KEGG   ENZYME: 5.1.1.22
Entry
EC 5.1.1.22                 Enzyme                                 
Name
4-hydroxyproline betaine 2-epimerase;
hpbD (gene name);
Hyp-B 2-epimerase;
(4R)-4-hydroxyproline betaine 2-epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
4-hydroxyproline betaine 2-epimerase
Reaction(IUBMB)
(1) trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine [RN:R11630];
(2) L-proline betaine = D-proline betaine [RN:R11631]
Reaction(KEGG)
R11630 R11631
Substrate
trans-4-hydroxy-L-proline betaine [CPD:C08269];
L-proline betaine [CPD:C10172]
Product
cis-4-hydroxy-D-proline betaine [CPD:C21513];
D-proline betaine [CPD:C21514]
Comment
The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.
History
EC 5.1.1.22 created 2017
Orthology
K21617  4-hydroxyproline betaine 2-epimerase
Genes
PSILPMA3_10220
BYIBYI23_B014710
BUEBRPE67_BCDS01700
MOPMesop_5034
MAMMesau_04624
MAMOA6B35_16510
MOHIHQ72_33425
AAKAA2016_6172
PHTBLM14_26775
SFHSFHH103_04926
SAMESAMCFNEI73_Ch0615
EMXFKV68_29025
NGGRG540_PA12520
LAPACP90_26460
LABRCHH27_13985
LAGGB0E33_10510
RCONK3740_09955
RSPRSP_4007
PDEPden_1187
PYEA6J80_02080
PPANESD82_09180
PTPRCA23_c27060
DONBSK21_09365
MDXBTO20_21615 BTO20_21695
ROPROP_23190
RKOJWS14_15355
ARQBWQ92_13295
GOBGobs_2848
PMADBAY61_13345
 » show all
Reference
1  [PMID:24056934]
  Authors
Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP
  Title
Discovery of new enzymes and metabolic pathways by using structure and genome context.
  Journal
Nature 502:698-702 (2013)
DOI:10.1038/nature12576
Reference
2  [PMID:24520058]
  Authors
Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE
  Title
Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.
  Journal
MBio 5:e00933-13 (2014)
DOI:10.1128/mBio.00933-13
  Sequence
[pde:Pden_1187] [rsp:RSP_4007]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.22
IUBMB Enzyme Nomenclature: 5.1.1.22
ExPASy - ENZYME nomenclature database: 5.1.1.22
BRENDA, the Enzyme Database: 5.1.1.22

DBGET integrated database retrieval system