KEGG   ENZYME: 4.3.99.5
Entry
EC 4.3.99.5                 Enzyme                                 
Name
nitrosuccinate lyase;
creD (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
Sysname
2-nitrobutanedioate lyase (fumarate-forming)
Reaction(IUBMB)
2-nitrobutanedioate = fumarate + nitrite [RN:R12947]
Reaction(KEGG)
R12947
Substrate
2-nitrobutanedioate [CPD:C22388]
Product
fumarate [CPD:C00122];
nitrite [CPD:C00088]
Comment
The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.
History
EC 4.3.99.5 created 2021
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K25597  nitrosuccinate lyase
Genes
MYE: AB431_04530
MDX: BTO20_27375
MRH: MycrhN_2393
MCRO: MI149_04805
MAB: MAB_0290
MMV: MYCMA_0155
MABB: MASS_0292
MABL: MMASJCM_0289
MCHE: BB28_01435
MIZ: BAB75_01985
MSAO: MYCSP_01265
MSAL: DSM43276_00246(pcaB)
NTP: CRH09_09110
SCB: SCAB_69771
SMAL: SMALA_1626
SSOI: I1A49_11270(pcaB)
SBH: SBI_03174
SDV: BN159_4421 BN159_7958(pcaB3)
SALS: SLNWT_1070
SFI: SFUL_3321
SGU: SGLAU_17370
STRE: GZL_07532
STRM: M444_36510
STRC: AA958_10045
SAMB: SAM23877_0157(pcaB)
SCZ: ABE83_19260
SCX: AS200_01105
SPAV: Spa2297_26590
SGS: AVL59_39890
SGM: GCM10017557_24330
SCAD: DN051_33880
SNR: SNOUR_34630
SPLU: LK06_026290 LK06_027150 LK06_029035
SNW: BBN63_20145
SAUO: BV401_11595
SALJ: SMD11_3244(pcaB)
SFK: KY5_6723
SQZ: FQU76_00320(pcaB)
SKA: CP970_07030
SGZ: C0216_00545(pcaB)
SVN: CP980_14845(pcaB)
SRK: FGW37_24840(pcaB)
SSPO: DDQ41_19485(pcaB)
SPAD: DVK44_34380(pcaB)
SCAV: CVT27_15275(pcaB)
SSEO: D0Z67_01810
SBY: H7H31_09705(pcaB) H7H31_25345(pcaB)
SSPB: CP982_28260(pcaB)
SHUN: DWB77_00269(pcaB)
SFEU: IM697_30745
SMOB: J7W19_14370
SROI: IAG44_34515(pcaB)
STRY: EQG64_16060(pcaB)
SLF: JEQ17_24410
SDEC: L3078_11360
SAKB: K1J60_34180
SCT: SCAT_5480(pcaB)
SCY: SCATT_54780
KSK: KSE_07790
STRI: C7M71_014695(pcaB)
STRH: GXP74_01845
ABRY: NYE86_02790(pcaB)
MYU: M8233_09630
AGRA: AGRA3207_000016(pcaB)
SACG: FDZ84_06755
AROO: NQK81_27460
APRE: CNX65_23225(pcaB)
AMI: Amir_4654
SESP: BN6_36100
SSYI: EKG83_10130(pcaB) EKG83_27600
KAL: KALB_2260
KPHY: AOZ06_18045 AOZ06_45895
MICB: MicB006_2941
MICH: FJK98_14150(pcaB)
MENO: Jiend_53580
PLK: CIK06_12450
DFU: Dfulv_23920(pcaB)
 » show all
Reference
1  [PMID:26689788]
  Authors
Sugai Y, Katsuyama Y, Ohnishi Y.
  Title
A nitrous acid biosynthetic pathway for diazo group formation in bacteria.
  Journal
Nat Chem Biol 12:73-5 (2016)
DOI:10.1038/nchembio.1991
  Sequence
[ag:BAU09301]
Reference
2  [PMID:30120394]
  Authors
Hagihara R, Katsuyama Y, Sugai Y, Onaka H, Ohnishi Y.
  Title
Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis.
  Journal
J Antibiot (Tokyo) 71:911-919 (2018)
DOI:10.1038/s41429-018-0088-1
  Sequence
[sdv:BN159_4421]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.5
IUBMB Enzyme Nomenclature: 4.3.99.5
ExPASy - ENZYME nomenclature database: 4.3.99.5
BRENDA, the Enzyme Database: 4.3.99.5

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (86)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (85)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (6)   
   InterPro (6)   
All databases (107)   

Download RDF
DBGET integrated database retrieval system