KEGG   ENZYME: 4.4.1.20
Entry
EC 4.4.1.20                 Enzyme                                 
Name
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
Reaction(IUBMB)
leukotriene C4 = leukotriene A4 + glutathione [RN:R03059]
Reaction(KEGG)
R03059
Substrate
leukotriene C4 [CPD:C02166]
Product
leukotriene A4 [CPD:C00909];
glutathione [CPD:C00051]
Comment
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
History
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00807  leukotriene-C4 synthase
Genes
HSA4056(LTC4S)
PTR739986(LTC4S)
PPS100983593(LTC4S)
GGO101148178(LTC4S)
PON100456952(LTC4S)
MCC705233(LTC4S)
MCF102141868(LTC4S)
CSAB103245108(LTC4S)
CATY105590406(LTC4S)
PANU101019292(LTC4S)
TGE112626468(LTC4S)
RRO104676203(LTC4S)
RBB108523369(LTC4S)
TFN117064350(LTC4S)
PTEH111527422(LTC4S)
CJC100385291(LTC4S)
MMUR105885202(LTC4S)
OGA100955913(LTC4S)
MMU17001(Ltc4s)
MCAL110305673(Ltc4s)
RNO114097(Ltc4s)
MCOC116077408(Ltc4s)
CGE113836822
PLEU114681491(Ltc4s)
NGI103749375(Ltc4s)
HGL101722474(Ltc4s)
CPOC100725689(Ltc4s)
CCAN109686722(Ltc4s)
DORD105996742(Ltc4s)
DSP122115470(Ltc4s)
NCAR124987187
OCU100341898(LTC4S)
OPI101526783(LTC4S)
CFA607316(LTC4S)
VVP112932405(LTC4S)
VLG121495583(LTC4S)
AML105238479(LTC4S)
UAH113261556(LTC4S)
UAR123790490(LTC4S)
ELK111158923
MPUF101681631(LTC4S)
ORO101378794(LTC4S)
EJU114201192(LTC4S)
ZCA113929399(LTC4S)
MLX118026475(LTC4S)
FCA101096198(LTC4S)
PYU121010522(LTC4S)
PBG122485987(LTC4S)
PTG102964525(LTC4S)
PPAD109278966(LTC4S)
AJU106970167(LTC4S)
HHV120245668(LTC4S)
BTA511749(LTC4S)
BOM102278603(LTC4S)
BBUB102414907(LTC4S)
OAS101119304(LTC4S)
CCAD122440584(LTC4S)
SSC100520063(LTC4S)
CFR116658955(LTC4S)
CBAI105062007(LTC4S)
CDK116148476(LTC4S)
BACU103011981(LTC4S)
LVE103085740(LTC4S)
OOR101285904(LTC4S)
DLE111169283(LTC4S)
PCAD102993996(LTC4S)
PSIU116751355(LTC4S)
ECB100067282(LTC4S)
EPZ103560012(LTC4S)
EAI106843724(LTC4S)
MMYO118658618(LTC4S)
PKL118725943(LTC4S)
HAI109392760(LTC4S)
DRO112296409(LTC4S)
SHON118995094(LTC4S)
AJM119042626(LTC4S)
PDIC114510033(LTC4S)
PHAS123808677(LTC4S)
MMF118615263(LTC4S)
RFQ117016804(LTC4S)
PALE102882511(LTC4S)
PGIG120616621(LTC4S)
PVP105299971(LTC4S)
RAY107512319(LTC4S)
MJV108401191(LTC4S)
TOD119236232(LTC4S)
SARA101547520(LTC4S)
LAV100675058(LTC4S)
TMU101361468
DNM101436622(LTC4S)
MDO100032154(LTC4S)
GAS123237460(LTC4S)
SHR116421692(LTC4S)
PCW110216768(LTC4S)
OAA114807422(LTC4S)
GGA770619(LTC4S) 770665(LTC4SL)
PCOC116232167 116232169
MGP100543887 100551070
CJO107320125 107320232
NMEL110405439 110405512
APLA101803851(LTC4S) 101804397
ACYG106032815 106032894
AFUL116494761 116494904
TGU100218541 100219450
LSR110482719 110482722
SCAN103817291 103817479(LTC4S)
PMOA120498564 120498613(LTC4S)
OTC121332393 121332400
PRUF121361386 121361397
GFR102044383 102044843(LTC4S)
FAB101806252 101806896(LTC4S)
PHI102109119 102111820(LTC4S)
PMAJ107210533 107210696
CCAE111935555 111935558
CCW104689587 104689589
ETL114065215(LTC4S) 114071247
ZAB102071342 102071700
FPG101917253 101919677(LTC4S)
FCH102054340 102055824
CLV102098046 102098404
EGZ104123601 104128439
NNI104014188 104018439
ACUN113485203(LTC4S) 113485336
TALA104357001 104357925
PADL103915754 103915829
ACHC115334117 115334443
AAM106493451 106493455
AROW112964865(LTC4S) 112964888
NPD112954367 112954407
DNE112996911(LTC4S) 112996946
ASN102373647 102374413
AMJ102568686(LTC4S) 102571710
CPOO109310147 109310151
GGN109289903 109289905
PSS102456931 102457340
CMY102936169 102936619
CPIC101945657 101946405
TST117882073 117882245
CABI116820058 116820064
MRV120370243 120370346
ACS103277893(ltc4s)
PVT110073491(LTC4S)
SUND121921085(LTC4S)
PBI103060000(LTC4S)
PMUR107296651(LTC4S)
TSR106538648(LTC4S)
PGUT117655377(LTC4S)
VKO123035857(LTC4S)
PMUA114591332(LTC4S)
ZVI118080408(LTC4S)
GJA107110314(LTC4S)
STOW125429074(LTC4S)
XLA108712616(ltc4s.1.S) 495166(ltc4s.2.L)
XTR100127769(ltc4s.2) 100379825(ltc4s.1)
NPR108785375
RTEM120932527 120932530
BBUF120986977 121008406(LTC4S)
BGAR122926480(LTC4S) 122928284
DRE100535432(ltc4s)
SRX107722431 107733419
SANH107660445 107667453
SGH107551000(ltc4s) 107578450
CCAR109081382 109102539
CAUA113113366 113113488
PPRM120464346(ltc4s)
MAMB125258692(ltc4s)
PHYP113542917(ltc4s)
SMEO124385679(ltc4s)
TFD113647746(ltc4s)
AMEX103033591(ltc4s)
EEE113584818(ltc4s)
TRU101079867
TNGGSTEN00024281G001
LCO104934865
SLUC116062541(ltc4s)
PFLV114563322(ltc4s)
GAT120817689(ltc4s)
PPUG119211050(ltc4s)
MSAM119888516(ltc4s)
CUD121516813(ltc4s)
MZE101463928(ltc4s)
ONL100701372(ltc4s)
OAU116329678(ltc4s)
OLA101165938(ltc4s)
OML112137898(ltc4s)
XMA102217258(ltc4s)
XCO114138731(ltc4s)
XHE116714057(ltc4s)
PRET103471803
PFOR103130782
PLAI106936341
PMEI106928913
GAF122837076(ltc4s)
CVG107083789
CTUL119784582(ltc4s)
GMU124860333(ltc4s)
NFU107380837
KMR108251405(ltc4s)
ALIM106530294
NWH119408828(ltc4s)
AOCE111581646
CSEM103391074(ltc4s)
POV109641734
SSEN122760853(ltc4s)
HHIP117769729(ltc4s)
LCF108873747
SDU111235924
SLAL111672941
XGL120785156(ltc4s)
HCQ109516552
BPEC110165507
MALB109956757
SASA106611597(ltc4s)
OTW112256314(ltc4s)
OMY110505101(ltc4s)
OGO124010924(ltc4s)
ONE115129530(ltc4s)
SALP111967563(ltc4s)
SNH120061991(ltc4s)
ELS105028348(ltc4s)
SFM108925352(ltc4s)
PKI111859874(ltc4s)
AANG118223010(ltc4s)
LOC102698624(ltc4s)
PSPA121296961 121323789
ARUT117413502 117431402
LCM102356667(LTC4S) 102366002
CMK103188230(ltc4s)
RTP109915474
 » show all
Reference
1  [PMID:6324687]
  Authors
Bach MK, Brashler JR, Morton DR Jr.
  Title
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
  Journal
Arch Biochem Biophys 230:455-65 (1984)
DOI:10.1016/0003-9861(84)90426-0
Reference
2  [PMID:2846379]
  Authors
Shimizu T.
  Title
Enzymes functional in the syntheses of leukotrienes and related compounds.
  Journal
Int J Biochem 20:661-6 (1988)
DOI:10.1016/0020-711x(88)90160-7
Reference
3  [PMID:12432940]
  Authors
Lam BK, Austen KF.
  Title
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
  Journal
Prostaglandins Other Lipid Mediat 68-69:511-20 (2002)
DOI:10.1016/S0090-6980(02)00052-7
Reference
4  [PMID:12023288]
  Authors
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ.
  Title
Membrane localization and topology of leukotriene C4 synthase.
  Journal
J Biol Chem 277:28902-8 (2002)
DOI:10.1074/jbc.M203074200
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.20
IUBMB Enzyme Nomenclature: 4.4.1.20
ExPASy - ENZYME nomenclature database: 4.4.1.20
BRENDA, the Enzyme Database: 4.4.1.20
CAS: 90698-32-1

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