 created 1992, modified 2019
Orthology
K18200  peptidylamidoglycolate lyase
K24006  peptidylglycine monooxygenase / peptidylamidoglycolate lyase
Genes
HSA5066(PAM)
PTR461974(PAM)
PPS100970635(PAM)
GGO101148887(PAM)
PON100449730(PAM)
PPYG129037163(PAM)
NLE100603954(PAM)
HMH116470968(PAM)
SSYN129492549(PAM)
MCC707733(PAM)
MCF101926659(PAM)
MTHB126957228
MNI105471068(PAM)
CSAB103244283(PAM)
CATY105576668(PAM)
PANU101026672(PAM)
TGE112626915(PAM)
MLEU105554887(PAM)
RRO104669199(PAM)
RBB108527716(PAM)
TFN117064857(PAM)
PTEH111542665(PAM)
CANG105524723(PAM)
CJC100396001(PAM)
SBQ101034151(PAM)
CIMI108291406(PAM)
ANAN105722350(PAM)
CSYR103263009(PAM)
MMUR105875983(PAM)
LCAT123648435(PAM)
PCOQ105807623(PAM)
OGA100956802(PAM)
MMU18484(Pam)
MCAL110305227(Pam)
MPAH110321660(Pam)
RNO25508(Pam)
MCOC116088825(Pam)
ANU117722233(Pam)
MUN110540758(Pam)
CGE100770162(Pam)
MAUA101829991(Pam)
PROB127226743(Pam)
PLEU114699806(Pam)
MORG121433406(Pam)
MFOT126508296
AAMP119820391(Pam)
NGI103738185(Pam)
HGL101716909(Pam)
CPOC100713254(Pam)
CCAN109689129(Pam) 109698017
DORD105989825(Pam)
DSP122117119(Pam)
PLOP125339850(Pam)
NCAR124986502
MMMA107140778(Pam)
OCU100352005
OPI101526566(PAM)
TUP102499925(PAM)
GVR103593467(PAM)
CFA479145(PAM)
CLUD112654112(PAM)
VVP112915565(PAM)
VLG121489468(PAM)
NPO129501613(PAM)
AML100484534(PAM)
UMR103656467(PAM)
UAH113255028(PAM)
UAR123799268(PAM)
ELK111148403
LLV125101073
MPUF101671790(PAM)
MNP132028823(PAM)
MLK131832499(PAM)
NVS122917187(PAM)
ORO101383156(PAM)
EJU114208638(PAM)
ZCA113929120(PAM)
MLX118017056(PAM)
NSU110590755(PAM)
LWW102745099(PAM)
FCA101084598(PAM)
PYU121012392(PAM)
PCOO112860269(PAM)
PBG122491636(PAM)
PVIV125161563(PAM)
LRUF124519496
PTG102961161(PAM)
PPAD109267636(PAM)
PUC125934337
AJU106982276
HHV120220005(PAM)
BTA280890(PAM)
BOM102271872(PAM)
BIU109562372(PAM)
BBUB102409727(PAM)
BBIS104982553(PAM)
CHX102190130(PAM)
OAS101112815(PAM)
BTAX128051451(PAM)
ODA120863478(PAM)
CCAD122439492(PAM)
MBEZ129558554(PAM)
SSC100526040(PAM)
CFR102509591(PAM)
CBAI105082012(PAM)
CDK105103083(PAM)
VPC102529765(PAM)
BACU103008694(PAM)
BMUS118893484(PAM)
LVE103088789(PAM)
OOR101274063(PAM)
DLE111183960(PAM)
PCAD102993897(PAM)
PSIU116750498(PAM)
NASI112396130(PAM)
ECB791244(PAM)
EPZ103555847(PAM)
EAI106831159(PAM)
MYB102257709(PAM)
MYD102752613(PAM)
MMYO118655718(PAM)
MLF102422620(PAM)
PKL118703757(PAM)
EFUS103288742(PAM)
MNA107544178(PAM)
DRO112307140(PAM)
SHON118977247(PAM)
AJM119047249(PAM)
PDIC114494537(PAM)
PHAS123818032(PAM)
MMF118641919(PAM)
PPAM129083931(PAM)
HAI109394174(PAM)
RFQ117024680(PAM)
PALE102894575(PAM)
PGIG120590776(PAM)
PVP105304427(PAM)
RAY107509145(PAM)
MJV108391703(PAM)
TOD119260954(PAM)
SARA101547265(PAM)
SETR126001926(PAM)
LAV100655604(PAM)
TMU101356870
ETF101662573(PAM)
DNM101428897(PAM)
MDO100030601(PAM)
GAS123236274(PAM)
SHR100929728(PAM)
AFZ127560527
PCW110199219(PAM)
TVP118830590(PAM)
OAA100073355(PAM)
GGA427274(PAM)
PCOC116229802(PAM)
CJO107306340(PAM)
TPAI128089489(PAM)
LMUT125687282(PAM)
NMEL110389678(PAM)
APLA101795983(PAM)
ACYG106043740(PAM)
CATA118260084(PAM)
AFUL116500419(PAM)
TGU100227923(PAM)
LSR110477851(PAM)
SCAN103822855(PAM)
PMOA120500582(PAM)
OTC121332561(PAM)
PRUF121355586(PAM)
GFR102039677(PAM)
FAB101821831(PAM)
OMA130264919(PAM)
PHI102114573(PAM)
PMAJ107215969(PAM)
CCAE111940620(PAM)
CCW104693194(PAM)
CBRC103613059(PAM)
ETL114064047(PAM)
ZAB102069666(PAM)
ZLE135459288(PAM)
SVG106863061(PAM)
MMEA130586850
HRT120765045(PAM)
FPG101920860(PAM)
FCH102052743(PAM)
CLV102087217(PAM)
EGZ104135057(PAM)
NNI104010298(PAM)
PCRI104029410(PAM)
PLET104619390(PAM)
EHS104507079(PAM)
PCAO104044911(PAM)
ACUN113489698(PAM)
TALA104363524(PAM)
PADL103920863(PAM)
AFOR103903061(PAM)
ACHC115336613(PAM)
HALD104316339(PAM)
HLE104830258(PAM)
AGEN126036477
GCL127027149
CCRI104158631(PAM)
CSTI104549454
CMAC104484951(PAM)
BREG104629990(PAM)
FGA104074433(PAM)
LDI104346787(PAM)
OHA104327527(PAM)
NNT104402404(PAM)
SHAB115619349(PAM)
DPUB104302573(PAM)
PGUU104464770(PAM)
ACAR104522283(PAM)
CPEA104397259(PAM)
AVIT104279353(PAM)
CVF104292311(PAM)
RTD128902291(PAM)
CUCA104058390(PAM)
TEO104374810(PAM)
AROW112970164(PAM)
NPD112951384(PAM)
TGT104568553(PAM)
DNE112988498 112992418
SCAM104140158(PAM)
ASN102374229(PAM)
AMJ102559599(PAM)
CPOO109308144(PAM)
GGN109297455(PAM)
PSS102462977(PAM)
CMY102946187(PAM)
CCAY125636433(PAM)
DCC119855451(PAM)
CPIC101942761(PAM)
TST117879396(PAM)
CABI116815270(PAM)
MRV120407700(PAM)
ACS100562563(pam)
ASAO132767177(PAM)
PVT110079386(PAM)
SUND121924102(PAM)
PBI103055156(PAM)
CTIG120306039(PAM)
TSR106548589(PAM)
PGUT117674609(PAM)
APRI131190111(PAM)
PTEX113448749(PAM)
NSS113415426(PAM)
VKO123031660(PAM)
PMUA114606841(PAM)
PRAF128423318(PAM)
ZVI118076918(PAM)
HCG128343029(PAM)
GJA107121208(PAM)
STOW125436547(PAM)
EMC129334290(PAM)
XLA379207(pam.L) 397736(pam.S)
XTR100170159(pam)
NPR108797815(PAM)
RTEM120931440(PAM)
BBUF120992549(PAM)
BGAR122924652(PAM)
MUO115463171(PAM)
GSH117352610(PAM)
DRE570822(pam)
SRX107715844 107737006
SANH107670040 107702561
SGH107558261(pam) 107560403
CCAR109097266 109098036
CAUA113053993 113109552
CGIB127966314 128021433
PTET122352678(pam)
LROH127171703(pam)
OMC131547997(pam)
PPRM120483160(pam)
MAMB125255806(pam)
CIDE127520520
MASI127432330 127433275
TROS130545926(pam)
TDW130411485(pam)
MANU129447594(pam)
IPU108277198
IFU128619989(pam)
PHYP113543505(pam)
SMEO124393835(pam)
TFD113639276(pam)
TVC132863745(pam)
TRN134332132(pam)
AMEX103031431(pam)
CMAO118824741(pam)
EEE113576732(pam)
CHAR105894612(pam)
TRU101062613(pam)
TFS130516843(pam)
TNGGSTEN00013653G001
LCO104938829(pam)
TBEN117474446(pam)
CGOB115017065(pam)
PGEO117455911(pam)
GACU117557435(pam)
EMAC134868393(pam)
ELY117269835(pam)
EFO125905793(pam)
PLEP121960283(pam)
SLUC116041373(pam)
ECRA117958843(pam)
PFLV114570620(pam)
GAT120831508(pam)
PPUG119226240(pam)
AFB129102660(pam)
CLUM117740491(pam)
PSWI130205500(pam)
MSAM119914308(pam)
SCHU122865869(pam)
CUD121525000(pam)
ALAT119030296(pam)
MZE101484633(pam)
ONL100700800(pam)
OAU116319154(pam)
OLA101164528(pam)
OML112140341(pam)
CSAI133455498(pam)
XMA102227462(pam)
XCO114149523(pam)
XHE116724732(pam)
PRET103473165(pam)
PFOR103152322
PLAI106947015(pam)
PMEI106922489(pam)
GAF122819675(pam)
PPRL129379781(pam)
CVG107098487(pam)
CTUL119797739(pam)
GMU124872307(pam)
NFU107395057(pam)
KMR108246466(pam)
ALIM106522199(pam)
NWH119424389(pam)
AOCE111579145(pam)
MCEP124996364(pam)
CSEM103389193(pam)
POV109637635(pam)
SSEN122758574(pam)
HHIP117771409(pam)
HSP118098063(pam)
PPLT128424769(pam)
SMAU118284799(pam)
LCF108877750
SDU111221118(pam)
SLAL111659622(pam)
XGL120806189(pam)
HCQ109530660(pam)
SSCV125979803
SBIA133490609(pam)
PEE133414017(pam)
PTAO133465262(pam)
BPEC110161642(pam)
MALB109960744(pam)
BSPL114867236(pam)
SJO128379787(pam)
SASA106571984(pam)
STRU115160105(pam)
OTW112219988(pam)
OMY110523161(pam)
OGO123989512(pam)
ONE115118014(pam)
OKI109868844(pam)
OKE118387260(pam)
SALP111961960(pam)
SNH120025478(pam)
CCLU121581954(pam)
ELS105020460(pam)
SFM108929922(pam)
PKI111835769(pam)
AANG118212765(pam)
LOC102682623(pam)
PSPA121302893(pam) 121315078
ARUT117409376 117963343
PSEX120532663(pam)
LCM102348819(PAM)
CMK103178402(pam)
RTP109919477(pam)
CPLA122559877(pam)
HOC132823331(pam)
LERI129695861(pam)
PMRN116950708 116954932
LRJ133360938(PAM)
BFO118407264 118409685
BBEL109470824 109482227
CIN100186640
SCLV120333720 120334207
SPU579753 587198
LPIC129261976
APLC110987818
ARUN117295427
SKO100370314 100373175 102808073
DMEDmel_CG12130(Pal1) Dmel_CG5472(Pal2)
DER6541448 6547868
DSE6608435 6615755
DSIDsimw501_GD10702(Dsim_GD10702) Dsimw501_GD11785(Dsim_GD11785)
DYADyak_GE14315 Dyak_GE19318
DAN6495917 6496404
DSR110177054 110180690
DPO4804533 4804713
DPE6592784 6593030
DMN108158680 108158961 117185951 117194126
DWI6641076 6652435
DGR6560913 6561212
DMODmoj_GI20014 Dmoj_GI20251
DAZ108616536 108616564
DNV108654373 108654454
DHE111593849 111600629
DVI6625579 6626018
CCAT101455585 101456470
BOD106620753 106624845
BDR105227732 105227807
RZE108361266 108376966
AOQ129245590 129247023
TDA119677971 119678536 119678831 119684223
MDE101897104 101897772
SCAC106080801 106091732
LCQ111681427 111681954
LSQ119600038 119609089
GFS119639718 119640309
ECOE129949407 129949782
CLON129611002 129611026
HIS119660118 119661513
AGA1269623 1276453
ACOZ120947392 120952938
AARA120893804 120894091
AMER121591391 121594156
ASTE118511439 118514168
AFUN125768688 125769331
AMOU128305296 128305443
AALI118467085 118467716
AAG5571279 5579975
AALB109417982 109622343
ASUA134210373 134214130
CQUCpipJ_CPIJ000256 CpipJ_CPIJ005687
CPII120427439 120428750
CNS116346954 116347859
BCOO119074112 119083604
AME408568
ACER108002175
ALAB122715792
ADR102671915
AFLR100869356
BIM100741817
BBIF117204104
BVK117239857
BVAN117158230
BTER100644430
BAFF126919397
BPYO122574499
BPAS132911018
FVI122534282
CCAL108630380
OBB114873553
OLG117601058
NMEA116426907
CGIG122405238
SOC105193621 105199939
MPHA105839940
AEC105153715 105154160
ACEP105622782 105626661
PBAR105424879 105429536
VEM105562634 105568363
HST105187606 105191264
DQU106741045 106741852
CFO105256161 105256681
FEX115236132 115241061
LHU105669317 105679657
PGC109860270 109862749
OBO105275266 105276820
PCF106788478 106788980
PFUC122520739 122522137
VPS122637433 122637841
VCRB124426015 124426021
VVE124946503 124957963
NVI100114818 100122955
CSOL105361409 105362823
TPRE106653543
LHT122503014
LBD127290501
MDL103569578 103570412
CGLO123259187 123268943
FAS105264633
DAM107038240 107043180
AGIF122850645 122853364
VCAN122412620 122415165
CCIN107266516 107275181
DSM124411322 124415995
NPT124218129 124218679
NFB124180068 124182996
NLO107225522 107227985
NVG124302555 124304458
AROA105684716 105690256
TCA657814
DPA109540523
SOY115885428 115890881
AGRG126742646
ATD109598830
CSET123308297
AGB108907151
LDC111506733
DVV114328644
NVL108563948
APLN108737040
PPYR116158659 116164887
OTU111423876
BMOR101742958 105841291
BMAN114242070 114247451
MSEX115444747 115448582 119191969
DPLKGM_202935 KGM_215724
BANY112045179 112050125
MJU123876018
NIQ126770237 126775113
VCD124533534 124537644
MCIX123654480 123661861
PMAC106714150 106716757
PPOT106099339 106102385
PXU106114412 106124772
PRAP110991508 111001871
PBX123712966 123714504
PNAP125056789 125059953
ZCE119831604 119838812
CCRC123697346 123699103
LSIN126968700 126971950
AAGE121737137
HAW110370575 110372930
HZE124632347 124638216
TNL113501766 113504497
SLIU111349264 111353138
OFU114359644 114366202
ATRA106129839 106132566
GMW113513236 113521567
PXY105390219 105395950
PGW126374659 126378508
LGLY125225069 125234982
CFEL113375565 113378033 113385684
CCRN123299196
API100162090 100166463
DNX107163745 107173682
AGS114128973 114132119
RMD113551314 113560512
ACOO126837348 126841143
DVT126893595 126904462
BTAB109031371 109035806 109036031
DCI103514212
CLEC106664759 106665330
HHAL106685326
NLU111046785 111049966 120348819
HVI124354564 124355488
MQU128996672 128997024 128997424
PHUPhum_PHUM262630 Phum_PHUM387350
FOC113213595 113217573
TPAL117642998 117647089
ZNE110830633 110837948
CSEC111862811 111866180
SGRE126271872
BROR134530494 134532643
IEL124165235 124165312
FCD110845914 110846222 110846791
DPXDAPPUDRAFT_327379 DAPPUDRAFT_330720
DMK116919032 116930770 123466817
DPZ124312136 124342993
PVM113800005 113815933 113815942
PJA122253825 122266205
PCHN125041365
PMOO119577876 119591754
HAME121866941 121870797
PCLA123745782 123757522
CQD128685583 128700964
PTRU123505879 123506128
ESN126980877 126988149 126993082
MNZ135199999 135218635
HAZT108671767
EAF111695161 111695791 111702393
LSM121121168 121129077
TCF131879040
PPOI119101386
DSV119433786 119442465
RSAN119405325
RMP119159463 119181443 119185517
TUT107362202 107370625
DPTE113796289 113799508
DFR124492876 124496248
CSCU111617460 111633922
PTEP107452529
ABRU129972994 129976626
UDV129229782
SDM118194459 118205964
LPOL106465021 106465024
PMEO129594725
CELCELE_F21F3.1(pgal-1) CELE_T19B4.1(pamn-1)
CBRCBG_14919(Cbr-pamn-1) CBG_20492(Cbr-pgal-1)
CRQGCK72_000272 GCK72_001307
NAINECAME_00981 NECAME_06614
LOALOAG_02126 LOAG_18084
TSPTsp_08245
HROHELRODRAFT_90150 HELRODRAFT_90186
LGILOTGIDRAFT_128636 LOTGIDRAFT_204047
PVUL126817066 126818801
PCAN112553876 112554259
BGT106059574 106074305
GAE121386141
HRF124143750 124146994 124147038
HRJ124288942
CRG105320938
CANU128175949
CVN111129912
MYI110443164 110453761
PMAX117334163
MCAF127734323
MMER123565313
RPHI132759442
DPOL127876651 127880052
MAEA128227433
OBI106870427 106875056
OSN115218053
LJP135473695 135474068
LAK106162187
SMMSmp_156530
SHXMS3_00006564
OVIT265_08837
EGLEGR_00446
LLON135482556 135483295
NVE5505959 5513959
EPA110253509 110253517
ATEN116290559 116306504
ADF107333635
AMIL114961864 114967143
PDAM113668474 113672672
SPIS111322235
DGT114522559 114541151
XEN124452262 124454721
HMG100212200
HSY130640814 130643790 130646165
RES135687062 135687547
TADTRIADDRAFT_63754
OLUOSTLU_15206(PAM1)
OTAOT_ostta04g04860
BPGBathy08g04470
MISMICPUN_70293
MPPMICPUCDRAFT_60313
EMVHQR01_11890
PNSA9D12_10760
EATEAT1b_2563
EXMU719_07590
STPStrop_2878
CATICS0771_54180
ROOG5S37_12440
PSEGD3H65_32540
PGINFRZ67_14645
FLSGLV81_02430
LACSH4075_12625
PSTYBFS30_16400
PGSCPT03_09935
SHTKO02_09560
SMIZ4412673_03632
MUHHYN43_024645
MRUBDEO27_026125
MGOSDIU38_029515
MMABHQ865_19780
AGDFRZ59_06715
SBXCA265_01595
CMRCycma_2166
CAMUCA2015_2102
FBCFB2170_01457
ZGAZOBELLIA_2005
PHALH9I45_14220
AALGAREALGSMS7_00469
AQDD1816_07170
FBEFF125_12995
 » show all
Reference
1  [PMID:2207061]
  Authors
Katopodis AG, Ping D, May SW.
  Title
A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation.
  Journal
Biochemistry 29:6115-20 (1990)
DOI:10.1021/bi00478a001
Reference
2  [PMID:9405058]
  Authors
Bell J, Ash DE, Snyder LM, Kulathila R, Blackburn NJ, Merkler DJ
  Title
Structural and functional investigations on the role of zinc in bifunctional rat  peptidylglycine alpha-amidating enzyme.
  Journal
Biochemistry 36:16239-46 (1997)
DOI:10.1021/bi970903d
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.5
IUBMB Enzyme Nomenclature: 4.3.2.5
ExPASy - ENZYME nomenclature database: 4.3.2.5
BRENDA, the Enzyme Database: 4.3.2.5
CAS: 131689-50-4

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