KEGG   ENZYME: 4.4.1.24
Entry
EC 4.4.1.24                 Enzyme                                 
Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambigious);
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
(2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + hydrogensulfite [RN:R07633]
Reaction(KEGG)
R07633
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
hydrogensulfite
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.
History
EC 4.4.1.24 created 2006, modified 2011
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K16845  (2R)-sulfolactate sulfo-lyase subunit alpha
K16846  (2R)-sulfolactate sulfo-lyase subunit beta
Genes
AHN: NCTC12129_02754 NCTC12129_02755(garD_1)
ASUB: NLZ15_10125 NLZ15_10130
GHO: AL542_00730 AL542_00735
GKD: K6Q96_22185 K6Q96_22190
SHAI: LMH63_10820 LMH63_10825
APRS: BI364_08775 BI364_08780
CSA: Csal_1765 Csal_1766
HBE: BEI_0833(suyA) BEI_0834(suyB)
HCAM: I4484_16845 I4484_16850
HQN: M0220_01620 M0220_01625
HSX: HNO51_16745 HNO51_16750
SVA: SVA_1848 SVA_1849
TSN: W908_01095 W908_01100
THIN: CRN91_00440 CRN91_00445
RPJ: N234_02625 N234_02630
CUH: BJN34_26750 BJN34_26755
REU: Reut_B3528 Reut_B3529 Reut_C6087 Reut_C6088
CTI: RALTA_B0839 RALTA_B0840
CBW: RR42_m0459 RR42_m0460
CGD: CR3_0181(suyA) CR3_0182(suyB)
COX: E0W60_13280 E0W60_13285
CCAX: KZ686_04905 KZ686_04910
CNAN: A2G96_27610 A2G96_27615
CUPR: IC580_01010 IC580_01015
CUPP: CTP10_R04930 CTP10_R04940
BURT: BTHE68_46260 BTHE68_46270
BFN: OI25_4407 OI25_4408
PARA: BTO02_21290 BTO02_21295
PGIS: I6I06_21455 I6I06_21460
PACS: FAZ98_25200 FAZ98_25205 FAZ98_25235
PEW: KZJ38_22645 KZJ38_22650
PDQ: CL55_00014410 CL55_00014420
PANI: DCO16_07880 DCO16_07885
PWU: A8O14_02445 A8O14_02450
POLT: TUM22923_11560 TUM22923_11570
PTX: ABW99_10885 ABW99_10890
PAND: DRB87_03410 DRB87_03415
CABA: SBC2_17550 SBC2_17560(suyB_1)
BUO: BRPE64_DCDS09670 BRPE64_DCDS09680
CABK: NK8_49340 NK8_49350
TVL: FAZ95_11645 FAZ95_11650 FAZ95_15385 FAZ95_15415 FAZ95_15420
BPT: Bpet0414 Bpet0415
BBRO: BAU06_18065 BAU06_18070
BFZ: BAU07_08210 BAU07_08215
BOH: AKI39_17260 AKI39_17265
BGM: CAL15_02275 CAL15_02280
BGV: CAL12_19005 CAL12_19010
AXY: AXYL_00473 AXYL_00474
AXO: NH44784_017111 NH44784_017121
AXN: AX27061_0479 AX27061_0480
AXX: ERS451415_00473(garD_1) ERS451415_00474
ADT: APT56_02500 APT56_02505
AIS: BUW96_28025 BUW96_28030
ACHR: C2U31_07150 C2U31_07155
ADY: HLG70_19595 HLG70_19600
ACHO: H4P35_02090 H4P35_02095
AMUI: PE062_26100 PE062_26105
APES: FOC84_10130 FOC84_10135
AAEG: RA224_02325 RA224_02330
ASEL: RAS12_19625 RAS12_19630
ACHM: V6V88_02090 V6V88_02095
AVH: WHX56_07215 WHX56_07220
ACHH: ABFG95_17130 ABFG95_17135
AKA: TKWG_23285
AMIM: MIM_c37580 MIM_c37590
PACR: FXN63_16930
PARK: LSG25_12690 LSG25_12695
VEI: Veis_0892 Veis_0893
VAP: Vapar_3818 Vapar_3819
VPD: VAPA_1c39310 VAPA_1c39320
LIH: L63ED372_00897(suyB) L63ED372_00898(suyA)
HYN: F9K07_27975 F9K07_27980
RGE: RGE_25210(suyB) RGE_25220
ATER: MW290_18635 MW290_18640
HAR: HEAR3336 HEAR3337(uxaA)
ACTB: RHM62_15000 RHM62_15005
URU: DSM104443_03898(suyB) DSM104443_03899(suyA)
UPL: DSM104440_03459(suyB) DSM104440_03460(suyA)
ACOM: CEW83_08370 CEW83_08375
BPRC: D521_1331 D521_1332
BEBA: BWI17_07545 BWI17_07550
NIY: FQ775_22320 FQ775_22325
MESO: BSQ44_12870 BSQ44_12875
CHEA: PVE73_02285 PVE73_02290
AMAX: ABWH92_10685 ABWH92_10690
KMN: HW532_06455 HW532_06460
EMX: FKV68_25180 FKV68_25185
OCC: KMS41_23515 KMS41_23520
OCA: OCAR_7557 OCAR_7558
OCG: OCA5_c05830 OCA5_c05840(garD)
OCO: OCA4_c05820 OCA4_c05830(garD)
PCAX: AFIC_002275 AFIC_002276
VGO: GJW-30_1_00129(suyB_1) GJW-30_1_00130(suyA)
BVV: BHK69_18025 BHK69_18030
BVES: QO058_00735 QO058_00740
BOP: AXW83_05570 AXW83_05575
BOS: BSY19_2608 BSY19_2609
BOI: BLM15_06715 BLM15_06720
BOSE: RMR04_15920 RMR04_15925
AQI: J5J86_06695 J5J86_06700
MRD: Mrad2831_5979 Mrad2831_5980
MNO: Mnod_3705 Mnod_3706
METI: DK427_02140 DK427_02145
MMES: MMSR116_04775 MMSR116_04780
RVA: Rvan_3576 Rvan_3577
RLAC: QMO75_13550 QMO75_13555
RHZ: RHPLAN_09780 RHPLAN_09790
CMET: K6K41_04840
AUB: LXB15_20865 LXB15_20870
LABR: CHH27_12020 CHH27_12025
LABP: FJ695_09910 FJ695_09915 FJ695_27770 FJ695_27775
RPOP: K1718_07230 K1718_07235
PSTG: E8M01_21840 E8M01_21845
PAQT: E8L99_13600 E8L99_13605
JOV: P8627_16250 P8627_16255
DSH: Dshi_2037 Dshi_2038
MALG: MALG_01233 MALG_01234
TPRO: Ga0080559_TMP3624 Ga0080559_TMP3625
ROM: EI983_18915 EI983_18920
MARU: FIU81_03600(suyA) FIU81_03605(suyB)
PSEW: JHW44_18550 JHW44_18555
PAEX: JHW48_16255 JHW48_16260
PFEO: E3U26_14770 E3U26_14775
RSU: NHU_04239 NHU_04240
RHM: B5V46_17720 B5V46_17725
POZ: I0K15_17255 I0K15_17260
CACT: HZ995_04865 HZ995_04870
CMAG: CBW24_05850 CBW24_05855
AMAQ: GO499_07055 GO499_07060
RBG: BG454_15335 BG454_15340
FAQ: G5B39_15415 G5B39_15420
ACIM: GT370_20030
RFL: Rmf_46720 Rmf_46730
SRF: LHU95_23315 LHU95_23320
ELIO: KO353_14440 KO353_14445
SHUM: STHU_05310 STHU_05320
SVC: STVA_07470 STVA_07480
STEL: STAQ_07090 STAQ_07100
NCB: C0V82_01500 C0V82_01505
VSU: P3M64_05665 P3M64_05670
NACI: NUH88_21480 NUH88_21485
THAR: T8K17_19795 T8K17_19800
PUB: SAR11_0842(garD) SAR11_0843
PEG: E5R92_01770 E5R92_01775
APM: HIMB5_00005030 HIMB5_00005040
DDS: Ddes_2374 Ddes_2375
DFI: AXF13_13575 AXF13_13580
DEF: CNY67_15440 CNY67_15445
DTR: RSDT_0106(suyA) RSDT_0107(suyB)
DMS: E8L03_07115 E8L03_07120 E8L03_07380 E8L03_07385
DVM: DvMF_2003 DvMF_2004 DvMF_2005 DvMF_2006
CLIH: KPS_002244 KPS_002245 KPS_002246 KPS_002247
TMUR: JBF11_07025 JBF11_07030
DBA: Dbac_2155 Dbac_2156
DRT: Dret_2324 Dret_2325
DEO: CAY53_05295 CAY53_05300
DALK: DSCA_63940 DSCA_63950
DTI: Desti_1900 Desti_1901 Desti_3262 Desti_3263
DMP: FAK_06060 FAK_06070 FAK_22130 FAK_22140
DTU: Dtur_0481 Dtur_0482
BACA: FAY30_23705 FAY30_23710
BON: A361_10260 A361_10265
CFIR: NAF01_04365
CPSS: M5V91_11065 M5V91_11070
APAK: AP3564_02000 AP3564_02005
ACOP: RI196_15585 RI196_15590
PCHU: QNI29_17410 QNI29_17415
NMK: CHR53_24455 CHR53_24460
FAF: OE104_10460 OE104_10465
PSAB: PSAB_19160 PSAB_19165
PSOP: KP014_25870 KP014_25875
PAUB: PUR_41330 PUR_41340
AFX: JZ786_13615 JZ786_13620
ADAU: NZD86_03690 NZD86_03695
ALIC: GI364_08780 GI364_08785
EFF: skT53_05830 skT53_05840
FFE: LSG31_04600 LSG31_04605
NTR: B0W44_06075 B0W44_06080
FAH: MTP37_00330
BIE: RFF05_00200 RFF05_01425
INT: RX717_14335
DSY: DSY0965 DSY0966 DSY3251 DSY3252
DHD: Dhaf_2050 Dhaf_2051 Dhaf_4418 Dhaf_4419
DDH: Desde_3797 Desde_3798
DDL: Desdi_3120 Desdi_3121 Desdi_3123 Desdi_3124
DRU: Desru_0086 Desru_0087 Desru_0600 Desru_0601 Desru_1694 Desru_1695 Desru_1700 Desru_1701
DKU: Desku_3257 Desku_3258
AACX: DEACI_3907 DEACI_3908
DGI: Desgi_0071 Desgi_0072
SAY: TPY_1962(uxaA) TPY_1963
SAP: Sulac_2158 Sulac_2159
MAS: Mahau_2704 Mahau_2705
SSID: SPSIL_034990(suyB) SPSIL_035000
SACV: SPACI_037790(suyB_3) SPACI_037800
LPIL: LIP_0417 LIP_0418 LIP_1984 LIP_1985
RHA: RHA1_ro08847(suyA) RHA1_ro08848(suyB)
RKO: JWS14_47765 JWS14_47770
SARM: DVA86_02095 DVA86_02100
SATK: SA2016_2187 SA2016_2188
GYU: FE374_10310
MPH: MLP_21600 MLP_21610
AMAZ: LUW76_22390 LUW76_22395
ACTQ: OG417_30915 OG417_30920
PLAN: A1s21148_06285 A1s21148_06290
PVN: A7sIIA15_00840 A7sIIA15_00845
RXY: Rxyl_2590 Rxyl_2591
RUB: GBA63_01435 GBA63_01440
LEPV: J4558_23785 J4558_23790
MRB: Mrub_2462 Mrub_2463
MRE: K649_10215 K649_10220
MTAI: Mtai_v1c20770 Mtai_v1c20780
MSV: Mesil_1011 Mesil_1012
TNA: CTN_1545 CTN_1546
TTA: Theth_1763 Theth_1764
PHY: AJ81_05180 AJ81_05185
TAC: Ta1392 Ta1393
STO: STK_25590 STK_25600
SSO: SSO1259(garD) SSO1260
SOL: Ssol_2216 Ssol_2217
SSOA: SULA_2250 SULA_2251
SSOL: SULB_2251 SULB_2252
SSOF: SULC_2248 SULC_2249
SSHI: J5U23_02055 J5U23_02056
SCAS: SACC_24590 SACC_24600
SIS: LS215_0489 LS215_0490
SIA: M1425_0434 M1425_0435
SIM: M1627_0445 M1627_0446
SID: M164_0471 M164_0472
SIY: YG5714_0443 YG5714_0444
SIN: YN1551_2572 YN1551_2573
SII: LD85_0490 LD85_0491
SIH: SiH_0939 SiH_0940
SIR: SiRe_0429 SiRe_0430
SIC: SiL_0462 SiL_0463
SULA: BFU36_12935 BFU36_12940
SULE: GFS03_03720 GFS03_03725
SULO: GFS33_07510 GFS33_07515
MSE: Msed_1123 Msed_1124
MEMJ: MJ1HA_1252 MJ1HA_1253
MHK: DFR87_12100 DFR87_12105
MPRU: DFR88_00905 DFR88_00910
MTEN: GWK48_07245 GWK48_07250
AHO: Ahos_0318 Ahos_0319
AMAN: B6F84_05000 B6F84_05005
ABRI: DFR85_12640 DFR85_12645
ACIH: HS5_05250 HS5_05260
CSTY: KN1_13270 KN1_13280
SAHS: HS7_03840 HS7_03850
CMA: Cmaq_1140 Cmaq_1141
TUZ: TUZN_0136 TUZN_0137
VMO: VMUT_1151 VMUT_1152
 » show all
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
  Sequence
[ag:AAW23058 AAW23059]
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
[csa:Csal_1765 Csal_1766]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.24
IUBMB Enzyme Nomenclature: 4.4.1.24
ExPASy - ENZYME nomenclature database: 4.4.1.24
BRENDA, the Enzyme Database: 4.4.1.24
CAS: 1256650-35-7

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Gene (22165)   
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Protein sequence (373)   
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   RefSeq(pep) (14)   
DNA sequence (205)   
   RefSeq(nuc) (22)   
   GenBank (95)   
   EMBL (88)   
Protein domain (5)   
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All databases (22748)   

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