KEGG   ENZYME: 4.4.1.37
Entry
EC 4.4.1.37                 Enzyme                                 
Name
pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase;
LarE;
P2CMN sulfurtransferase;
pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase;
P2TMN synthase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine pyridin-1-ium-3,5-dicarbothioate-mononucleotide-lyase (ATP-consuming)
Reaction(IUBMB)
(1) [LarE]-L-cysteine + pyridin-1-ium-3,5-dicarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + AMP + diphosphate (overall reaction) [RN:R12062];
(1a) ATP + pyridin-1-ium-3,5-dicarboxylate mononucleotide = diphosphate + 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [RN:R12059];
(1b) 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine [RN:R12060];
(1c) [LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [RN:R12061];
(2) [LarE]-L-cysteine + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide + ATP = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide + AMP + diphosphate (overall reaction) [RN:R12066];
(2a) ATP + pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide = diphosphate + 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [RN:R12063];
(2b) 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + [LarE]-L-cysteine = AMP + [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine [RN:R12064];
(2c) [LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine = [LarE]-dehydroalanine + pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide [RN:R12065]
Reaction(KEGG)
Substrate
[LarE]-L-cysteine;
pyridin-1-ium-3,5-dicarboxylate mononucleotide [CPD:C21851];
ATP [CPD:C00002];
5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21877];
[LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine;
pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [CPD:C21878];
1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21879];
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine
Product
[LarE]-dehydroalanine;
pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide [CPD:C21878];
AMP [CPD:C00020];
diphosphate [CPD:C00013];
5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21877];
[LarE]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium-3-carbonyl]-L-cysteine;
pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide [CPD:C21767];
1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate [CPD:C21879];
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine
Comment
This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. The process starts when one enzyme molecule adenylates pyridinium-3,5-dicarboxylate mononucleotide (P2CMN) and covalently binds the adenylated product to an intrinsic cysteine residue. Next, the enzyme cleaves the carbon-sulfur bond, liberating pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN) and leaving a 2-aminoprop-2-enoate (dehydroalanine) residue attached to the protein. Since the cysteine residue is not regenerated in vivo, the enzyme is inactivated during the process. A second enzyme molecule then repeats the process with PCTMN, adenylating it and covalently binding it to the same cysteine residue, followed by liberation of pyridinium-3,5-bisthiocarboxylate mononucleotide (P2TMN) and the inactivation of the second enzyme molecule.
History
EC 4.4.1.37 created 2018
Orthology
K06864  pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase
Genes
SLIGGTU79_05810(larE)
TCIA7K98_01710
VSHBSZ05_17080
EMODM558_01530
CATEC2869_06445 C2869_22210
THIPN838_07935(larE) N838_08690
GAIIMCC3135_06240
KUSB9G99_09400
KMAB9H00_05450
KUYFY550_02755(larE)
AHAAHA_1096
AHYAHML_05865
AHDAI20_13750
AHHRY45_05850
AHIVU14_17210
AAJBOQ57_05290
ASAASA_3235
AEOO23A_p2530
AVRB565_3117
AVOAMS64_18350
AMEDB224_4192
ASRWL1483_2033
ADHCK627_20680
AEMCK911_01420
AEAC2U39_17080
ARVC7N77_08810
AESC2U30_20060
AELNCTC12917_03300
ASIMFE240_12690
AALLI6G90_11430
AJDI6H43_05665
ARIVKYK33_06015
ASAAKXJ75_18585
BUMAXG89_23665 AXG89_29025
SUTTSUTMEG_10620
SUTKFG381_12145
SWSI6J16_06240
BBAYA4V04_07840
WSUWS0138
CCVCCV52592_1718
CCOCCC13826_1003
CGRACGRAC_1983
CSPFCSF_0736
CRXCRECT_2012
CMUCCMCT_0035
CSHOCSHOW_0339
SDLSdel_1279
SBASulba_1327
SMULSMUL_1676
SHALSHALO_1631
SULSSdiek1_1722
SULJSJPD1_1638
SULTFA592_00725(larE)
GSUGSU0536
GSKKN400_0525
GMEGmet_2987
GPIGPICK_13685
GAOA2G06_02865
GBZJZM60_02970(larE)
GEMGM21_0342
GEBGM18_0439
GEFFO488_13660(larE) FO488_17545(larE)
GURGura_3906
GEOGeob_1404
GLOGlov_2938
GBMGbem_0361
GBNGEOBRER4_03440 GEOBRER4_19830
GSBGSUB_13570
GERKP004_00865(larE)
GSUBKP001_14640(larE)
GNTKP003_00545(larE)
GPLM1B72_20030(larE)
PCAPcar_2431
PACEA6070_03155
PEFA7E78_13745
PPDPpro_1049
DESDSOUD_0766
DEUDBW_3157
DVEDESUT3_33990
DEPAOP6_0503
DVUDVU_2939
DVLDvul_0429
DVMDvMF_1465
DVGDeval_2714
DDSDdes_0092
DPGDESPIGER_1965
DEFCNY67_00515
DTRRSDT_0256
DFLDFE_2711
DSDGD606_05120
DMADMR_16550
DCBC3Y92_07465(larE)
DGGDGI_1164
DDEDde_3008
DMSE8L03_07255(larE) E8L03_15165
DSADesal_0486
DHYDESAM_20532
DAFDesaf_0882
DASDaes_0011
DPIBN4_20236
DEJAWY79_02870
PPRFDPRO_1954
PSELGM415_09185(larE)
DDNDND132_2261
DSXGD604_10560
PBIZLWC08_11725
DBADbac_0017
DRTDret_2468
DPSDP2170
DSFUWK_02634
DAKDaAHT2_0621
DPRDespr_1536
DEOCAY53_00020
DOGHP555_11115(larE)
DBKDGMP_14510
DOLDole_1596
DMLDmul_26820
DALDalk_2473
DATHRM2_17990
DTOTOL2_C16280
DOVDSCO28_20430
DWDDSCW_14280
DALKDSCA_01530
DLIdnl_37450(larE)
DMMdnm_087980(larE)
DEKDSLASN_01880
ADEAdeh_1542
ACPA2cp1_2413
AFWAnae109_2271
ANKAnaeK_2325
AORYAMOR_53880
APAUAMPC_09240
MXAMXAN_4063
MSDMYSTI_03867
MYMA176_002833
MFBMFUL124B02_20780
CCXCOCOR_03887
MFULILAB_28485
MMASMYMAC_003985
SURSTAUR_4519
AGEAA314_05997
AVMJQX13_43985(larE)
MBDMEBOL_006427
CFUSCYFUS_003920
VINAKJ08_2134
SCLsce5850
SCUSCE1572_34825
CCROCMC5_073440
PAUUE8A73_002445(larE)
LLUAKJ09_09237
MRMA7982_11826
HOHHoch_4189
SATSYN_00475
DAODesac_0387
DTIDesti_4487
SFUSfum_1060
DAXFDQ92_09505(larE)
DBRDeba_1477
BSEDDN745_16030(larE)
PCAYFRD00_11125(larE)
BBAEFRD01_11630(larE)
KAIK32_38510
SNOSnov_3498
STARG3545_21875
ANCGBB76_11560
APOLK9D25_07185
MRDMrad2831_1357
METM446_3800
MORMOC_1719
MAQUMaq22A_c11770
MPHYMCBMB27_01013
MEEDA075_01265
METXA3862_24025
METIDK427_11380
MMESMMSR116_17345
MTEADK419_02900
MINDmvi_36300
MTADM6G65_08955
BBARRHAL1_03399
RBMTEF_02790
LABPFJ695_05660
LIZLGH83_08250
ACUTMRB58_15045
MALGMALG_04019
SULDB5M07_17160
SDOSD1155_05780
SINLDSM14862_03981(larE)
SPSESULPSESMR1_03848
HATRC74_17075
LSALKBK07_18075
PZHCX676_17670
PAROCUV01_00725
BLASBSY18_3645
RMTIAI58_08805
LCKHN018_05385
RAPRHOA_PC0188
SKTIGS68_04150
SMUCJL100_004320
SROEJL101_004070
MGMMmc1_3710
BDZDOM22_17000
BWHA9C19_14220 A9C19_14270
BACAFAY30_06705(larE)
BCOHBC6307_01195
BMQBMQ_3431
BMDBMD_3422
BMHBMWSH_1758
PKSIE339_08235(larE)
BAGBcoa_1741
BKWBkAM31D_16130
CFIRNAF01_22300(larE)
OCNCUC15_13700
OCBCV093_14540(larE)
GKAGK1965
GTMGT3921_09725
GTNGTNG_1864
GCTGC56T3_1549
GJFM493_05005
GSRGS3922_11555
GEJA0V43_07465
PCALBV455_03527
PARGPspKH34_22170
ASEDIRT44_10805(larE)
HMNHM131_18325
HLIHLI_15690
PBUTDTO10_00755(larE)
PFRIL8956_13650(larE)
GRCGI584_07250(larE)
SCIBHUG20_02620(larE)
POFGS400_06170(larE)
NMKCHR53_07480
NDTL1999_05485(larE)
MSEMGMB29_06950(larE) GMB29_07365(larE)
BLENNCTC4824_00691 NCTC4824_02468
STEAC0679_13170
SERSERP0255
SEPSE_0373
SEPPSEB_00295
SEPSDP17_1680
SSPSSP0176
SPASSTP1_1687
SXYBE24_11080
SXLSXYLSMQ121_0202
SXOSXYL_00201
SCAPAYP1020_2354
SEQOSE1039_23810
SCOHBZ166_05530
SNLBJD96_01300
SKLC7J89_02925(larE)
SCARDWB96_11235(larE)
SARLSAP2_03240
SLLOISP08_01745(larE)
SPSDJMB28_01550(larE)
STASHYI43_10715(larE)
BAGRBA6348_20645
BCHSJNE38_09065(larE)
BCOPJD108_16175(larE) JD108_19125(larE)
PJDPjdr2_1791
PMSKNP414_03013
PMQPM3016_3251
PMWB2K_16835
PDUPDUR_14915
PAEJH70737_15695
PBJVN24_06055
PNPIJ22_20320
PCXLPB68_19160
PPSCEHS13_06835(larE)
COHEAV92_16205(larE)
COHNKCTCHS21_48020
CCHLFPL14_24555(larE)
AADTC41_0789
AFXJZ786_03335(larE)
AACOK1I37_09600(larE)
ACURJZ785_16045(larE)
KYRCVV65_06325
TUMCBW65_00200
TABCIG75_06095
EFFskT53_12490
PHCBBI08_12010
SPAEE2C16_10330(larE)
PANCE2636_15535(larE)
PABSJIR001_06500
SLATJ4854_09205(larE)
LCSLCBD_p44
LCWBN194_P0270
LPLlp_0109(larE)
LPJJDM1_0110
LPTzj316_0318(larE)
LPSLPST_C0090
LPRLBP_cg0091
LPZLp16_0102
LPBSH83_00470
LPXASU28_03275
LPGBB562_00460
LARGLPA65_00500
LFELAF_1729
LFRLC40_1098
LFFLBFF_1912
LNGBSQ50_05850 BSQ50_10040
LHWBSQ49_00460 BSQ49_08370
LMALLM596_00655(larE)
LBRLVIS_1852
LBKLVISKB_1835
LZYLZ3411_1660
LSUAH3M12_11140(larE)
LBTAYR52_09955
LCYLC20004_11455
LNNF0161_06420(larE)
LPDAYR62_03160
PPEPEPE_1690
PPENT256_08315
PCEPECL_1779
LSALCA_0790
LCVFBA2_04125
LGMLG542_05655(larE) LG542_08120(larE)
WCOG7084_07425(larE)
EFIOG1RF_11540
EGVEGCR1_11140(larE) EGCR1_11185 EGCR1_12085(larE)
ESGEsVE80_25510
AURHMPREF9243_1764
AUNAWM73_01180
GADK8O88_05655(larE)
CACCA_C0775
CAESMB_G0791
CAYCEA_G0786
CBOCBO0104 CBO1183
CBACLB_0140 CLB_1214
CBHCLC_0152 CLC_1226
CBYCLM_0147 CLM_1334
CBLCLK_0618 CLK_3279
CBBCLD_0682 CLD_3386
CBICLJ_B0142 CLJ_B1224
CBFCLI_0159 CLI_1265
CBMCBF_0132 CBF_1238
CBJH04402_00095 H04402_01251
CBECbei_0560
CBZCbs_0560
CBEILF65_00621 LF65_03283
CKLCKL_2501
CKRCKR_2212
CLJCLJU_c26710
CCBClocel_4272
CLSCXIVA_14630 CXIVA_19610
CLBClo1100_3205
CSRCspa_c14240 Cspa_c30300
CPASClopa_0770 Clopa_4087
CPATCLPA_c16040 CLPA_c32990
CPAECPAST_c16040 CPAST_c32990
CSBCLSA_c17600
CAHCAETHG_0752(larE) CAETHG_2397(larE)
CSQCSCA_0239 CSCA_1722
CLDCLSPO_c01300 CLSPO_c11830
CACECACET_c05410 CACET_c13920
CCKCcar_05980
CBUTATN24_17715
CTYKCTK_C22000
CEUA7L45_10325
CFMBJL90_08420 BJL90_12415
CDRKB9W14_10670
CDYF3K33_03240(larE) F3K33_11350(larE)
CFERD4Z93_06665(larE)
CLOSDMR38_13820(larE)
CMAHC1I91_18045
CRWCROST_013180(larE)
CFBCLFE_035310(larE)
CAUNCLAUR_015880(larE)
CNNCNEO_0877
CGELpsyc5s11_08520
AMTAmet_0482
GFEGferi_16415 Gferi_18010
CALEFDN13_14140(larE)
CRSFQB35_14405(larE)
SARJHH195_01560(larE)
PBIFKXZ80_10320(larE)
HHJNQ487_22085(larE)
CLOHMPREF0868_0965
CTHCthe_1841
CTXClo1313_2533
CCLClocl_2731
HSCHVS_07435
RBPB6259_02565
CCECcel_0923
RHEREHE19_005585(larE)
CTHDCDO33_09585
CCELCCDG5_1156
FPLAA4U99_13410
EHAEthha_0253
RGVNQ502_01635(larE)
CAPREQM14_02360(larE) EQM14_12585(larE)
OVAOBV_12500
OBJEIO64_06800(larE)
CLFGJQ69_07885(larE)
PFAAMM59RIKEN_21350
ACOLK5I23_15255(larE)
BPBbpr_I1983
BFICIY_11370
BHUbhn_I0284
RHORHOM_04515
RIXRO1_19180
CCTCC1_07280
BYLA4V09_05110
BHANCGC63_08095
BPROPMF13cell1_04356(nadE_2)
BLABEYS05_09720(larE)
BLIQINP51_08380(larE)
BWXNQ550_11990(larE)
LACYA4V08_22715
CSCIHDCHBGLK_00381(nadE_1) HDCHBGLK_02444(nadE_2)
CSHClosa_3053
ARFAR1Y2_0544
ACACEYQ97_14260(larE)
EHLEHLA_1081
PXVFXF36_11035(larE)
ANRAna3638_10440(larE) Ana3638_13555(larE)
ACELacsn021_20640
ACHTbsdcttw_23910
RTORTO_25320
CBOLCGC65_25490
CASPNQ535_05750(larE)
QDOH9Q78_04925(larE)
WHJH9Q79_05920(larE)
MFORNQ534_06965(larE)
LBWC3V36_11975(larE)
CDFCD630_17790
PDCCDIF630_01977(larE)
CDCCD196_1699
CDLCDR20291_1674
PDFCD630DERM_17790
CSTCLOST_1751
PSORRSJ16_12165
ROCHF520_06010(larE)
TEMJW646_00735(larE)
TGCL0P85_07600(larE)
TEBT8CH_0459 T8CH_1850 T8CH_P0032
IBRNQ514_08960(larE)
CMICcaldi_12840
SLPSlip_1661
SALQSYNTR_1278
CALKHUE98_04225(larE)
DSYDSY3982
DHDDhaf_1385
DDHDesde_1305
DDLDesdi_1171
DMTDESME_04210
SGYSgly_2368
DORDesor_3247
DAIDesaci_2947
DMIDesmer_2508
DEDDHBDCA_p1745
DECDCF50_p1754
DRSDEHRE_12495
DCADesca_1938
PTHPTH_0252 PTH_2629
DRMDred_0151
DRUDesru_0224
DFGB0537_01565
DAEDtox_2118
DKUDesku_0577
DAUDaud_2226
TFRBR63_18685(larE)
FWADCMF_27540
AACXDEACI_2248 DEACI_2545
TJRTherJR_2999
DGIDesgi_0600
HMOHM1_1687
HCVFTV88_0846(larE)
ELMELI_0450
EMTCPZ25_014820(larE)
ELIMB2M23_01620
AWOAwo_c14730
AWICHL1_002283(larE) CHL1_002400(larE)
ALKAJ0B03_03360(larE)
CMIUB1H56_04695
VGUHYG85_13535(larE)
VPYHZI73_08185(larE)
STHRBXT84_03280
CTHMCFE_2757
MDVC5Q96_07585(larE)
AMIJEQM06_00140(larE)
AMICAmi3637_07355(larE)
ABUTAmi103574_00920(larE)
ETMCE91St48_13510
BPRSCK3_07910
TTETTE0769
TEXTeth514_2220
THXThet_0714
TPDTeth39_1540
TITThit_0727
TMTTmath_0778
TBOThebr_1576
TWIThewi_0878
TKITKV_c07440
CHYCHY_0016 CHY_1281
MTAMoth_2511
MTHOMOTHE_c25970(guaA2)
MTHZMOTHA_c26680(guaA2)
TPZTph_c08290
CSCCsac_1655 Csac_1715
ATEAthe_1202 Athe_1637
COBCOB47_0945
CHDCalhy_1115 Calhy_1524
COWCalow_1381
CKICalkr_1184 Calkr_1649
CLCCalla_1046
CKNCalkro_1088 Calkro_1497
CCHAELD05_07750(larE) ELD05_08065(larE)
CDIACaldiYA01_08960 CaldiYA01_13060
TTMTthe_1034
TTOThethe_00991 Thethe_01835
TXYThexy_1688
TSHTsac_1491
MASMahau_0749
TEPTepRe1_1688
TAETepiRe1_1820
TOCToce_0386
NTHNther_2865
NCDACONDI_00114 ACONDI_02385
HASHalsa_2216
HALSD7D81_09415(larE)
IFNGM661_06540(larE)
AARAcear_0264
HHLHalha_0306
AFTBBF96_12650
APRApre_1704
AMEILV469_03815(larE)
PIVNCTC13079_00330
CAZOG3A45_06895(larE)
VPRVpar_0987
VATB7L28_04780
VRM44547418_01866
MEDMELS_2163
MHWACT01_11110
MEGDKB62_10865(larE)
MMAXLCQ47_11580(larE)
DHODia5BBH33_16940
SSGSelsp_1391
SRISELR_02550
SELTBCS37_10135
MHGMHY_28770
MFUNGXM21_00885(larE)
PUFUFO1_0761 UFO1_1330
PFTJBW_02956
MANAMAMMFC1_03248 MAMMFC1_04188
STEDSPTER_04730(larE)
AFNAcfer_1002
AINAcin_0148
PFACPFJ30894_00129
ERMEYR00_11820(larE)
FITFi14EGH31_12950
AMUOKWG62_13025(larE)
CMITNQ499_11365(larE)
MKNMKAN_19195
MBAIMB901379_01965
MRHMycrhN_2386
CGTcgR_2379
CGSC624_12135
CGGC629_12140
CGXSB89_11515
CEFCE2359
CMDB841_10450
CDOCDOO_12435
CUTCUTER_10190
CCJZccrud_11075
CRLNCTC7448_00761
CSURN24_2541
CCYSSAMEA4530656_2528
BFVC628_11990
ROAPd630_LPD01931
SRCM271_02635
SCWTU94_27860
STRCAA958_02865
SLEsle_12210(sle_12210)
SNZDC008_00245(larE)
SGEDWG14_08160
SBYH7H31_31765
SROIIAG44_41895(larE)
YIALO772_29255(larE)
ABRYNYE86_22785
BFABfae_31120
BRXBH708_12755
BRVCFK39_07895
BGGCFK41_00400
BRZCFK38_03120
BSAUDWV08_13400(larE)
BRRC1N80_03100(larE)
BRHANLU66_03460(larE)
DVADAD186_03280
ALXLVQ62_06040(larE)
IVAIsova_2550
PSEIGCE65_08170(larE)
ICAIntca_2470
SERJSGUI_3205
ORNDV701_00855(larE)
ORZFNH13_03630(larE)
GEZFE251_10195(larE)
GYUFE374_08980(larE)
HALTIM660_11170
RHALLQF10_10785
RSUALQF12_09610
PACDEGX94_05515(larE)
PAUSNCTC13651_02633
MPHMLP_05660
MIKFOE78_14115(larE)
MICGGJV80_06150(larE)
RAINRai3103_10330(larE)
PRVG7070_00350(larE)
BRTJ4N02_06655(larE)
NCANoca_3933
NDKI601_0491(gph_1)
NSNEXE58_04295(larE)
NANOG5V58_01575(larE)
NMESH9L09_05070
NCQK6T13_14500
MGGMPLG2_3153
KFLKfla_5922
KQIF1D05_14210(larE)
STRREKD16_16015
SAIUJ4H86_02075(larE)
ACTWF7P10_09295(larE)
NOWGBF35_28950
FREFranean1_0147
FRIFraEuI1c_0096
FSYFsymDg_0162
GOBGobs_1558
BSDBLASA_3121
BLAPMVA48_22065
MMARMODMU_4370
AMDAMED_3082
AMNRAM_15675
AMMAMES_3048
AMZB737_3049
PDXPsed_1615
PSEEFRP1_11810
PSEQAD006_19165
PECQAD017_27005
PAUTPdca_54860
PBROHOP40_10100(larE)
ASEACPL_3389
ACTNL083_6347
AFSAFR_19500
ACTSACWT_3261
AIHAiant_82390
ACTRAsp14428_28440
PFLAPflav_037480
ATLAthai_03320
ASERAsera_04000
CATICS0771_15390
DFUDfulv_21110(larE)
NHYJQS43_25650(larE)
CCAZCOUCH_19575
CAICaci_4914
SNASnas_6080
GLYK3N28_16435(larE)
FLHEJ997_03655(larE)
RXYRxyl_1079
RRDRradSPS_1039
RUBGBA63_08135(larE)
RMARGBA65_12840(larE)
AFOAfer_1841
AYMYM304_36770
ATQGH723_15745(larE)
AQZKSP35_12015(larE)
IAMHC251_15235(larE)
SHIShel_04890
ELEElen_1058
EYYEGYY_20440
EGDGS424_005350
AEQAEQU_0759
AHATADCFC_15860
RTSCE91St31_05380
EBZJ7S26_01750
OLOADJ70_04035
PCATPcatena_02470
CGOCorgl_0079
CAERCSV91_07365
CSTCLK434_07970
SYNslr1717
SYZMYO_113410
SYYSYNGTS_1329(slr1717)
SYTSYNGTI_1329(slr1717)
SYSSYNPCCN_1328(slr1717)
SYQSYNPCCP_1328(slr1717)
SYJD082_32380
SYOC7I86_06890(larE)
SYCsyc0168_c
SYUM744_09660
SYFSynpcc7942_1387
SYDSyncc9605_0392
SYESyncc9902_1937
SYGsync_0454
SYRSynRCC307_2095
SYXSynWH7803_0450
SYPSYNPCC7002_A0394
CYACYA_0568
CYBCYB_1309
SYNESyn6312_1512
SYNPSyn7502_01153
SYNKKR100_03470
SYNRKR49_11030
SYNDKR52_00470
SYHSyncc8109_0404
SYNWSynWH8103_02358
SYVAWQ23_02145
SYLAWQ21_02065
SYNCCB0101_10575(larE)
DSLDacsa_2224
SYWSYNW2051
CGCCyagr_1671
CYICBM981_1836
PMAPro_1726
PMMPMM1571
PMTPMT_1717
PMNPMN2A_1143
PMIPMT9312_1663
PMBA9601_17781
PMCP9515_17581
PMFP9303_22871
PMGP9301_17621
PMHP9215_18431
PMJP9211_16911
PMENATL1_20171
PRCEW14_1929
PRMEW15_2090
CMPCha6605_3594
AMRAM1_5419
WNAKA717_17505(larE)
TVNNIES2134_113810
SLWBRW62_03950
TELtll1241
THNNK55_04015
THECFFX45_07730(larE)
LEPLepto7376_3828
LENLEP3755_05650
LETO77CONTIG1_03689
LBOLBWT_57270
KOVK9N68_19600(larE)
LSCKIK02_06055(larE)
LSKJ5X98_18195(larE)
HHGXM38_044690(nadE_2)
PSEUPse7367_0760
PSERABRG53_1561(exsB)
THEUHPC62_08160(larE)
GLPGlo7428_4128
GENGM3709_2565
GEEGM3708_1693
CHONNIES4102_03900
MARMAE_02020
MPKVL20_6280
MIQB5D77_07340
MVZmyaer102_37110
CANCyan10605_2838
CSNCyast_1731
CYLAA637_08485
HAOPCC7418_1248
ENNFRE64_09745(larE)
CYTcce_0166
CWACwatDRAFT_3155
CYPPCC8801_1583
CYHCyan8802_1608
CYCPCC7424_1063
CYJCyan7822_1019
CYNCyan7425_3314
TERTery_4689
ARPNIES39_L03190
PAGHNIES204_14310
PPSUNO713_05572
OXYHCG48_19755(larE)
MVAGD0A34_15480(larE)
LFSHFV01_04905(larE)
MICMic7113_0772
GEIGEI7407_1560
OACOscil6304_0486
ONIOsc7112_1738
MPROBJP34_05340
PHORJWS08_01610(larE)
PYHNEA10_11890(larE)
CEPCri9333_2236
GVIgll2047
GLJGKIL_1205
GMLISF26_15315(larE)
ANAalr1286
NPUNpun_R3824
NOSNos7107_2566
NOPNos7524_3684
NONNOS3756_18130
NFLCOO91_04593
NOECLI64_23080
NSHGXM_02973
NEDHUN01_15110(larE)
AVAAva_3010
NAZAazo_2203
ANBANA_C12431
ACYAnacy_4825
AWAAA650_13180
ANNEH233_13095(larE)
CSGCylst_1757
RSINB6N60_01376
CALOCal7507_4729
CALTCal6303_5178
CALHIJ00_10880
CALNNIES2098_52010
RIVRiv7116_6437
FISFIS3754_06710
NSPBMF81_01729(nadE_2)
NSPHBDGGKGIB_02456(larE)
DOUBMF77_04593(nadE_2)
DFSHGD76_07520(larE)
CCURIAR63_05645(larE)
CRKL3I90_06110(larE)
AFLOHEQ12_02550(larE)
TOQHCG51_13185(larE)
NCNBZZ01_19070
CTHEChro_0658
PLPPle7327_3744
SCSSta7437_4312
STANSTA3757_37080
CEOETSB_1369
CERRGRSB_1642
RRSRoseRS_1342
RCARcas_1629
TROtrd_0620
ATMANT_23240 ANT_30630
LEKhrd7_08550
ABAOBEQ56_02455
CAPCLDAP_20490
KBSEPA93_43495(larE)
TTRTter_1708
CCZCCALI_01221
CAACaka_1889
AMUAmuc_1595
AGLPYTT_2054
VBSEGM51_10255(larE)
RBARB5730
PSLPsta_4402
PIRVN12_02725
RULUC8_35910
RMLFF011L_25530
ROLCA51_18250
AHELQ31a_52550
LCREPla8534_64020
AAGGETAA8_52700
BVOPan97_15460
RLCK227x_29120
TTFTHTE_2519
LPAVPLANPX_3277
AMUCPan181_25760
PNDPla175_19970
AMOBHG15A2_30220
PLMPlim_2185
PEHSpb1_29600
PBSPlabr_2606
PLSVT03_18995
PLHVT85_25410
FMRFuma_01618
GMRGmarT_21670
GIMF1728_03555(larE)
GPNPan110_21030
MRIMal4_09170
SDYNMal52_28490
PLONPla110_14520
GESVT84_29015
GOGC1280_11315
GMSSOIL9_08210
TIMGMBLW1_01000
LRSPX52LOC_04999
FTJFTUN_0475
ULIETAA1_20890
TSPHKIH39_06985(larE)
IPAIsop_1940
SACISinac_0253
PBORBSF38_03270(nadE_1)
AGVOJF2_00330
KSTKSMBR1_3335
BROCIPI25_08885(larE)
BPITBPIT_22490
JETL3J17_00470(larE)
PHMPSMK_26140
PCORKS4_17010
MCADPan265_06830(nadE_1)
PBUL21SP3_01888
PBPSTSP1_01365
PBASSMSP2_00400
ALUSSTSP2_02408
VBLL21SP4_00054
TAERGT409_13250(larE)
VBCC5Q97_15480
VAIBU251_00350
TSUTresu_1703
TPITREPR_3215
TPEDTPE_1023
TPAVHRQ91_05945(larE)
SSMSpirs_3840
STASTHERM_c18740
STQSpith_1918
ABAAcid345_0159
ACAACP_0085
ACMAciX9_2065
GMAAciX8_0743
GRWFTO74_05175(larE)
GRBGOB94_11695(larE)
TSAAciPR4_1690
TRSTerro_4321
TALBFTW19_20105(larE)
ABASACPOL_5634
EDAGWR55_06530(larE)
EDGH7846_13230(larE)
ADINH7849_14060(larE)
ORPMOP44_06715(larE)
SUSAcid_3974
PFERIRI77_10270(larE)
CTMCabther_B0780
CVLJ8C06_14980(larE)
CHLOJ8C02_12395(larE)
ABACLuPra_01255
EPOEpro_1180
ETIRSTT_618
RSDTGRD_657
FULC4N20_13055(larE)
ACOAmico_1792
TLITlie_1862
AMOAnamo_2098
SBRSY1_06510
CPORBED41_01325
PPIOCE91St28_21490
GBAJ421_2914
PROJKDN43_12620(larE)
MCOSGM418_06880(larE)
ASXCDL62_08535
FOPFNB79_14670(larE)
TMATM0966 TM1075
TMMTmari_0968 Tmari_1079
TMITHEMA_08980 THEMA_09515
TMWTHMA_0989 THMA_1097
TMQTHMB_0989 THMB_1097
TMXTHMC_0989 THMC_1097
TPTTpet_1669 Tpet_1781
TNPTnap_1692 Tnap_1782
TRQTRQ2_1742 TRQ2_1824
TNACTN_1494 CTN_1610
THQT2812B_08615 T2812B_09090
THZCELL2_08690
THRTRQ7_08930 TRQ7_09465
TLETlet_0612
TTATheth_0711
TMETmel_1605
TAFTHA_1812
THPBG95_08730
THERY592_08835
FRRIB67_07620
PMOPmob_0537
MPZMarpi_1396
MARNLN42_07455
OCSOF820_11195
KOLKole_2141
MPGTheba_1256
MINFMESINF_2434
ASACATHSA_1770
DDFDEFDS_1637
DAPDacet_2274
GTLEP073_05165
CNICalni_1892
FSIFlexsi_0587
MSCHN508_000771(larE)
DTHDICTH_1659
DTUDtur_1769
DTPJZK55_05280
NDENIDE3731
NMVNITMOv2_4178
NIONITINOP_1391
NJANSJP_0489
NKFNkreftii_000447
NIFW02_18740
TIDThein_1354
TAVG4V39_02835(larE)
TMAIFVE67_05870(larE)
NLIG3M70_01525(larE)
ALAMRT761_00970 RT761_02574(nadE_3)
MJAMJ_0830
MFEMefer_0920
MVUMetvu_0128
MFSMFS40622_1333
MIFMetin_0705
MJHJH146_1074
MESGMLAUSG7_0326
MESAMLASG1_1504
MIGMetig_0712
MMPMMP1239
MMQMmarC5_0352
MMXMmarC6_1434
MMZMmarC7_0485
MMDGYY_07030
MMAKMMKA1_14140 MMKA1_14310 MMKA1_14480 MMKA1_14650
MMAOMMOS7_13470
MMADMMJJ_16060
MAEMaeo_0184
MVNMevan_0553
MVOMvol_0156
MOKMetok_0265
METFCFE53_05300
MTHMTH_990
MMGMTBMA_c13730
MWOMWSIV6_1377
MTEEMTTB_04320
METCMTCT_0899
METEtca_00952(tilS)
METZMETMT2_1018
METKFVF72_06655(larE)
MTHMFZP57_06575(larE)
METJFZP68_04085(larE)
MSTMsp_1275
MRUmru_0666
MSIMsm_0482
MEBAbm4_0396
MMILsm9_0536 sm9_1605
MEYETL18_02430 TL18_06600
MOLYLM1_0307
MAROMarbSA_17450
METVK4897_02920(larE)
MELMetbo_2234
MEWMSWAN_0407
METHMBMB1_0457
MFCBRM9_1801
MFIDSM1535_2442
MCUBMCBB_0420
MSUBBK009_00345
METNBK008_08155
METTCIT01_02685
METOCIT02_04515
MEMEHYG87_04025(larE)
MFVMfer_0481
MKAMK0071
AFUAF_0559 AF_1556
AFGAFULGI_00005690 AFULGI_00018090
APOArcpr_0047
AVEArcve_1319
ASTAsulf_00413
FPLFerp_2505
GACGACE_0076
GAHGAH_00296
MBAMbar_A0722
MBYMSBRM_0323
MBWMSBRW_0279
MBARMSBR2_2058
MBAKMSBR3_0835 MSBR3_2119
MACMA_0240
MMAMM_1520
MMAZMmTuc01_1579
MMJMSMAS_3147
MMACMSMAC_3167
MVCMSVAZ_0321 MSVAZ_1405
MEKMSKOL_0305 MSKOL_1347
MLSMSLAZ_0097
METMMSMTP_3045
MEFMSWH1_0167
MEQMSWHS_0166
MSJMSSAC_0226
MSZMSSIH_0195
MSWMSSIT_0199
MTHRMSTHT_2045
MTHEMSTHC_1241
MHORMSHOH_3885
MFZAOB57_009540(larE)
MBUMbur_1431
MMETMCMEM_1198 MCMEM_1915
MELOJ7W08_08545(larE)
MMHMmah_0379
MHAZBHR79_01615
MEVMetev_1872
MZHMzhil_1816
MPYMpsy_2077
MZIHWN40_12190(larE)
MHZMetho_2210
MTPMthe_0693
MCJMCON_2758
MHIMhar_2227
MHUMhun_2185
MRTJKHC33_15340(larE)
MLAMlab_0368
MEMMemar_1612
MBGBN140_0830
MEMAMMAB1_1090
MCHKMchiMG62_15240 MchiMG62_18020
MPIMpet_2672
MENDL6E24_08480(larE)
MBNMboo_2123
MFOMetfor_0805 Metfor_2454
MPLMpal_1151 Mpal_1214
MPDMCP_2272
MEZMtc_0969 Mtc_1602
RCIRCIA125 RCIX867
HJEHacjB3_01070
HALREFA46_003585(larE)
HAADMW046_03135(larE)
HALXM0R89_05410(larE)
HAXZM0R88_05410(larE)
SALIL593_08055
SAIMK0C01_03880(larE)
HMArrnAC2860(trmU)
HHIHAH_0136(trmU)
HHNHISP_00760
HABSG26_08630
HTABVU17_00645
HALJG9465_02205(larE)
HSINKDQ40_12980(larE)
NMONmlp_3774
NHOHWV23_09730(larE)
NSALHWV07_13045(larE)
HUTHuta_1028
HTIHTIA_0886
HALAHrd1104_10865(larE)
HMUHmuk_1000
HALZE5139_08160(larE)
HALLLC1Hm_0230
HAZPGBQ70_08155(larE)
HALIBV210_09760
HSNDV733_11570(larE)
HRRHZS55_02920(larE)
HPELHZS54_02640(larE)
HLTI7X12_09035(larE)
HARCHARCEL1_11040(larE)
HDOMUK72_01945(larE)
SSAIN0B31_12885(larE)
HWAHQ_3682A
HWCHqrw_4096
HVOHVO_0190
HMEHFX_0189(trmU)
HGIABY42_00900
HALEG3A49_01345(larE)
HLSKU306_05575(larE)
HBOHbor_00410
HAQDU484_02240(larE)
HAJDU500_02645(larE)
HAERDU502_00510(larE)
HRAEI982_13005(larE)
HLMDV707_01550(larE)
HALMFCF25_07555(larE)
HLAHlac_2603
HALPDOS48_13070(larE)
HALBEKH57_10880(larE)
HEZZEO776_15160(larE)
HALQHrr1229_007315(larE)
HSSJ7656_01760(larE)
HSAIHPS36_07265(larE)
HAZZKI388_13145(larE)
SRUBC2R22_19285
HAEhalTADL_2191
HALGHUG10_11545(larE)
HALUHUG12_03485(larE)
HMPK6T50_08405(larE)
HREK6T36_08195(larE)
HRMK6T25_07650(larE)
HACBHbl1158_00360(larE)
HDFAArcSl_2033
HAHHalar_3174
HTUHtur_0177
HDABB347_15170
HSALJMJ58_08400(larE)
HLOJ0X27_10990(larE)
HAKZJ0X25_07385(larE)
NMGNmag_2054
HXAHalxa_1557
NPENatpe_0149
NVRFEJ81_00785(larE)
NAYHYG81_09885(larE)
HALYHYG82_14240(larE)
HJTDVR14_10155(larE)
NOUNatoc_3902
HLRHALLA_19010
HLCCHINAEXTREME03720
NAJB1756_07880
NAGAArcMg_0122
NANAArc1_0125
SAWLNGM29_06690(larE)
MELUMTLP_08330
MEAMMU439_03945(larE)
TARTALC_00267
MAXMMALV_02510
MERMMINT_10900
MEARMpt1_c07910(guaAB1)
MEUZKRP56_05415(larE)
MARCAR505_1594
IAGIgag_1828
SACDHS1genome_2145
NMRNmar_0340
NIRNSED_01635
NKRNKOR_01550
NIDNPIRD3C_0744
NINNADRNF5_1912
NIWNisw_03205(larE)
NCLC5F47_01805(larE)
NOXC5F49_01800(larE)
NUEC5F50_02415(larE)
NIPNsoK4_07065(larE)
NCTNMSP_1366
NICDSQ20_01970(larE)
CSYCENSYa_1573
NGANgar_c01930
NVNNVIE_1402
NEVNTE_02779
TAANMY3_01943
NFNNFRAN_2750
NCVNCAV_1611
NBVT478_0271
TAHSU86_004250
NIUDSQ19_01870(larE)
NDVNDEV_0296
KCRKcr_0481
BARBAOA66_0333(nadE_1)
FLTSv326_0938
LOKILokiarch_00690(tilS)
PSYTDSAG12_00023
 » show all
Reference
1  [PMID:24710389]
  Authors
Desguin B, Goffin P, Viaene E, Kleerebezem M, Martin-Diaconescu V, Maroney MJ, Declercq JP, Soumillion P, Hols P
  Title
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.
  Journal
Nat Commun 5:3615 (2014)
DOI:10.1038/ncomms4615
  Sequence
[lpl:lp_0109]
Reference
2  [PMID:27114550]
  Authors
Desguin B, Soumillion P, Hols P, Hausinger RP
  Title
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.
  Journal
Proc Natl Acad Sci U S A 113:5598-603 (2016)
DOI:10.1073/pnas.1600486113
  Sequence
[lpl:lp_0109]
Reference
3  [PMID:28784764]
  Authors
Fellner M, Desguin B, Hausinger RP, Hu J
  Title
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
  Journal
Proc Natl Acad Sci U S A 114:9074-9079 (2017)
DOI:10.1073/pnas.1704967114
  Sequence
[lpl:lp_0109]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.37
IUBMB Enzyme Nomenclature: 4.4.1.37
ExPASy - ENZYME nomenclature database: 4.4.1.37
BRENDA, the Enzyme Database: 4.4.1.37

DBGET integrated database retrieval system