KEGG ENZYME: 5.1.1.15

ENZYME: 5.1.1.15

Entry

EC 5.1.1.15                 Enzyme

Name

2-aminohexano-6-lactam racemase;
alpha-amino-epsilon-caprolactam racemase

Class

Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives

Sysname

2-aminohexano-6-lactam racemase

Reaction(IUBMB)

(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam [RN:R04736]

Reaction(KEGG)

R04736

Substrate

(S)-2-aminohexano-6-lactam [CPD:C02837]

Product

(R)-2-aminohexano-6-lactam [CPD:C05328]

Comment

Contains pyridoxal 5'-phosphate. Also racemises 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH2 of C-4). It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.

History

EC 5.1.1.15 created 1999

Reference

Authors

Ahmed SA, Esaki N, Tanaka H, Soda K.

Title

L-alpha-Amino-beta-thio-epsilon-caprolactam, a new sulfur-containing substrate for alpha-amino-epsilon-caprolactam racemase.

Journal

FEBS Lett 174:76-79 (1984)

Reference

2 [PMID:3955003]

Authors

Ahmed SA, Esaki N, Tanaka H, Soda K.

Title

Mechanism of alpha-amino-epsilon-caprolactam racemase reaction.

Journal

Biochemistry 25:385-8 (1986)
DOI:10.1021/bi00350a017

Reference

3 [PMID:19146406]

Authors

Okazaki S, Suzuki A, Mizushima T, Kawano T, Komeda H, Asano Y, Yamane T

Title

The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae.

Journal

Biochemistry 48:941-50 (2009)
DOI:10.1021/bi801574p

Other DBs

ExplorEnz - The Enzyme Database:

5.1.1.15

IUBMB Enzyme Nomenclature:

5.1.1.15

ExPASy - ENZYME nomenclature database:

5.1.1.15

BRENDA, the Enzyme Database:

5.1.1.15

CAS:	52652-64-9

All links

Protein sequence (14)   
   UniProt (8)   
   SWISS-PROT (1)   
   PDBSTR (5)   
DNA sequence (9)   
   GenBank (5)   
   EMBL (4)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   InterPro (5)   
All databases (31)   

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