Entry
Name
nitrosuccinate lyase;
creD (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
BRITE hierarchy
Sysname
2-nitrobutanedioate lyase (fumarate-forming)
Reaction(IUBMB)
2-nitrobutanedioate = fumarate + nitrite [RN:
R12947 ]
Reaction(KEGG)
Substrate
2-nitrobutanedioate [CPD:
C22388 ]
Product
Comment
The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.
History
EC 4.3.99.5 created 2021
Pathway
ec00998 Biosynthesis of various antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
MSAL : DSM43276_00246(pcaB)
SDV : BN159_4421 BN159_7958(pcaB3)
SAMB : SAM23877_0157(pcaB)
SPLU : LK06_026290 LK06_027150 LK06_029035
SBY : H7H31_09705(pcaB) H7H31_25345(pcaB)
AGRA : AGRA3207_000016(pcaB)
SSYI : EKG83_10130(pcaB) EKG83_27600
KPHY : AOZ06_18045 AOZ06_45895
» show all
Taxonomy
Reference
Authors
Sugai Y, Katsuyama Y, Ohnishi Y.
Title
A nitrous acid biosynthetic pathway for diazo group formation in bacteria.
Journal
Sequence
Reference
Authors
Hagihara R, Katsuyama Y, Sugai Y, Onaka H, Ohnishi Y.
Title
Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.5
ExPASy - ENZYME nomenclature database: 4.3.99.5