KEGG ENZYME: 4.4.1.20

ENZYME: 4.4.1.20

Entry

EC 4.4.1.20                 Enzyme

Name

leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)

Class

Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)

Sysname

leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)

Reaction(IUBMB)

leukotriene C4 = leukotriene A4 + glutathione [RN:R03059]

Reaction(KEGG)

R03059

Substrate

leukotriene C4 [CPD:C02166]

Product

leukotriene A4 [CPD:C00909];
glutathione [CPD:C00051]

Comment

The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.

History

EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20

Pathway

ec00590

Arachidonic acid metabolism

ec01100

Metabolic pathways

Orthology

K00807

leukotriene-C4 synthase

Genes

HSA:	4056(LTC4S)

PTR:	739986(LTC4S)

PPS:	100983593(LTC4S)

GGO:	101148178(LTC4S)

PON:	100456952(LTC4S)

MCC:	705233(LTC4S)

MCF:	102141868(LTC4S)

CSAB:

103245108(LTC4S)

CATY:

105590406(LTC4S)

PANU:

101019292(LTC4S)

TGE:	112626468(LTC4S)

RRO:	104676203(LTC4S)

RBB:	108523369(LTC4S)

TFN:	117064350(LTC4S)

PTEH:

111527422(LTC4S)

CJC:	100385291(LTC4S)

MMUR:

105885202(LTC4S)

OGA:	100955913(LTC4S)

MMU:	17001(Ltc4s)

MCAL:

110305673(Ltc4s)

RNO:	114097(Ltc4s)

MCOC:

116077408(Ltc4s)

CGE:

113836822

PLEU:

114681491(Ltc4s)

NGI:	103749375(Ltc4s)

HGL:	101722474(Ltc4s)

CPOC:

100725689(Ltc4s)

CCAN:

109686722(Ltc4s)

DORD:

105996742(Ltc4s)

DSP:	122115470(Ltc4s)

NCAR:

124987187

OCU:	100341898(LTC4S)

OPI:	101526783(LTC4S)

CFA:	607316(LTC4S)

VVP:	112932405(LTC4S)

VLG:	121495583(LTC4S)

AML:	105238479(LTC4S)

UAH:	113261556(LTC4S)

UAR:	123790490(LTC4S)

ELK:

111158923

MPUF:

101681631(LTC4S)

ORO:	101378794(LTC4S)

EJU:	114201192(LTC4S)

ZCA:	113929399(LTC4S)

MLX:	118026475(LTC4S)

FCA:	101096198(LTC4S)

PYU:	121010522(LTC4S)

PBG:	122485987(LTC4S)

PTG:	102964525(LTC4S)

PPAD:

109278966(LTC4S)

AJU:	106970167(LTC4S)

HHV:	120245668(LTC4S)

BTA:	511749(LTC4S)

BOM:	102278603(LTC4S)

BBUB:

102414907(LTC4S)

OAS:	101119304(LTC4S)

CCAD:

122440584(LTC4S)

SSC:	100520063(LTC4S)

CFR:	116658955(LTC4S)

CBAI:

105062007(LTC4S)

CDK:	116148476(LTC4S)

BACU:

103011981(LTC4S)

LVE:	103085740(LTC4S)

OOR:	101285904(LTC4S)

DLE:	111169283(LTC4S)

PCAD:

102993996(LTC4S)

PSIU:

116751355(LTC4S)

ECB:	100067282(LTC4S)

EPZ:	103560012(LTC4S)

EAI:	106843724(LTC4S)

MMYO:

118658618(LTC4S)

PKL:	118725943(LTC4S)

HAI:	109392760(LTC4S)

DRO:	112296409(LTC4S)

SHON:

118995094(LTC4S)

AJM:	119042626(LTC4S)

PDIC:

114510033(LTC4S)

PHAS:

123808677(LTC4S)

MMF:	118615263(LTC4S)

RFQ:	117016804(LTC4S)

PALE:

102882511(LTC4S)

PGIG:

120616621(LTC4S)

PVP:	105299971(LTC4S)

RAY:	107512319(LTC4S)

MJV:	108401191(LTC4S)

TOD:	119236232(LTC4S)

SARA:

101547520(LTC4S)

LAV:	100675058(LTC4S)

TMU:

101361468

DNM:	101436622(LTC4S)

MDO:	100032154(LTC4S)

GAS:	123237460(LTC4S)

SHR:	116421692(LTC4S)

PCW:	110216768(LTC4S)

OAA:	114807422(LTC4S)

GGA:	770619(LTC4S) 770665(LTC4SL)

PCOC:

116232167 116232169

MGP:	100543887 100551070

CJO:	107320125 107320232

NMEL:

110405439 110405512

APLA:

101803851(LTC4S) 101804397

ACYG:

106032815 106032894

AFUL:

116494761 116494904

TGU:	100218541 100219450

LSR:	110482719 110482722

SCAN:

103817291 103817479(LTC4S)

PMOA:

120498564 120498613(LTC4S)

OTC:	121332393 121332400

PRUF:

121361386 121361397

GFR:	102044383 102044843(LTC4S)

FAB:	101806252 101806896(LTC4S)

PHI:	102109119 102111820(LTC4S)

PMAJ:

107210533 107210696

CCAE:

111935555 111935558

CCW:	104689587 104689589

ETL:	114065215(LTC4S) 114071247

ZAB:	102071342 102071700

FPG:	101917253 101919677(LTC4S)

FCH:	102054340 102055824

CLV:	102098046 102098404

EGZ:	104123601 104128439

NNI:	104014188 104018439

ACUN:

113485203(LTC4S) 113485336

TALA:

104357001 104357925

PADL:

103915754 103915829

ACHC:

115334117 115334443

AAM:	106493451 106493455

AROW:

112964865(LTC4S) 112964888

NPD:	112954367 112954407

DNE:	112996911(LTC4S) 112996946

ASN:	102373647 102374413

AMJ:	102568686(LTC4S) 102571710

CPOO:

109310147 109310151

GGN:	109289903 109289905

PSS:	102456931 102457340

CMY:	102936169 102936619

CPIC:

101945657 101946405

TST:	117882073 117882245

CABI:

116820058 116820064

MRV:	120370243 120370346

ACS:	103277893(ltc4s)

PVT:	110073491(LTC4S)

SUND:

121921085(LTC4S)

PBI:	103060000(LTC4S)

PMUR:

107296651(LTC4S)

TSR:	106538648(LTC4S)

PGUT:

117655377(LTC4S)

VKO:	123035857(LTC4S)

PMUA:

114591332(LTC4S)

ZVI:	118080408(LTC4S)

GJA:	107110314(LTC4S)

STOW:

125429074(LTC4S)

XLA:	108712616(ltc4s.1.S) 495166(ltc4s.2.L)

XTR:	100127769(ltc4s.2) 100379825(ltc4s.1)

NPR:

108785375

RTEM:

120932527 120932530

BBUF:

120986977 121008406(LTC4S)

BGAR:

122926480(LTC4S) 122928284

DRE:	100535432(ltc4s)

SRX:	107722431 107733419

SANH:

107660445 107667453

SGH:	107551000(ltc4s) 107578450

CCAR:

109081382 109102539

CAUA:

113113366 113113488

PPRM:

120464346(ltc4s)

MAMB:

125258692(ltc4s)

PHYP:

113542917(ltc4s)

SMEO:

124385679(ltc4s)

TFD:	113647746(ltc4s)

AMEX:

103033591(ltc4s)

EEE:	113584818(ltc4s)

TRU:

101079867

TNG:	GSTEN00024281G001

LCO:

104934865

SLUC:

116062541(ltc4s)

PFLV:

114563322(ltc4s)

GAT:	120817689(ltc4s)

PPUG:

119211050(ltc4s)

MSAM:

119888516(ltc4s)

CUD:	121516813(ltc4s)

MZE:	101463928(ltc4s)

ONL:	100701372(ltc4s)

OAU:	116329678(ltc4s)

OLA:	101165938(ltc4s)

OML:	112137898(ltc4s)

XMA:	102217258(ltc4s)

XCO:	114138731(ltc4s)

XHE:	116714057(ltc4s)

PRET:

103471803

PFOR:

103130782

PLAI:

106936341

PMEI:

106928913

GAF:	122837076(ltc4s)

CVG:

107083789

CTUL:

119784582(ltc4s)

GMU:	124860333(ltc4s)

NFU:

107380837

KMR:	108251405(ltc4s)

ALIM:

106530294

NWH:	119408828(ltc4s)

AOCE:

111581646

CSEM:

103391074(ltc4s)

POV:

109641734

SSEN:

122760853(ltc4s)

HHIP:

117769729(ltc4s)

LCF:

108873747

SDU:

111235924

SLAL:

111672941

XGL:	120785156(ltc4s)

HCQ:

109516552

BPEC:

110165507

MALB:

109956757

SASA:

106611597(ltc4s)

OTW:	112256314(ltc4s)

OMY:	110505101(ltc4s)

OGO:	124010924(ltc4s)

ONE:	115129530(ltc4s)

SALP:

111967563(ltc4s)

SNH:	120061991(ltc4s)

ELS:	105028348(ltc4s)

SFM:	108925352(ltc4s)

PKI:	111859874(ltc4s)

AANG:

118223010(ltc4s)

LOC:	102698624(ltc4s)

PSPA:

121296961 121323789

ARUT:

117413502 117431402

LCM:	102356667(LTC4S) 102366002

CMK:	103188230(ltc4s)

RTP:

109915474

» show all

Reference

1 [PMID:6324687]

Authors

Bach MK, Brashler JR, Morton DR Jr.

Title

Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.

Journal

Arch Biochem Biophys 230:455-65 (1984)
DOI:10.1016/0003-9861(84)90426-0

Reference

2 [PMID:2846379]

Authors

Shimizu T.

Title

Enzymes functional in the syntheses of leukotrienes and related compounds.

Journal

Int J Biochem 20:661-6 (1988)
DOI:10.1016/0020-711x(88)90160-7

Reference

3 [PMID:12432940]

Authors

Lam BK, Austen KF.

Title

Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.

Journal

Prostaglandins Other Lipid Mediat 68-69:511-20 (2002)
DOI:10.1016/S0090-6980(02)00052-7

Reference

4 [PMID:12023288]

Authors

Christmas P, Weber BM, McKee M, Brown D, Soberman RJ.

Title

Membrane localization and topology of leukotriene C4 synthase.

Journal

J Biol Chem 277:28902-8 (2002)
DOI:10.1074/jbc.M203074200

Other DBs

ExplorEnz - The Enzyme Database:

4.4.1.20

IUBMB Enzyme Nomenclature:

4.4.1.20

ExPASy - ENZYME nomenclature database:

4.4.1.20

BRENDA, the Enzyme Database:

4.4.1.20

CAS:	90698-32-1

DBGET integrated database retrieval system