KEGG   ENZYME: 4.4.1.2
Entry
EC 4.4.1.2                  Enzyme                                 
Name
homocysteine desulfhydrase;
homocysteine desulfurase;
L-homocysteine hydrogen-sulfide-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
Reaction(IUBMB)
L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate (overall reaction) [RN:R01283];
(1a) L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate [RN:R08633];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
R01283 R08633
Substrate
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Product
hydrogen sulfide [CPD:C00283];
NH3 [CPD:C00014];
2-oxobutanoate [CPD:C00109];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase
History
EC 4.4.1.2 created 1961
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K17217  cystathionine gamma-lyase / homocysteine desulfhydrase
Genes
PPAVLOZ86_14560
GKNPVT67_04235
PFEPSF113_4197
PBCCD58_21630
PYMAK972_5187
PZAHU749_021595
MBSMRBBS_2486(mdeA)
MPQABA45_11705
SDOSD1155_04930
BOMBGT348_03645
ECOGFIV45_10075
DALDalk_0849
BSUBSU27250(yrhB)
BSRI33_2767(yrhB)
BSLA7A1_0367
BSHBSU6051_27250(mccB)
BSYI653_12940
BSUTBSUB_02907(mccB)
BSULBSUA_02907(mccB)
BSUSQ433_14680
BSOBSNT_09119(yrhB)
BSNBSn5_04410
BSQB657_27250(mccB)
BSXC663_2562(mccB)
BSPU712_13395
BSSBSUW23_13180(mccB)
BSTGYO_2965(yrhB)
BITBIS30_03010
BLIBL02018(yrhB)
BLDBLi02853(mccB)
BLHBaLi_c29540(mccB)
BAYRBAM_024350
BAQBACAU_2449(yrhB)
BYABANAU_2593(yrhB)
BAMPB938_12585
BAMLBAM5036_2375(mccB)
BAMARBAU_2572(mccB)
BAMNBASU_2378(mccB)
BAMBBAPNAU_1127(yrhB)
BAMTAJ82_13760
BAMYV529_27190(yrhB)
BMPNG74_02557(mccB)
BAOBAMF_2533(mccB)
BAZBAMTA208_13370(mccB)
BQLLL3_02811(mccB)
BXHBAXH7_02735(yrhB)
BAMIKSO_007200
BAMCU471_25270
BAMFU722_13215
BSIACWD84_08705
BAEBATR1942_11340
BVMB9C48_12455
BSONS101395_01638(mccB)
BHTDIC78_18030
BMOJHC660_25280(mccB)
BTEQG4P54_13885
BIQAN935_13310
BSTRQI003_16790(mccB)
BANBA_4600
BARGBAA_4600
BATBAS4268
BAHBAMEG_4637
BAIBAA_4620
BAXH9401_4389
BANTA16_45980
BANRA16R_60345
BANSBAPAT_4415
BANHHYU01_22435
BANVDJ46_3277(mccB)
BCEBC4366
BCABCE_4454(metC)
BCZBCE33L4116(metC)
BCRBCAH187_A4505
BCBBCB4264_A4491
BCUBCAH820_4452
BCGBCG9842_B0745
BCQBCQ_4156(metC)
BCXBCA_4484
BALBACI_c43580(metC2)
BNCBCN_4282
BCFbcf_21745
BCERBCK_13335
BCEFBcrFT9_03441
BCYBcer98_3084
BTKBT9727_4105(metC)
BTLBALH_3957(metC)
BTBBMB171_C4033
BTTHD73_4680
BTHRYBT1520_23210
BTHIBTK_23050
BTCCT43_CH4389
BTFYBT020_21535
BTMMC28_3663
BTGBTB_c45120(mccB)
BTIBTG_27215
BTNBTF1_20465
BTHTH175_ch4458
BTHUYBT1518_24315
BTWBF38_126(mccB)
BTHYAQ980_07960
BWEBcerKBAB4_4219
BWWbwei_0567(mccB)
BMYOBG05_1654
BTYBtoyo_1609
BMYCDJ92_1469(mccB)
BBYCY96_21035
BWDCT694_23485
BTROFJR70_15650
BMOBMLA2C4_22810
BNTGSN03_20800
BPACLMD38_05145
BPANNLJ82_21250
BALUQRY64_24755
BPUBPUM_2360
BPUMBW16_12815
BPUSUP12_11885
BIFN288_18655
BMETBMMGA3_12170(mccB)
BSMBSM4216_1794
BGYBGLY_3172(mccB)
BXIBK049_15170
BALTCFN77_12615
BAERBAE_00305
BSAFBSL056_12965
BSHILGQ02_13715
BCABEFK13_13835
BRYM0696_13610
BJSMY9_2706
BACIB1NLA3E_16320
GSTHW35_04705
BACWQR42_11960
BACPSB24_16520
BACBOY17_15455
BACYQF06_11815
BACLBS34A_29730(yrhB)
BALMBsLM_2694
BACSAUL54_17640
BACAFAY30_17470
BAQUK6959_18320
BZHNF868_10630
BHAIKJK41_15815
BCAOLC087_07935
BARDQRY57_21565
BAEIRE735_07970
BHKB4U37_15535
BCOHBC6307_15895
BCIRC2I06_10455
NTXNQZ71_07960
NILL8T27_013795
BMQBMQ_4594(mccB)
BMDBMD_4580(mccB)
BMEGBG04_1586 BG04_4883
BEOBEH_16500
BFXBC359_04745
PKSIE339_19400
BCLABC1945
BLEBleG1_1700
SHUAPQ477_17365
BGIBGM20_07520
BONA361_02835
BKOCKF48_17425
CGOTJ1899_15725
CSUAIM538_17675
CFIRNAF01_02895
CSOALIS82_19845
CSPGLS684_14025
CPSSM5V91_19240
OIHOB1109(metC)
OCNCUC15_07025
GKAGK2540
GTEGTCCBUS3UF5_28630
GTKGT3570_12440
GTMGT3921_06745
GLIGLN3_05575
BCALCWI35_15570
GTNGTNG_2473
GWCGWCH70_2474
GYCGYMC61_0979
GYAGYMC52_2573
GCTGC56T3_0952
GMCGY4MC1_1027
GGHGHH_c26140(mcc)
GJFM493_13170
GEAGARCT_02594(mccB)
GELIB49_04570
GSEGT50_04120
GSRGS3922_03475
GEJA0V43_10570
GZAIC807_08840
GTHGeoth_1097
PTLAOT13_17155
PTBDER53_00265
PCALBV455_02801(mccB)
PARGPspKH34_09440
AFLAflv_0761
AGNAFK25_10605
ANMGFC28_3612
AAMYGFC30_2789
ANLGFC29_1821
ANDGRQ40_13470
ACAIISX45_10945
ASEDIRT44_02020
HHDHBHAL_2023(mccB)
HMNHM131_16225
HLIHLI_06375
HNZP9989_05815
HSANMUN89_17580
HSHIMUO14_19475
HAMYMUO15_07760
TAPGZ22_04630
TAIDKS242_05465
VIRX953_04960
VHLBME96_04135
VILCFK37_01100
VNECFK40_17135
VIMGWK91_05705
VNTOLD84_06875
VIKKFZ58_06635
LEXLen3610_01585
FPNABE65_014675
FARABE41_013445
FECQNH15_16605
BSJUP17_16915
BMURABE28_015665
PBUTDTO10_03730
PASABAOM_3878(mccB)
PPSRI6J18_20135
PFRIL8956_17555
AQTFN924_05330
RAXKO561_05555
BTHVCQJ30_10390
PSYHD0S48_17720
PSYOPB01_15150
PSYBKD050_05310
GRCGI584_17700
GCSMUN88_11630
GSMMUN87_07235
POFGS400_02555
PCHUQNI29_02085
PONAIMZ31_01975
NTMBTDUT50_12135
NDTL1999_22110
NCMQNK12_23485
NNVQNH39_19435
MSEMGMB29_13390
MDGK8L98_18130
BLENNCTC4824_00046(mccB)
SEDDERJ70_04085
BVQFHE72_15530
RMFD5E69_15360
RAZU9J35_15730
BCKBCO26_2430
BAGBcoa_1961
BCOABF29_1572(mccB)
BVJI5776_17570
BOUI5818_21615
CTHUHUR95_16170
MCUIG8O30_08385
PSUAFLK61_25195
SLMSMM221_11375
MJOFOF60_09740
MSUTLC048_11955
ECTOMUG87_08350
ALKGMOJ78_14250
PHJLC071_04670
STEAC0679_09625
SAUSA0419(metB)
SAVSAV0460(yrhB)
SAWSAHV_0458(yrhB)
SAHSaurJH1_0495
SAJSaurJH9_0482
SAMMW0415(metB)
SASSAS0418
SARSAR0460
SACSACOL0503
SAASAUSA300_0434(metB)
SAOSAOUHSC_00422
SAENWMN_0425(metB)
SADSAAV_0403
SUUM013TW_0425
SUVSAVC_01890
SUESAOV_0478
SUJSAA6159_00410
SUKSAA6008_00464(metB)
SUCECTR2_394
SUTSAT0131_00500
SUQHMPREF0772_10062
SUZMS7_0434(mccB)
SUDST398NM01_0526
SUXSAEMRSA15_03860
SUWSATW20_05290
SUGSAPIG0526
SUFSARLGA251_03940
SAUASAAG_00915
SAUERSAU_000393
SAUNSAKOR_00444
SAUSSA40_0399
SAUUSA957_0414
SAUGSA268_0412
SAUZSAZ172_0462
SAUTSAI1T1_2003360(yrhB)
SAUJSAI2T2_1003360(yrhB)
SAUKSAI3T3_1003360(yrhB)
SAUQSAI4T8_1003360(yrhB)
SAUVSAI7S6_1003360(metB)
SAUWSAI5S5_1003350(metB)
SAUXSAI6T6_1003360(metB)
SAUYSAI8T7_1003360(metB)
SAUFX998_0487
SABSAB0410
SUYSA2981_0436(metB)
SAUBC248_0510
SAUMBN843_4430
SAUCCA347_454(mccB)
SAURSABB_02175(mccB)
SAUIAZ30_02230
SAUDCH52_03550
SAMSNI36_02155
SUHSAMSHR1132_04050
SERSERP0095
SEPSE_2323
SEPPSEB_02318
SEPSDP17_1515
SHASH2548(metB)
SHHShL2_02333(metB_2)
SSPSSP0253
SCASCA_0087(metC)
SLGSLGD_02456
SLNSLUG_23510
SSDSPSINT_0116
SDTSPSE_2355(metB2)
SDPNCTC12225_02561(metB2)
SWAA284_11085
SPASSTP1_1535
SXYBE24_10690
SXLSXYLSMQ121_0281
SXOSXYL_00285(metB)
SHUSHYC_11450(mccB)
SCAPAYP1020_2183(mccB)
SSCHLH95_11030
SSCZRN70_11795
SAGQEP23_10730
SEQOSE1039_22900
SSIFAL483_09470
SCVA4G25_07300
SLZB5P37_06600
SKLC7J89_03245
SFQC7J90_02460
SHOMEGX58_04080
SMUSC7J88_06865
SCARDWB96_12385
SCHRDWB92_11605
SPICSAMEA4384060_2443(metC_1)
SSHNCTC13712_00386(mccB)
SSIMSAMEA4384339_0378(mccB)
SDBCNQ82_00630
SLLOISP08_02060
SAULI6G39_10115
SRAILN051_10780
SPSDJMB28_01925
STASHYI43_11695
SEDAMNY58_01480
SCAQQMO72_01560
SDEVQ2T90_07425
SROTML435_01985
STAPAOB58_2111
SHSIQQM35_02135
SSCUCEP64_10520
SFFFOB90_08365
SSTESAMEA4384403_2191(metB2)
MVTI6J10_00355
MACRBHM04_11955
MARYLAU42_10670
MBRUMGG13_10090
MEPIKFV12_11885
MEQUKFV11_10180
MBOCQSV55_10290
MCLMCCL_1790
MCAKMCCS_23060(mccB)
MBOEHT586_11100
SBACBVH56_07765
ESIExig_2343
EATEAT1b_0608
EANEab7_2188
EXMU719_00325 U719_12900
EXUESP131_15010
EAPKB235_07395
EACEKKI46_12845
EAURNMQ00_06115
EMMPTI97_08760
EPFOE059_05815
BBEBBR47_47850(mccB)
BLRBRLA_c040910
BFMBP422_19710
BAGRBA6348_07560
BRWGOP56_13100
BCHSJNE38_25755
BCOPJD108_05020
BPABPSE45_22780
BHUILOK74_16635
BAYDBSPP4475_03825
BBORRFB14_05025
BRUMNDK47_05855
PJDPjdr2_5104
PPYPPE_02107
PPMPPSC2_11035(yrhB)
PPOPPM_2116(yrhB)
PPOLX809_11380
PPQPPSQR21_021960
PPOYRE92_01315
PTAHPL003_19390
PBJVN24_22970
PIHUB51_24975
PPEOABE82_11210
PBVAR543_13270
PXLBS614_24800
PKBB4V02_14230
PAIHASL14_00325
PPRTET464_13385
PKAPQ456_10635
PAMYP9222_15305
PNKAASFL403_08255
ANXACH33_03440
ASOCCB4_01041(mccB_2)
ATHEK3F53_15475
AUDPO771_03285
PLNPlano_2471
PKUAUO94_03270
PRTAUC31_13730
PLLI858_010425
PANABBH88_06555
PDGBCM40_02840
PHCBBI08_09600
PMARB0X71_15400
PPLABBI15_08580
PFAEAJGP001_14280
PLXCW734_14630
PMATBBI11_14200
PDECH1Q58_13505
PLAYDNR44_007335
JEOJMA_30770
SPSYAZE41_06760
SPOOJ3U78_10515
RSTATY39_01120
PAEKD3873_09800
PANCE2636_04660
VIJJNUCC6_21815
NTRB0W44_09000
LFBC1X05_03180
TVUAB849_002175
KPULGXN76_04270
KEBGXN75_04830
PABSJIR001_06880
CMICcaldi_03410(metC)
ACAEHYG86_02780
SAYTPY_1267(metC)
SAPSulac_2385
HFVR50_0413(mccB) R50_0742(mccB)
CTHMCFE_0259
BACGD2962_10705
STEDSPTER_12980(mccB_2)
SVESVEN_3489 SVEN_6204
ACTRAsp14428_15180
LEPTJVX88_00190
OLEK0B96_16580
PBORBSF38_05025(mccB)
GMAAciX8_2098
GRBGOB94_03575
EDAGWR55_01120
EDGH7846_07325
ORPMOP44_12640
SCORJ3U87_06265
FVAFV113G1_02250
CPICpin_1963
CBAECOR50_21245
CHITFW415_09465
CHIHGWR21_25265
CFILMYF79_09760
CHORMKQ68_15740
CSACSIO70_11175
NIAA8C56_12875
RHOZGXP67_11625
FLIFleli_0126
HAEIMUN82_11060
CHKD4L85_07900
FMMLVD15_06280
FUALVD17_07615
FLWLVD16_02685
TPELP0M28_21480
FPSZAMR72_00130
FATDVK85_10105
FKIFK004_10650
FPALHYN49_09540
FALBHYN59_11470
FAKFUA48_15650
COCCoch_1685
COLAM608_00910
CAPNCBG49_00030
CSPUCGC55_09095
MARMYQ22_16555
MARTBTR34_16640
AICJK629_00045
NULR1T42_07130
MYRMYRA21_1478(mccB)
MODAS202_07005
AUEC5O00_08315 C5O00_10905
SINHLS482_14990
SAHNJRG66_13300
FBQD1817_07655
APIBG8C43_00490
BPIBPLAN_072(metB)
BBQBLBBOR_564
BLUK645_2681
OHOOweho_2590
SRUSRU_1368
SRMSRM_01563(metB)
MEMEHYG87_01500
 » show all
Reference
1  [PMID:14917685]
  Authors
KALLIO RE.
  Title
Function of pyridoxal phosphate in desulfhydrase systems of Proteus morganii.
  Journal
J Biol Chem 192:371-7 (1951)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.2
IUBMB Enzyme Nomenclature: 4.4.1.2
ExPASy - ENZYME nomenclature database: 4.4.1.2
BRENDA, the Enzyme Database: 4.4.1.2
CAS: 9024-41-3

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