KEGG ENZYME: 4.4.1.37

ENZYME: 4.4.1.37

Entry

EC 4.4.1.37                 Enzyme

Name

intrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase;
LarE (ambiguous);
P2CMN sulfurtransferase (ambiguous);
pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase (ambiguous);
P2TMN synthase (ambiguous);
pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase (ambiguous)

Class

Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)

Sysname

[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine pyridin-1-ium-3,5-dicarbothioate-mononucleotide-lyase (ATP-consuming)

Reaction(IUBMB)

(1) [LarE]-L-cysteine + pyridin-1-ium-3,5-dicarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + AMP + diphosphate (overall reaction) [RN:R12062];
(1a) ATP + pyridin-1-ium-3,5-dicarboxylate mononucleotide = diphosphate + 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [RN:R12059];
(1b) 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine [RN:R12060];
(1c) [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [RN:R12061];
(2) [LarE]-L-cysteine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide + AMP + diphosphate (overall reaction) [RN:R12066];
(2a) ATP + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide = diphosphate + 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [RN:R12063];
(2b) 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine [RN:R12064];
(2c) [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide [RN:R12065]

Reaction(KEGG)

R12059 R12060 R12061 R12062 R12063 R12064 R12065 R12066

Substrate

[LarE]-L-cysteine;
pyridin-1-ium-3,5-dicarboxylate mononucleotide [CPD:C21851];
ATP [CPD:C00002];
5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21877];
[LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine;
pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [CPD:C21878];
1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21879];
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine

Product

[LarE]-dehydroalanine;
pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [CPD:C21878];
AMP [CPD:C00020];
diphosphate [CPD:C00013];
5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21877];
[LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine;
pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide [CPD:C21767];
1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21879];
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine

Comment

This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. The process starts when one enzyme molecule adenylates pyridinium-3,5-dicarboxylate mononucleotide (P2CMN) and covalently binds the adenylated product to an intrinsic cysteine residue. Next, the enzyme cleaves the carbon-sulfur bond, liberating pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN) and leaving a 2-aminoprop-2-enoate (dehydroalanine) residue attached to the protein. Since the cysteine residue is not regenerated in vivo, the enzyme is inactivated during the process. A second enzyme molecule then repeats the process with PCTMN, adenylating it and covalently binding it to the same cysteine residue, followed by liberation of pyridinium-3,5-bisthiocarboxylate mononucleotide (P2TMN) and the inactivation of the second enzyme molecule. cf. EC 4.4.1.45, extrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase.

History

EC 4.4.1.37 created 2018, modified 2025

Orthology

K06864

cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase

Genes

SUPE:

P0H77_19430

SLIG:

GTU79_05810(larE)

TCI:	A7K98_01710

VSH:	BSZ05_17080

EMO:	DM558_01530

SPSR:

EGC80_15435(larE)

CATE:

C2869_06445 C2869_22210

MNY:	R50073_19240(larE)

THIP:

N838_07935(larE) N838_08690

GAI:	IMCC3135_06240

MFRA:

D5125_11910

KUS:	B9G99_09400

KMA:	B9H00_05450

KUY:	FY550_02755(larE)

AHA:

AHA_1096

AHY:	AHML_05865

AHD:	AI20_13750

AHH:	RY45_05850

AHI:	VU14_17210

AAJ:	BOQ57_05290

ASA:

ASA_3235

AEO:	O23A_p2530

AVR:

B565_3117

AVO:	AMS64_18350

AMED:

B224_4192

ASR:	WL1483_2033

ADH:	CK627_20680

AEM:	CK911_01420

AEA:	C2U39_17080

ARV:	C7N77_08810

AES:	C2U30_20060

AEL:	NCTC12917_03300

ASIM:

FE240_12690

AALL:

I6G90_11430

AJD:	I6H43_05665

ARIV:

KYK33_06015

ASAA:

KXJ75_18585

AEJ:	E5E97_10095

ABES:

IU367_05060

AERO:

CK910_23190

AERZ:

E5E96_12800

CBLY:

IPM89_04110(larE)

BUM:	AXG89_23665 AXG89_29025

SUTT:

SUTMEG_10620

SUTK:

FG381_12145

SWS:	I6J16_06240

BBAY:

A4V04_07840

KAI:

K32_38510

PCAX:

AFIC_000928

STAR:

G3545_21875

SNO:

Snov_3498

ANC:	GBB76_11560

APOL:

K9D25_07185

AQI:	J5J86_06820

MRD:	Mrad2831_1357

MET:

M446_3800

MOR:

MOC_1719

MAQU:

Maq22A_c11770

MPHY:

MCBMB27_01013

MEE:	DA075_01265

METX:

A3862_24025

METI:

DK427_11380

MMES:

MMSR116_17345

MTEA:

DK419_02900

MIND:

mvi_36300

MTAD:

M6G65_08955

MFUJ:

ABC766_02260

MENS:

LOK46_07155

BBAR:

RHAL1_03399

RBM:

TEF_02790

LABP:

FJ695_05660

LIZ:	LGH83_08250

ACUT:

MRB58_15045

MALG:

MALG_04019

SULD:

B5M07_17160

SDO:	SD1155_05780

SINL:

DSM14862_03981(larE)

SFAV:

PL335_15750

SDUB:

R1T39_16165

SPSE:

SULPSESMR1_03848

HAT:	RC74_17075

LSAL:

KBK07_18075

PZH:	CX676_17670

PARO:

CUV01_00725

PSAP:

JHX88_00660

PALS:

PAF20_06325

NOL:	NSDW_22670(larE)

BLAS:

BSY18_3645

LCK:	HN018_05385

RAP:	RHOA_PC0188

RMT:	IAI58_08805

SKT:	IGS68_04150

SMUC:

JL100_004320

SROE:

JL101_004070

MGM:

Mmc1_3710

WSU:

WS0138

CCV:	CCV52592_1718

CCO:	CCC13826_1003

CGRA:

CGRAC_1983

CSPF:

CSF_0736

CRX:	CRECT_2012

CMUC:

CMCT_0035

CSHO:

CSHOW_0339

CCAQ:

CCAL_0301

SDL:

Sdel_1279

SBA:	Sulba_1327

SMUL:

SMUL_1676

SHAL:

SHALO_1631

SULS:

Sdiek1_1722

SULJ:

SJPD1_1638

SULT:

FA592_00725(larE)

GSU:

GSU0536

GSK:	KN400_0525

GME:

Gmet_2987

GPI:	GPICK_13685

GAO:	A2G06_02865

GBZ:	JZM60_02970(larE)

GEM:

GM21_0342

GEB:

GM18_0439

GEF:	FO488_13660(larE) FO488_17545(larE)

GEV:	GSVR_17120

GEC:	GEO60473_34290(larE)

GUR:

Gura_3906

GEO:

Geob_1404

GLO:

Glov_2938

TAMM:

GEAMG1_2757

GBM:

Gbem_0361

GBN:	GEOBRER4_03440 GEOBRER4_19830

GER:	KP004_00865(larE)

GSUB:

KP001_14640(larE)

GNT:	KP003_00545(larE)

GPL:	M1B72_20030(larE)

GSB:	GSUB_13570

GHC:	L9S41_15435(larE)

PCA:

Pcar_2431

PACE:

A6070_03155

PEF:	A7E78_13745

PPD:

Ppro_1049

DEU:

DBW_3157

DVE:	DESUT3_33990

DEP:

AOP6_0503

DES:	DSOUD_0766

DDS:

Ddes_0092

DPG:	DESPIGER_1965

DEF:	CNY67_00515

DTR:

RSDT_0256

DFL:

DFE_2711

PSYF:

N1030_16525

DSB:	LN040_15300

DMA:

DMR_16550

DCB:	C3Y92_07465(larE)

DGG:

DGI_1164

DDE:

Dde_3008

DMS:	E8L03_07255(larE) E8L03_15165

DSA:	Desal_0486

DHY:	DESAM_20532

DAF:	Desaf_0882

DAS:

Daes_0011

DPI:

BN4_20236

DEJ:	AWY79_02870

PPRF:

DPRO_1954

PSEL:

GM415_09185(larE)

DDN:	DND132_2261

PNW:

SYK_30540

PTHE:

LF599_16620

PMEN:

V8V93_02530(larE) V8V93_17610(larE)

DSX:	GD604_10560

DSD:	GD606_05120

PBIZ:

LWC08_11725

DVU:

DVU_2939

DVL:

Dvul_0429

DVM:

DvMF_1465

DVG:	Deval_2714

CLIH:

KPS_001749

TMUR:

JBF11_01790

BWS:	WCP94_004515

DBA:

Dbac_0017

DESU:

NLA06_00080

DRT:

Dret_2468

DPS:

DP2170

DSF:

UWK_02634

DLM:	DPPLL_15450

DAK:	DaAHT2_0621

DPR:	Despr_1536

DEO:	CAY53_00020

DOG:	HP555_11115(larE)

DBK:	DGMP_14510

DDU:

GF1_17170

ECOM:

QTN59_05145(larE)

EAJ:	Q3M24_15865(larE)

ELAX:

KKHLCK_03015

ESD:	SD837_16045(larE)

EAQ:	LDFHOB_08930(larE)

DOL:

Dole_1596

DAL:

Dalk_2473

DAT:	HRM2_17990

DTO:	TOL2_C16280

DHG:	EYB58_13290(larE)

DOV:	DSCO28_20430

DWD:	DSCW_14280

DALK:

DSCA_01530

DVR:	Dvar_42720

DML:	Dmul_26820

DLI:	dnl_37450(larE)

DMM:	dnm_087980(larE)

DEK:	DSLASN_01880

SAT:

SYN_00475

DAO:	Desac_0387

DTI:	Desti_4487

SFU:

Sfum_1060

DAX:	FDQ92_09505(larE)

DBR:

Deba_1477

DMP:

FAK_19620

TID:	Thein_1354

TAV:	G4V39_02835(larE)

TMAI:

FVE67_05870(larE)

DAW:	HS1_000383

ADE:

Adeh_1542

ACP:	A2cp1_2413

AFW:	Anae109_2271

ANK:	AnaeK_2325

AORY:

AMOR_53880

APAU:

AMPC_09240

MXA:

MXAN_4063

MSD:	MYSTI_03867

MFB:	MFUL124B02_20780

MYX:	QEG98_21760(larE)

MLAN:

JY572_07295(larE)

MYM:	A176_002833

CCX:	COCOR_03887

MFU:	LILAB_28485

MMAS:

MYMAC_003985

PPAK:

JY651_12620(larE)

SUR:	STAUR_4519

AGE:	AA314_05997

AVM:	JQX13_43985(larE)

MBD:	MEBOL_006427

CFUS:

CYFUS_003920

VIN:	AKJ08_2134

PBRU:

LZC95_30955(larE)

PRUE:

LVJ94_30165(larE)

PALJ:

LZC94_11895(larE)

SCL:

sce5850

SCU:	SCE1572_34825

CCRO:

CMC5_073440

PAUU:

E8A73_002445(larE)

MRM:	A7982_11826

LLU:	AKJ09_09237

HOH:

Hoch_4189

BDZ:	DOM22_17000

TRO:

trd_0620

CAA:

Caka_1889

PPHT:

GA004_04315(larE)

MTAR:

DF168_00945(larE)

AMU:

Amuc_1595

AGL:

PYTT_2054

ABIW:

Abiwalacus_01450

AMAK:

J5W79_09320(larE)

VEG:	SAMN05444156_0411

FPES:

NXS98_02035(larE)

VBS:	EGM51_10255(larE)

RBA:

RB5730

RHOI:

PSR62_12415(larE)

PSL:

Psta_4402

PIR:	VN12_02725

RUL:

UC8_35910

RML:	FF011L_25530

ROL:	CA51_18250

RUV:

EC9_16480

RCF:	Poly24_15660

AHEL:

Q31a_52550

LCRE:

Pla8534_64020

AAGG:

ETAA8_52700

BVO:	Pan97_15460

BREM:

PSR63_03085(larE)

RLC:	K227x_29120

SMAM:

Mal15_14680

SNEP:

Enr13x_52290

SMAE:

TBK1r_60920

TTF:

THTE_2519

LPAV:

PLANPX_3277

LLH:

I41_32000

AMUC:

Pan181_25760

PND:	Pla175_19970

AMOB:

HG15A2_30220

BMEI:

Spa11_17690

BGOK:

Pr1d_29930

PLM:

Plim_2185

PEH:	Spb1_29600

PBS:	Plabr_2606

PLS:	VT03_18995

PLH:	VT85_25410

FMR:	Fuma_01618

GMR:	GmarT_21670

GIM:	F1728_03555(larE)

GPN:	Pan110_21030

GFM:	Enr17x_22780

GAZ:	Pan241w_22120

GAW:	V144x_37620

GAX:	Pan161_13130

MRI:	Mal4_09170

SDYN:

Mal52_28490

PLON:

Pla110_14520

ACAF:

CA12_40100

SVP:	Pan189_37400

TPOL:

Mal48_48150

CHYA:

V22_32900

CCOS:

Pan44_44050

PVAR:

SH412_002782(larE)

CCOP:

Mal65_22510

SCHL:

QJS52_08685(larE)

GES:	VT84_29015

GOG:	C1280_11315

GMS:	SOIL9_08210

TIM:	GMBLW1_01000

LRS:	PX52LOC_04999

FTJ:

FTUN_0475

ULI:	ETAA1_20890

TSPH:

KIH39_06985(larE)

IPA:

Isop_1940

SACI:

Sinac_0253

PBOR:

BSF38_03270(nadE_1)

AGV:	OJF2_00330

TPLA:

ElP_69800

KST:	KSMBR1_3335

BROC:

IPI25_08885(larE)

BPIT:

BPIT_22490

JET:	L3J17_00470(larE)

PHM:	PSMK_26140

PCOR:

KS4_17010

MCAD:

Pan265_06830(nadE_1)

PBU:	L21SP3_01888

PBP:	STSP1_01365

PBAS:

SMSP2_00400

ALUS:

STSP2_02408

VBL:	L21SP4_00054

TAER:

GT409_13250(larE)

LPRO:

PQO03_13010(larE)

VBC:	C5Q97_15480

LBV:	JYG24_09515(larE)

LBAC:

LJT99_11985(larE)

VAI:	BU251_00350

TSU:	Tresu_1703

TPI:	TREPR_3215

TPED:

TPE_1023

TPAV:

HRQ91_05945(larE)

SSM:	Spirs_3840

STA:	STHERM_c18740

STQ:	Spith_1918

ABA:	Acid345_0159

ACA:

ACP_0085

ACM:	AciX9_2065

GMA:	AciX8_0743

GRW:	FTO74_05175(larE)

GRB:	GOB94_11695(larE)

TSA:	AciPR4_1690

TRS:	Terro_4321

TALB:

FTW19_20105(larE)

ABAS:

ACPOL_5634

EDA:	GWR55_06530(larE)

EDG:	H7846_13230(larE)

EPL:	P4G45_08615(larE)

ADIN:

H7849_14060(larE)

ORP:	MOP44_06715(larE)

TGI:	RBB81_14630(larE)

TEMP:

RBB75_19815(larE)

TPSC:

RBB77_10945(larE)

CTM:	Cabther_B0780

CVL:	J8C06_14980(larE)

CHLO:

J8C02_12395(larE)

SUS:

Acid_3974

PFER:

IRI77_10270(larE)

ABAC:

LuPra_01255

EPO:

Epro_1180

ETI:

RSTT_618

RSD:

TGRD_647

GBA:

J421_2914

PSPC:

Strain318_000951(larE)

PROJ:

KDN43_12620(larE)

LFG:	ABNK31_16140(larE)

MCOS:

GM418_06880(larE)

ANF:

AQPE_1923

GHY:	ACOIT5_11195(larE)

ASX:	CDL62_08535

TPEL:

P0M28_01695(larE)

FOP:	FNB79_14670(larE)

DDF:	DEFDS_1637

DAP:	Dacet_2274

GTL:	EP073_05165

CNI:	Calni_1892

FSI:	Flexsi_0587

MSCH:

N508_000771(larE)

DTH:	DICTH_1659

DTU:

Dtur_1769

DTP:	JZK55_05280

NDE:

NIDE3731

NMV:	NITMOv2_4178

NIO:	NITINOP_1391

NJA:

NSJP_0489

NKF:	Nkreftii_000447

NIF:

W02_18740

NTI:	DNFV4_03880

NALL:

PP769_01805(larE)

NNEO:

PQG83_12995(larE)

NLI:	G3M70_01525(larE)

NWT:	NSPWAT_0870

NVA:	G3M78_14450(larE)

ALAM:

RT761_00970 RT761_02574(nadE_3)

TVX:	QBE54_01440(larE) QBE54_07110

ATHO:

M15_06800 M15_18280(larE)

BSED:

DN745_16030(larE)

PCAY:

FRD00_11125(larE)

BBAE:

FRD01_11630(larE)

BWH:	A9C19_14220 A9C19_14270

BACA:

FAY30_06705(larE)

BCOH:

BC6307_01195

NTX:	NQZ71_22540(larE)

NIL:	L8T27_023070(larE)

BMQ:

BMQ_3431

BMD:

BMD_3422

BMH:	BMWSH_1758

PKS:	IE339_08235(larE)

BKW:	BkAM31D_16130

CFIR:

NAF01_22300(larE)

OCN:	CUC15_13700

OCB:	CV093_14540(larE)

OON:	NP440_05840(larE) NP440_16065(larE)

HMN:	HM131_18325

HLI:

HLI_15690

HNZ:	P9989_17275(larE)

VNT:	OLD84_03940(larE)

VIK:	KFZ58_06210(larE)

SAPL:

U0355_08760(larE)

PBUT:

DTO10_00755(larE)

PFRI:

L8956_13650(larE)

PERI:

RE409_16000(larE)

PERJ:

JNUCC41_22980(larE)

GRC:	GI584_07250(larE)

GCS:	MUN88_21115(larE)

GSM:	MUN87_20505(larE)

SCIB:

HUG20_02620(larE)

POF:	GS400_06170(larE)

NMK:	CHR53_07480

NDT:	L1999_05485(larE)

NCM:	QNK12_05675(larE)

MSEM:

GMB29_06950(larE) GMB29_07365(larE)

BLEN:

NCTC4824_00691 NCTC4824_02468

BAG:

Bcoa_1741

DOM:	RRU94_04255(larE)

BBAM:

RJD24_17885(larE)

FEC:	QNH15_22355(larE)

GKA:

GK1965

GTM:	GT3921_09725

GTN:

GTNG_1864

GCT:	GC56T3_1549

GJF:	M493_05005

GSR:	GS3922_11555

GEJ:	A0V43_07465

PARG:

PspKH34_22170

PCAL:

BV455_03527

STEA:

C0679_13170

SER:

SERP0255

SEP:

SE_0373

SEPP:

SEB_00295

SEPS:

DP17_1680

SSP:

SSP0176

SPAS:

STP1_1687

SXY:	BE24_11080

SXL:	SXYLSMQ121_0202

SXO:	SXYL_00201

SCAP:

AYP1020_2354

SEQO:

SE1039_23810

SCOH:

BZ166_05530

SURY:

MUA21_11745(larE)

SNL:	BJD96_01300

SKL:	C7J89_02925(larE)

SCAR:

DWB96_11235(larE)

SARL:

SAP2_03240

SLLO:

ISP08_01745(larE)

SPSD:

JMB28_01550(larE)

STAS:

HYI43_10715(larE)

SEDA:

MNY58_01095(larE)

SCAQ:

QMO72_01215(larE)

SDEV:

Q2T90_08310(larE)

STAP:

AOB58_2012

SGAI:

K3U27_07335(larE)

BAGR:

BA6348_20645

BCHS:

JNE38_09065(larE)

BCOP:

JD108_16175(larE) JD108_19125(larE)

BPAB:

PSE45_08245(larE)

BHUI:

LOK74_13985(larE)

BAYD:

BSPP4475_14725(larE)

BBOR:

RFB14_18440(larE)

BRUM:

NDK47_19225(larE) NDK47_22985(larE)

BREH:

HP435_08380(larE)

ASED:

IRT44_10805(larE)

PJD:	Pjdr2_1791

PMS:	KNP414_03013

PMQ:	PM3016_3251

PMW:

B2K_16835

PDU:	PDUR_14915

PAEJ:

H70737_15695

PBJ:	VN24_06055

PNP:	IJ22_20320

PCX:	LPB68_19160

PPSC:

EHS13_06835(larE)

PPOG:

QPK24_13770(larE)

PAUN:

MJA45_05975(larE)

PKP:	SK3146_00714

PHEX:

L0M14_21900(larE)

PROO:

MJB10_05560(larE)

PELG:

ACJ7K1_14460(larE)

ANEU:

PP175_14120(larE) PP175_24700(larE)

COH:	EAV92_16205(larE)

COHN:

KCTCHS21_48020

CCHL:

FPL14_24555(larE)

PLIG:

NAG76_17275(larE)

AAD:

TC41_0789

AFX:	JZ786_03335(larE)

AACO:

K1I37_09600(larE)

ACUR:

JZ785_16045(larE)

ADAU:

NZD86_13065(larE)

AFAS:

NZD89_00680(larE)

ACYC:

JI721_01490(larE)

ALIC:

GI364_18425(larE)

KYR:	CVV65_06325

TUM:	CBW65_00200

TAB:	CIG75_06095

EFF:	skT53_12490

FFE:	LSG31_10895(larE) LSG31_10985(larE)

PHC:	BBI08_12010

PSHE:

QWY16_17730(larE)

SPAE:

E2C16_10330(larE)

SURL:

BI350_14350

SPOH:

GGGNBK_02650(larE)

PANC:

E2636_15535(larE)

PABS:

JIR001_06500

SLAT:

J4854_09205(larE)

SLIN:

SM123_01960(larE)

LCS:

LCBD_p44

LCW:	BN194_P0270

LPL:	lp_0109(larE)

LPJ:

JDM1_0110

LPT:	zj316_0318(larE)

LPS:	LPST_C0090

LPR:	LBP_cg0091

LPZ:

Lp16_0102

LPB:	SH83_00470

LPX:	ASU28_03275

LPG:	BB562_00460

LARG:

LPA65_00500

LBS:	MH1LPH_07160(larE)

LFE:

LAF_1729

LFR:

LC40_1098

LFF:

LBFF_1912

LNG:	BSQ50_05850 BSQ50_10040

LHW:	BSQ49_00460 BSQ49_08370

LMAL:

LM596_00655(larE)

LBR:

LVIS_1852

LBK:	LVISKB_1835

LZY:	LZ3411_1660

LSUA:

H3M12_11140(larE)

LBT:	AYR52_09955

LCY:	LC20004_11455

LNN:	F0161_06420(larE)

LPD:	AYR62_03160

PPE:

PEPE_1690

PPEN:

T256_08315

PCE:

PECL_1779

LSA:

LCA_0790

LCV:	FBA2_04125

LGM:	LG542_05655(larE) LG542_08120(larE)

WCO:	G7084_07425(larE)

EFI:	OG1RF_11540

EGV:	EGCR1_11140(larE) EGCR1_11185 EGCR1_12085(larE)

ESG:	EsVE80_25510

AUR:	HMPREF9243_1764

AUN:	AWM73_01180

ALOY:

CJ190_001320(larE)

AMIT:

DBT49_0001415(larE)

ATJ:	DBT50_007400(larE)

GAD:	K8O88_05655(larE)

GEG:	LK443_03375(larE)

CAC:

CA_C0775

CAE:

SMB_G0791

CAY:

CEA_G0786

CBO:	CBO0104 CBO1183

CBA:	CLB_0140 CLB_1214

CBH:	CLC_0152 CLC_1226

CBY:	CLM_0147 CLM_1334

CBL:	CLK_0618 CLK_3279

CBB:	CLD_0682 CLD_3386

CBI:	CLJ_B0142 CLJ_B1224

CBF:	CLI_0159 CLI_1265

CBM:	CBF_0132 CBF_1238

CBJ:	H04402_00095 H04402_01251

CBE:

Cbei_0560

CBZ:

Cbs_0560

CBEI:

LF65_00621 LF65_03283

CKL:

CKL_2501

CKR:

CKR_2212

CLJ:	CLJU_c26710

CCB:	Clocel_4272

CLS:	CXIVA_14630 CXIVA_19610

CLB:	Clo1100_3205

CSR:	Cspa_c14240 Cspa_c30300

CPAS:

Clopa_0770 Clopa_4087

CPAT:

CLPA_c16040 CLPA_c32990

CPAE:

CPAST_c16040 CPAST_c32990

CSB:	CLSA_c17600

CAH:	CAETHG_0752(larE) CAETHG_2397(larE)

CSQ:	CSCA_0239 CSCA_1722

CLD:	CLSPO_c01300 CLSPO_c11830

CACE:

CACET_c05410 CACET_c13920

CCK:	Ccar_05980

CBUT:

ATN24_17715

CTYK:

CTK_C22000

CEU:	A7L45_10325

CFM:	BJL90_08420 BJL90_12415

CDRK:

B9W14_10670

CDY:	F3K33_03240(larE) F3K33_11350(larE)

CFER:

D4Z93_06665(larE)

CLOS:

DMR38_13820(larE)

CMAH:

C1I91_18045

CRW:	CROST_013180(larE)

CFB:	CLFE_035310(larE)

CAUN:

CLAUR_015880(larE)

CNN:

CNEO_0877

CGEL:

psyc5s11_08520

CTAG:

LL095_00640(larE)

CINT:

HZF06_03275(larE)

CTHD:

CDO33_09585

CLOL:

ONV75_18590(larE)

CLOM:

AXY43_17605

CLOO:

RCG18_23715(larE)

CALE:

FDN13_14140(larE)

CRS:	FQB35_14405(larE)

SARJ:

HH195_01560(larE)

OCW:	OW730_08255(larE)

CLO:	HMPREF0868_0965

CTH:

Cthe_1841

CTX:	Clo1313_2533

CCL:	Clocl_2731

HSC:

HVS_07435

CCE:

Ccel_0923

RHER:

EHE19_005585(larE)

RPAY:

P0092_18350(larE)

FPLA:

A4U99_13410

EHA:	Ethha_0253

RGV:	NQ502_01635(larE)

OVA:

OBV_12500

OBJ:	EIO64_06800(larE)

CLF:	GJQ69_07885(larE)

PFAA:

MM59RIKEN_21350

ACOL:

K5I23_15255(larE)

PETR:

QKW49_13200(larE) QKW49_17725(larE)

BIE:	RFF05_06135(larE)

OKO:	Ruko_25660

RBP:	B6259_02565

CCEL:

CCDG5_1156

CAPR:

EQM14_02360(larE) EQM14_12585(larE)

CMIC:

caldi_12840

SLP:

Slip_1661

SALQ:

SYNTR_1278

DSY:

DSY3982

DHD:

Dhaf_1385

DDH:	Desde_1305

DDL:	Desdi_1171

DMT:	DESME_04210

SGY:

Sgly_2368

DOR:	Desor_3247

DAI:	Desaci_2947

DMI:	Desmer_2508

DED:	DHBDCA_p1745

DEC:	DCF50_p1754

DRS:	DEHRE_12495

DCA:	Desca_1938

PTH:	PTH_0252 PTH_2629

DRM:

Dred_0151

DRU:	Desru_0224

DFG:	B0537_01565

DAE:

Dtox_2118

DKU:	Desku_0577

TFR:	BR63_18685(larE)

FWA:	DCMF_27540

AACX:

DEACI_2248 DEACI_2545

PHOS:

ABFY19_13780(larE)

TJR:	TherJR_2999

DGI:	Desgi_0600

HMO:

HM1_1687

HCV:	FTV88_0846(larE)

ELM:

ELI_0450

EMT:	CPZ25_014820(larE)

ELIM:

B2M23_01620

EVN:	NQ558_05170(larE)

AWO:	Awo_c14730

AWI:	CHL1_002283(larE) CHL1_002400(larE)

ALKA:

J0B03_03360(larE)

STHR:

BXT84_03280

CTHM:

CFE_2757

BPEN:

NQ488_02815(larE)

BPRS:

CK3_07910

BPB:

bpr_I1983

BFI:

CIY_11370

BHU:

bhn_I0284

RHO:	RHOM_04515

RIX:

RO1_19180

RRK:	H8S51_001995(larE)

CCT:

CC1_07280

BYL:	A4V09_05110

BHAN:

CGC63_08095

BPRO:

PMF13cell1_04356(nadE_2)

BLAB:

EYS05_09720(larE)

BLIQ:

INP51_08380(larE)

BWX:	NQ550_11990(larE)

BMAS:

LK422_13980(larE)

BLAR:

LC508_02335(larE)

BLUI:

Blut17040_21030(larE)

BCOC:

BLCOC_33800(larE)

BHV:	BLHYD_29250(larE)

LACY:

A4V08_22715

CSCI:

HDCHBGLK_00381(nadE_1) HDCHBGLK_02444(nadE_2)

CHYL:

CE91St63_28130

CSH:	Closa_3053

LXA:	OW255_00720(larE)

LSIA:

VIG27_17165(larE)

ARF:	AR1Y2_0544

ACAC:

EYQ97_14260(larE)

EHL:

EHLA_1081

PXV:	FXF36_11035(larE)

ANR:	Ana3638_10440(larE) Ana3638_13555(larE)

ACEL:

acsn021_20640

ACHT:

bsdcttw_23910

RTO:

RTO_25320

CBOL:

CGC65_25490

CASP:

NQ535_05750(larE)

ECLF:

QMP25_34535(larE)

SCAZ:

ACI3DN_13755(larE)

QDO:	H9Q78_04925(larE)

WHJ:	H9Q79_05920(larE)

MFOR:

NQ534_06965(larE)

AHB:	bsdtb5_06530

HHJ:	NQ487_22085(larE)

LBW:	C3V36_11975(larE)

LBX:

lbkm_2451

LBP:	V1224_03620(larE)

VGU:	HYG85_13535(larE)

VPY:	HZI73_08185(larE)

MDV:	C5Q96_07585(larE)

MNL:	QU661_00175(larE)

AMIJ:

EQM06_00140(larE)

AMIC:

Ami3637_07355(larE)

ABUT:

Ami103574_00920(larE)

ETM:	CE91St48_13510

EMJ:	V1225_06925(larE)

AHAD:

FRZ06_08685(larE) FRZ06_12875(larE)

AMT:

Amet_0482

GFE:	Gferi_16415 Gferi_18010

CSPO:

QNI18_03920(larE)

PBIF:

KXZ80_10320(larE)

PSOR:

RSJ16_12165

CDF:	CD630_17790

PDC:	CDIF630_01977(larE)

CDC:	CD196_1699

CDL:	CDR20291_1674

PDF:	CD630DERM_17790

ROC:	HF520_06010(larE)

RIL:

CRIB_916

RHOM:

FRIFI_1629

TEM:	JW646_00735(larE)

TGC:	L0P85_07600(larE)

TMY:	TEMA_15250(larE)

TPET:

TPHSE_16350(larE)

TEB:	T8CH_0459 T8CH_1850 T8CH_P0032

THYR:

P4S50_08455(larE)

IBR:	NQ514_08960(larE)

CST:	CLOST_1751

CMIU:

B1H56_04695

DAU:

Daud_2226

TTE:

TTE0769

TEX:	Teth514_2220

THX:

Thet_0714

TPD:	Teth39_1540

TIT:

Thit_0727

TMT:	Tmath_0778

TBO:	Thebr_1576

TWI:	Thewi_0878

TKI:	TKV_c07440

THEZ:

OEI98_001814(larE)

CHY:	CHY_0016 CHY_1281

TPZ:	Tph_c08290

TTM:

Tthe_1034

TTO:	Thethe_00991 Thethe_01835

TXY:	Thexy_1688

TSH:

Tsac_1491

THED:

SAMN05660242_2853

MAS:	Mahau_0749

MTA:

Moth_2511

MTHO:

MOTHE_c25970(guaA2)

MTHZ:

MOTHA_c26680(guaA2)

NCJ:	MCACP_28170(larE)

DBC:	MFMK1_000341(larE) MFMK1_001320(larE)

TEP:	TepRe1_1688

TAE:	TepiRe1_1820

BACG:

D2962_13635(larE)

TOC:

Toce_0386

NTH:	Nther_2865

NCD:	ACONDI_00114 ACONDI_02385

HAS:	Halsa_2216

HALS:

D7D81_09415(larE)

IFN:	GM661_06540(larE)

AAR:	Acear_0264

HHL:	Halha_0306

AFT:	BBF96_12650

APR:

Apre_1704

ANZ:	ACKRLN_07005(larE)

PEQU:

O6R05_04845(larE)

AMEI:

LV469_03815(larE)

PIV:	NCTC13079_00330

MFOM:

VZL98_10600(larE)

CAZO:

G3A45_06895(larE)

VPR:

Vpar_0987

VAT:	B7L28_04780

VRM:	44547418_01866

MED:

MELS_2163

MHW:	ACT01_11110

MEG:	DKB62_10865(larE)

MMAX:

LCQ47_11580(larE)

DHO:	Dia5BBH33_16940

SSG:	Selsp_1391

SRI:	SELR_02550

SELT:

BCS37_10135

SELM:

TAMA11512_18680(larE)

MHG:

MHY_28770

MFUN:

GXM21_00885(larE)

PUF:	UFO1_0761 UFO1_1330

PFT:

JBW_02956

MANA:

MAMMFC1_03248 MAMMFC1_04188

STED:

SPTER_04730(larE)

SSPH:

SPSPH_008250(larE_1) SPSPH_015930(larE_2)

SOVA:

SOV_07800

SSID:

SPSIL_005380(larE_1) SPSIL_008520(larE_2)

SACV:

SPACI_002300(larE_1) SPACI_039890(larE_2)

SCAO:

SCACP_07260(larE_1) SCACP_14680(larE_2)

AFN:	Acfer_1002

AIN:

Acin_0148

PFAC:

PFJ30894_00129

AMUO:

KWG62_13025(larE)

FIT:	Fi14EGH31_12950

ERM:	EYR00_11820(larE)

CMIT:

NQ499_11365(larE)

CALK:

HUE98_04225(larE)

CSC:	Csac_1655 Csac_1715

ATE:	Athe_1202 Athe_1637

COB:	COB47_0945

CHD:	Calhy_1115 Calhy_1524

COW:	Calow_1381

CKI:	Calkr_1184 Calkr_1649

CLC:	Calla_1046

CKN:	Calkro_1088 Calkro_1497

CCHA:

ELD05_07750(larE) ELD05_08065(larE)

CDIA:

CaldiYA01_08960 CaldiYA01_13060

CNAG:

OTJ99_001594(larE)

CMOR:

OTK00_001483(larE)

CDAN:

SOJ16_001159(larE) SOJ16_001605(larE)

FBS:	N510_001736(larE)

OLO:	ADJ70_04035

PCAT:

Pcatena_02470

CGO:	Corgl_0079

CAER:

CSV91_07365

CSTC:

LK434_07970

SHI:	Shel_04890

ELE:

Elen_1058

EYY:	EGYY_20440

EGD:	GS424_005350

AEQ:

AEQU_0759

AHAT:

ADCFC_15860

RTS:	CE91St31_05380

EBZ:	J7S26_01750

MKN:	MKAN_19195

MBAI:

MB901379_01965

MRH:	MycrhN_2386

CGT:

cgR_2379

CGS:	C624_12135

CGG:	C629_12140

CGX:	SB89_11515

CEF:

CE2359

CMD:	B841_10450

CDO:	CDOO_12435

CUT:	CUTER_10190

CCJZ:

ccrud_11075

CRL:	NCTC7448_00761

CSUR:

N24_2541

CCYS:

SAMEA4530656_2528

CFAC:

CFAEC_10775

CGF:	CGUA_10700

CBRE:

QP027_12110(larE)

BFV:	C628_11990

ROA:	Pd630_LPD01931

SRC:	M271_02635

SCW:	TU94_27860

STRC:

AA958_02865

SLE:	sle_12210(sle_12210)

SNZ:	DC008_00245(larE)

SGE:	DWG14_08160

SBY:	H7H31_31765

SROI:

IAG44_41895(larE)

STRZ:

OYE22_31740

KCM:	ABWK59_05160

YIA:	LO772_29255(larE)

ABRY:

NYE86_22785

AGLA:

OIE69_02085(larE)

BFA:	Bfae_31120

BRX:	BH708_12755

BRV:	CFK39_07895

BGG:	CFK41_00400

BRZ:	CFK38_03120

BSAU:

DWV08_13400(larE)

BRR:	C1N80_03100(larE)

BRHA:

NLU66_03460(larE)

DVA:	DAD186_03280

DHM:	CYJ49_004195(larE)

ALX:	LVQ62_06040(larE)

IVA:	Isova_2550

PSEI:

GCE65_08170(larE)

ICA:	Intca_2470

SERJ:

SGUI_3205

ORN:	DV701_00855(larE)

ORZ:	FNH13_03630(larE)

OCP:	NF557_15190(larE)

OFA:	NF556_02685(larE)

GEZ:	FE251_10195(larE)

GYU:	FE374_08980(larE)

GEW:	MF406_17515(larE)

HALT:

IM660_11170

RHAL:

LQF10_10785

RSUA:

LQF12_09610

PACD:

EGX94_05515(larE)

PAUS:

NCTC13651_02633

MPH:

MLP_05660

MIK:	FOE78_14115(larE)

MICG:

GJV80_06150(larE)

RAIN:

Rai3103_10330(larE)

PRV:	G7070_00350(larE)

BRT:	J4N02_06655(larE)

PSOI:

PCC79_06650(larE)

PROP:

QQ658_08075(larE)

BROO:

brsh051_03180(larE)

AFUV:

AADG42_02200(larE)

NCA:

Noca_3933

NDK:	I601_0491(gph_1)

NSN:	EXE58_04295(larE)

NANO:

G5V58_01575(larE)

NMES:

H9L09_05070

NCQ:	K6T13_14500

NOF:	MF408_16055

NOCL:

KM427_21905

MGG:	MPLG2_3153

KFL:

Kfla_5922

KQI:	F1D05_14210(larE)

KSL:	OG809_05045(larE)

KRI:	OX958_07265(larE)

STRR:

EKD16_16015

SAIU:

J4H86_02075(larE)

ACTW:

F7P10_09295(larE)

AWS:	ACN3XK_61110(larE) ACN3XK_61265(larE)

ACTQ:

OG417_21775(larE)

NOW:	GBF35_28950

MHAI:

OHB01_32365(larE)

FRE:	Franean1_0147

FSY:	FsymDg_0162

FRI:	FraEuI1c_0096

NAKA:

H7F38_15555(larE)

GOB:

Gobs_1558

BSD:	BLASA_3121

BLAP:

MVA48_22065

BBRG:

U6N30_21210(larE)

BMON:

ABDB74_10865

MMAR:

MODMU_4370

AMD:

AMED_3082

AMN:

RAM_15675

AMM:

AMES_3048

AMZ:

B737_3049

AMOG:

QRX60_22435

PDX:

Psed_1615

PSEE:

FRP1_11810

PSEQ:

AD006_19165

PECQ:

AD017_27005

PAUT:

Pdca_54860

PBRO:

HOP40_10100(larE)

PSDS:

K1T35_07945(larE)

ASE:

ACPL_3389

ACTN:

L083_6347

ACTS:

ACWT_3261

AIH:	Aiant_82390

ACTR:

Asp14428_28440

ACTL:

L3i22_063100

AOU:	ACTOB_003528(larE)

AFS:

AFR_19500

PFLA:

Pflav_037480

ATL:	Athai_03320

ASER:

Asera_04000

CATI:

CS0771_15390

DFU:	Dfulv_21110(larE)

NHY:	JQS43_25650(larE)

CCAZ:

COUCH_19575

CAI:

Caci_4914

SNA:

Snas_6080

GLY:	K3N28_16435(larE)

AUO:	R3I39_01095(larE)

FLH:	EJ997_03655(larE)

SAPP:

SAC06_06200

RXY:

Rxyl_1079

RRD:	RradSPS_1039

RUB:	GBA63_08135(larE)

RMAR:

GBA65_12840(larE)

AFO:

Afer_1841

AYM:	YM304_36770

ATQ:	GH723_15745(larE)

AQZ:	KSP35_12015(larE)

IAM:	HC251_15235(larE)

IMA:	PO878_08560(larE)

SYN:

slr1717

SYZ:	MYO_113410

SYY:	SYNGTS_1329(slr1717)

SYT:	SYNGTI_1329(slr1717)

SYS:	SYNPCCN_1328(slr1717)

SYQ:	SYNPCCP_1328(slr1717)

SYJ:	D082_32380

SYO:	C7I86_06890(larE)

SYNH:

HTZ78_13005(larE)

SYNS:

OLK001_22190

SYC:

syc0168_c

SYU:	M744_09660

SYF:	Synpcc7942_1387

SYD:	Syncc9605_0392

SYE:	Syncc9902_1937

SYG:

sync_0454

SYR:	SynRCC307_2095

SYX:	SynWH7803_0450

CYA:

CYA_0568

CYB:

CYB_1309

SYNE:

Syn6312_1512

SYNP:

Syn7502_01153

SYNK:

KR100_03470

SYNR:

KR49_11030

SYND:

KR52_00470

SYH:	Syncc8109_0404

SYNW:

SynWH8103_02358

SYNC:

CB0101_10575(larE)

SYNZ:

H8F24_08450(larE)

SYNL:

KJJ24_09465(larE)

SYNO:

LY254_06335(larE)

SYNU:

SynWH8101_0490

SYW:

SYNW2051

CGC:	Cyagr_1671

CYI:	CBM981_1836

PMA:

Pro_1726

PMM:

PMM1571

PMT:

PMT_1717

PMN:	PMN2A_1143

PMI:	PMT9312_1663

PMB:	A9601_17781

PMC:	P9515_17581

PMF:	P9303_22871

PMG:	P9301_17621

PMH:	P9215_18431

PMJ:	P9211_16911

PME:	NATL1_20171

PRC:

EW14_1929

PRM:

EW15_2090

WNA:	KA717_17505(larE)

CMP:	Cha6605_3594

CYN:	Cyan7425_3314

CEP:	Cri9333_2236

TVN:	NIES2134_113810

SLW:	BRW62_03950

TEL:

tll1241

THN:	NK55_04015

THEC:

FFX45_07730(larE)

THEY:

JW907_11820(larE)

TSQ:	D3A95_02140(larE)

AMR:

AM1_5419

ACAM:

HRE53_22580(larE)

TSZ:	OOK60_13310(larE)

LEN:	LEP3755_05650

LET:	O77CONTIG1_03689

LBO:	LBWT_57270

LEPB:

GFS31_06480

LEPI:

EDM05_018780(larE)

KOV:	K9N68_19600(larE)

LSC:	KIK02_06055(larE)

LSK:	J5X98_18195(larE)

SFRI:

RBJ76_03950(larE)

HHG:	XM38_044690(nadE_2)

DSL:	Dacsa_2224

PSEU:

Pse7367_0760

PSER:

ABRG53_1561(exsB)

PGX:	OA858_20400(larE)

THEU:

HPC62_08160(larE)

TOG:	HNI00_19885(larE)

TSIN:

OXH18_12750(larE)

GLP:	Glo7428_4128

CHON:

NIES4102_03900

GDU:	P0S91_06455(larE)

GEN:	GM3709_2565

GEE:	GM3708_1693

CAN:	Cyan10605_2838

CSN:	Cyast_1731

CYL:	AA637_08485

CYR:	A5482_001480(larE)

CYD:	Dongsha4_06315(larE)

SYP:	SYNPCC7002_A0394

SYV:	AWQ23_02145

SYL:	AWQ21_02065

LEP:	Lepto7376_3828

SYNN:

NIES970_02770

PIP:	FEK30_06055(larE)

MAR:

MAE_02020

MPK:

VL20_6280

MIQ:	B5D77_07340

MVZ:	myaer102_37110

HAO:	PCC7418_1248

ENN:	FRE64_09745(larE)

CYT:

cce_0166

CWA:	CwatDRAFT_3155

CYP:	PCC8801_1583

CYH:	Cyan8802_1608

CYC:	PCC7424_1063

CYJ:	Cyan7822_1019

TER:

Tery_4689

PAGH:

NIES204_14310

PPSU:

NO713_05572

PRUN:

PCC7821_01758

MVAG:

D0A34_15480(larE)

LFS:	HFV01_04905(larE)

LIX:	H2674_20665(larE)

ARP:	NIES39_L03190

CSAU:

ACL6C3_04115(larE)

OXY:	HCG48_19755(larE)

OAC:	Oscil6304_0486

PHOR:

JWS08_01610(larE)

PYH:	NEA10_11890(larE)

ONI:	Osc7112_1738

MIC:	Mic7113_0772

MPRO:

BJP34_05340

GEI:	GEI7407_1560

GVI:

gll2047

GLJ:

GKIL_1205

GML:	ISF26_15315(larE)

ANA:

alr1286

NPU:	Npun_R3824

NOS:	Nos7107_2566

NOP:	Nos7524_3684

NON:	NOS3756_18130

NFL:	COO91_04593

NOE:	CLI64_23080

NSH:

GXM_02973

NED:	HUN01_15110(larE)

NPZ:	ACX27_10125

NLK:	NIES25_20790

NCW:	NIES2107_04530

NCF:	ANSO36C_23290

NOST:

GJB62_17935(larE)

NOSU:

JYQ62_03235(larE)

NOSQ:

PQG02_23375(larE)

AVA:

Ava_3010

NAZ:

Aazo_2203

ANB:	ANA_C12431

ACY:	Anacy_4825

AWA:	AA650_13180

ANN:	EH233_13095(larE)

CSG:	Cylst_1757

RSIN:

B6N60_01376

HBQ:	QI031_09405(larE)

NSP:	BMF81_01729(nadE_2)

NSPH:

BDGGKGIB_02456(larE)

AEE:	IM676_07320(larE)

CALO:

Cal7507_4729

CALT:

Cal6303_5178

CALH:

IJ00_10880

CALN:

NIES2098_52010

CALS:

NIES3974_35720

RIV:	Riv7116_6437

MDP:	NIES3275_52880

FIS:	FIS3754_06710

DOU:	BMF77_04593(nadE_2)

DFS:	HGD76_07520(larE)

DCM:	NIES806_34040

DOT:	EZY12_20580(larE)

DOZ:	HEP80_08960(larE)

DOC:	HEQ26_22575(larE)

CCUR:

IAR63_05645(larE)

CRK:	L3I90_06110(larE)

AFLO:

HEQ12_02550(larE)

STOQ:

K2F26_20160(larE)

SKV:	NIES73_18850

RCS:	NIES932_30750

OCF:	WJM97_06055(larE)

TOQ:	HCG51_13185(larE)

TTQ:	NIES37_00490

ALAX:

NIES50_19350

SCYT:

SAMD_07890

SCYS:

NIES4073_08050

BSEN:

DP114_02935(larE)

BOX:	DP113_02890(larE)

NCN:	BZZ01_19070

CTHE:

Chro_0658

PLP:	Ple7327_3744

SCS:	Sta7437_4312

STAN:

STA3757_37080

GLT:	GlitD10_0043

GCY:	LQF76_02795(larE)

CEO:

ETSB_1369

CER:	RGRSB_1642

CEEC:

P3F56_06950(larE)

LMAJ:

GKN94_02845(larE)

RRS:	RoseRS_1342

RCA:

Rcas_1629

CALL:

OZ401_000120(larE)

TTR:

Tter_1708

ATM:	ANT_23240 ANT_30630

LEK:	hrd7_08550

ABAO:

BEQ56_02455

CAP:	CLDAP_20490

KBS:	EPA93_43495(larE)

KBB:	ccbrp13_64250

CCZ:	CCALI_01221

CCOT:

CCAX7_18030

VAB:

WPS_07520

CPOR:

BED41_01325

ACO:	Amico_1792

AMIZ:

RBH88_00300

SBR:

SY1_06510

TLI:

Tlie_1862

AMO:	Anamo_2098

PPIO:

CE91St28_21490

PYY:	RAH42_11445(larE)

ARAM:

KAR29_00340(larE)

APRP:

KIH16_00340(larE)

TMA:	TM0966 TM1075

TMM:	Tmari_0968 Tmari_1079

TMI:	THEMA_08980 THEMA_09515

TMW:	THMA_0989 THMA_1097

TMQ:	THMB_0989 THMB_1097

TMX:	THMC_0989 THMC_1097

TPT:	Tpet_1669 Tpet_1781

TNP:	Tnap_1692 Tnap_1782

TRQ:	TRQ2_1742 TRQ2_1824

TNA:	CTN_1494 CTN_1610

THQ:	T2812B_08615 T2812B_09090

THZ:	CELL2_08690

THR:	TRQ7_08930 TRQ7_09465

TLE:

Tlet_0612

TTA:	Theth_0711

TME:

Tmel_1605

TAF:

THA_1812

THP:	BG95_08730

THER:

Y592_08835

FIA:	NA23_06850

FRR:	IB67_07620

FNG:	JM64_09550

PMO:

Pmob_0537

MPZ:	Marpi_1396

MARN:

LN42_07455

MAEO:

JRV97_04835

OCS:	OF820_11195

KOL:

Kole_2141

MPG:	Theba_1256

MINF:

MESINF_2434

ASAC:

ATHSA_1770

FUL:	C4N20_13055(larE)

SCHV:

BRCON_0236

FSH:	Q2T83_17000(larE)

MJA:

MJ_0830

MFE:	Mefer_0920

MVU:	Metvu_0128

MFS:	MFS40622_1333

MIF:	Metin_0705

MJH:	JH146_1074

MESG:

MLAUSG7_0326

MESA:

MLASG1_1504

MIG:	Metig_0712

MMP:

MMP1239

MMQ:	MmarC5_0352

MMX:	MmarC6_1434

MMZ:	MmarC7_0485

MMD:

GYY_07030

MMAK:

MMKA1_14140 MMKA1_14310 MMKA1_14480 MMKA1_14650

MMAO:

MMOS7_13470

MMAD:

MMJJ_16060

MAE:

Maeo_0184

MVN:	Mevan_0553

MVO:

Mvol_0156

MOK:	Metok_0265

METF:

CFE53_05300

MTH:

MTH_990

MMG:	MTBMA_c13730

MWO:	MWSIV6_1377

MTEE:

MTTB_04320

METC:

MTCT_0899

METE:

tca_00952(tilS)

METZ:

METMT2_1018

METK:

FVF72_06655(larE)

MTHM:

FZP57_06575(larE)

METJ:

FZP68_04085(larE)

MST:

Msp_1275

MEIS:

PXD04_10715(larE)

MRU:

mru_0666

MSI:

Msm_0482

MEB:

Abm4_0396

MMIL:

sm9_0536 sm9_1605

MEYE:

TL18_02430 TL18_06600

MOL:

YLM1_0307

MARO:

MarbSA_17450

METV:

K4897_02920(larE)

MEL:	Metbo_2234

MEW:	MSWAN_0407

METH:

MBMB1_0457

MFC:

BRM9_1801

MFI:	DSM1535_2442

MCUB:

MCBB_0420

MSUB:

BK009_00345

METN:

BK008_08155

METT:

CIT01_02685

METO:

CIT02_04515

MEME:

HYG87_04025(larE)

MFEG:

GCM10025860_13600

MEER:

NKF70_08930(larE)

MRID:

FGU46_02785(larE)

MFV:

Mfer_0481

MKA:

MK0071

AFU:	AF_0559 AF_1556

AFG:	AFULGI_00005690 AFULGI_00018090

APO:	Arcpr_0047

AVE:	Arcve_1319

AST:	Asulf_00413

FPL:

Ferp_2505

GAC:

GACE_0076

GAH:

GAH_00296

MBA:	Mbar_A0722

MBY:	MSBRM_0323

MBW:	MSBRW_0279

MBAR:

MSBR2_2058

MBAK:

MSBR3_0835 MSBR3_2119

MAC:

MA_0240

MMA:

MM_1520

MMAZ:

MmTuc01_1579

MMJ:	MSMAS_3147

MMAC:

MSMAC_3167

MVC:	MSVAZ_0321 MSVAZ_1405

MEK:	MSKOL_0305 MSKOL_1347

MLS:	MSLAZ_0097

METM:

MSMTP_3045

MEF:	MSWH1_0167

MEQ:	MSWHS_0166

MSJ:	MSSAC_0226

MSZ:	MSSIH_0195

MSW:	MSSIT_0199

MTHR:

MSTHT_2045

MTHE:

MSTHC_1241

MHOR:

MSHOH_3885

MFZ:	AOB57_009540(larE)

MHAB:

RSJ42_06380(larE) RSJ42_17090(larE)

METW:

AAY43_04280

MBU:

Mbur_1431

MMET:

MCMEM_1198 MCMEM_1915

MELO:

J7W08_08545(larE)

MMH:

Mmah_0379

MHAZ:

BHR79_01615

MPOT:

BKM01_06855

MEV:	Metev_1872

MZH:	Mzhil_1816

MPY:

Mpsy_2077

MZI:	HWN40_12190(larE)

MMAV:

RE476_12565(larE)

MSEB:

RE474_08270(larE)

MHZ:	Metho_2210

MEHF:

MmiHf6_13130(larE)

MEES:

MmiEs2_15560(larE)

MTP:

Mthe_0693

MCJ:

MCON_2758

MHI:

Mhar_2227

MHU:

Mhun_2185

MRTJ:

KHC33_15340(larE)

MLA:

Mlab_0368

MEM:	Memar_1612

MBG:	BN140_0830

MEMA:

MMAB1_1090

MCHK:

MchiMG62_15240 MchiMG62_18020

MSUM:

OH143_02270(larE)

MRC:	R6Y96_02765(larE)

MPI:

Mpet_2672

MEND:

L6E24_08480(larE)

MEFW:

F1737_00105(larE)

MAQE:

RJ40_10745

MFK:	E2N92_10990

MOU:	OU421_07055(larE)

MESB:

L1S32_10480(larE)

MANQ:

L1994_00685(larE) L1994_02170(larE)

MBN:

Mboo_2123

MFO:	Metfor_0805 Metfor_2454

MPL:	Mpal_1151 Mpal_1214

MPD:

MCP_2272

MEZ:	Mtc_0969 Mtc_1602

RCI:	RCIA125 RCIX867

MJK:	N2V74_06650(larE)

HAHS:

HSRCO_2772

HALR:

EFA46_003585(larE)

HJE:	HacjB3_01070

HDO:	MUK72_01945(larE)

HALX:

M0R89_05410(larE)

HAXZ:

M0R88_05410(larE)

HAYC:

NGM10_07510(larE)

HAXY:

NGM07_10475(larE)

SALI:

L593_08055

SAIM:

K0C01_03880(larE)

HMA:	rrnAC2860(trmU)

HSIN:

KDQ40_12980(larE)

HHI:	HAH_0136(trmU)

HHN:	HISP_00760

HAB:	SG26_08630

HTA:	BVU17_00645

HALJ:

G9465_02205(larE)

NMO:

Nmlp_3774

NHO:	HWV23_09730(larE)

NSAL:

HWV07_13045(larE)

HUT:

Huta_1028

HTI:

HTIA_0886

HALA:

Hrd1104_10865(larE)

HASV:

SVXHr_0585

HABN:

HBNXHr_0563

HMU:

Hmuk_1000

HALZ:

E5139_08160(larE)

HALL:

LC1Hm_0230

HAZP:

GBQ70_08155(larE)

HALI:

BV210_09760

HSN:	DV733_11570(larE)

HRR:	HZS55_02920(larE)

HPEL:

HZS54_02640(larE)

HLT:	I7X12_09035(larE)

HARC:

HARCEL1_11040(larE)

SSAI:

N0B31_12885(larE)

HAAD:

MW046_03135(larE)

HWA:

HQ_3682A

HWC:

Hqrw_4096

HVO:

HVO_0190

HALE:

G3A49_01345(larE)

HLN:	SVXHx_0193(lare)

HME:	HFX_0189(trmU)

HGI:	ABY42_00900

HLS:	KU306_05575(larE)

HBO:	Hbor_00410

HAQ:	DU484_02240(larE)

HAJ:	DU500_02645(larE)

HAER:

DU502_00510(larE)

HRA:	EI982_13005(larE)

HLM:	DV707_01550(larE)

HALM:

FCF25_07555(larE)

HLA:

Hlac_2603

HALP:

DOS48_13070(larE)

HALB:

EKH57_10880(larE)

HEZZ:

EO776_15160(larE)

HALQ:

Hrr1229_007315(larE)

HSS:	J7656_01760(larE)

HSAI:

HPS36_07265(larE)

HAZZ:

KI388_13145(larE)

SRUB:

C2R22_19285

HAE:	halTADL_2191

HALG:

HUG10_11545(larE)

HALU:

HUG12_03485(larE)

HMP:	K6T50_08405(larE)

HRE:	K6T36_08195(larE)

HRM:	K6T25_07650(larE)

HACB:

Hbl1158_00360(larE)

HDF:	AArcSl_2033

HAAA:

AArcCO_1824

HAH:	Halar_3174

HTU:

Htur_0177

HSAL:

JMJ58_08400(larE)

HAKZ:

J0X25_07385(larE)

NMG:

Nmag_2054

HXA:	Halxa_1557

NPE:	Natpe_0149

NVR:	FEJ81_00785(larE)

NAY:	HYG81_09885(larE)

HALY:

HYG82_14240(larE)

HJT:	DVR14_10155(larE)

HLO:	J0X27_10990(larE)

HLC:	CHINAEXTREME03720

SAWL:

NGM29_06690(larE)

HALV:

NGM15_15975(larE)

NOU:	Natoc_3902

HLR:	HALLA_19010

NAJ:	B1756_07880

NAG:	AArcMg_0122

NAN:	AArc1_0125

NARA:

QQ977_09050(larE)

HDA:	BB347_15170

MELU:

MTLP_08330

MEAM:

MU439_03945(larE)

MEAE:

QEN48_06235(larE)

TAR:	TALC_00267

MAX:	MMALV_02510

MER:	MMINT_10900

MEAR:

Mpt1_c07910(guaAB1)

MEUZ:

KRP56_05415(larE)

MARC:

AR505_1594

IAG:

Igag_1828

SACD:

HS1genome_2145

KCR:

Kcr_0481

MVJ:	ACO0C9_07400(larE)

NMR:

Nmar_0340

NIR:	NSED_01635

NKR:	NKOR_01550

NID:	NPIRD3C_0744

NIN:	NADRNF5_1912

NIW:	Nisw_03205(larE)

NCL:	C5F47_01805(larE)

NOX:	C5F49_01800(larE)

NUE:	C5F50_02415(larE)

NIP:	NsoK4_07065(larE)

NZT:	NZOSNM25_001702

NCT:

NMSP_1366

NIC:	DSQ20_01970(larE)

NGA:	Ngar_c01930

NVN:

NVIE_1402

NEV:

NTE_02779

TAA:	NMY3_01943

NFN:	NFRAN_2750

NCV:

NCAV_1611

NDV:

NDEV_0296

CSY:	CENSYa_1573

NBV:

T478_0271

TAH:	SU86_004250

NIU:	DSQ19_01870(larE)

NCK:	QVH35_05640(larE)

BARB:

AOA66_0333(nadE_1)

FLT:	Sv326_0938

LOKI:

Lokiarch_00690(tilS)

LOB:	NEF87_001689

PSYT:

DSAG12_00023(larE)

» show all

Reference

1 [PMID:24710389]

Authors

Desguin B, Goffin P, Viaene E, Kleerebezem M, Martin-Diaconescu V, Maroney MJ, Declercq JP, Soumillion P, Hols P

Title

Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.

Journal

Nat Commun 5:3615 (2014)
DOI:10.1038/ncomms4615

Sequence

[lpl:lp_0109]

Reference

2 [PMID:27114550]

Authors

Desguin B, Soumillion P, Hols P, Hausinger RP

Title

Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.

Journal

Proc Natl Acad Sci U S A 113:5598-603 (2016)
DOI:10.1073/pnas.1600486113

Sequence

[lpl:lp_0109]

Reference

3 [PMID:28784764]

Authors

Fellner M, Desguin B, Hausinger RP, Hu J

Title

Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.

Journal

Proc Natl Acad Sci U S A 114:9074-9079 (2017)
DOI:10.1073/pnas.1704967114

Sequence

[lpl:lp_0109]

Other DBs

ExplorEnz - The Enzyme Database:

4.4.1.37

IUBMB Enzyme Nomenclature:

4.4.1.37

ExPASy - ENZYME nomenclature database:

4.4.1.37

BRENDA, the Enzyme Database:

4.4.1.37

All links

Gene (12422)   
   MGENES (9629)   
   RefGene (2793)   
Protein sequence (28)   
   UniProt (27)   
   SWISS-PROT (1)   
DNA sequence (168)   
   GenBank (89)   
   EMBL (79)   
Protein domain (4)   
   InterPro (4)   
All databases (12622)   

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