KEGG   ENZYME: 5.1.3.11
Entry
EC 5.1.3.11                 Enzyme                                 
Name
cellobiose epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
cellobiose 2-epimerase
Reaction(IUBMB)
cellobiose = 4-O-beta-D-glucopyranosyl-D-mannose [RN:R01445 R06245]
Reaction(KEGG)
R01445 R06245(G);
(other) R10810
Substrate
cellobiose [CPD:C00185]
Product
4-O-beta-D-glucopyranosyl-D-mannose [CPD:C02964]
Comment
The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.
History
EC 5.1.3.11 created 1972
Orthology
K16213  cellobiose epimerase
Genes
VFUvfu_B00537
VFLAL536_06135
ALEAV939_12180
ALZAV940_11945
APELCA267_016830
GAGGlaag_3289
PMESFX988_01605
CATEC2869_05850
AGQLQZ07_22450
CATTOLW01_01895
CJACJA_0243(unk2)
CEBB0D95_16675
CELLCBR65_15155
CEKD0B88_02295
CEGD0C16_07760 D0C16_14115 D0C16_18795
SDESde_0508
TTUTERTU_4095
SAGAM5M_16785
MARQMARGE09_P2967
GILNHM04_09040
MICCAUP74_03277(ce_1)
HALCEY643_17615 EY643_17675
STELSTAQ_17780
BCOBcell_0277
AXLAXY_22460
PRDF7984_12605
GRCGI584_07530
MEKUHUW50_05295
MLITKDJ21_026460
SLMSMM221_05570
PJDPjdr2_2154
GYMGYMC10_3611
PPYPPE_04652
PPMPPSC2_24205(rnbP)
PPOPPM_4806(rnbP)
PPOLX809_40740
PPQPPSQR21_049040
PPOYRE92_13070
PMSKNP414_02124
PMQPM3016_2411
PMWB2K_12220
PTAHPL003_05775
PBDPBOR_10045
PGMPGRAT_09435
PODPODO_08035
PAENP40081_09765
PAEFR50345_08085
PAEQR50912_09090
PSTEPSTEL_08715
PAEAR70723_09065
PAEER70331_08915
PAEHH70357_09440
PAEJH70737_07850
PRIPRIO_2006(bfce)
PSONJI735_18250
PPEOABE82_24405
PBVAR543_12195
PXLBS614_01570
PDHB9T62_03530
PIBBBD41_27505
PCXLPB68_13480
PKBB4V02_01070
PAIHASL14_13515
PLWD5F53_12180
PLENEIM92_12120
PPSCEHS13_07920
PLUTEI981_08160
PRZGZH47_00825
PLYCGXP70_16220
PTRIKDC22_17225
PALOE6C60_0805
PCELHUB94_13190 HUB94_22925
PTJJRJ22_07460
PALRHGI30_21530
TCOTheco_0999
COHEAV92_11235
CCHLFPL14_24305
CHEBHH215_01835
SACAFFV09_14425
CAWQ783_10200
CCBClocel_3198
CLBClo1100_3758
CEUA7L45_06540
FSAC5Q98_00290
CCECcel_3002
CSSCst_c14700
CSDClst_1418
CTHDCDO33_11735
ESRES1_19350
ESUEUS_11950
EHAEthha_0905
RALRumal_0019
RCHRUM_08680
RUSRBI_II00318(ce)
FPAFPR_17230
CAMLH6X83_11005
RHORHOM_11450
RIXRO1_18080
RIMROI_36330
COOCCU_23010
CEVLK421_05075
BYLA4V09_07555
CPYCphy_2262
ANRAna3638_04600
ACELacsn021_43450
ACHTbsdcttw_02300
SSUNH9Q77_01910
MFORNQ534_10880
CLEClole_3362
CEWEKH84_20040
CBARPATL70BA_2548
VPYHZI73_19025
CSCCsac_0294
ATEAthe_2557
COBCOB47_2182
CHDCalhy_0278
CKICalkr_2194
CLCCalla_0266
CKNCalkro_0294
CCHAELD05_01485
CDIACaldiYA01_02560
TTMTthe_1937
TTOThethe_01945
TSHTsac_2329
MASMahau_2100
HALSD7D81_09485
AHKNCTC10172_01381
HAUHaur_0887
ATMANT_18730
OTEOter_2309 Oter_2742
OBGVerru16b_01806(ce_1) Verru16b_02092(ce_2)
MFFMFFC18_14270(ce)
AHELQ31a_20900(ce_1)
ALUSSTSP2_01937(ce)
TBETrebr_1916
STASTHERM_c00950
STQSpith_0082
SLRL21SP2_2183
SASSMUG09_02555
PFERIRI77_28255
BFRBF0849
BFSBF9343_0739
BFGBF638R_0832(age)
BFBVU15_03585
BHLBache_0225
BOABovatus_02923(bfce)
BCELBcellWH2_02021(bfce)
BZGC4H11_10955
BHFC3V43_14595
BISDXK01_001885
BUNBun01g_02460 Bun01g_06710 Bun01g_06780
BNOK8P02_00735
BHUMJXR92_001575 JXR92_003660 JXR92_003700
BSABacsa_1717
BDOEL88_18345
PBTING2E5B_0328 ING2E5B_2178(bfce)
PSACPSM36_3109
DYSG7050_02455
PPNPalpr_1812
PDIBDI_0057
PARCCI960_03395
DUNFDZ78_08870
COPRCop2CBH44_28010
PRUPRU_1723
PDNHMPREF9137_1953
POCNCTC13071_01500
PMUFJ4864_09095
PHISJ5A62_10990
PHERprwr041_21370
PVFJ5A55_08625
PBYL6471_05570
AOKA3BBH6_12800
ACOUA5CBH24_10330
ADAA5CPEGH6_09170
ASENNQ519_08090
DORIFH5T_02000 FH5T_03390
MCOSGM418_03030 GM418_17185
ASXCDL62_07300
ALKQM9189_11265
MBASALGA_0932
RMRRmar_2439
RMGRhom172_2440
RBARAWN76_012255
CPICpin_5399
CBAECOR50_11650
COYHF329_18125
NKONiako_4392
ARKD6B99_05370
AGIFSB73_16955
ARACE0W69_014610
FLNFLA_5531
PSEGD3H65_07900
PGINFRZ67_03315
PGOFSB84_12440
FLSGLV81_05220
FLVKJS94_00070
HHYHalhy_0144 Halhy_5540
PHEPhep_3983
PSNPedsa_2972
SHGSph21_0932
STHANCTC11429_04418
SMUII6J00_10090
SFAEMUK51_12150
SCNSolca_2509
MUCMuYL_1513
MGOTMgSA37_00580(ce_1) MgSA37_03676(bfce)
MUHHYN43_001765 HYN43_016240
MGINFRZ54_11630
MGKFSB76_21755
MRUBDEO27_016585 DEO27_016850
MGOSDIU38_000930 DIU38_017135
MMABHQ865_05355
MROBHH214_11655
CMRCycma_4636
CAMUCA2015_4446
SLISlin_0271
SRDSD10_06950
SMONAWR27_14145
SPIRCWM47_13160
SPIKEXU85_28295
SPIBG8759_13670
STAEHNV11_05175
RHOZGXP67_16780
DFEDfer_1975
DSNHWI92_08395
DYCNFI80_09215
LBYLbys_3430
RSIRunsl_3647 Runsl_4586
RUNDR864_03550 DR864_07595
RUPDTQ70_09315
FAEFAES_1969
FIBA6C57_20430
ALSDJ013_19300
MAQALAG90_09345
HYPA0257_01745
HYZAXW84_13475
HNVDDQ68_01360
HTBMTX78_01845
PKOPKOR_09255
RUFTH63_14905
RTIDC20_05260 DC20_06375
ADDHUW48_19165
ASWUHUW51_11915
FPFDCC35_09340
FLMMY04_5415
FLLEI427_17605
FYAKMW28_21530
FKAKM029_25000
FBTD770_13195 D770_23740
CHKD4L85_32470
GRSC7S20_04555 C7S20_04610
FPSZAMR72_02965
FJOFjoh_4956
FJGBB050_02608(bfce)
FATDVK85_01175
FKIFK004_17240
FALBHYN59_00885
FCRHYN56_24400
FSEDI487_13645
FNKE1750_12030 E1750_16665
FAKFUA48_00770
FFLHYN86_20445
FENJ0383_16470
FPBNLJ00_24425
FBIL0669_23065
ZPRZPR_0358 ZPR_3474
FBCFB2170_14788
MARBCJ263_08600
POBLPB03_05820 LPB03_10220
TJETJEJU_2836
LULLPB138_13105
SALTAO058_04390
MARFCJ739_714
AQDD1816_19015
EMARD1013_00700
SINHLS482_08400 LS482_09970
FLGLV716_01420
FLBLV704_02325
SABUMBM09_07310 MBM09_07805
FBEFF125_04080
FBMMQE35_05840
CHRZCO230_01230
KAQL0B70_12215
MROMROS_0506 MROS_2629
DTHDICTH_0488
DTUDtur_0652
SALIL593_06560
HRRHZS55_21510
HPELHZS54_24970
HLTI7X12_15110
HTUHtur_4659
HSALJMJ58_21300
HALYHYG82_04125
HLRHALLA_01820
 » show all
Reference
1  [PMID:6069974]
  Authors
Tyler TR, Leatherwood JM.
  Title
Epimerization of disaccharides by enzyme preparations from Ruminococcus albus.
  Journal
Arch Biochem Biophys 119:363-7 (1967)
DOI:10.1016/0003-9861(67)90466-3
Reference
2  [PMID:18392616]
  Authors
Ito S, Taguchi H, Hamada S, Kawauchi S, Ito H, Senoura T, Watanabe J, Nishimukai M, Ito S, Matsui H
  Title
Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme.
  Journal
Appl Microbiol Biotechnol 79:433-41 (2008)
DOI:10.1007/s00253-008-1449-7
  Sequence
Reference
3  [PMID:23462136]
  Authors
Fujiwara T, Saburi W, Inoue S, Mori H, Matsui H, Tanaka I, Yao M
  Title
Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar.
  Journal
FEBS Lett 587:840-6 (2013)
DOI:10.1016/j.febslet.2013.02.007
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.11
IUBMB Enzyme Nomenclature: 5.1.3.11
ExPASy - ENZYME nomenclature database: 5.1.3.11
BRENDA, the Enzyme Database: 5.1.3.11
CAS: 37318-37-9

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