| Entry |
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| Name |
protoporphyrin ferrochelatase;
ferro-protoporphyrin chelatase;
iron chelatase (ambiguous);
heme synthetase (ambiguous);
heme synthase (ambiguous);
protoheme ferro-lyase;
ferrochelatase (ambiguous)
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| Class |
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
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| Sysname |
protoheme ferro-lyase (protoporphyrin-forming)
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| Reaction(IUBMB) |
protoheme + 2 H+ = protoporphyrin + Fe2+ [RN: R00310]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.
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| History |
EC 4.99.1.1 created 1965, modified 2016
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| Pathway |
| ec00860 | Porphyrin and chlorophyll metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01772 | protoporphyrin/coproporphyrin ferrochelatase |
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| Genes |
» show all
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| Reference |
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| Authors |
Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG. |
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| Title |
The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase. |
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| Journal |
J Biol Chem 262:667-71 (1987) |
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| Reference |
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| Authors |
PORRA RJ, JONES OT. |
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| Title |
Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract. |
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| Journal |
Biochem J 87:181-5 (1963) |
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| Reference |
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| Authors |
PORRA RJ, JONES OT. |
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| Title |
Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups. |
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| Journal |
Biochem J 87:186-92 (1963) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.99.1.1 |
| ExPASy - ENZYME nomenclature database: | 4.99.1.1 |
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