KEGG ENZYME: 5.1.1.24

ENZYME: 5.1.1.24

Entry

EC 5.1.1.24                 Enzyme

Name

histidine racemase;
cntK (gene name)

Class

Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives

Sysname

histidine racemase

Reaction(IUBMB)

L-histidine = D-histidine [RN:R12313]

Reaction(KEGG)

R12313

Substrate

L-histidine [CPD:C00135]

Product

D-histidine [CPD:C06419]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.

History

EC 5.1.1.24 created 2019

Pathway

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K01780

histidine racemase

Genes

SDO:	SD1155_03785

CGEO:

CGEO_0432

CBLA:

CBLAS_1471

CCOR:

CCORG_1384

DDS:

Ddes_1977

DFI:	AXF13_11085

DPG:	DESPIGER_2298

DEF:	CNY67_02250

DFL:

DFE_2755

DSB:	LN040_15640

DVU:

DVU_2746

DVL:

Dvul_0561

DVM:

DvMF_1168

DVG:	Deval_2536

CLIH:

KPS_001439

DBA:

Dbac_1615

DOA:	AXF15_03775

DESU:

NLA06_05780

THEW:

TDMWS_15840

BSON:

S101395_03013

BBAD:

K7T73_01185

BHA:

BH2071

AND:	GRQ40_16010

LYB:	C3943_14835

LMAC:

I6G82_11185

VNE:	CFK40_16070

MEKU:

HUW50_21740

SA2258

SAV:

SAV2470

SAW:

SAHV_2454

SAH:	SaurJH1_2546

SAJ:	SaurJH9_2497

SAM:

MW2394

SAS:

SAS2361

SAR:

SAR2557

SAC:

SACOL2479

SAX:	USA300HOU_2461

SAA:	SAUSA300_2414

SAO:	SAOUHSC_02770

SAE:

NWMN_2367

SAD:

SAAV_2536

SUU:	M013TW_2430(cntK)

SUV:	SAVC_11220

SUE:	SAOV_2520c

SUJ:	SAA6159_02367(cntK)

SUK:	SAA6008_02511(dapF)

SUC:	ECTR2_2327

SUT:	SAT0131_02669

SUQ:	HMPREF0772_10719

SUZ:

MS7_2483

SUD:	ST398NM01_2520

SUX:	SAEMRSA15_23680

SUW:	SATW20_25980

SUG:

SAPIG2520

SUF:	SARLGA251_22500

SAUA:

SAAG_00296

SAUE:

RSAU_002308

SAUN:

SAKOR_02454

SAUS:

SA40_2218

SAUU:

SA957_2302

SAUG:

SA268_2375

SAUZ:

SAZ172_2573

SAUT:

SAI1T1_2018400

SAUJ:

SAI2T2_1018410

SAUK:

SAI3T3_1018400

SAUQ:

SAI4T8_1018410

SAUV:

SAI7S6_1018400

SAUW:

SAI5S5_1018340

SAUX:

SAI6T6_1018340

SAUY:

SAI8T7_1018380

SAUF:

X998_2454

SAB:

SAB2353c

SUY:	SA2981_2407

SAUB:

C248_2520

SAUM:

BN843_25100

SAUC:

CA347_2549

SAUR:

SABB_02982

SAUI:

AZ30_12970

SAUD:

CH52_06635

SAMS:

NI36_12280

SUH:	SAMSHR1132_22950

SER:

SERP2375

SEP:

SE_0201

SEPP:

SEB_00129

SEPS:

DP17_1263

SSD:	SPSINT_0076

SDT:

SPSE_2401

SDP:	NCTC12225_02596

SWA:	A284_00410

SPAS:

STP1_1306

SXY:	BE24_11765

SXL:	SXYLSMQ121_0067

SXO:	SXYL_00068

SHU:	SHYC_11655

SCAP:

AYP1020_1968

SSCH:

LH95_11160

SSCZ:

RN70_11910

SAGQ:

EP23_10510(cntK)

SLZ:	B5P37_06425

SFQ:	C7J90_03765

SCHR:

DWB92_11730(cntK)

SSH:	NCTC13712_02422

SLLO:

ISP08_00440(cntK)

SRAI:

LN051_10985(cntK)

SPSD:

JMB28_00735(cntK)

SEDA:

MNY58_00455(cntK)

SROT:

ML435_11885(cntK)

SFF:	FOB90_08230(cntK)

SSTE:

SAMEA4384403_1088

BBE:	BBR47_28200

BFM:	BP422_09275

BAGR:

BA6348_01055

BPAB:

PSE45_01825

GYM:	GYMC10_2835

PMS:	KNP414_01893

PMQ:	PM3016_2178

PMW:

B2K_11195

PAEA:

R70723_16820

PNP:	IJ22_24990

PVO:	PVOR_17339

PLW:	D5F53_15610

PCHI:

PC41400_19310

PBAC:

HUB98_11430

PTRI:

KDC22_17085

PALO:

E6C60_2224

PUI:	PUW25_11730

PAMY:

P9222_12190

PNK:	AASFL403_06940

PPAB:

KET34_28295

PANA:

BBH88_13395

SURE:

SporoP32a_07155

SPOS:

DV702_00150

LTI:	JW886_02775

CTC:

CTC_02312

CTET:

BN906_02523

CACE:

CACET_c28190

CFM:	BJL90_00610 BJL90_20915

CCOH:

SAMEA4530647_1986

CRS:	FQB35_12585

PROQ:

P6M73_10415

OVA:

OBV_13890

VFA:	MM35RIKEN_15870

DMT:	DESME_14740

FWA:	DCMF_00910 DCMF_25690

ALAC:

JYE50_00510

AHC:	JYE49_01350

CBAF:

JS518_08295

BYL:	A4V09_20630

BHAN:

CGC63_14650

BLAU:

DQQ01_02000

BPRO:

PMF13cell1_01326

BLAR:

LC508_21065

BCOC:

BLCOC_52500(cntK)

CPRO:

CPRO_28700(dapF_2)

ANV:	RBQ60_14505

VPY:	HZI73_24760

AMIC:

Ami3637_14300

ETM:	CE91St48_30360

AMT:

Amet_2050

TEB:

T8CH_1255

TEP:	TepRe1_0771

TAE:	TepiRe1_0835

BACG:

D2962_04760

KME:	H0A61_01263

PED:	ING2D1G_0166

PHAR:

NCTC13077_00489

PEQU:

O6R05_00740

TIS:	P3962_06630

MED:

MELS_2057

MHW:	ACT01_00490

MEG:	DKB62_02595

MMAX:

LCQ47_11300

SSG:	Selsp_0678

AFN:	Acfer_1540

AIN:

Acin_0749

GPD:	GII33_20960

AAI:	AARI_10880

GAR:	AOZ07_05765

GLU:	F0M17_05425

GNC:	QQS42_05440

PAEY:

KUF55_05510

APRE:

CNX65_19690

AMI:

Amir_3920

UME:	RM788_04620

PLK:	CIK06_26255

TPI:	TREPR_0956

TAZ:	TREAZ_1278

FNU:

FN1732

FNC:	HMPREF0946_01324

FNT:	HMPREF0405_00071

FUS:	HMPREF0409_01840

FNE:	FSDG_02337

FHW:	RN87_01210

FPD:	CTM68_03690

FNF:	BSQ88_10095

FPEI:

C4N17_08665

FCI:	I6I83_02190

FPOL:

ERS445057_00315

CSOM:

MKD34_13680

» show all

Reference

1 [PMID:27230378]

Authors

Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P

Title

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.

Journal

Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018

Sequence

[sav:SAV2470]

Other DBs

ExplorEnz - The Enzyme Database:

5.1.1.24

IUBMB Enzyme Nomenclature:

5.1.1.24

ExPASy - ENZYME nomenclature database:

5.1.1.24

BRENDA, the Enzyme Database:

5.1.1.24

DBGET integrated database retrieval system