Entry
Name
FAD-AMP lyase (cyclizing);
FMN cyclase;
FAD AMP-lyase (cyclic-FMN-forming)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming)
Reaction(IUBMB)
FAD = AMP + riboflavin cyclic-4',5'-phosphate [RN:
R07636 ]
Reaction(KEGG)
Substrate
Product
AMP [CPD:
C00020 ];
riboflavin cyclic-4',5'-phosphate [CPD:
C16071 ]
Comment
Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN.
History
EC 4.6.1.15 created 2002
Orthology
K00863 triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing)
Genes
PPRM : 120469829 120470392
PPRL : 129356671 129379938
LERI : 129705830(tkfc) 129705831
BBEL : 109472260 109475013
APLC : 110976236 110988379
AALB : 109409004 109412500 109621976 115257995 115264944
ASUA : 134215613 134216411
CQU : CpipJ_CPIJ006434 CpipJ_CPIJ016133
CPII : 120412634 120422699
RSAN : 119376668 119401707
CEL : CELE_W02H5.8(W02H5.8)
PVUL : 126821117 126822675
CANU : 128176691 128176693
SCE : YFL053W(DAK2) YML070W(DAK1)
SEUB : DI49_1319 DI49_4021
SPAO : SPAR_F00070 SPAR_M00620
LTH : KLTH0B00418g KLTH0D16412g
CGR : 2890962(GVI51_L11319)
NCS : NCAS_0A06130(NCAS0A06130)
NDI : NDAI_0D03110(NDAI0D03110)
TPF : TPHA_0B01670(TPHA0B01670)
TBL : TBLA_0B06340(TBLA0B06340)
TDL : TDEL_0C00180(TDEL0C00180) TDEL_0D00840(TDEL0D00840)
KAF : KAFR_0I00330(KAFR0I00330)
KNG : KNAG_0E04050(KNAG0E04050)
ZMK : HG535_0B00260 HG535_0E01760
DHA : DEHA2A03542g DEHA2A12342g DEHA2B12892g DEHA2F01034g
PIC : PICST_31117(DAK1.1) PICST_57462(DAK2)
SPAA : SPAPADRAFT_139806 SPAPADRAFT_151697 SPAPADRAFT_72612
CAL : CAALFM_C109190CA(DAK2)
CTEN : 18246129(DAK2) 18250712(PSN45_004205)
YLI : 2908059(YALI2_F00970g) 2908330(YALI2_F00182g)
SLB : AWJ20_2310(DAK1) AWJ20_3444(DAK2)
OPA : HPODL_01039 HPODL_04538
NCR : NCU03779(dak-1) NCU04400
NTE : NEUTE1DRAFT121216(NEUTE1DRAFT_121216) NEUTE1DRAFT58250(NEUTE1DRAFT_58250)
SMP : SMAC_02626 SMAC_07350
PAN : PODANSg7445 PODANSg9015
PBEL : QC761_211570(dak1) QC761_601010
PPSD : QC762_211570(dak1) QC762_601010
PPSP : QC763_211570(dak1) QC763_601010
PPSA : QC764_211570(dak1) QC764_601010
TTT : THITE_2040308 THITE_2108431 THITE_2114839
MTM : MYCTH_2302225 MYCTH_40719
PPEI : PpBr36_04491 PpBr36_09502
PGRI : PgNI_06903 PgNI_10247
TMN : UCRPA7_1104 UCRPA7_6890 UCRPA7_7089
SSCK : SPSK_04142 SPSK_07274
FGR : FGSG_07017 FGSG_08042
FPU : FPSE_02329 FPSE_02774
FPOA : FPOAC1_010775 FPOAC1_013122
FVR : FVEG_08163 FVEG_10244
FOX : FOXG_01790 FOXG_04497 FOXG_11580 FOXG_13047
NHE : NECHADRAFT_63627 NECHADRAFT_81277 NECHADRAFT_94691
FFC : NCS54_00864000 NCS54_01150900 NCS54_01503900
FKR : NCS57_00476800 NCS57_00906100 NCS57_01141300
FMU : J7337_002794 J7337_010366 J7337_011510
TRE : TRIREDRAFT_108835 TRIREDRAFT_4480 TRIREDRAFT_68466
TRR : M419DRAFT_130671 M419DRAFT_26548 M419DRAFT_36354
TATV : 25783807(TrAtP1_011340) 25786124(TrAtP1_003042)
MAW : 19245494(J3458_004465) 19250278(dak1)
MBRN : 26238890(DAK) 26245064(dak1)
PCHM : VFPPC_03185 VFPPC_05893 VFPPC_08304 VFPPC_08312
CMT : CCM_01642 CCM_03212 CCM_08253
AMUS : LMH87_001276 LMH87_002450 LMH87_003445
PLJ : 28890151(PLICBS_009492) 28891152(PLICBS_004546) 28891460(PLICBS_010466) 90642803(PLICBS_003861)
PTKZ : JDV02_002356 JDV02_005068(dak1) JDV02_009403
VAL : VDBG_07518 VDBG_07610 VDBG_07776
VDA : VDAG_09239 VDAG_09331 VDAG_09648
CFJ : CFIO01_01160 CFIO01_02503 CFIO01_03078 CFIO01_06023
CLUP : CLUP02_07917 CLUP02_12908 CLUP02_16847 CLUP02_17623
CHIG : CH63R_04175 CH63R_06617 CH63R_12165
ELA : UCREL1_5454 UCREL1_9085
PFY : PFICI_02687 PFICI_02699 PFICI_05817 PFICI_07807 PFICI_08547
PSCO : LY89DRAFT_281960 LY89DRAFT_638105
GLZ : GLAREA_02829 GLAREA_06224
ACHE : ACHE_41301S ACHE_80736A
POU : POX_d05390 POX_f08145
TMF : EYB26_001827 EYB26_008813
PNO : SNOG_10035 SNOG_10451
PTRR : 6344242(PtrM4_103030)
BZE : COCCADRAFT_27327 COCCADRAFT_9558
BSC : COCSADRAFT_141387 COCSADRAFT_29733
BOR : COCMIDRAFT_33722 COCMIDRAFT_3711
AALT : CC77DRAFT_1022806 CC77DRAFT_929939
ARAB : EKO05_0005282 EKO05_0007737
ZTR : MYCGRDRAFT_54399 MYCGRDRAFT_76425
PFJ : MYCFIDRAFT_158677 MYCFIDRAFT_59700
FFU : CLAFUR5_01064 CLAFUR5_03250 CLAFUR5_08051
CBET : CB0940_01334 CB0940_02325
BCOM : BAUCODRAFT_192470 BAUCODRAFT_420155
SPO : 2541809(dak1) 2541810(dak2)
CNG : CNAG_00826 CNAG_02799
CGI : CGB_A9430C CGB_C6280C
CDEU : CNBG_1112 CNBG_3454
TMS : TREMEDRAFT_29967 TREMEDRAFT_32898
TASA : A1Q1_00056 A1Q1_01002
CCAC : CcaHIS019_0103320(CcaverHIS019_0103320) CcaHIS019_0411730(CcaverHIS019_0411730)
SHS : STEHIDRAFT_137393 STEHIDRAFT_139617 STEHIDRAFT_58915
HIR : HETIRDRAFT_122126 HETIRDRAFT_64180
FME : FOMMEDRAFT_166668 FOMMEDRAFT_73790
GTR : GLOTRDRAFT_74971 GLOTRDRAFT_96970
ABP : AGABI1DRAFT90110(AGABI1DRAFT_90110)
ABV : AGABI2DRAFT222826(AGABI2DRAFT_222826) AGABI2DRAFT229242(AGABI2DRAFT_229242)
MRR : Moror_17275 Moror_9773
MORE : E1B28_006914 E1B28_007669
SCM : SCHCO_02545094(SCHCODRAFT_02545094) SCHCO_02619084(SCHCODRAFT_02619084)
CPUT : CONPUDRAFT_138892 CONPUDRAFT_83570
SLA : SERLADRAFT_357185 SERLADRAFT_450606
WSE : WALSEDRAFT_32383(DAK-1) WALSEDRAFT_53995(DAK-1)
WIC : J056_000580 J056_004718
» show all
Taxonomy
Reference
Authors
Fraiz FJ, Pinto RM, Costas MJ, Aavalos M, Canales J, Cabezas A, Cameselle JC.
Title
Enzymic formation of riboflavin 4',5'-cyclic phosphate from FAD: evidence for a specific low-Km FMN cyclase in rat liver1.
Journal
Reference
Authors
Cabezas A, Pinto RM, Fraiz F, Canales J, Gonzalez-Santiago S, Cameselle JC
Title
Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.15
ExPASy - ENZYME nomenclature database: 4.6.1.15