KEGG   ENZYME: 5.1.1.23
Entry
EC 5.1.1.23                 Enzyme                                 
Name
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase;
murL (gene name);
UDP-MurNAc-L-Ala-L-Glu epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate L-glutamate-epimerase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + H2O = AMP + diphosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [RN:R12271]
Reaction(KEGG)
R12271
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [CPD:C22053];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692]
Comment
The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. The reaction proceeds only in one direction and involves an adenylated intermediate. The combined activity of this enzyme and EC 6.3.2.53, UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.
History
EC 5.1.1.23 created 2018
Pathway
ec00550  Peptidoglycan biosynthesis
ec01100  Metabolic pathways
Orthology
K23170  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase
Genes
XFAXF_1117
XFTPD_0409
XFMXfasm12_0462
XFNXfasM23_0403
XFFXFLM_07440
XFLP303_01515
XFSD934_03160
XFHXFHB_09985
XTWAB672_02630
XCCXCC2739
XCBXC_1374
XCAxcc-b100_1422
XCPXCR_3104
XCVXCV3054
XAXXACM_2841
XACXAC2909
XCIXCAW_03186
XCTJ151_03094
XCJJ158_03073
XCUJ159_03069
XCNJ169_03092
XCWJ162_03072
XCRJ163_03069
XCMJ164_03069
XCFJ172_03085
XFUXFF4834R_chr17300
XAOXAC29_14790
XOMXOO1319(XOO1319)
XOOXOO1435
XOPPXO_02012
XOYAZ54_17290
XORXOC_1506
XOZBE73_15875
XALXALC_1039
XSASB85_19220
XTNFD63_12885
XFRBER92_13380
XVEBJD12_05420
XPEBJD13_02100
XHRXJ27_01675
XGABI317_14835
XPHXppCFBP6546_21365(XppCFBP6546P_21365)
XVAC7V42_14845
XANAC801_14455
XARXB05_09290
XHYFZ025_02785
XCZEBN15_12520
XTHG4Q83_06630
XEUXSP_002829
XHDLMG31886_14440(murL)
SMLSmlt1169
SMTSmal_1012
BUJBurJV3_1006
SMZSMD_1090
SACZAOT14_11450
SRHBAY15_1164
SLMBIZ42_14375
STENCCR98_05425
STEMCLM74_05415
STESMG068_05040
SINCDAIF1_10560
SPAQSTNY_R11330
PSUPsesu_0812
PSUWWQ53_12430
PSDDSC_05870
PMEXH4W19_08630
PJPLAG73_03190
PDDMNQ95_10945
LABLA76x_1651
LAQGLA29479_623
LCPLC55x_1439
LGULG3211_3706
LEZGLE_3731
LEMLEN_1403
LMBC9I47_0892
LYTDWG18_03450
LUEDCD74_07530
LYJFKV23_04205
LSOLGOY17_14345
LSXH8B22_02550
LAREHIV01_000505
LHXLYSHEL_19040
LCASLYSCAS_19040
LCICINQ41_04410
LUMCNR27_12540
LUSE5843_04840
LUGFPZ22_04130
THESFHQ07_12075
THEHG7079_04615
TCNH9L16_01120
TBVH9L17_12620
XBCELE36_04535
FAUFraau_2759
RHDR2APBS1_3190
RGLCS053_04845
RTHLRK53_15940
DJICH75_01995
DJAHY57_07395
DTXATSB10_38170
DYEEO087_15595
DCSISN74_03620
DTLH8F01_14055
DKOI596_816
LRZBJI69_02830
LPYFIV34_16570
XBAC7S18_07685
RBDALSL_0762
SUASaut_0606
SPALFM071_02345
SSEIFJR45_03350
PHLKKY_2207
DEQXM25_12455
DEIC4375_13240
DEAFPZ08_10310
DSALK1X15_14520
MMYRMXMO3_01241
YTIFNA67_16180
MBRYB1812_02580
PBRPB2503_10394
FSAC5Q98_01700
ESRES1_22020
ESUEUS_07930
BFICIY_04050
RIXRO1_21090
LACYA4V08_15960
PXVFXF36_08205
CBOLCGC65_00540
LBWC3V36_02645
CBARPATL70BA_0974
MGROFZ046_18260
MDFK0O62_13460
MNED174_13160
MYNMyAD_12920
MMAGMMAD_25830
MARZMARA_13730
MAUBMAUB_03030
MPHUMPHO_09780
MMUCC1S78_013340
MSEIMSEDJ_37820
PSAIC3B54_111518
SALCC2138_03500
SALDFVA74_09835
NOIFCL41_11760
NDPE2C04_12310
FSYFsymDg_3109
GOBGobs_4628
STPStrop_3006
SAQSare_3230
MAUMicau_4223
MILML5_4079
MICBMicB006_3214
MTUACSH63_03515
MICHFJK98_22635
MTEMGCE86_15460
MCABHXZ27_21495
MSAGGCM10017556_04320
VMAVAB18032_25495
MCRAID554_25215
ASEACPL_1937
AMSAMIS_16900
ACTNL083_2283
AFSAFR_11170
ACTSACWT_1815
AIHAiant_62810
PLKCIK06_19245
PLABC6361_25075
PLATC6W10_33120
PFLAPflav_048870
PSUUPsuf_006660
VERHUT12_22130
PRYPrubr_01410
DVCDvina_11705
AQZKSP35_00790
MINMinf_2247
MKCkam1_2042
MEAPMTHMO_2233
UAMUABAM_01025
SHYRLA303_08775
PRFPeribacterA2_0608
MIBUY43_C0001G0611
 » show all
Reference
1  [PMID:28294606]
  Authors
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T
  Title
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
  Journal
J Am Chem Soc 139:4243-4245 (2017)
DOI:10.1021/jacs.7b01221
  Sequence
[xom:XOO1319]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.23
IUBMB Enzyme Nomenclature: 5.1.1.23
ExPASy - ENZYME nomenclature database: 5.1.1.23
BRENDA, the Enzyme Database: 5.1.1.23

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