KEGG   ENZYME: 4.3.99.5
Entry
EC 4.3.99.5                 Enzyme                                 
Name
nitrosuccinate lyase;
creD (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
Sysname
2-nitrobutanedioate lyase (fumarate-forming)
Reaction(IUBMB)
2-nitrobutanedioate = fumarate + nitrite [RN:R12947]
Reaction(KEGG)
R12947
Substrate
2-nitrobutanedioate [CPD:C22388]
Product
fumarate [CPD:C00122];
nitrite [CPD:C00088]
Comment
The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.
History
EC 4.3.99.5 created 2021
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K25597  nitrosuccinate lyase
Genes
MYEAB431_04530
MDXBTO20_27375
MRHMycrhN_2393
MCROMI149_04805
MABMAB_0290
MMVMYCMA_0155
MABBMASS_0292
MABLMMASJCM_0289
MCHEBB28_01435
MIZBAB75_01985
MSAOMYCSP_01265
MSALDSM43276_00246(pcaB)
NTPCRH09_09110
SFISFUL_3321
SANLKZO11_09810(pcaB)
SGRFSGFS_087140
SCBSCAB_69771
SMALSMALA_1626
SSOII1A49_11270(pcaB)
SBHSBI_03174
SDVBN159_4421 BN159_7958(pcaB3)
SALSSLNWT_1070
SGUSGLAU_17370
STREGZL_07532
STRMM444_36510
STRCAA958_10045
SAMBSAM23877_0157(pcaB)
SCZABE83_19260
SCXAS200_01105
SPAVSpa2297_26590
SGSAVL59_39890
SGMGCM10017557_24330
SCADDN051_33880
SNRSNOUR_34630
SPLULK06_026290 LK06_027150 LK06_029035
SNWBBN63_20145
SAUOBV401_11595
SALJSMD11_3244(pcaB)
SFKKY5_6723
SQZFQU76_00320(pcaB) FQU76_33420(pcaB)
SKACP970_07030
SGZC0216_00545(pcaB)
SVNCP980_14845(pcaB)
SRKFGW37_24840(pcaB)
SSPODDQ41_19485(pcaB)
SPADDVK44_34380(pcaB)
SCAVCVT27_15275(pcaB)
SSEOD0Z67_01810
SBYH7H31_09705(pcaB) H7H31_25345(pcaB)
SSPBCP982_28260(pcaB)
SHUNDWB77_00269(pcaB)
SFEUIM697_30745
SMOBJ7W19_14370
SROIIAG44_34515(pcaB)
STRYEQG64_16060(pcaB)
SLFJEQ17_24410
SDECL3078_11360
SAKBK1J60_34180
SCIRSTRCI_003010(pcaB) STRCI_004223(pcaB)
SXTKPP03845_106228(pcaB) KPP03845_300045(pcaB)
SGKPET44_33950(pcaB)
SYUNMOV08_34915(pcaB)
STRZOYE22_09340(pcaB) OYE22_24640(pcaB)
SPRFK4G22_13865
SCTSCAT_5480(pcaB)
SCYSCATT_54780
KSKKSE_07790
STRIC7M71_014695(pcaB)
STRHGXP74_01845
ABRYNYE86_02790(pcaB)
AWWG8758_12055
MYUM8233_09630
MLYCJ228_008140
MPORKW076_03915
PALUCJ193_005665
NCGKGD84_13305
AGRAAGRA3207_000016(pcaB)
AMAZLUW76_01405(pcaB)
ACIROG979_40115(pcaB)
SPIQOHA34_05290(pcaB)
MHAIOHB01_07995(pcaB) OHB01_28505(pcaB)
SACGFDZ84_06755
ARHDVSH64_39005(pcaB)
AMOGQRX60_22460
APRECNX65_23225(pcaB)
AMIAmir_4654
SESPBN6_36100
SSYIEKG83_10130(pcaB) EKG83_27600
KALKALB_2260
KPHYAOZ06_18045 AOZ06_45895
UMERM788_05835(pcaB) RM788_07365(pcaB)
MICBMicB006_2941
MICHFJK98_14150(pcaB)
MENOJiend_53580
MCHLPVK74_09660
PLKCIK06_12450
DFUDfulv_23920(pcaB)
 » show all
Reference
1  [PMID:26689788]
  Authors
Sugai Y, Katsuyama Y, Ohnishi Y.
  Title
A nitrous acid biosynthetic pathway for diazo group formation in bacteria.
  Journal
Nat Chem Biol 12:73-5 (2016)
DOI:10.1038/nchembio.1991
  Sequence
Reference
2  [PMID:30120394]
  Authors
Hagihara R, Katsuyama Y, Sugai Y, Onaka H, Ohnishi Y.
  Title
Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis.
  Journal
J Antibiot (Tokyo) 71:911-919 (2018)
DOI:10.1038/s41429-018-0088-1
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.5
IUBMB Enzyme Nomenclature: 4.3.99.5
ExPASy - ENZYME nomenclature database: 4.3.99.5
BRENDA, the Enzyme Database: 4.3.99.5

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