KEGG   ENZYME: 5.1.3.23
Entry
EC 5.1.3.23                 Enzyme                                 
Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase;
UDP-GlcNAc3NAcA 2-epimerase;
UDP-alpha-D-GlcNAc3NAcA 2-epimerase;
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase;
WbpI;
WlbD
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [RN:R09600]
Reaction(KEGG)
R09600
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Product
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [CPD:C19745]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].
History
EC 5.1.3.23 created 2007
Pathway
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
Orthology
K13019  UDP-GlcNAc3NAcA epimerase
Genes
PLUplu4804(wblH)
PLUMA4R40_23895
PAYPAU_04319(wblH)
PTTVY86_07555
PAKHB0X70_24585
PLUICE143_24625
XGRQL128_20510(wecB)
AVTNCTC3438_01782(mnaA)
DYGDYGSA30_29580(wbpI)
PAEPA3148(wbpI)
PAEVN297_3260
PAEIN296_3260
PAECM802_3258
PAEOM801_3125
PDRH681_23245
PSESPSCI_2869
PANHHU763_007170(wecB)
PHEFPSH57_20390(wecB)
PSKPKU43P_39500(wbpI)
PDEUQEP73_22545(wecB)
MARIACP86_02290
MARAD0851_05390
MARJMARI_04700(wbpI)
ADSFPL17_13915
AVIVLF296_18030(wecB)
SSESsed_2967
SGLAFJ709_05420
SVMKDH10_000090(wecB)
PPISB1L02_14620
PVBJ5X90_03260(wecB)
PFLICTT31_02675
PMAZR5H13_02690(wecB)
AAUSEP12_05170
ALTBIUA53_14965(wecB)
LALAT746_12790
CATEC2869_15630
ALKMNKI27_13895(wecB)
CBRVR0137_17080
CBUCBU_0842(wecB)
CBSCOXBURSA331_A1108
CBDCBUD_0907
CBGCbuG_1159(wecB)
CBCCbuK_0710(wecB)
CEYCleRT_10730
LSSNCTC12082_00069(wecB)
FRXF7310_06795
CYYCPC19_11130
TLHNR989_02545(wecB)
THIMKFB96_04765(wecB)
TLRThiosp_02507(wbpI)
TNITVNIR_0699(wecB_[C])
TTITHITH_05805
HTTHZS52_20515(wecB)
MMWMmwyl1_0835
MPRIMP3633_3239
MFOIJSY38_06670(wecB)
TORR615_06315
MGEOCFI10_13585
OMEOLMES_5518
SUTRL0B52_03945(wecB)
VMSLVJ82_06325(wecB)
CKSH9L41_03360(wecB)
LHKLHK_02802
PPNODA70_17285
LMIRNCTC12852_00313(mnaA_2)
BPEBP0090(bplD)
BPCBPTD_0086(bplD)
BPERBN118_0159(wlbD)
BPETB1917_0093(bplD)
BPEUQ425_2030(bplD)
BPARBN117_0150(wlbD)
BPABPP0152(bplD)
BBHBN112_3259(wlbD)
BBRBB0152(bplD)
BBMBN115_0141(wlbD)
BBXBBS798_0151(bplD)
BPTBpet4819(wlbD)
BHOD560_1331
BHMD558_1320
BHZACR54_00107(wbpI)
BTRMSAMEA390648701339(wlbD)
BPDZBBN53_20155
AVHWHX56_03780(wecB)
TEQTEQUI_1017
TEAKUI_0418
TEGKUK_0136
CGINABRZ00_06080(wecB)
OUEI6G29_01430(wecB)
ACKC380_07320
AAVAave_0953
DLAI6G47_27680(wecB)
VAERZE79_05630(wecB)
HYLLPB072_07130
MASWAM586_10875
MASHLP419_28510(wecB)
TMJP0M04_31055(wecB)
TTWLCC91_03265(wecB)
ETBN7L95_14840(wecB)
EAAI862_07330
MESPC1M53_01175
PMOBHG718_00065(wecB)
RBSRHODOSMS8_00383(wbpI)
AGCBSY240_4586
SZOK8M09_00485(wecB)
BRKCWS35_31810
BQBJ4P68_0006725(wecB)
BAUTQA635_15605(wecB)
BBRAQA636_16055(wecB)
BPAHQA639_29450(wecB)
MIVC4E04_13610 C4E04_13650
MICOGDR74_06705
HNIW911_00410
DRPPSQ90_07600(wecB)
CMBCSW64_01275
RCONK3740_17755(wecB)
SPOTG6548_17145(wecB)
PZHCX676_22395
LVRT8T21_17175(wecB) T8T21_20775
HBCAEM38_13070 AEM38_13090
SPHOC3E99_07045
SPHUSPPYR_1658(wbpI)
PHAOHF685_11090(wecB)
ERRDVR09_11335
TLUR1T41_00940
PAQIKW060_14990(wecB)
HMSHMU06640
HBIHBZC1_15210
HETBBW65_04710
HCLNCTC13205_01069(mnaA)
HSHNHP194022_04670(wbpI)
HPULNCTC13154_00521(wecB)
WSUWS2189(WBPI)
TDNSuden_1418
SDIZWCY31_12095(wecB)
CCOCCC13826_0521
CBLACBLAS_0721
ABUAbu_0692
PACOAACT_0957
HBVABIV_0881
GLOGlov_1505
GPLM1B72_07930(wecB)
GSBGSUB_15300
PEFA7E78_01570
DPGDESPIGER_0543
DSBLN040_10500(wecB)
DHYDESAM_20348
DDNDND132_2429
PSEFPSDVSF_24170
DSXGD604_09830
DSFUWK_02413
DEOCAY53_06115
DOLDole_1828
DHGEYB58_14860
DWDDSCW_06940
DAODesac_2653
BDCDOE51_07915
BREYMNR06_04610(wecB)
MAIMICA_1024
MANA11S_979
SBFJCM31447_25060
PUVPUV_00130
AHELQ31a_45020(wbpI_1)
LCREPla8534_69410(wbpI)
PBSPlabr_1618
BPITBPIT_28910
TPEDTPE_0207
TRMJO41_03110
TRZGWP43_02850
TMEDDWB79_01350
TRPABH09_02785(wecB)
SPEREW093_13210 EW093_13440
TPXTurpa_0308
ABAAcid345_3306
GMAAciX8_3530
TRSTerro_1265
TALBFTW19_11825
BUNBun01g_30650(wbpI)
BSTEK6V31_02460(wecB)
PPNPalpr_1323
PGOLK6V26_13515(wecB)
PFAINXY11_03060(wecB)
PABCNEE14_015210(wecB)
TFOBFO_2566
TOHBCB71_09295
OSPOdosp_0942
BVIRI6J59_01690(wecB) I6J59_14280(wecB)
BFHF1611_14865
TTZFHG85_09800
BACCBRDCF_p1451(wecB)
DORIFH5T_09075
CPICpin_4757
CPOLWJU16_11305(wecB)
NIAA8C56_08555
FLASY85_01715
PGINFRZ67_02945
PCAUHWD63_02910(wecB)
SBXCA265_19270
SPIBG8759_15505(wecB)
SOQLQ777_25975(wecB)
SENFGJR95_18960
RUNDR864_23725
MARPQYS47_34855(wecB)
FKAKM029_13900(wecB)
CHRWKA713_08525(wecB)
CAPHCGC49_04830
ZGAZOBELLIA_1741(wecB)
ZLAQ5W13_08585(wecB)
PHGKCTC32516_01587(wbpI)
TDIAUW17_08820
TENLPB136_00970
TMPF9Y86_02255 F9Y86_04655
TOVPG911_13370(wecB)
TRTPG912_05095(wecB)
TPACPG913_03655(wecB)
TFIPJJ26_09410(wecB)
TSIGD6T69_11755
LUTLupro_12975
LULLPB138_15100
WFUAXE80_02790
SALTAO058_00370
EMARD1013_01185
PSYNE9099_06875
ASAGFGM00_16585
SPONHME9304_01541(wbpI)
FBEFF125_16525
LUYQZH61_11470(wecB)
CARHEGY05_16490
FTEFluta_0726 Fluta_2189
FLUCHH17_06355
CRMK6119_19005(wecB)
OHOOweho_1403
CHYDH4K34_02735(wecB)
PTANCRYO30217_01158(wbpI_2)
SHYRLA303_04925(wecB)
BBAUAEM51_07985
RMRRmar_0573
RMGRhom172_0568
RLOGQ464_017900(wecB)
RBARAWN76_007345
MROMROS_2673
CPRVCYPRO_2717
CACICLOAM1218(wecB)
FMLFMIA91_07050(wecB_2)
SAFSULAZ_0353
CNICalni_1804
DTHDICTH_0427
DTUDtur_0574
NTIDNFV4_03091
ALAMRT761_00505(wbpI)
BMETBMMGA3_15100
BACIB1NLA3E_20895
BONA361_24855
CFIRNAF01_22635(wecB)
CSOALIS82_24390(wecB)
BDAFSZ17_21460
CSUAIM538_21360(wecB)
HNZP9989_16280(wecB) P9989_18360(wecB)
HSHIMUO14_06110(wecB)
HAMYMUO15_18465(wecB)
VNECFK40_05105
VNTOLD84_03170(wecB)
VIKKFZ58_02650(wecB)
VSSPD280_03305(wecB)
LAOAOX59_11995
LEXLen3610_17430
AQTFN924_03245
RAXKO561_03475(wecB)
PSYHD0S48_07325
PSYOPB01_04645
RUEDT065_00075
MLITKDJ21_007830(wecB)
MENLMVE64_10685(wecB)
MEBZLPC09_22640(wecB)
MSEEWCV65_18880(wecB)
MHRFQLQ22_07100(wecB)
MSUTLC048_00415(wecB)
GKAGK3162
GTEGTCCBUS3UF5_35310
GTKGT3570_15435
GTMGT3921_03270
BCALCWI35_12110
GYCGYMC61_3253
GYAGYMC52_3284
GCTGC56T3_3173
GGHGHH_c32370(mnaA)
GELIB49_07975
GSEGT50_07665
GZAIC807_11880(wecB)
PTBDER53_03255(wecB)
AAMYGFC30_485
MARYLAU42_03945(wecB)
PODPODO_28510
PNPIJ22_38280
PALBEJC50_29130
ATHEK3F53_17210(wecB)
CHEBHH215_20205(wecB)
SURLBI350_15330
LFBC1X05_15860
TVUAB849_005655
KPULGXN76_15365(wecB)
KEBGXN75_16725(wecB)
PABSJIR001_30170
CBOCBO3100
CBACLB_3129
CBHCLC_3002
CBYCLM_3506
CBLCLK_2494
CBKCLL_A3182
CBBCLD_1440
CBICLJ_B3366
CBTCLH_2927
CBFCLI_3159
CBMCBF_3148
CBJH04402_03177
CBECbei_4627
CBZCbs_4627
CBEILF65_05170
CKLCKL_3166
CKRCKR_2804
CLJCLJU_c34070
CCBClocel_3137
CSRCspa_c53520
CSBCLSA_c41270
CAHCAETHG_1305(wecB)
CSQCSCA_4791
CLDCLSPO_c18630 CLSPO_c31990
CCKCcar_17245
CBUTATN24_15745
CTYKCTK_C08720
CEUA7L45_12065
CTAEBGI42_12630
CDRKB9W14_20915
CDYF3K33_23555
CFERD4Z93_01765
CGASJ1C67_09865(wecB)
CLOSDMR38_17075
CGELpsyc5s11_49940
CTAGLL095_12275(wecB)
CLOLONV75_14945(wecB)
CLOMAXY43_11175
HHWNCTC503_01993(wecB)
OCWOW730_12080(wecB)
EHAEthha_0669
CAMLH6X83_09690(wecB)
CLFGJQ69_02340
CARLPXC00_03595(wecB)
TMELNOG13_06690(wecB)
RBPB6259_08160
CCELCCDG5_0710
CAPREQM14_12865
CFEMHCR03_17330(wecB)
DORDesor_5330
DAIDesaci_4441
DMIDesmer_4332
PTHPTH_0384(WecB) PTH_1103(WecB)
DFGB0537_15540
DKUDesku_0874
AACXDEACI_0260
ELMELI_2561
SAYTPY_3671(wecB)
SAPSulac_3370
STHRBXT84_14970
MDVC5Q96_07715
MNLQU661_00465(wecB)
TTETTE0661(WecB2)
MASMahau_0358
FMAFMG_0502
MHAPJFY71_06675(wecB)
MFOMVZL98_08175(wecB)
SSIDSPSIL_042240(wbpI_1)
TBZBK011_02350
ELEElen_0637
EUZDVS28_a1719
BSOLFSW04_03495
BALADSM104299_05813(wbpI)
PBAJLRS13_03655(wecB)
CWOCwoe_5917
PARNNBH00_24920(wecB)
PARQDSM112329_05342(wbpI)
SBAEDSM104329_04159(wbpI_1) DSM104329_05200(wbpI_2)
TALUJDY09_09735(wecB)
LEPVJ4558_19250(wecB)
HHGXM38_017570(wbpI)
PGXOA858_09585(wecB)
GLPGlo7428_3721
PIPFEK30_06140
OXYHCG48_01150(wecB)
GEIGEI7407_2308
GLJGKIL_0481(wecB)
CALHIJ00_16800
DEWDGWBC_0899
DFODform_01826(wecB)
RRSRoseRS_4430
RCARcas_0784
CAGCagg_1972
PSUBPelsub_P0628
CAPCLDAP_36180
THUGKNN16_05605(wecB)
DSWQR90_12670
DRDLMT64_11870(wecB)
TTHTT_C0285
ACOAmico_1720
AMIZRBH88_00735(wecB)
TLITlie_1813
AMOAnamo_1187
TMATM0610
TMMTmari_0610
TMITHEMA_01615
TMWTHMA_0626
TMQTHMB_0626
TMXTHMC_0626
TPTTpet_0300 Tpet_0308
TNPTnap_0392 Tnap_0427
TRQTRQ2_0326
THQT2812B_01620
THZCELL2_01685
TLETlet_1207
TTATheth_1610
PHYAJ81_08730
TMETmel_0366
THPBG95_04935
THERY592_05005
FNOFnod_0568
FPEFerpe_0132
FIANA23_00760(wecB)
FNGJM64_01510
OCYOSSY52_03120
PMOPmob_0933 Pmob_1288
MPZMarpi_1253
MARNLN42_06735
MAEOJRV97_05625(wecB)
OCSOF820_08755(wecB)
KOLKole_1631
ASACATHSA_0040
FCII6I83_02405(wecB)
BIHBIP78_0584
MMPMMP0357
MVNMevan_0198
MVOMvol_0232
MFIDSM1535_0247
METTCIT01_00335
PFUPF0794
PFIPFC_03140
PYCTQ32_02915
TSITSIB_2024
THMCL1_0830
THSTES1_1887
TTDA3L14_00440
THYA3L12_02955
THEIK1720_03030(wecB)
MBAMbar_A0052 Mbar_A2140
MBYMSBRM_0005 MSBRM_0792
MBWMSBRW_0943 MSBRW_2602
MBARMSBR2_0018
MBAKMSBR3_1166 MSBR3_1605
MMACMSMAC_1844
MVCMSVAZ_0005
MEKMSKOL_0025
MLSMSLAZ_1033 MSLAZ_1853 MSLAZ_1949
METMMSMTP_0932
MEFMSWH1_0729
MEQMSWHS_0769 MSWHS_0879
MSJMSSAC_1840 MSSAC_3566
MSZMSSIH_3108 MSSIH_3704
MSWMSSIT_2437 MSSIT_3165 MSSIT_3783
MBUMbur_2022
MELOJ7W08_11300(wecB)
MHZMetho_1732
MTPMthe_1235
MCJMCON_2577(wecB)
MHUMhun_0382
MRTJKHC33_15080(wecB)
MEMMemar_1605
MBGBN140_0822(wecB1) BN140_2091(wecB3)
MEMAMMAB1_1080 MMAB1_2721
MCHKMchiMG62_18100
MSUMOH143_02235(wecB)
MRCR6Y96_07515(wecB)
MAQERJ40_10725
MOUOU421_12420(wecB)
MANQL1994_03180
MFOMetfor_1414
RCIRCIX1930(wecB)
ACFAciM339_0818
TPETpen_1715
THBN186_08030
MVJACO0C9_03705(wecB)
NIPNsoK4_08535(wecB)
NVNNVIE_008910
NEVNTE_02143
NFNNFRAN_0194
NDVNDEV_0205(wecB2)
BARBAOA66_0912
WARHYS32_02725(wecB)
AGWQT03_C0001G0650
 » show all
Reference
1  [PMID:17346239]
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:123-30 (2007)
DOI:10.1042/BJ20070017
  Sequence
[pae:PA3148] [bpe:BP0090]
Reference
2
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:625 (2007)
Reference
3  [PMID:11526328]
  Authors
Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH.
  Title
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1310-2 (2001)
DOI:10.1107/S0907444901010885
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.23
IUBMB Enzyme Nomenclature: 5.1.3.23
ExPASy - ENZYME nomenclature database: 5.1.3.23
BRENDA, the Enzyme Database: 5.1.3.23

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