KEGG   ENZYME: 5.1.1.23Help
Entry
EC 5.1.1.23                 Enzyme                                 

Name
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase;
murL (gene name);
UDP-MurNAc-L-Ala-L-Glu epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate L-glutamate-epimerase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + H2O = AMP + diphosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [RN:R12271]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [CPD:C22053];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692]
Comment
The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. The reaction proceeds only in one direction and involves an adenylated intermediate. The combined activity of this enzyme and EC 6.3.2.53, UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.
History
EC 5.1.1.23 created 2018
Pathway
ec00471  D-Glutamine and D-glutamate metabolism
ec01100  Metabolic pathways
Orthology
K23170  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase
Genes
XFA: XF_1117
XFT: PD_0409
XFM: Xfasm12_0462
XFN: XfasM23_0403
XFF: XFLM_07440
XFL: P303_01515
XFS: D934_03160
XFH: XFHB_09985
XTW: AB672_02630
XCC: XCC2739
XCB: XC_1374
XCP: XCR_3104
XCV: XCV3054
XAX: XACM_2841
XAC: XAC2909
XOO: XOO1435
XOM: XOO1319(XOO1319)
XOP: PXO_02012
XOR: XOC_1506
XAL: XALC_1039
XPH: XppCFBP6546_21365(XppCFBP6546P_21365)
SML: Smlt1169
SMT: Smal_1012
SMZ: SMD_1090
PSUW: WQ53_12430
PSD: DSC_05870
LEZ: GLE_3731
LEM: LEN_1403
DKO: I596_816
RBD: ALSL_0762
SUA: Saut_0606
PHL: KKY_2207
ESR: ES1_22020
ESU: EUS_07930
BFI: CIY_04050
RIX: RO1_21090
GOB: Gobs_4628
SAQ: Sare_3230
MIL: ML5_4079
ASE: ACPL_1937
ACTN: L083_2283
AFS: AFR_11170
ACTS: ACWT_1815
MIN: Minf_2247
MKC: kam1_2042
 » show all
Taxonomy
Reference
1  [PMID:28294606]
  Authors
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T
  Title
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
  Journal
J Am Chem Soc 139:4243-4245 (2017)
DOI:10.1021/jacs.7b01221
  Sequence
[xom:XOO1319]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.23
IUBMB Enzyme Nomenclature: 5.1.1.23
ExPASy - ENZYME nomenclature database: 5.1.1.23
BRENDA, the Enzyme Database: 5.1.1.23

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