KEGG   ENZYME: 4.3.2.8Help
Entry
EC 4.3.2.8                  Enzyme                                 

Name
gamma-glutamylamine cyclotransferase;
GGACT
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
epsilon-(gamma-L-glutamyl)-L-lysine gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
Reaction(IUBMB)
epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline [RN:R11862]
Reaction(KEGG)
Substrate
epsilon-(gamma-L-glutamyl)-L-lysine [CPD:C21730]
Product
L-lysine [CPD:C00047];
5-oxo-L-proline [CPD:C01879]
Comment
The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
EC 4.3.2.8 created 2017
Reference
1  [PMID:6107907]
  Authors
Fink ML, Chung SI, Folk JE
  Title
gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
  Journal
Proc Natl Acad Sci U S A 77:4564-8 (1980)
DOI:10.1073/pnas.77.8.4564
Reference
2  [PMID:20110353]
  Authors
Oakley AJ, Coggan M, Board PG
  Title
Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.
  Journal
J Biol Chem 285:9642-8 (2010)
DOI:10.1074/jbc.M109.082099
  Sequence
[hsa:87769]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.8
IUBMB Enzyme Nomenclature: 4.3.2.8
ExPASy - ENZYME nomenclature database: 4.3.2.8
BRENDA, the Enzyme Database: 4.3.2.8

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