KEGG   ENZYME: 4.4.1.9
Entry
EC 4.4.1.9                  Enzyme                                 
Name
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
Reaction(IUBMB)
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]
Reaction(KEGG)
R03524;
(other) R02846
Substrate
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]
Product
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]
Comment
Contains pyridoxal phospate.
History
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13034  L-3-cyanoalanine synthase/ cysteine synthase
Genes
ATHAT3G61440(CYSC1)
ALY9312681 9319720
CRB17886219
CSAT104699755 104747140 104749184 104788433
EUSEUTSA_v10006044mg
BRP103841966 103862824
BNA106393304 106396803 106415606 106415702 106415710 106444997
BOE106311835 106336914 106338498
RSZ108855811 108863440
THJ104802038 104817302
CPAP110820910
CIT102609716
CICCICLE_v10020662mg
PVY116134250
MINC123217493
TCC18614120
GRA105802709 105802711
GHI107911578 107911579 107924412
GAB108473707 108473708
DZI111304748
EGR104443429
GMX100101899(OAS-TL3) 100806420
GSJ114397550 114425218
PVUPHAVU_008G061100g
VRA106759445
VAR108329722
VUN114186237
CCAJ109802499
APRC113860583
MTRMTR_7g078070
CAM101512608
LJALj1g3v2682510.1(Lj1g3v2682510.1)
ADU107472470 107485772
AIP107621508 107635094
AHF112726280 112730543 112744150 112797478
LANG109338383 109339915
FVE101292050
RCN112172959 112181707
PPER18786519
PMUM103342779
PAVI110751794
PDUL117619863
MDM103401891 103405317
PXB103940809 103957376
ZJU107404050
MNT21395612
CSV101220896
CMO103497706
BHJ120068144
MCHA111024353
CMAX111499275
CMOS111460401
CPEP111807524
RCU8261899 8278514
JCU105642966
HBR110649537 110660627
MESC110615325 110615780
POP7457347 7494093
PEU105124856 105132437 105134042
PALZ118041630 118057778
JRE109021531
QSU111999906 112022627
QLO115986890 115994564
TWL120003285
VVI100255091
VRI117912144 117931555
SLY101253940 101255033
SPEN107008051 107032363
SOT102601315(PCAS-2) 102604154(PCAS-1)
CANN107839203
NTA107787097 107788814 107793495 107795843
NSY104231967 104243686
NTO104117492 104118550
NAU109231094 109243119
INI109171635 109184868
ITR116016603 116030521
SIND105172766
OEU111390009
EGT105963830
SSPL121795227 121798141
HAN110864795 110937631
ECAD122591207
LSV111902665
CCAV112526366
DCR108210215
CSIN114281509
BVG104887240
SOE110789773
CQI110714064 110731553
NNU104610634
MING122066723 122075314 122075315
TSS122662430 122662748
PSOM113274742
NCOL116265690
OSA4335048
DOSAOs04t0165700-01(Os04g0165700)
OBR102715851
BDI100835065
ATS109731680
TDC119302459 119311137
TAES100682425 123104403 123122184
SBI8066013
ZMA100216722
SITA101779131
SVS117863762
PVIR120639762 120682197
PHAI112899701
PDA103715474
EGU105043037
MUS103985756
DCT110097663
PEQ110025102
AOF109837549
ATR18422839
 » show all
Reference
1  [PMID:1055433]
  Authors
Akopyan TN, Braunstein AE, Goryachenkova EV.
  Title
Beta-cyanoalanine synthase: purification and characterization.
  Journal
Proc Natl Acad Sci U S A 72:1617-21 (1975)
DOI:10.1073/pnas.72.4.1617
Reference
2  [PMID:5001194]
  Authors
Castric PA, Conn EE.
  Title
Formation of  -cyanoalanine by O-acetylserine sulfhydrylase.
  Journal
J Bacteriol 108:132-6 (1971)
DOI:10.1128/JB.108.1.132-136.1971
Reference
3
  Authors
Hendrickson, H.R.
  Title
The beta-cyanoalanine synthase of blue lupine.
  Journal
Fed Proc 27:593 (1968)
Reference
4  [PMID:5769995]
  Authors
Hendrickson HR, Conn EE.
  Title
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
  Journal
J Biol Chem 244:2632-40 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.9
IUBMB Enzyme Nomenclature: 4.4.1.9
ExPASy - ENZYME nomenclature database: 4.4.1.9
BRENDA, the Enzyme Database: 4.4.1.9
CAS: 9059-53-4

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