Entry |
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Name |
isopenicillin-N epimerase
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Class |
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
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Sysname |
penicillin-N 5-amino-5-carboxypentanoyl-epimerase
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Reaction(IUBMB) |
isopenicillin N = penicillin N [RN: R04147]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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History |
EC 5.1.1.17 created 2002
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Pathway |
ec00311 | Penicillin and cephalosporin biosynthesis |
ec01130 | Biosynthesis of antibiotics |
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Orthology |
K04127 | isopenicillin-N epimerase |
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Genes |
» show all
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Reference |
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Authors |
Usui S, Yu CA. |
Title |
Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus. |
Journal |
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Sequence |
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Reference |
2 |
Authors |
Laiz, L., Liras, P., Castro, J.M. and Martin, J.F. |
Title |
Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans. |
Journal |
J Gen Microbiol 136:663-671 (1990) |
Reference |
|
Authors |
Cantwell C, Beckmann R, Whiteman P, Queener SW, Abraham EP. |
Title |
Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway. |
Journal |
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Reference |
4 |
Authors |
Yeh, W.K., Ghag, S.K. and Queener, S.W. |
Title |
Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3'-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering. |
Journal |
Ann NY Acad Sci 672:396-408 (1992) |
Other DBs |
ExplorEnz - The Enzyme Database: | 5.1.1.17 |
ExPASy - ENZYME nomenclature database: | 5.1.1.17 |
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