KEGG   ENZYME: 4.4.1.17
Entry
EC 4.4.1.17                 Enzyme                                 

Name
holocytochrome-c synthase;
cytochrome c heme-lyase;
holocytochrome c synthetase;
holocytochrome-c apocytochrome-c-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
holocytochrome-c apocytochrome-c-lyase (heme-forming)
Reaction(IUBMB)
holocytochrome c = apocytochrome c + heme [RN:R02480]
Reaction(KEGG)
R02480
Substrate
holocytochrome c [CPD:C00524]
Product
apocytochrome c [CPD:C02248];
heme [CPD:C00032]
Comment
In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.
History
EC 4.4.1.17 created 1990
Pathway
ec00860  Porphyrin and chlorophyll metabolism
Orthology
K01764  cytochrome c heme-lyase
Genes
HSA: 3052(HCCS)
PTR: 465489(HCCS)
PPS: 100982890
GGO: 101144727
PON: 100171510(HCCS)
NLE: 100581904
MCC: 709878
MCF: 102130747
CSAB: 103231586(HCCS)
RRO: 104668988
RBB: 108521718
CJC: 100390250(HCCS)
SBQ: 101031607
MMU: 15159(Hccs)
MCAL: 110286786
MPAH: 110313967
RNO: 317444(Hccs)
MUN: 110541444
CGE: 100763541
NGI: 103749976
HGL: 101700661
CCAN: 109700658
OCU: 100356413
TUP: 102502642
CFA: 480834(HCCS)
VVP: 112932370
AML: 100468148
UMR: 103668095
UAH: 113240740
ORO: 101380132
ELK: 111157120
FCA: 101085440
PTG: 102965890
PPAD: 109248283
AJU: 106971058
BTA: 506250(HCCS)
BOM: 102285652
BIU: 109555378
BBUB: 102402715
CHX: 102172983
OAS: 101118248 114113165
SSC: 100524598
CFR: 102518576
CDK: 105100574
BACU: 103012604
LVE: 103085147
OOR: 101283199
DLE: 111167219
PCAD: 102977168
ECB: 100053680(HCCS)
EPZ: 103554122
EAI: 106840188
MYB: 102241906
MYD: 102773356
MNA: 107536025
HAI: 109387356
DRO: 112313404
PALE: 102896586
RAY: 107503431
MJV: 108407068
LAV: 100667706
TMU: 101350601
MDO: 100018151
SHR: 100924913 116421065
PCW: 110221540
OAA: 100080272
GGA: 424482(HCCS)
MGP: 100543527
CJO: 107317472
NMEL: 110402471
APLA: 101802937
ACYG: 106039420
TGU: 100224495
LSR: 110468052
SCAN: 103814878
GFR: 102033497
FAB: 101813169
PHI: 102102125
PMAJ: 107208137
CCAE: 111932775
CCW: 104695360
ETL: 114055613
FPG: 101919200
FCH: 102059144
CLV: 102098938
EGZ: 104134000
NNI: 104015503
ACUN: 113482733
PADL: 103925107
AAM: 106486379 106499767
ASN: 102384511
AMJ: 102575147(HCCS)
PSS: 102456344
CMY: 102929734
CPIC: 101941245
ACS: 100566296
PVT: 110076505
PBI: 103050626
PMUR: 107300008
TSR: 106545327
PMUA: 114598737
GJA: 107120140
XLA: 380272(hccs.L) 447038(hccs.S)
XTR: 448226(hccs)
NPR: 108791802
DRE: 101882578(hccsa.2) 436771(hccsa.1) 58016(hccsb)
SRX: 107710606 107712780 107739016
SANH: 107657763 107677261 107700523
SGH: 107560652 107578870 107594665
CCAR: 109049114 109055621 109066001 109088535
IPU: 108273189 108278403
PHYP: 113534127 113539254
AMEX: 103025288 103031157
EEE: 113580517 113588446
TRU: 101061825
TNG: GSTEN00002264G001 GSTEN00026456G001
LCO: 104935677
NCC: 104967228
MZE: 101478944
ONL: 100692842
XMA: 102227589
XCO: 114149729
PRET: 103482232
CVG: 107105126
NFU: 107382602
KMR: 108249834
ALIM: 106519007
AOCE: 111569575
CSEM: 103376865
POV: 109638441
LCF: 108898461
SDU: 111220508
SLAL: 111673058
HCQ: 109530268
BPEC: 110174639
MALB: 109965559
SASA: 106578494(CCHL) 106599140
OTW: 112215541 112227047
SALP: 111973129 111979647
ELS: 105022587
SFM: 108935039
PKI: 111858468
LCM: 102361996
CMK: 103174637
RTP: 109924358
BFO: 118431246
CIN: 100181858
SPU: 583826
APLC: 110977445
SKO: 102806122 102806234
DME: Dmel_CG6022(Cchl)
DER: 6555413
DSE: 6607369
DSI: Dsimw501_GD18482(Dsim_GD18482)
DYA: Dyak_GE24063
DAN: 6499741
DSR: 110190970
DPO: Dpse_GA19303 Dpse_GA27084
DPE: 6588377 6588608
DMN: 108154413 108156246
DWI: 6650821
DGR: Dgri_GH19837
DMO: Dmoj_GI22295
DAZ: 108613645
DNV: 108648995
DHE: 111597876
DVI: 6630971
MDE: 101892476
LCQ: 111686863
AGA: AgaP_AGAP003843
AAG: 5564809
AALB: 109397080 115258008
CQU: CpipJ_CPIJ002377
AME: 408968
BIM: 100749146
BTER: 100642708
CCAL: 108632806 108632807
OBB: 114880461
SOC: 105207876
MPHA: 105836789
AEC: 105151758
ACEP: 105622130
PBAR: 105425111
VEM: 105569497
HST: 105192514
DQU: 106749061
CFO: 105253198
LHU: 105668986
PGC: 109851809
OBO: 105280589
PCF: 106785851
NVI: 100120531
CSOL: 105363769
MDL: 103576057 106693073
TCA: 655015
DPA: 109539650
ATD: 109601266
NVL: 108564329
BMOR: 101739921
BMAN: 114253450
DPL: KGM_207600
PMAC: 106715065
PRAP: 110999891
HAW: 110384079
TNL: 113495479
PXY: 105388417 105397207
API: 100168949
DNX: 107163790
AGS: 114119729 114126093
RMD: 113553470
BTAB: 109041205
CLEC: 106671883
PHU: Phum_PHUM494150
ZNE: 110828439
FCD: 110844792
DPX: DAPPUDRAFT_302793
PVM: 113807043 113819030
ISC: IscW_ISCW018129
TUT: 107359978
DPTE: 113794199
CSCU: 111633898
PTEP: 107453805
CEL: CELE_T06D8.6(cchl-1)
CBR: CBG02944(Cbr-cchl-1)
BMY: Bm1_07670
LOA: LOAG_08710
NAI: NECAME_17093
TSP: Tsp_01197 Tsp_01200 Tsp_01207 Tsp_01210
HRO: HELRODRAFT_115899
LGI: LOTGIDRAFT_120834
PCAN: 112573516
CRG: 105334822
MYI: 110466583
OBI: 106881756
LAK: 106171234 106171247
SMM: Smp_022320.1
SHX: MS3_07992
OVI: T265_09929
EGL: EGR_02170
NVE: 5517208
EPA: 110235145
AMIL: 114970206
PDAM: 113682948
SPIS: 111323133
DGT: 114526350
HMG: 100208954 101237304
TAD: TRIADDRAFT_28549
AQU: 100632281
QSU: 111985390 112019657 112022127 112029061
SMO: SELMODRAFT_4287 SELMODRAFT_4288
CRE: CHLREDRAFT_121344(HCS2) CHLREDRAFT_176161(HCS3) CHLREDRAFT_184910(HCS1) CHLREDRAFT_192603
VCN: VOLCADRAFT_105944 VOLCADRAFT_75232
MNG: MNEG_11780
CSL: COCSUDRAFT_36847
CVR: CHLNCDRAFT_35847 CHLNCDRAFT_56330
APRO: F751_1016 F751_2256
OLU: OSTLU_10461 OSTLU_13359
OTA: OT_ostta17g01000 OT_ostta17g01450
BPG: Bathy06g00700 Bathy06g03560
MIS: MICPUN_76259 MICPUN_76264
MPP: MICPUCDRAFT_5948 MICPUCDRAFT_6472
CCP: CHC_T00002615001
SCE: YAL039C(CYC3) YKL087C(CYT2)
AGO: AGOS_ADR154W AGOS_ADR382W
ERC: Ecym_3404 Ecym_5037
KLA: KLLA0_C13123g KLLA0_F25894g
KMX: KLMA_60164(CYT2) KLMA_80238(CYC3)
LTH: KLTH0C01100g KLTH0D01320g
VPO: Kpol_1058p50 Kpol_461p20
ZRO: ZYRO0D04818g ZYRO0E00814g
CGR: CAGL0L05280g CAGL0M12012g
NCS: NCAS_0A07580(NCAS0A07580) NCAS_0H03340(NCAS0H03340)
NDI: NDAI_0C00320(NDAI0C00320) NDAI_0H01140(NDAI0H01140)
TPF: TPHA_0N00340(TPHA0N00340) TPHA_0N01700(TPHA0N01700)
TBL: TBLA_0C00880(TBLA0C00880) TBLA_0F01590(TBLA0F01590)
TDL: TDEL_0B07380(TDEL0B07380) TDEL_0H04130(TDEL0H04130)
KAF: KAFR_0K00500(KAFR0K00500)
ZMK: HG535_0E02440 HG535_0H00430
PPA: PAS_chr2-2_0290 PAS_chr2-2_0293
DHA: DEHA2E12056g DEHA2G18128g
PIC: PICST_33494(CYC3) PICST_37815(CYT2)
PGU: PGUG_03373
SPAA: SPAPADRAFT_139387 SPAPADRAFT_58655
LEL: LELG_03719 LELG_04209
CAL: CAALFM_C402130WA(CYT2) CAALFM_C501130WA(CYC3)
CTP: CTRG_00019 CTRG_05366
COT: CORT_0E00660 CORT_0E06040
CDU: CD36_42020 CD36_51200(CYC3)
CTEN: CANTEDRAFT_114157 CANTEDRAFT_114733
YLI: YALI0C12918g YALI0E06215g
CLU: CLUG_00858 CLUG_05021
CLUS: A9F13_03g02134 A9F13_10g01375
CAUR: CJI97_000424 CJI97_001211
SLB: AWJ20_1725(CYT2) AWJ20_3176(CYC3)
PKZ: C5L36_0C05560 C5L36_0D04740
BNN: FOA43_000910 FOA43_001105(CYC3)
NCR: NCU05601(cyt-2) NCU08138
NTE: NEUTE1DRAFT131836(NEUTE1DRAFT_131836) NEUTE1DRAFT86485(NEUTE1DRAFT_86485)
SMP: SMAC_03315 SMAC_03609
PAN: PODANSg0992 PODANSg1077
TTT: THITE_2118090 THITE_74570
MTM: MYCTH_2305747 MYCTH_68944
CTHR: CTHT_0046440
MGR: MGG_05607 MGG_09748
TMN: UCRPA7_6766 UCRPA7_8817
SSCK: SPSK_03527 SPSK_07694
FGR: FGSG_08386 FGSG_10422
FPU: FPSE_07435 FPSE_09002
FVR: FVEG_02310 FVEG_03161
FOX: FOXG_03436 FOXG_04974
NHE: NECHADRAFT_49910 NECHADRAFT_67121
TRE: TRIREDRAFT_77758 TRIREDRAFT_79769
TRR: M419DRAFT_113588 M419DRAFT_24621
MAW: MAC_01748 MAC_04750
MAJ: MAA_02304 MAA_05447
CMT: CCM_04455 CCM_08580
PLJ: VFPFJ_02645 VFPFJ_03891
VAL: VDBG_02887 VDBG_09579
VDA: VDAG_03797 VDAG_04812
CFJ: CFIO01_01187 CFIO01_02578
SAPO: SAPIO_CDS6244
ELA: UCREL1_1001 UCREL1_11669
PFY: PFICI_08662 PFICI_09985
SSL: SS1G_03957 SS1G_04774
BFU: BCIN_01g03060(Bccyc3) BCIN_04g01900(Bccyt2)
MBE: MBM_06089 MBM_08034
PSCO: LY89DRAFT_653739 LY89DRAFT_682461
GLZ: GLAREA_00023 GLAREA_09017
ANI: AN4415.2 AN6990.2
AFM: AFUA_4G04600 AFUA_4G07120
ACT: ACLA_046430 ACLA_053760
NFI: NFIA_028760 NFIA_109100
AOR: AO090023000863 AO090206000030
ANG: ANI_1_1608184(An04g01535) ANI_1_44124(An14g00240)
AFV: AFLA_007215 AFLA_012997
PCS: Pc13g05830 Pc22g18310
PDP: PDIP_12900 PDIP_14980
TMF: PMAA_027170 PMAA_085990
TRG: TRUGW13939_02007 TRUGW13939_03405
CIM: CIMG_04155 CIMG_08537
CPW: CPC735_002640 CPC735_061960
PBL: PAAG_01468 PAAG_07590
PBN: PADG_00312 PADG_08289
URE: UREG_02601 UREG_05589
ABE: ARB_01601 ARB_06101
TVE: TRV_00324
AJE: HCAG_05597 HCAG_07691
BGH: BDBG_02641 BDBG_09133
PNO: SNOG_04831 SNOG_08294
PTE: PTT_07871 PTT_15059
BZE: COCCADRAFT_110134 COCCADRAFT_86313
BSC: COCSADRAFT_174262 COCSADRAFT_33308
BOR: COCMIDRAFT_35311 COCMIDRAFT_96815
AALT: CC77DRAFT_1017667 CC77DRAFT_211153
ZTR: MYCGRDRAFT_111377 MYCGRDRAFT_35508
PFJ: MYCFIDRAFT_168848 MYCFIDRAFT_210968
BCOM: BAUCODRAFT_68383 BAUCODRAFT_77263
NPA: UCRNP2_7007 UCRNP2_7751
TML: GSTUM_00005253001 GSTUM_00008492001
SPO: SPAC24C9.02c SPBC26H8.12
CNE: CNA00150 CNF00970
CNB: CNBA0140 CNBF3730
CGI: CGB_B0150C CGB_F5320C
TMS: TREMEDRAFT_28522 TREMEDRAFT_74912
TASA: A1Q1_00112
TVS: TRAVEDRAFT_28071 TRAVEDRAFT_64986
DSQ: DICSQDRAFT_100946 DICSQDRAFT_77440
PCO: PHACADRAFT_105614
SHS: STEHIDRAFT_166440 STEHIDRAFT_79252
HIR: HETIRDRAFT_420076 HETIRDRAFT_43172
PSQ: PUNSTDRAFT_115422
ADL: AURDEDRAFT_23157
FME: FOMMEDRAFT_73292 FOMMEDRAFT_79763
GTR: GLOTRDRAFT_115655 GLOTRDRAFT_23433
LBC: LACBIDRAFT_247446
MPR: MPER_05879
MRR: Moror_14849 Moror_17278
CCI: CC1G_00860 CC1G_05134
SCM: SCHCODRAFT_54345
ABP: AGABI1DRAFT111393(AGABI1DRAFT_111393) AGABI1DRAFT111983(AGABI1DRAFT_111983)
ABV: AGABI2DRAFT193225(AGABI2DRAFT_193225) AGABI2DRAFT216724(AGABI2DRAFT_216724)
CPUT: CONPUDRAFT_135151 CONPUDRAFT_59341
SLA: SERLADRAFT_351042 SERLADRAFT_472834
WSE: WALSEDRAFT_20182 WALSEDRAFT_60258
UMA: UMAG_04702 UMAG_11653
PFP: PFL1_01119 PFL1_04421
MGL: MGL_3980
MRT: MRET_1670 MRET_4211
MSYM: MSY001_0021 MSY001_2210
PGR: PGTG_00085 PGTG_01941
MLR: MELLADRAFT_28382 MELLADRAFT_48758
MBR: MONBRDRAFT_27974 MONBRDRAFT_38782
SRE: PTSG_04025 PTSG_07135
DDI: DDB_G0275895(cchl)
DPP: DICPUDRAFT_42199
DFA: DFA_07027(cchl)
ACAN: ACA1_373860
PFA: PF3D7_1203600 PF3D7_1224600
PFD: PFDG_04064
PFH: PFHG_02931 PFHG_05120
PYO: PY17X_0605100 PY17X_1442000
PCB: PCHAS_060440(PC000789.03.0) PCHAS_144150(PC300668.00.0)
PBE: PBANKA_0602600 PBANKA_1439500
PKN: PKH_130230 PKH_144130
PVX: PVX_084225 PVX_123860
PCY: PCYB_131240 PCYB_145030
TAN: TA06210 TA15105
TPV: TP01_0886 TP02_0784
TOT: TOT_010000834 TOT_020000776
BEQ: BEWA_027130 BEWA_040630
BBO: BBOV_III011500(17.m07981) BBOV_IV008890(23.m05868)
BMIC: BMR1_03g00830 BmR1_04g08205
TGO: TGME49_293390 TGME49_314042
SMIN: v1.2.025477.t1(symbB.v1.2.025477.t1) v1.2.033285.t1(symbB.v1.2.033285.t1)
PTI: PHATRDRAFT_40930 PHATRDRAFT_6437
FCY: FRACYDRAFT_163984 FRACYDRAFT_202199 FRACYDRAFT_261492
TPS: THAPSDRAFT_28667
PIF: PITG_00110 PITG_00442
PSOJ: PHYSODRAFT_334052 PHYSODRAFT_506708
SPAR: SPRG_03495 SPRG_05268
EHX: EMIHUDRAFT_435905 EMIHUDRAFT_439014 EMIHUDRAFT_440203 EMIHUDRAFT_464044 EMIHUDRAFT_465131
GTT: GUITHDRAFT_65435 GUITHDRAFT_73289
 » show all
Reference
1  [PMID:3034577]
  Authors
Dumont ME, Ernst JF, Hampsey DM, Sherman F
  Title
Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae.
  Journal
EMBO J 6:235-41 (1987)
DOI:10.1002/j.1460-2075.1987.tb04744.x
  Sequence
[sce:YAL039C]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.17
IUBMB Enzyme Nomenclature: 4.4.1.17
ExPASy - ENZYME nomenclature database: 4.4.1.17
BRENDA, the Enzyme Database: 4.4.1.17
CAS: 75139-03-6

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (5138)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (620)   
   KEGG MGENES (480)   
   RefGene (4037)   
Protein sequence (4307)   
   UniProt (4244)   
   SWISS-PROT (12)   
   RefSeq(pep) (51)   
DNA sequence (444)   
   RefSeq(nuc) (83)   
   GenBank (195)   
   EMBL (166)   
Protein domain (2)   
   InterPro (1)   
   PROSITE(DOC) (1)   
All databases (9899)   

Download RDF
DBGET integrated database retrieval system