KEGG   ENZYME: 4.99.1.11
Entry
EC 4.99.1.11                Enzyme                                 

Name
sirohydrochlorin nickelchelatase;
cfbA (gene name)
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
Sysname
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Reaction(IUBMB)
Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ [RN:R11626]
Reaction(KEGG)
R11626
Substrate
Ni-sirohydrochlorin [CPD:C21510];
H+ [CPD:C00080]
Product
sirohydrochlorin [CPD:C05778];
Ni2+ [CPD:C19609]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.
History
EC 4.99.1.11 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K22011  sirohydrochlorin cobalto/nickelchelatase
Genes
MJA: MJ_0970
MFE: Mefer_0855
MVU: Metvu_0528
MFS: MFS40622_1021
MIF: Metin_1283
MJH: JH146_1257
MIG: Metig_0269
MMP: MMP0164(cbiX(s))
MMQ: MmarC5_1511
MMX: MmarC6_0786
MMD: GYY_00840
MMAK: MMKA1_01690(cbiX)
MMAO: MMOS7_01950(cbiX)
MMAD: MMJJ_09200(cbiX)
MAE: Maeo_1381
MVO: Mvol_1554
MTH: MTH_1397
MMG: MTBMA_c17830(cbiX)
METC: MTCT_1270
MWO: MWSIV6_1777(cbiX)
METE: tca_01350(cbiX)
METK: FVF72_04600(cfbA)
MTHM: FZP57_08700(cfbA)
MST: Msp_1563(cbiX)
MSI: Msm_1281
MEB: Abm4_0618(cbiX1)
MMIL: sm9_2307(cbiX1)
MEYE: TL18_00210
METH: MBMB1_1943
MFC: BRM9_0750(cbiX) BRM9_2283
MCUB: MCBB_2224(cbiX)
MFV: Mfer_0962
MKA: MK0428
MEAR: Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
MBAR: MSBR2_1804
MBAK: MSBR3_2859
MAC: MA_3631(cbiX)
MMA: MM_0517
MMAC: MSMAC_0768
MTHR: MSTHT_2448
MTHE: MSTHC_0834
MHOR: MSHOH_0892
MFZ: AOB57_003185(cfbA)
MBU: Mbur_1035(cbiXS)
MMET: MCMEM_1517
MMH: Mmah_1410
MPY: Mpsy_2755
MZI: HWN40_08895(cfbA)
MTP: Mthe_0104
MCJ: MCON_1928(cbiX)
MHI: Mhar_2389
MHU: Mhun_0668
MBG: BN140_0720(cbiX)
MPI: Mpet_1000
MBN: Mboo_1417
MPL: Mpal_0681
MPD: MCP_0361(cbiX-1)
MEZ: Mtc_0061(cbiX)
RCI: RCIX2006(cbiX-1)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3631]
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.11
IUBMB Enzyme Nomenclature: 4.99.1.11
ExPASy - ENZYME nomenclature database: 4.99.1.11
BRENDA, the Enzyme Database: 4.99.1.11

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