KEGG ENZYME: 4.6.1.6

ENZYME: 4.6.1.6

Entry

EC 4.6.1.6                  Enzyme

Name

cytidylate cyclase;
3',5'-cyclic-CMP synthase;
cytidylyl cyclase;
cytidyl cyclase;
CTP diphosphate-lyase (cyclizing);
pycC (gene name) (ambiguous)

Class

Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)

Sysname

CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)

Reaction(IUBMB)

CTP = 3',5'-cyclic CMP + diphosphate [RN:R00574]

Reaction(KEGG)

R00574

Substrate

CTP [CPD:C00063]

Product

3',5'-cyclic CMP [CPD:C00941];
diphosphate [CPD:C00013]

Comment

In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.

History

EC 4.6.1.6 created 1989

Reference

1 [PMID:23778]

Authors

Cech SY, Ignarro LJ.

Title

Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver.

Journal

Biochem Biophys Res Commun 80:119-25 (1978)
DOI:10.1016/0006-291X(78)91112-9

Reference

Authors

Newton, R.P., Salih, S.G., Hakeem, N.A., Kingston, E.E. and Beynon, J.H.

Title

3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues.

Journal

Biochem Soc Trans 13:1134-1135 (1985)

Reference

3 [PMID:34644530]

Authors

Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.

Title

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.

Journal

Cell 184:5728-5739.e16 (2021)
DOI:10.1016/j.cell.2021.09.031

Other DBs

ExplorEnz - The Enzyme Database:

4.6.1.6

IUBMB Enzyme Nomenclature:

4.6.1.6

ExPASy - ENZYME nomenclature database:

4.6.1.6

BRENDA, the Enzyme Database:

4.6.1.6

CAS:	65357-82-6

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (15)   
   UniProt (4)   
   SWISS-PROT (3)   
   RefSeq(pep) (8)   
DNA sequence (29)   
   RefSeq(nuc) (27)   
   GenBank (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (3)   
All databases (52)   

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