Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
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2-aminohexano-6-lactam racemase

(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam [RN:R04736]

R04736
Reaction

(S)-2-aminohexano-6-lactam [CPD:C02837]

Contains pyridoxal 5'-phosphate. Also racemises 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH2 of C-4). It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.

EC 5.1.1.15 created 1999

1

Ahmed, S.A., Esaki, N., Tanaka, H., Soda, K.

L-alpha-Amino-beta-thio-epsilon-caprolactam, a new sulfur-containing substrate for alpha-amino-epsilon-caprolactam racemase.

FEBS Lett 174:76-79 (1984)

2  [PMID:3955003]

Ahmed SA, Esaki N, Tanaka H, Soda K.

Mechanism of alpha-amino-epsilon-caprolactam racemase reaction.

Biochemistry 25:385-8 (1986)
DOI:10.1021/bi00350a017

3  [PMID:19146406]

Okazaki S, Suzuki A, Mizushima T, Kawano T, Komeda H, Asano Y, Yamane T

The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae.

Biochemistry 48:941-50 (2009)
DOI:10.1021/bi801574p