Entry
Name
cystathionine gamma-lyase;
homoserine deaminase;
homoserine dehydratase;
cystine desulfhydrase;
cysteine desulfhydrase;
gamma-cystathionase;
cystathionase;
homoserine deaminase-cystathionase;
gamma-CTL;
cystalysin;
cysteine lyase;
L-cystathionine cysteine-lyase (deaminating);
CGL
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
Reaction(IUBMB)
L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction) [RN:
R01001 ];
(1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate [RN:
R08632 ];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
Product
Comment
A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC
3.5.99.10 , 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.
History
EC 4.4.1.1 created 1961 (EC 4.2.1.15 created 1961, incorporated 1972)
Pathway
ec00260 Glycine, serine and threonine metabolism
ec00270 Cysteine and methionine metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K01758 cystathionine gamma-lyase
K17217 cystathionine gamma-lyase / homocysteine desulfhydrase
Genes
MMUR : 105884227 105884239 105884242
OGA : 100963157(CTH) 105888269
MUN : 110539376 110565788(Cth)
CCAN : 109676172 109680922 109696950(Cth)
NCAR : 124992710 124993705
BIU : 109556843(CTH) 109561076
RFQ : 117016100 117027487(CTH)
PMOA : 120502927 120502929
OTC : 121332660 121332662(CTH)
GFR : 102037173 102044932(CTH)
FAB : 101809409(CTH) 101816380
PHI : 102103541(CTH) 102111557
PMAJ : 107207894(CTH) 107207896
CCAE : 111932882 111932942
XLA : 108715515(cth.S) 494673(cth.L)
DRE : 322055(cth) 445818(cthl)
SRX : 107711102(cth) 107726514
SANH : 107673554 107673555 107685307
SGH : 107582733 107585162 107585163
CAUA : 113050543 113101437
MSAM : 119900609 119900615
AOCE : 111569365 111584154(cth)
SLAL : 111649469 111658496(cth)
SASA : 100194964(cgl) 106573862
SALP : 111952371 111975559
LCM : 102355425(CTH) 102360189
RTP : 109917056 109922452(cth)
BBEL : 109467071 109476828
SKO : 100367547 100370087 100373567
DSI : Dsimw501_GD11400(Dsim_GD11400)
AALB : 109427735 109431389
CQU : CpipJ_CPIJ003148 CpipJ_CPIJ006619
CPII : 120418082 120419865 120427808
CNS : 116340426 116344146 116344220 116348536
NMEA : 116424809 116424832
ACEP : 105623573 105623576
PBAR : 105431015 105431062
TPRE : 106652685 106658680
CSET : 123308508 123313887 123320861
AGB : 108911351 108911352 108911357
LDC : 111513248 111513250 111515835
APLN : 108734932 108734934 108738603 108741735 108742392 112906288
MSEX : 115443788 119193555
BANY : 112052093 112052100
HAW : 110377760 110377771 110379322
TNL : 113501889 113502162 113502163 113502164
DNX : 107169464 107169465 107170564
AGS : 114119347 114125115 114125121
BTAB : 109035030 109040361
HHAL : 106688270 106688342 106688422 106688423 106688426 106688427 106690851 106690853
CSEC : 111868437 111872528
FCD : 110845886 110853951 110861059 110862193
DPX : DAPPUDRAFT_119078 DAPPUDRAFT_304533 DAPPUDRAFT_306997
PCLA : 123750623 123760937 123774107 123774118
HAZT : 108668617 108668619
CSCU : 111638532 111638536
PTEP : 107437845 107443281
CEL : CELE_F22B8.6(cth-1) CELE_ZK1127.10(cth-2)
HRO : HELRODRAFT_111430 HELRODRAFT_156911 HELRODRAFT_185538
PCAN : 112573962 112573963 112573975
GAE : 121374218 121376186 121392218
PMAX : 117320412 117325050
ADF : 107327476 107355774 107355787
AMIL : 114962670 114962673
PDAM : 113682601 113682742
TAD : TRIADDRAFT_36312 TRIADDRAFT_64137
NCS : NCAS_0F01520(NCAS0F01520)
NDI : NDAI_0H02400(NDAI0H02400)
TPF : TPHA_0L00570(TPHA0L00570)
TBL : TBLA_0E02240(TBLA0E02240)
TDL : TDEL_0H03530(TDEL0H03530)
KAF : KAFR_0K00760(KAFR0K00760)
SPAA : SPAPADRAFT_59236(CYS3)
CAL : CAALFM_CR08340WA(CYS3)
NTE : NEUTE1DRAFT126996(NEUTE1DRAFT_126996)
BFU : BCIN_02g03490(Bccys3)
ANG : ANI_1_1172144(An16g08720)
APUU : APUU_10376S(CYS3_1) APUU_21781S(CYS3_2)
PPL : POSPLDRAFT_35980 POSPLDRAFT_88894
FME : FOMMEDRAFT_166049 FOMMEDRAFT_77828
LBC : LACBIDRAFT_185287 LACBIDRAFT_191633 LACBIDRAFT_253660
MRR : Moror_7277 Moror_8693
ABP : AGABI1DRAFT62583(AGABI1DRAFT_62583)
ABV : AGABI2DRAFT209095(AGABI2DRAFT_209095)
PTM : GSPATT00013229001 GSPATT00024749001 GSPATT00029327001
KOC : AB185_10990 AB185_19465
KLW : DA718_04315 DA718_12445
KGR : JJJ10_03755 JJJ10_12315
ROR : RORB6_16910 RORB6_22300
RAO : DSD31_03770 DSD31_23775
RTG : NCTC13098_00955(metC_3) NCTC13098_03206(metC_4)
CLAP : NCTC11466_02216(metC_2)
YAL : AT01_1035 AT01_3688(metC)
YIN : CH53_218 CH53_471(metB)
YMA : DA391_14725 DA391_18150
SFJ : SAMEA4384070_1670(metC_1)
SOF : NCTC11214_01521(metB_1) NCTC11214_05287(metC_3)
XDO : XDD1_0530 XDD1_3039(metC)
XPO : XPG1_0660(metC) XPG1_3366(metC)
PRG : RB151_031470(metC_3)
XPH : XppCFBP6546_16310(XppCFBP6546P_16310)
XHD : LMG31886_36920(metC)
SACZ : AOT14_06070(cys1_1)
LHX : LYSHEL_08840(metB_1)
LCAS : LYSCAS_08840(metB_1)
DJI : CH75_01035 CH75_24115
PSEC : CCOS191_3987(metC) CCOS191_4038
PSOS : POS17_3702(SVEN_6204)
PYM : AK972_2578 AK972_5187
PZA : HU749_014965 HU749_021595
LLG : 44548918_00921(metC)
GAI : IMCC3135_27080(metB)
ABRE : pbN1_08220(metB1) pbN1_27450(metB2)
AVM : JQX13_13025 JQX13_28590
CCRO : CMC5_025910(metB) CMC5_050890(metB)
PAUU : E8A73_024300 E8A73_040800
MLN : A9174_04330 A9174_18385
MCI : Mesci_0840 Mesci_3140
MOP : Mesop_0889 Mesop_3531
MAM : Mesau_00764 Mesau_03411
MAMO : A6B35_03975 A6B35_23030
MESW : A9K65_004345 A9K65_017025
MESM : EJ066_07275 EJ066_26810
MESP : C1M53_03475 C1M53_22405
MHUA : MCHK_3188 MCHK_5666
MJR : EB229_04390 EB229_18665
MERD : EB233_04320 EB233_15990
MESR : FGU64_06320 FGU64_15265
AAK : AA2016_0567 AA2016_2798
AMIH : CO731_00551(metC_1) CO731_02780(mccB)
RPA : RPA0371(metB) RPA2357
VGO : GJW-30_1_02183(metC_1)
BVY : NCTC9239_02029(metC)
TSV : DSM104635_02814(metC)
PSEB : EOK75_06785 EOK75_17675
BAZ : BAMTA208_13370(mccB)
BSON : S101395_01638(mccB)
BMET : BMMGA3_02500(mdeA1) BMMGA3_12170(mccB)
BMEG : BG04_1586 BG04_4883
PTB : DER53_00265 DER53_05630
PCAL : BV455_00419(metB) BV455_02801(mccB)
ACAI : ISX45_10945 ISX45_16750
BLEN : NCTC4824_00046(mccB)
CTHU : HUR95_01450 HUR95_16170
SAUT : SAI1T1_2003360(yrhB)
SAUJ : SAI2T2_1003360(yrhB)
SAUK : SAI3T3_1003360(yrhB)
SAUQ : SAI4T8_1003360(yrhB)
SAUV : SAI7S6_1003360(metB)
SAUW : SAI5S5_1003350(metB)
SAUX : SAI6T6_1003360(metB)
SAUY : SAI8T7_1003360(metB)
SDP : NCTC12225_02561(metB2)
SPIC : SAMEA4384060_2443(metC_1)
SSH : NCTC13712_00386(mccB)
SSIM : SAMEA4384339_0378(mccB)
SSTE : SAMEA4384403_2191(metB2)
EXM : U719_00325 U719_12900
PABS : JIR001_06880 JIR001_31160(mdeA)
MANA : MAMMFC1_00303(metC_1)
STED : SPTER_12980(mccB_2)
MPHL : MPHLCCUG_02066(mccB)
MTHN : 4412656_01566(mdeA_2)
MAUU : NCTC10437_01995(metB_1)
MFLV : NCTC10271_03397(mccB)
MSAL : DSM43276_03082(metC)
RRT : 4535765_03144(mdeA_1)
RCR : NCTC10994_04102(metC)
SVE : SVEN_3489 SVEN_3699 SVEN_6204
SAMB : SAM23877_3735(cysA)
SRW : TUE45_03787(metB_2) TUE45_04031(mccB)
SLE : sle_36370(sle_36370)
SGM : GCM10017557_41470(cysA)
STUI : GCM10017668_34600(cysA)
SATA : C5746_21080 C5746_25455
SCAL : I6J39_17330 I6J39_29825
MTEM : GCE86_00815 GCE86_31415 GCE86_31450
MSAG : GCM10017556_39180(cysA)
PFLA : Pflav_062420 Pflav_085560(cysA_2)
PSUU : Psuf_048500(cysA_1)
DVC : Dvina_08130 Dvina_33780
SYH : Syncc8109_2097(metB)
SYNW : SynWH8103_00773(metB_CysA)
PNL : PNK_0515(metC) PNK_0966(metB)
LCRE : Pla8534_11090(metC)
AAGG : ETAA8_14960(metC_1)
AMUC : Pan181_32920(metC_1)
TIM : GMBLW1_32860 GMBLW1_42540
PBOR : BSF38_05025(mccB) BSF38_05619(metC)
ACM : AciX9_2857 AciX9_3902
TALB : FTW19_00825 FTW19_06300
EDA : GWR55_00065 GWR55_01120
SCOR : J3U87_06265 J3U87_24845
GAU : GAU_0234 GAU_2431(metC)
GPH : GEMMAAP_01630 GEMMAAP_12265
GGR : HKW67_02330 HKW67_14405
SRM : SRM_01563(metB) SRM_02583(sufS)
CHIH : GWR21_18100 GWR21_25265
SMIZ : 4412673_01091(metC)
SDJ : NCTC13534_03632(metC)
MGOT : MgSA37_02896(metC_1)
RHOZ : GXP67_11625 GXP67_16385
HRS : HER32_02990 HER32_06520
CHK : D4L85_07900 D4L85_14485
FKI : FK004_03850 FK004_10650
FALB : HYN59_05385 HYN59_11470
MART : BTR34_07235 BTR34_16640
SPON : HME9304_01273(metC)
AALG : AREALGSMS7_01003(metC)
AUE : C5O00_08315 C5O00_10905
KOS : KORDIASMS9_00892(metC)
KAN : IMCC3317_31160(metC)
CGLE : NCTC11432_02082(metC)
CTAI : NCTC12078_00231(metC)
CTAK : 4412677_00992(metC)
CJG : NCTC13459_01308(metC)
CANT : NCTC13489_02881(metC)
OHO : Oweho_2135 Oweho_2590
PYA : PYCH_08680 PYCH_09080
HSL : OE_2173F(metB2) OE_2681F(metB1)
HAGS : JT689_04550 JT689_06095
HALX : M0R89_03500 M0R89_15460
NHO : HWV23_00115 HWV23_10840
NSAL : HWV07_06330 HWV07_15380 HWV07_16265
HDO : MUK72_01930 MUK72_18410
HME : HFX_2761(metC) HFX_2939(metB2)
HGI : ABY42_13775 ABY42_14680
HALE : G3A49_00030 G3A49_17440
HBO : Hbor_03110 Hbor_12180
HALM : FCF25_01280 FCF25_05165
HALP : DOS48_04180 DOS48_07500
HALQ : Hrr1229_000680 Hrr1229_013955
HSS : J7656_07445 J7656_10980
HDF : AArcSl_0322(metB) AArcSl_1835
HJT : DVR14_16240 DVR14_20360
HSAL : JMJ58_16940 JMJ58_21085 JMJ58_21490
HXA : Halxa_0671 Halxa_4076
NVR : FEJ81_07440 FEJ81_22240
NAY : HYG81_03130 HYG81_19965 HYG81_19985
NGE : Natgr_2150 Natgr_3575
HRU : Halru_0203 Halru_1384
TVO : TVG0183353(TVG0183353)
» show all
Taxonomy
Reference
1
Authors
Braunstein, A.E. and Azarkh, R.M.
Title
[Participation of vitamin B6 in enzymic formation of hydrogen sulfide from L-cysteine.].
Journal
Dokl Akad Nauk SSSR 71:93-96 (1950)
Reference
Authors
BRAUNSHTEIN AE, AZARKH RM
Title
[Role of pyridoxal phosphate in anaerobic deamination of homoserine and serine].
Journal
Dokl Akad Nauk SSSR 85:385-8 (1952)
Reference
Authors
FLAVIN M, SEGAL A.
Title
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA.
Journal
J Biol Chem 239:2220-7 (1964)
Reference
Authors
MATSUO Y, GREENBERG DM.
Title
A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activators, and inhibitors.
Journal
J Biol Chem 234:507-15 (1959)
Reference
Authors
MATSUO Y, GREENBERG DM.
Title
A crystalline enzyme that cleaves homoserine and cystathionine. IV. Mechanism of action, reversibility, and substrate specificity.
Journal
J Biol Chem 234:516-9 (1959)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.1
ExPASy - ENZYME nomenclature database: 4.4.1.1
BRENDA, the Enzyme Database: 4.4.1.1