KEGG   ENZYME: 5.1.1.21
Entry
EC 5.1.1.21                 Enzyme                                 
Name
isoleucine 2-epimerase;
BCAA racemase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
isoleucine 2-epimerase
Reaction(IUBMB)
L-isoleucine = D-allo-isoleucine [RN:R11078]
Reaction(KEGG)
R11078
Substrate
L-isoleucine [CPD:C00407]
Product
D-allo-isoleucine [CPD:C21092]
Comment
A pyridoxal phosphate protein. The enzyme, characterized from the bacterium Lactobacillus buchneri, specifically catalyses racemization of nonpolar amino acids at the C-2 position.
History
EC 5.1.1.21 created 2015
Orthology
K20708  isoleucine 2-epimerase
Genes
LPLlp_1721(gabT)
LPJJDM1_1447
LPTzj316_1716(gabT)
LPSLPST_C1376
LPRLBP_cg1326
LPZLp16_1324
LPBSH83_07165
LPXASU28_07165
LPGBB562_08840
LARGLPA65_06875
LBHLbuc_2316
LBNLBUCD034_2418(gabT)
LPARFAM21731_01082
LCUPL11_004250
LKFDNL43_04685
LHILG8J22_02749
LMURCPS94_00170
LHOLOOC260_108580
LGNABM34_06730
LHIJP39_09825
LCTBI355_1853
LALWBTM29_04760
LFMLF20184_02105
LZHD1B17_10680
LFTFG051_01725
CPABG6534_00625
OOEOEOE_0387
OENDSM07_07305
LBEMOO44_04000
 » show all
Reference
1  [PMID:24039265]
  Authors
Mutaguchi Y, Ohmori T, Wakamatsu T, Doi K, Ohshima T
  Title
Identification, purification, and characterization of a novel amino acid racemase, isoleucine 2-epimerase, from Lactobacillus species.
  Journal
J Bacteriol 195:5207-15 (2013)
DOI:10.1128/JB.00709-13
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.21
IUBMB Enzyme Nomenclature: 5.1.1.21
ExPASy - ENZYME nomenclature database: 5.1.1.21
BRENDA, the Enzyme Database: 5.1.1.21

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