KEGG   ENZYME: 4.4.1.19
Entry
EC 4.4.1.19                 Enzyme                                 
Name
phosphosulfolactate synthase;
(2R)-phospho-3-sulfolactate synthase;
(2R)-O-phospho-3-sulfolactate sulfo-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
(2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming)
Reaction(IUBMB)
(2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite [RN:R07476]
Reaction(KEGG)
R07476
Substrate
(2R)-2-O-phospho-3-sulfolactate
Product
phosphoenolpyruvate [CPD:C00074];
sulfite [CPD:C00094]
Comment
Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.
History
EC 4.4.1.19 created 2003
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08097  phosphosulfolactate synthase
Genes
LOKLoa_02096
BGMCAL15_12810
PARKLSG25_12670
DPGDESPIGER_2203
BSUBSU10950(yitD)
BSRI33_1230(yitD)
BSLA7A1_0911
BSHBSU6051_10950(yitD)
BSYI653_05540
BSUTBSUB_01192(yitD)
BSULBSUA_01192(yitD)
BSUSQ433_06185
BSNBSn5_17370
BSQB657_10950(slpS)
BSXC663_1118(comA)
BSPU712_05605
BSSBSUW23_05550(yitD)
BSTGYO_1401(yitD)
BLIBL02005(yitD)
BLDBLi02155(yitD)
BLHBaLi_c22300(yitD)
BAEBATR1942_03110
BSONS101395_02481(comA)
BHTDIC78_04125
BMOJHC660_11500(slpS)
BTEQG4P54_05790
BIQAN935_05675
BGYBGLY_2293(yitD)
BITBIS30_16185
BFDNCTC4823_02234(yitD)
BBADK7T73_17360
BCABEFK13_06160
BRYM0696_06070
BJSMY9_1193
BACIB1NLA3E_03505
GSTHW35_17420
BACYQF06_04410
BACLBS34A_12090(yitD)
BALMBsLM_1140
BCOBcell_3136
BCKBCO26_1398(yitD)
BAGBcoa_3122
BCOABF29_414(yitD)
BGIBGM20_20755
CSUAIM538_15050
ASEDIRT44_13665
AQTFN924_04655
BTHVCQJ30_09390
NMKCHR53_10645
NDTL1999_01910
MSEMGMB29_21975
SEDDERJ70_05480
BOUI5818_11455
CTHUHUR95_14485 HUR95_14535
BBEBBR47_23190(comA)
BLRBRLA_c016650
BFMBP422_06795
BAGRBA6348_17500
BRWGOP56_01235
BCHSJNE38_12030
BCOPJD108_13260
PJDPjdr2_2292
PMSKNP414_02661
PMQPM3016_2903
PMWB2K_14740
PLVERIC2_c33000(comA)
PBJVN24_25310
PNPIJ22_24320
POWIJ21_30190
PSWUSY83_19300
PIBBBD41_01685
PCXLPB68_18080
PLENEIM92_09255
PPSCEHS13_20600
PALBEJC50_13865
PCHIPC41400_11100
PBKBack11_24680
PRZGZH47_05160
PLYCGXP70_11135
TCOTheco_1988
ANXACH33_09010
ATHEK3F53_10080
COHEAV92_09850
COHNKCTCHS21_24650
CCHLFPL14_26030
CHEBHH215_03195
AACAaci_1301 Aaci_2433
AADTC41_1228 TC41_2723(comA)
AFXJZ786_18120
AACOK1I37_09205 K1I37_19950
ACURJZ785_26830
BTSBtus_1783
KYRCVV65_07600
TUMCBW65_20240
TABCIG75_09285
EFFskT53_03360
NTRB0W44_13255
LFBC1X05_06540
TVUAB849_012595
KPULGXN76_06790
KEBGXN75_07905
PABSJIR001_13220
LHWBSQ49_02940
LMALLM596_03095
LOLLACOL_1489
LPDAYR62_02825
LMAEFGL90_02275
OOEOEOE_0441
OENDSM07_07720
STHSTH2643
DCADesca_1257
PTHPTH_1816
DRMDred_1677
DRUDesru_2345
DFGB0537_07980
DAEDtox_2359
DKUDesku_1279
DAUDaud_1309
TFRBR63_07920
FWADCMF_00480 DCMF_06185 DCMF_23970 DCMF_24000 DCMF_24020
TJRTherJR_1470
DGIDesgi_3259
HMOHM1_0946
HCVFTV88_0865(comA)
TMRTmar_1045
THEFE1B22_08890
THEPDYI95_005195
SAYTPY_1196(comA)
SAPSulac_2457
STHRBXT84_11625
MTAMoth_0118
MTHOMOTHE_c01240(yitD)
MTHZMOTHA_c01240(yitD)
ADGAdeg_1603
HORHore_21790
HALSD7D81_00820
IFNGM661_16850
AARAcear_1343
HHLHalha_1510
AFTBBF96_13960
LPILLIP_0779
MSAMycsm_01875
MCBMycch_5452 Mycch_5966
MRHMycrhN_2934
NTPCRH09_05130
SALSSLNWT_0539
HUWFPZ11_11375
NCANoca_4816 Noca_4839
FRIFraEuI1c_5954
AMQAMETH_2056
AACDLWP59_21930
PDXPsed_1619 Psed_6288
PAUTPdca_54820
PBROHOP40_10125
ATLAthai_13720
BSOLFSW04_04285
CWOCwoe_0088
PARNNBH00_00670
SBAEDSM104329_00137(yitD)
SYDSyncc9605_1170
SYNKKR100_08215
CALNNIES2098_68410
HAUHaur_1567
SUSAcid_4865
TTZFHG85_06135
SRUSRU_0020
SRMSRM_00021(comA)
RMRRmar_0022
RMGRhom172_0022
RBARAWN76_012815
CPICpin_1670 Cpin_5589
CBAECOR50_10035 COR50_19515
CHITFW415_17205 FW415_22305
CHIHGWR21_08495 GWR21_23760
COYHF329_20590
CFILMYF79_08415 MYF79_23445
CHFKTO58_18310
NKONiako_4703
NSONIASO_11290
NIAA8C56_02190 A8C56_07490
FLASY85_06285
FGGFSB75_08920 FSB75_11205
ARBA9P82_00090
ARKD6B99_09500
AGIFSB73_00150 FSB73_02050
ARACE0W69_019830
ATEEK9M52_00385 K9M52_02775
FLNFLA_0115
PSEGD3H65_14745
PGINFRZ67_08215
PGOFSB84_29760
FLSGLV81_14000
LACSH4075_14410
FEIK9M53_02595
FLPLK994_07710
FLCKJS93_09500
FLVKJS94_07630
PHEPhep_4158
PEPAQ505_01190
PCMAY601_4372
PSTYBFS30_06080
PGSCPT03_17685
PEJFYC62_13355
PEKFFJ24_020435
PROEH9L23_21340
PEXIZT61_14710
PMUOLOK61_18165
PSNPedsa_3036
SHGSph21_1338
SCNSolca_4247
MUPA0256_08050
MUCMuYL_0731
MGOTMgSA37_00444(yitD)
MUHHYN43_025745
MGINFRZ54_05565
MGKFSB76_15775
MRUBDEO27_026680
MGOSDIU38_023370
MMABHQ865_24085
MGIKGO620_012620
MDJLLH06_20430
OLIFKG96_03635
SBXCA265_19750
CMRCycma_1455
CAMUCA2015_1351
BBDBelba_0911
EVIEchvi_1147
ESTDN752_12365
ECHIFKX85_04590
EMAIKZP23_05300
ALMAO498_02300
MDAIPZ59_03960
CHUCHU_0004
SLISlin_0707
SRDSD10_06655
SMONAWR27_12200
SPIRCWM47_32745
SPIKEXU85_09435
SPIBG8759_16150
STAEHNV11_10215
SRHOHH216_12315
PSEZHME7025_00418(comA)
AANHG9X63_01495
RHOZGXP67_16360
DFEDfer_4445
DSNHWI92_15595
LBYLbys_3154
RSIRunsl_3058
RUNDR864_10290
RUPDTQ70_17910
EOLEmtol_2406
FAEFAES_0308
FIBA6C57_14855
ALSDJ013_06600
FLIFleli_2960
HSWHsw_3670
HYMN008_11020
HYDPK28_15930
HYEAM218_00550
HYGAUC43_05885
HYPA0257_15910
HYZAXW84_18180
HNVDDQ68_13060
HYHD3Y59_15825
HYJFHG12_11365
HQIH9L05_09945
HRSHER32_08165
HBNGUY19_16500
HTSHMJ29_04375
HMTMTP16_04680
HTBMTX78_20000
PKOPKOR_08170
PACTCA264_19065
RUFTH63_00780
RTIDC20_11260
RUDTH61_09245
NIBGU926_15000
ADDHUW48_26315
ASWUHUW51_10645
MTTFtrac_2674
FPFDCC35_19385
FLMMY04_3220
FLLEI427_18430
FYAKMW28_00030
FKAKM029_12810
FBTD770_13430
CHKD4L85_01040
FUVJR347_17825
FTEFluta_3660
FLUCHH17_09260
CRMK6119_06110
PTANCRYO30217_01774(yitD)
SHYRLA303_10445
BBAUAEM51_13675
MJAMJ_0255
MFEMefer_0102
MVUMetvu_1522
MFSMFS40622_0491
MIFMetin_1007
MJHJH146_0170
MESGMLAUSG7_1546(comA)
MESAMLASG1_1128(comA)
MIGMetig_0856
MMPMMP0273(comA)
MMQMmarC5_1399
MMXMmarC6_0679
MMZMmarC7_1277
MMDGYY_01400
MMAKMMKA1_02800(comA)
MMAOMMOS7_03070(comA)
MMADMMJJ_07850(yitD)
MAEMaeo_0153
MVNMevan_1285
MVOMvol_1330
MOKMetok_0167
METFCFE53_04670(comA)
MTHMTH_1674
MMGMTBMA_c02530(comA)
MWOMWSIV6_0212(comA)
MTEEMTTB_14140
METCMTCT_1527
METEtca_01621(yitD)
METZMETMT2_1504
METKFVF72_03295(comA)
MTHMFZP57_00950(comA)
METJFZP68_05960(comA)
MSTMsp_1270(comA)
METBAW729_09300
MSIMsm_0086
MEBAbm4_0691(comA)
MMILsm9_0980(comA)
MEYETL18_05470
MOLYLM1_0878
MAROMarbSA_09310
METVK4897_00855(comA)
MELMetbo_2244
MEWMSWAN_0399
METHMBMB1_0449(comA)
MFCBRM9_1809(comA)
MFIDSM1535_2450(comA)
MCUBMCBB_0411(comA)
MSUBBK009_00305
METNBK008_08110
METTCIT01_07045(comA)
METOCIT02_04555(comA)
MEMEHYG87_07735(comA)
MFVMfer_1060
MKAMK0394(comA)
NAYHYG81_24210
MELUMTLP_02880
FACFACI_IFERC01G1194
NGANgar_c10400(comA) Ngar_c26460
NVNNVIE_024140(comA) NVIE_028040
NEVNTE_01035 NTE_03133
TAANMY3_01362(yitD_1) NMY3_02409(yitD_2)
NFNNFRAN_2269(yitD) NFRAN_3066(yitD)
 » show all
Reference
1  [PMID:11830598]
  Authors
Graham DE, Xu H, White RH
  Title
Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.
  Journal
J Biol Chem 277:13421-9 (2002)
DOI:10.1074/jbc.M201011200
  Sequence
[mja:MJ_0255]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.19
IUBMB Enzyme Nomenclature: 4.4.1.19
ExPASy - ENZYME nomenclature database: 4.4.1.19
BRENDA, the Enzyme Database: 4.4.1.19
CAS: 473575-53-0

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