Entry
Name
methionine gamma-lyase;
L-methioninase;
methionine lyase;
methioninase;
methionine dethiomethylase;
L-methionine gamma-lyase;
L-methionine methanethiol-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)
Reaction(IUBMB)
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate (overall reaction) [RN:
R00654 ];
(1a) L-methionine = methanethiol + 2-aminobut-2-enoate [RN:
R08635 ];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
Product
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC
3.5.99.10 , 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism.
History
EC 4.4.1.11 created 1976
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
Genes
CSAT : 104714835 104753135
MINC : 123199747 123204173 123204579 123212473
GHI : 107890721 107930180 107947156 121211163
GAB : 108455437 108456338 108479904
DZI : 111287425 111290112 111308047 111315809
GMX : 100777207 100781016 100808736
GSJ : 114371031 114382697 114384810
PVU : PHAVU_001G082000g PHAVU_004G090200g
CCAJ : 109790676 109794388
APRC : 113857874 113873241
TPRA : 123909499 123911127 123911140 123922172
PSAT : 127083418 127083420 127091731
LJA : Lj0g3v0108489.1(Lj0g3v0108489.1)
AHF : 112740223 112775751 112795594
LANG : 109336486 109350675 109357780
MDM : 103437427 103446265 103452551
MSYL : 126584530 126599972 126625134
MCHA : 111014781 111026086
CMAX : 111465256 111469051 111498738
CMOS : 111431210 111453379
CPEP : 111783976 111799643 111810859
MESC : 110607553 110608299
PEU : 105122878 105123158 105127260
PALZ : 118033951 118054700 118054701 118054702
CILL : 122282621 122290250
SPEN : 107028083 107028327
SSTN : 125841281 125842154
CANN : 107853488 107863655
NTA : 107759737 107767855 107799551 107818807
SIND : 105156049 105179940
SSPL : 121753528 121756487 121759451 121769209 121770755
APAN : 127240277 127263846
LSV : 111919006 111919214 111919222
CCAV : 112528645 112528755
CSIN : 114292050 114314970
MING : 122060499 122061124 122067489 122077792 122080622 122083243 122088832 122089180 122090851
TSS : 122639165 122640215 122640216 122640217 122664562
PSOM : 113302624 113303940 113338109
DOSA : Os10t0517500-02(Os10g0517500)
TDC : 119271774 119284317 119336475
TAES : 123048811 123124488 123134874 123135275 123177006 123181337
LPER : 127306364 127313828
PVIR : 120648426 120688414
SMO : SELMODRAFT_76894 SELMODRAFT_82714
SFJ : SAMEA4384070_0830(mdeA)
TPTY : NCTC11468_00993(mdeA)
PMR : PMI1248 PMI2254(mdeA)
PMIB : BB2000_1268 BB2000_2386(mdeA)
PVL : AOB99_08210 AOB99_13185
PVG : CRN77_07760 CRN77_12880
PHAU : PH4a_03500 PH4a_15355
PROT : BTA34_07640 BTA34_13090
PCOL : F1325_09410 F1325_14685
PCIB : F9282_09395 F9282_15125
PPEE : I6G31_00935 I6G31_13100
PRG : RB151_035050(mdeA_2)
PHEI : NCTC12003_00711(mdeA_2) NCTC12003_00938(mdeA_3)
PRJ : NCTC6933_03116(mdeA_2)
PVC : G3341_03350 G3341_04535(megL)
PMAG : JI723_03780 JI723_04970(megL)
PPRC : PFLCHA0_c35550(mdeA2)
PMUD : NCTC8068_03300(mdeA)
PFW : PF1751_v1c22100(megL)
PTAE : NCTC10697_01754(mdeA)
SBN : Sbal195_0316 Sbal195_1645
SBP : Sbal223_0317 Sbal223_2732
SBT : Sbal678_0323 Sbal678_1685
SBS : Sbal117_0415 Sbal117_1735
SBB : Sbal175_2716 Sbal175_3937
SPC : Sputcn32_0729 Sputcn32_1507
SHP : Sput200_0659 Sput200_1519
SHW : Sputw3181_2594 Sputw3181_3444
SHEW : CKQ84_18275 CKQ84_23340(megL)
SCAA : TUM17387_24990(mdeA)
TACT : SG35_022060(megL) SG35_030105
TVD : SG34_006675(megL) SG34_031800
MICC : AUP74_02846(mdeA_2)
RHH : E0Z06_05170(megL) E0Z06_13565
GAI : IMCC3135_27095(mdeA)
AEL : NCTC12917_02326(mdeA_2)
BTRM : SAMEA390648700106(cysD1_1)
AXY : AXYL_03670(megL1) AXYL_04293(megL2)
AXO : NH44784_051941 NH44784_057751
AXN : AX27061_3330 AX27061_4036
AXX : ERS451415_03310(mdeA_3) ERS451415_04055(mdeA_4) ERS451415_06128(mdeA_5)
ADT : APT56_16425 APT56_18865
AIS : BUW96_08075 BUW96_10670
ACHR : C2U31_16560 C2U31_22220
ADY : HLG70_02600 HLG70_04810
ACHO : H4P35_14740 H4P35_16725
AMUI : PE062_11470 PE062_13710
HYL : LPB072_01595 LPB072_02515
SIMP : C6571_01480 C6571_17020
MAMO : A6B35_23200 A6B35_32500
MHUA : MCHK_11235 MCHK_3230 MCHK_8331
AMIH : CO731_03996(mdeA_2)
SMEL : SM2011_c01666(mdeA)
SFD : USDA257_c19900(mdeA1) USDA257_c45790(mdeA4)
SAME : SAMCFNEI73_Ch2548(mdeA) SAMCFNEI73_pA0091
EAK : EKH55_2262 EKH55_5815
EAD : OV14_3720 OV14_b0073(metZ)
RIR : BN877_II0768 BN877_p0261(mdeA2) BN877_p0348(mdeA3)
REC : RHECIAT_PC0000024(mdeAc)
REL : REMIM1_PF00020(mdeA)
REP : IE4803_PC00026(mdeA)
REI : IE4771_PD00026(mdeA)
RLU : RLEG12_00365 RLEG12_06260
RGA : RGR602_CH00598(mdeA)
RPHA : AMC79_PD00024(mdeA)
RLN : J0663_25065 J0663_30340
RLS : HB780_02170 HB780_12995
RAW : NE851_08390 NE851_32755
BBAN : J4G43_035395 J4G43_054285
BVV : BHK69_12645 BHK69_25975
BOF : FQV39_06330 FQV39_11135
LNE : FZC33_09505 FZC33_12200
MAQU : Maq22A_c06180(metC)
MTEA : DK419_03695 DK419_24755
MHEY : H2LOC_016435 H2LOC_020710
PLEO : OHA_1_00549(mdeA_1)
CAUL : KCG34_09560 KCG34_23085
BVY : NCTC9239_03458(mdeA_2)
PHP : PhaeoP97_01668(mdeA)
PPIC : PhaeoP14_01562(mdeA)
SINL : DSM14862_04007(mdeA)
SPSE : SULPSESMR1_04836(mgl)
HYT : HXX25_06800 HXX25_13130
NOG : GKE62_03005 GKE62_13815
STER : AOA14_11615 AOA14_12205
SPLK : AV944_03730 AV944_17065
SBIN : SBA_ch1_05180(mdeA)
SFLA : SPHFLASMR4Y_01598(mgl)
PMEA : KTC28_08815 KTC28_10780
AEP : AMC99_00447 AMC99_00610
ERR : DVR09_04515 DVR09_07345
RAP : RHOA_0250(mdeA) RHOA_5341
PAQI : KW060_00745 KW060_02520 KW060_11065 KW060_12025
BMET : BMMGA3_04825(mdeA2)
BFD : NCTC4823_00485(megL)
BACQ : DOE78_12090 DOE78_18685
BKW : BkAM31D_14135(mdeA_2)
GMC : GY4MC1_0190 GY4MC1_1463
GTH : Geoth_0214 Geoth_1557
PTL : AOT13_01935 AOT13_15035
VNE : CFK40_02695 CFK40_04865
PBUT : DTO10_14515 DTO10_21835
BFM : BP422_11490 BP422_23380
BAGR : BA6348_04575 BA6348_14070
BCHS : JNE38_07555 JNE38_20135(megL) JNE38_29220
BCOP : JD108_10665 JD108_21125
BPAB : PSE45_15485 PSE45_26350
PSAB : PSAB_05075 PSAB_23605
PDU : PDUR_06370 PDUR_27030
TUM : CBW65_13630 CBW65_22430
TAB : CIG75_07365(megL) CIG75_15095
SPSY : AZE41_02770 AZE41_07545
SURL : BI350_06420 BI350_14570
CCK : Ccar_00035 Ccar_13610 Ccar_17665
CDRK : B9W14_04850 B9W14_17680
CCOH : SAMEA4530647_1478(megL_1) SAMEA4530647_2231(megL_2)
PDF : CD630DERM_35770(mdeA)
PSOR : RSJ16_10460 RSJ16_13810
TEM : JW646_02075(megL) JW646_12110(megL)
TEB : T8CH_1526(megL) T8CH_2574
ACAE : HYG86_05870(megL) HYG86_07855 HYG86_12475(megL)
TMT : Tmath_1414 Tmath_1425
TBO : Thebr_0909 Thebr_0922
TWI : Thewi_1511 Thewi_1526
TEP : TepRe1_0438 TepRe1_0862 TepRe1_1923
TAE : TepiRe1_0485(cysA) TepiRe1_0932(mdeA) TepiRe1_2071(mdeA)
NTH : Nther_2455 Nther_2677
HPK : Hprae_0061 Hprae_0066
MHW : ACT01_09655 ACT01_12575 ACT01_12995 ACT01_13005
MPUT : MPUT9231_4470(megL)
SCO : SCO1294(SCBAC36F5.05c)
SSOI : I1A49_37990 I1A49_44105
SVT : SVTN_05740 SVTN_21085
SLE : sle_58030(sle_58030)
STAA : LDH80_18230 LDH80_20750 LDH80_33155
MAUR : BOH66_12140 BOH66_14735
AMAU : DSM26151_14910(mgl)
AROO : NQK81_28300 NQK81_33210
KUT : JJ691_26020 JJ691_49770 JJ691_85880(metB_2)
KPHY : AOZ06_12255 AOZ06_34120
ACTU : Actkin_01883(mdeA_1) Actkin_05386(mdeA_3)
MTEM : GCE86_03470 GCE86_16295
DMR : Deima_0170 Deima_2142
ABAC : LuPra_03204(mdeA_2)
FVA : FV113G1_04630 FV113G1_21160 FV113G1_30660 FV113G1_33160
FUL : C4N20_03970 C4N20_07405(megL) C4N20_08560(megL)
FMO : C4N19_01930(megL) C4N19_04590(megL) C4N19_06325(megL)
FPOL : ERS445057_02025(mdeA_2)
PCRE : NCTC12858_01232(mdeA)
PCAG : NCTC12856_01453(mdeA_2)
PSOE : CE91St14_11430(megL)
KOS : KORDIASMS9_03086(mgl)
KAN : IMCC3317_45750(mgl_2)
FLB : LV704_06080 LV704_17000
CGLE : NCTC11432_05148(mccB)
CTAI : NCTC12078_00826(mccB)
CTAK : 4412677_00856(mdeA_1)
CSAL : NBC122_00383(mgl_2)
CJG : NCTC13459_01272(mdeA)
CANT : NCTC13489_01417(mdeA_1)
SHYR : LA303_06775 LA303_09385
IAL : IALB_0448(metZ) IALB_2699
CABY : Cabys_1339 Cabys_1806
» show all
Taxonomy
Reference
Authors
Kreis W, Hession C.
Title
Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes.
Journal
Cancer Res 33:1862-5 (1973)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.11
ExPASy - ENZYME nomenclature database: 4.4.1.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.4.1.11