Entry |
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Name |
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
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Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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Sysname |
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
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Reaction(IUBMB) |
leukotriene C4 = leukotriene A4 + glutathione [RN: R03059]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
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History |
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
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Pathway |
ec00590 | Arachidonic acid metabolism |
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Orthology |
K00807 | leukotriene-C4 synthase |
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Genes |
GGA: | 770619(LTC4S) 770665(LTC4SL) |
PCOC: | 116232167 116232169 |
NMEL: | 110405439 110405512 |
APLA: | 101803851(LTC4S) 101804397 |
ACYG: | 106032815 106032894 |
AFUL: | 116494761 116494904 |
SCAN: | 103817291 103817479(LTC4S) |
PMOA: | 120498564 120498613(LTC4S) |
PRUF: | 121361386 121361397 |
GFR: | 102044383 102044843(LTC4S) |
FAB: | 101806252 101806896(LTC4S) |
PHI: | 102109119 102111820(LTC4S) |
PMAJ: | 107210533 107210696 |
CCAE: | 111935555 111935558 |
ETL: | 114065215(LTC4S) 114071247 |
FPG: | 101917253 101919677(LTC4S) |
ACUN: | 113485203(LTC4S) 113485336 |
TALA: | 104357001 104357925 |
PADL: | 103915754 103915829 |
ACHC: | 115334117 115334443 |
AROW: | 112964865(LTC4S) 112964888 |
DNE: | 112996911(LTC4S) 112996946 |
AMJ: | 102568686(LTC4S) 102571710 |
CPOO: | 109310147 109310151 |
CPIC: | 101945657 101946405 |
CABI: | 116820058 116820064 |
XLA: | 108712616(ltc4s.1.S) 495166(ltc4s.2.L) |
XTR: | 100127769(ltc4s.2) 100379825(ltc4s.1) |
RTEM: | 120932527 120932530 |
BBUF: | 120986977 121008406(LTC4S) |
BGAR: | 122926480(LTC4S) 122928284 |
SANH: | 107660445 107667453 |
SGH: | 107551000(ltc4s) 107578450 |
CCAR: | 109081382 109102539 |
CAUA: | 113113366 113113488 |
PSPA: | 121296961 121323789 |
ARUT: | 117413502 117431402 |
LCM: | 102356667(LTC4S) 102366002 |
» show all
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Reference |
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Authors |
Bach MK, Brashler JR, Morton DR Jr. |
Title |
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase. |
Journal |
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Reference |
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Authors |
Shimizu T. |
Title |
Enzymes functional in the syntheses of leukotrienes and related compounds. |
Journal |
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Reference |
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Authors |
Lam BK, Austen KF. |
Title |
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. |
Journal |
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Reference |
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Authors |
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ. |
Title |
Membrane localization and topology of leukotriene C4 synthase. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 4.4.1.20 |
ExPASy - ENZYME nomenclature database: | 4.4.1.20 |
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