KEGG   ENZYME: 4.99.1.8
Entry
EC 4.99.1.8                 Enzyme                                 
Name
heme ligase;
heme detoxification protein;
HDP;
hemozoin synthase
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
Sysname
Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming)
Reaction(IUBMB)
2 ferriprotoporphyrin IX = beta-hematin
Substrate
ferriprotoporphyrin IX
Product
beta-hematin
Comment
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.
History
EC 4.99.1.8 created 2009
Orthology
K17949  heme ligase
Genes
PFAPF3D7_1446800
PFDPFDG_04534
PFHPFHG_04214
PGABPGSY75_1446800
PYOPY17X_1314400
PCBPCHAS_1313900
PBEPBANKA_1310600
PVVPVVCY_1301220
PKNPKNH_1235400
PVXPVX_118155
PCYPCYB_126830
TANTA11080
TPVTP04_0891
TOTTOT_040000052
BEQBEWA_011450
BBOBBOV_III009730(17.m07844)
BBIGBBBOND_0313490
 » show all
Reference
1  [PMID:18437218]
  Authors
Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D
  Title
HDP-a novel heme detoxification protein from the malaria parasite.
  Journal
PLoS Pathog 4:e1000053 (2008)
DOI:10.1371/journal.ppat.1000053
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.8
IUBMB Enzyme Nomenclature: 4.99.1.8
ExPASy - ENZYME nomenclature database: 4.99.1.8
BRENDA, the Enzyme Database: 4.99.1.8

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