KEGG ENZYME: 4.6.1.6

ENZYME: 4.6.1.6

Entry

EC 4.6.1.6                  Enzyme

Name

cytidylate cyclase;
3',5'-cyclic-CMP synthase;
cytidylyl cyclase;
cytidyl cyclase;
CTP diphosphate-lyase (cyclizing);
pycC (gene name) (ambiguous)

Class

Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)

Sysname

CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)

Reaction(IUBMB)

CTP = 3',5'-cyclic CMP + diphosphate [RN:R00574]

Reaction(KEGG)

R00574

Substrate

CTP [CPD:C00063]

Product

3',5'-cyclic CMP [CPD:C00941];
diphosphate [CPD:C00013]

Comment

In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.

History

EC 4.6.1.6 created 1989

Pathway

ec00240

Pyrimidine metabolism

Orthology

K27604

cytidylate cyclase

Genes

CUI:	AFK65_02745

EPY:

EpC_31910

EPR:	EPYR_03445

PEY:	EE896_05820

VVY:

VV1757

VAN:

VAA_03008

LAG:	N175_18200

VAU:	VANGNB10_cII0235c

PFO:	Pfl01_5693

PRX:	HRH33_23115

PMAO:

PMYSY11_2822

HAES:

LO767_03810

MALL:

PBN92_11215

PSM:

PSM_A2062

PSJS:

GZH31_05560

PSKA:

KAN5_06600

KUS:	B9G99_06370

AEO:	O23A_p2169

AERO:

CK910_21420

BCEN:

DM39_6012

PGP:	CUJ91_18420

JAG:

GJA_3396

DVE:	DESUT3_27090

AHEL:

Q31a_44040

FPAL:

HYN49_09565

NSD:	BST91_02660

VPT:	KBP50_03670

SUX:	SAEMRSA15_00430

SUF:	SARLGA251_00540

EFL:

EF62_1084

EFN:	DENG_00746

EFQ:

DR75_2659

EDU:

LIU_01765

ELAC:

I4Q40_06215

» show all

Reference

1 [PMID:23778]

Authors

Cech SY, Ignarro LJ.

Title

Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver.

Journal

Biochem Biophys Res Commun 80:119-25 (1978)
DOI:10.1016/0006-291X(78)91112-9

Reference

Authors

Newton RP, Salih SG, Hakeem NA, Kingston EE, Beynon JH.

Title

3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues.

Journal

Biochem Soc Trans 13:1134-1135 (1985)

Reference

3 [PMID:34644530]

Authors

Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.

Title

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.

Journal

Cell 184:5728-5739.e16 (2021)
DOI:10.1016/j.cell.2021.09.031

Sequence

[ag:WP_053265929]

Other DBs

ExplorEnz - The Enzyme Database:

4.6.1.6

IUBMB Enzyme Nomenclature:

4.6.1.6

ExPASy - ENZYME nomenclature database:

4.6.1.6

BRENDA, the Enzyme Database:

4.6.1.6

CAS:	65357-82-6

All links

Protein sequence (70)   
   UniProt (5)   
   SWISS-PROT (3)   
   RefSeq(pep) (58)   
   PDBSTR (4)   
DNA sequence (2310)   
   RefSeq(nuc) (2119)   
   GenBank (100)   
   EMBL (91)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   InterPro (3)   
All databases (2385)   

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