KEGG ENZYME: 4.99.1.2

ENZYME: 4.99.1.2

Entry

EC 4.99.1.2                 Enzyme

Name

alkylmercury lyase;
organomercury lyase;
organomercurial lyase;
alkylmercury mercuric-lyase

Class

Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses

Sysname

alkylmercury mercury(II)-lyase (alkane-forming)

Reaction(IUBMB)

an alkylmercury + H+ = an alkane + Hg2+ [RN:R03529]

Reaction(KEGG)

R03529 > R09339

Substrate

alkylmercury [CPD:C01343];
H+ [CPD:C00080]

Product

alkane [CPD:C01371];
Hg2+ [CPD:C00703]

Comment

Acts on CH3Hg+ and a number of other alkylmercury compounds, in the presence of cysteine or other thiols, liberating mercury as a mercaptide.

History

EC 4.99.1.2 created 1978

Orthology

K00221

alkylmercury lyase

Genes

EUN:	pUMNK88_145(merB)

SEE:	SNSL254_p_0164(merB)

EHM:	AB284_00875

KLL:	BJF97_30980

PAZO:

AYR47_00245

PUM:	HGP31_24370(merB) HGP31_25850(merB)

PTZ:	HU718_021355(merB) HU718_021380(merB)

MAQ:

Maqu_0243

MARA:

D0851_16925(merB)

MFLI:

ACGK9W_01020(merB) ACGK9W_06330(merB) ACGK9W_16135(merB) ACGK9W_16155(merB)

AJO:	RZ95_18695 RZ95_18770

ADV:	DJ533_01870(merB) DJ533_01955(merB)

MORX:

MOXK23_22660(merB)

AMC:	MADE_1005535 MADE_1005595

MTHA:

VSX76_00540(merB)

CZA:	CYCME_0208(merB) CYCME_2512(merB2)

HAXI:

HAALTHF_21200n(merB_1) HAALTHF_21350n(merB_2)

REV:	HUE57_17010

BSAV:

WS86_30230

BMK:

DM80_6094

BMEC:

WJ16_21395

BAEN:

L3V59_42920(merB)

BYI:	BYI23_E002720(merB) BYI23_E002860

BFN:	OI25_7578(merB) OI25_8287(merB)

LIMN:

HKT17_07530

VBO:	CKY39_25245

MEAA:

ACG873_11140

BRK:	CWS35_37295

MEE:	DA075_33940

MMR:	Mmar10_2330

SMAZ:

LH19_05245

SBD:	ATN00_21245

SBAR:

H5V43_01300

GXY:

GLX_31480

GBM:

Gbem_0319

GNT:	KP003_12325(merB)

SMUI:

I6J00_08410

BBD:	Belba_2844

ZPR:

ZPR_4027

MARB:

CJ263_16230

SALT:

AO058_06440

SMIS:

LDL76_13295

CGLE:

NCTC11432_01486(merB)

MEBZ:

LPC09_11750(merB2) LPC09_11755

GEA:	GARCT_03142(merB)

SUW:	SATW20_00610(merB) SATW20_p1010(merB)

SAUA:

SAAG_03506

SAUZ:

SAZ172_0061(merB) SAZ172_p119(merB)

SAUT:

SAI1T1_10180(merB)

SAUJ:

SAI2T2_20180(merB)

SAUK:

SAI3T3_20180(merB)

SAUQ:

SAI4T8_20180(merB)

SAUX:

SAI6T6_20190(merB)

SAUR:

SABB_01777(merB)

SEP:

SE_0086

JEA:	JEM45_07880(merB)

EACE:

KKI46_16640(merB2) KKI46_16645(merB)

ERZ:	ER308_15625

EUZ:	DVS28_a1446

MMI:	MMAR_p10(merB)

MDX:	BTO20_38560

MXE:	MYXE_04590

MLJ:	MLAC_02650

MBRD:

MBRA_27840

MSHJ:

MSHI_15300

MMEH:

M5I08_11550(merB)

MADI:

A7U43_01930

MGI:

Mflv_3214

MSP:	Mspyr1_25010

MCB:	Mycch_5492 Mycch_5642 Mycch_5855

MDU:	MDUV_25770

MAUB:

MAUB_63750

MPHU:

MPHO_07630

MFLV:

NCTC10271_02228(merB_1) NCTC10271_02260(merB_2) NCTC10271_02390(merB_3)

MMON:

EWR22_13170(merB) EWR22_13615(merB)

MGRO:

FZ046_13780(merB)

MAUS:

JN090_13840(merB)

MFRE:

EXE63_01660(merB)

MKR:	MKOR_17760 MKOR_34280 MKOR_34290

MAB:

MAB_p08

CUV:	CUREI_04375

CDO:	CDOO_08070

CSPH:

CSPHI_00990

CGK:	CGERO_00525(merB)

CPSL:

KBP54_03000(merB)

CAFE:

CAFEL_02800(merB)

CIK:	H0194_08530(merB)

CORN:

BJP05_07805

CGP:	KBP53_03010(merB)

NAH:	F5544_04905

NIE:	KV110_14400(merB)

RHOD:

AOT96_34060

ROZ:	CBI38_35490

RGOR:

NMQ04_11180(merB)

RHOY:

QNA09_24630(merB)

RHS:	A3Q41_05015(merB)

GBR:

Gbro_2647

GTA:	BCM27_13480

GOC:	CXX93_04540

GRU:	GCWB2_23315(merB)

GOS:	QAD21_12815(merB)

GOJ:	GR168_12575(merB)

GOI:	LK459_12280(merB)

GHN:	MVF96_12930(merB) MVF96_24320(merB)

GAMI:

IHQ52_14150(merB)

GSI:	P5P27_17720(merB)

DTM:	BJL86_1893

STRC:

AA958_19120

SALF:

SMD44_04521

SGOB:

test1122_05730(merB)

SAOV:

G3H79_17555

SHAU:

K9S39_03960(merB) K9S39_39045(merB)

SFP:	QUY26_18680(merB)

KBU:	Q4V64_44625(merB)

SARM:

DVA86_18715(merB)

LEIF:

HF024_01840(merB)

LSE:	F1C12_18150(merB)

MHOS:

CXR34_00810

MOY:	CVS54_00759(merB)

ARQ:	BWQ92_19165

ACH:

Achl_4512

GMY:	XH9_16990(merB)

MICK:

B1A86_00010260(merB)

MPOR:

KW076_11140(merB)

KSE:	Ksed_25630

JTE:	ASJ30_01305

BRI:	FDF13_13850(merB)

BCAU:

I6G59_15415(merB)

BREB:

PGC08_13160(merB)

NCA:

Noca_4942

NRO:	K8W59_19780(merB)

NGV:	CDO52_16015

AMD:

AMED_2700

AMN:

RAM_13730

AMM:

AMES_2672

AMZ:

B737_2673

AOI:

AORI_2677

AJA:	AJAP_25435

AMYB:

BKN51_06025

AORI:

SD37_14485

APRT:

MUY14_22890(merB)

AROO:

NQK81_01730(merB) NQK81_08710

AMOG:

QRX60_27275(merB)

ACOR:

LCL61_31930(merB)

ANW:	QP939_04355(merB) QP939_48890(merB)

AMYE:

MJQ72_03390(merB)

AMYS:

CVV72_15715

PDX:

Psed_1314

PBRO:

HOP40_20285(merB) HOP40_35015(merB)

SSYI:

EKG83_24645

ALO:

CRK55259

SACE:

GIY23_03330 GIY23_03340(merB)

SNA:

Snas_5374

TBER:

QPC17_01175(merB)

JCY:	M6B22_10545(merB)

IAM:	HC251_04795

KBS:	EPA93_34845(merB)

KBB:	ccbrp13_01770

PMET:

G4Y79_01330(merB)

MHD:	Marky_2021

SCAS:

SACC_13720

NVN:	NVIE_012660

NEV:

NTE_02676

» show all

Reference

1 [PMID:9382]

Authors

Tezuka T, Tonomura K.

Title

Purification and properties of an enzyme catalyzing the splitting of carbon-mercury linkages from mercury-resistant Pseudomonas K-62 strain. I. Splitting enzyme 1.

Journal

J Biochem (Tokyo) 80:79-87 (1976)
DOI:10.1093/oxfordjournals.jbchem.a131261

Other DBs

ExplorEnz - The Enzyme Database:

4.99.1.2

IUBMB Enzyme Nomenclature:

4.99.1.2

ExPASy - ENZYME nomenclature database:

4.99.1.2

UM-BBD (Biocatalysis/Biodegradation Database):

4.99.1.2

BRENDA, the Enzyme Database:

4.99.1.2

CAS:	72560-99-7

DBGET integrated database retrieval system