KEGG   ENZYME: 5.1.3.23
Entry
EC 5.1.3.23                 Enzyme                                 
Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase;
UDP-GlcNAc3NAcA 2-epimerase;
UDP-alpha-D-GlcNAc3NAcA 2-epimerase;
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase;
WbpI;
WlbD
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [RN:R09600]
Reaction(KEGG)
R09600
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Product
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [CPD:C19745]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].
History
EC 5.1.3.23 created 2007
Pathway
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
Orthology
K13019  UDP-GlcNAc3NAcA epimerase
Genes
PLU: plu4804(wblH)
PLUM: A4R40_23895
PAY: PAU_04319(wblH)
PTT: VY86_07555
PAKH: B0X70_24585
PLUI: CE143_24625
XGR: QL128_20510(wecB)
AVT: NCTC3438_01782(mnaA)
DYG: DYGSA30_29580(wbpI)
PAE: PA3148(wbpI)
PAEV: N297_3260
PAEI: N296_3260
PAEC: M802_3258
PAEO: M801_3125
PDR: H681_23245
PSES: PSCI_2869
PANH: HU763_007170(wecB)
PHEF: PSH57_20390(wecB)
PSKP: KU43P_39500(wbpI)
PDEU: QEP73_22545(wecB)
MARI: ACP86_02290
MARA: D0851_05390
MARJ: MARI_04700(wbpI)
ADS: FPL17_13915
AVIV: LF296_18030(wecB)
SSE: Ssed_2967
SGLA: FJ709_05420
SVM: KDH10_000090(wecB)
PPIS: B1L02_14620
PVB: J5X90_03260(wecB)
PFLI: CTT31_02675
PMAZ: R5H13_02690(wecB)
AAUS: EP12_05170
ALTB: IUA53_14965(wecB)
LAL: AT746_12790
CATE: C2869_15630
ALKM: NKI27_13895(wecB)
CBRV: R0137_17080
CBU: CBU_0842(wecB)
CBS: COXBURSA331_A1108
CBD: CBUD_0907
CBG: CbuG_1159(wecB)
CBC: CbuK_0710(wecB)
CEY: CleRT_10730
LSS: NCTC12082_00069(wecB)
FRX: F7310_06795
CYY: CPC19_11130
TLH: NR989_02545(wecB)
THIM: KFB96_04765(wecB)
TLR: Thiosp_02507(wbpI)
TNI: TVNIR_0699(wecB_[C])
TTI: THITH_05805
HTT: HZS52_20515(wecB)
MMW: Mmwyl1_0835
MPRI: MP3633_3239
MFOI: JSY38_06670(wecB)
TOR: R615_06315
MGEO: CFI10_13585
OME: OLMES_5518
SUTR: L0B52_03945(wecB)
VMS: LVJ82_06325(wecB)
CKS: H9L41_03360(wecB)
LHK: LHK_02802
PPNO: DA70_17285
LMIR: NCTC12852_00313(mnaA_2)
BPE: BP0090(bplD)
BPC: BPTD_0086(bplD)
BPER: BN118_0159(wlbD)
BPET: B1917_0093(bplD)
BPEU: Q425_2030(bplD)
BPAR: BN117_0150(wlbD)
BPA: BPP0152(bplD)
BBH: BN112_3259(wlbD)
BBR: BB0152(bplD)
BBM: BN115_0141(wlbD)
BBX: BBS798_0151(bplD)
BPT: Bpet4819(wlbD)
BHO: D560_1331
BHM: D558_1320
BHZ: ACR54_00107(wbpI)
BTRM: SAMEA390648701339(wlbD)
BPDZ: BBN53_20155
AVH: WHX56_03780(wecB)
TEQ: TEQUI_1017
TEA: KUI_0418
TEG: KUK_0136
CGIN: ABRZ00_06080(wecB)
OUE: I6G29_01430(wecB)
ACK: C380_07320
AAV: Aave_0953
DLA: I6G47_27680(wecB)
VAE: RZE79_05630(wecB)
HYL: LPB072_07130
MASW: AM586_10875
MASH: LP419_28510(wecB)
TMJ: P0M04_31055(wecB)
TTW: LCC91_03265(wecB)
ETB: N7L95_14840(wecB)
EAA: I862_07330
MESP: C1M53_01175
PMOB: HG718_00065(wecB)
RBS: RHODOSMS8_00383(wbpI)
AGC: BSY240_4586
SZO: K8M09_00485(wecB)
BRK: CWS35_31810
BQB: J4P68_0006725(wecB)
BAUT: QA635_15605(wecB)
BBRA: QA636_16055(wecB)
BPAH: QA639_29450(wecB)
MIV: C4E04_13610 C4E04_13650
MICO: GDR74_06705
HNI: W911_00410
DRP: PSQ90_07600(wecB)
CMB: CSW64_01275
RCON: K3740_17755(wecB)
SPOT: G6548_17145(wecB)
PZH: CX676_22395
LVR: T8T21_17175(wecB) T8T21_20775
HBC: AEM38_13070 AEM38_13090
SPHO: C3E99_07045
SPHU: SPPYR_1658(wbpI)
PHAO: HF685_11090(wecB)
ERR: DVR09_11335
TLU: R1T41_00940
PAQI: KW060_14990(wecB)
HMS: HMU06640
HBI: HBZC1_15210
HET: BBW65_04710
HCL: NCTC13205_01069(mnaA)
HSH: NHP194022_04670(wbpI)
HPUL: NCTC13154_00521(wecB)
WSU: WS2189(WBPI)
TDN: Suden_1418
SDIZ: WCY31_12095(wecB)
CCO: CCC13826_0521
CBLA: CBLAS_0721
ABU: Abu_0692
PACO: AACT_0957
HBV: ABIV_0881
GLO: Glov_1505
GPL: M1B72_07930(wecB)
GSB: GSUB_15300
PEF: A7E78_01570
DPG: DESPIGER_0543
DSB: LN040_10500(wecB)
DHY: DESAM_20348
DDN: DND132_2429
PSEF: PSDVSF_24170
DSX: GD604_09830
DSF: UWK_02413
DEO: CAY53_06115
DOL: Dole_1828
DHG: EYB58_14860
DWD: DSCW_06940
DAO: Desac_2653
BDC: DOE51_07915
BREY: MNR06_04610(wecB)
MAI: MICA_1024
MAN: A11S_979
SBF: JCM31447_25060
PUV: PUV_00130
AHEL: Q31a_45020(wbpI_1)
LCRE: Pla8534_69410(wbpI)
PBS: Plabr_1618
BPIT: BPIT_28910
TPED: TPE_0207
TRM: JO41_03110
TRZ: GWP43_02850
TMED: DWB79_01350
TRP: ABH09_02785(wecB)
SPER: EW093_13210 EW093_13440
TPX: Turpa_0308
ABA: Acid345_3306
GMA: AciX8_3530
TRS: Terro_1265
TALB: FTW19_11825
BUN: Bun01g_30650(wbpI)
BSTE: K6V31_02460(wecB)
PPN: Palpr_1323
PGOL: K6V26_13515(wecB)
PFAI: NXY11_03060(wecB)
PABC: NEE14_015210(wecB)
TFO: BFO_2566
TOH: BCB71_09295
OSP: Odosp_0942
BVIR: I6J59_01690(wecB) I6J59_14280(wecB)
BFH: F1611_14865
TTZ: FHG85_09800
BACC: BRDCF_p1451(wecB)
DORI: FH5T_09075
CPI: Cpin_4757
CPOL: WJU16_11305(wecB)
NIA: A8C56_08555
FLA: SY85_01715
PGIN: FRZ67_02945
PCAU: HWD63_02910(wecB)
SBX: CA265_19270
SPIB: G8759_15505(wecB)
SOQ: LQ777_25975(wecB)
SENF: GJR95_18960
RUN: DR864_23725
MARP: QYS47_34855(wecB)
FKA: KM029_13900(wecB)
CHRW: KA713_08525(wecB)
CAPH: CGC49_04830
ZGA: ZOBELLIA_1741(wecB)
ZLA: Q5W13_08585(wecB)
PHG: KCTC32516_01587(wbpI)
TDI: AUW17_08820
TEN: LPB136_00970
TMP: F9Y86_02255 F9Y86_04655
TOV: PG911_13370(wecB)
TRT: PG912_05095(wecB)
TPAC: PG913_03655(wecB)
TFI: PJJ26_09410(wecB)
TSIG: D6T69_11755
LUT: Lupro_12975
LUL: LPB138_15100
WFU: AXE80_02790
SALT: AO058_00370
EMAR: D1013_01185
PSYN: E9099_06875
ASAG: FGM00_16585
SPON: HME9304_01541(wbpI)
FBE: FF125_16525
LUY: QZH61_11470(wecB)
CARH: EGY05_16490
FTE: Fluta_0726 Fluta_2189
FLU: CHH17_06355
CRM: K6119_19005(wecB)
OHO: Oweho_1403
CHYD: H4K34_02735(wecB)
PTAN: CRYO30217_01158(wbpI_2)
SHYR: LA303_04925(wecB)
BBAU: AEM51_07985
RMR: Rmar_0573
RMG: Rhom172_0568
RLO: GQ464_017900(wecB)
RBAR: AWN76_007345
MRO: MROS_2673
CPRV: CYPRO_2717
CACI: CLOAM1218(wecB)
FML: FMIA91_07050(wecB_2)
SAF: SULAZ_0353
CNI: Calni_1804
DTH: DICTH_0427
DTU: Dtur_0574
NTI: DNFV4_03091
ALAM: RT761_00505(wbpI)
BMET: BMMGA3_15100
BACI: B1NLA3E_20895
BON: A361_24855
CFIR: NAF01_22635(wecB)
CSOA: LIS82_24390(wecB)
BDA: FSZ17_21460
CSUA: IM538_21360(wecB)
HNZ: P9989_16280(wecB) P9989_18360(wecB)
HSHI: MUO14_06110(wecB)
HAMY: MUO15_18465(wecB)
VNE: CFK40_05105
VNT: OLD84_03170(wecB)
VIK: KFZ58_02650(wecB)
VSS: PD280_03305(wecB)
LAO: AOX59_11995
LEX: Len3610_17430
AQT: FN924_03245
RAX: KO561_03475(wecB)
PSYH: D0S48_07325
PSYO: PB01_04645
RUE: DT065_00075
MLIT: KDJ21_007830(wecB)
MENL: MVE64_10685(wecB)
MEBZ: LPC09_22640(wecB)
MSEE: WCV65_18880(wecB)
MHRF: QLQ22_07100(wecB)
MSUT: LC048_00415(wecB)
GKA: GK3162
GTE: GTCCBUS3UF5_35310
GTK: GT3570_15435
GTM: GT3921_03270
BCAL: CWI35_12110
GYC: GYMC61_3253
GYA: GYMC52_3284
GCT: GC56T3_3173
GGH: GHH_c32370(mnaA)
GEL: IB49_07975
GSE: GT50_07665
GZA: IC807_11880(wecB)
PTB: DER53_03255(wecB)
AAMY: GFC30_485
MARY: LAU42_03945(wecB)
POD: PODO_28510
PNP: IJ22_38280
PALB: EJC50_29130
ATHE: K3F53_17210(wecB)
CHEB: HH215_20205(wecB)
SURL: BI350_15330
LFB: C1X05_15860
TVU: AB849_005655
KPUL: GXN76_15365(wecB)
KEB: GXN75_16725(wecB)
PABS: JIR001_30170
CBO: CBO3100
CBA: CLB_3129
CBH: CLC_3002
CBY: CLM_3506
CBL: CLK_2494
CBK: CLL_A3182
CBB: CLD_1440
CBI: CLJ_B3366
CBT: CLH_2927
CBF: CLI_3159
CBM: CBF_3148
CBJ: H04402_03177
CBE: Cbei_4627
CBZ: Cbs_4627
CBEI: LF65_05170
CKL: CKL_3166
CKR: CKR_2804
CLJ: CLJU_c34070
CCB: Clocel_3137
CSR: Cspa_c53520
CSB: CLSA_c41270
CAH: CAETHG_1305(wecB)
CSQ: CSCA_4791
CLD: CLSPO_c18630 CLSPO_c31990
CCK: Ccar_17245
CBUT: ATN24_15745
CTYK: CTK_C08720
CEU: A7L45_12065
CTAE: BGI42_12630
CDRK: B9W14_20915
CDY: F3K33_23555
CFER: D4Z93_01765
CGAS: J1C67_09865(wecB)
CLOS: DMR38_17075
CGEL: psyc5s11_49940
CTAG: LL095_12275(wecB)
CLOL: ONV75_14945(wecB)
CLOM: AXY43_11175
HHW: NCTC503_01993(wecB)
OCW: OW730_12080(wecB)
EHA: Ethha_0669
CAML: H6X83_09690(wecB)
CLF: GJQ69_02340
CARL: PXC00_03595(wecB)
TMEL: NOG13_06690(wecB)
RBP: B6259_08160
CCEL: CCDG5_0710
CAPR: EQM14_12865
CFEM: HCR03_17330(wecB)
DOR: Desor_5330
DAI: Desaci_4441
DMI: Desmer_4332
PTH: PTH_0384(WecB) PTH_1103(WecB)
DFG: B0537_15540
DKU: Desku_0874
AACX: DEACI_0260
ELM: ELI_2561
SAY: TPY_3671(wecB)
SAP: Sulac_3370
STHR: BXT84_14970
MDV: C5Q96_07715
MNL: QU661_00465(wecB)
TTE: TTE0661(WecB2)
MAS: Mahau_0358
FMA: FMG_0502
MHAP: JFY71_06675(wecB)
MFOM: VZL98_08175(wecB)
SSID: SPSIL_042240(wbpI_1)
TBZ: BK011_02350
ELE: Elen_0637
EUZ: DVS28_a1719
BSOL: FSW04_03495
BALA: DSM104299_05813(wbpI)
PBAJ: LRS13_03655(wecB)
CWO: Cwoe_5917
PARN: NBH00_24920(wecB)
PARQ: DSM112329_05342(wbpI)
SBAE: DSM104329_04159(wbpI_1) DSM104329_05200(wbpI_2)
TALU: JDY09_09735(wecB)
LEPV: J4558_19250(wecB)
HHG: XM38_017570(wbpI)
PGX: OA858_09585(wecB)
GLP: Glo7428_3721
PIP: FEK30_06140
OXY: HCG48_01150(wecB)
GEI: GEI7407_2308
GLJ: GKIL_0481(wecB)
CALH: IJ00_16800
DEW: DGWBC_0899
DFO: Dform_01826(wecB)
RRS: RoseRS_4430
RCA: Rcas_0784
CAG: Cagg_1972
PSUB: Pelsub_P0628
CAP: CLDAP_36180
THUG: KNN16_05605(wecB)
DSW: QR90_12670
DRD: LMT64_11870(wecB)
TTH: TT_C0285
ACO: Amico_1720
AMIZ: RBH88_00735(wecB)
TLI: Tlie_1813
AMO: Anamo_1187
TMA: TM0610
TMM: Tmari_0610
TMI: THEMA_01615
TMW: THMA_0626
TMQ: THMB_0626
TMX: THMC_0626
TPT: Tpet_0300 Tpet_0308
TNP: Tnap_0392 Tnap_0427
TRQ: TRQ2_0326
THQ: T2812B_01620
THZ: CELL2_01685
TLE: Tlet_1207
TTA: Theth_1610
PHY: AJ81_08730
TME: Tmel_0366
THP: BG95_04935
THER: Y592_05005
FNO: Fnod_0568
FPE: Ferpe_0132
FIA: NA23_00760(wecB)
FNG: JM64_01510
OCY: OSSY52_03120
PMO: Pmob_0933 Pmob_1288
MPZ: Marpi_1253
MARN: LN42_06735
MAEO: JRV97_05625(wecB)
OCS: OF820_08755(wecB)
KOL: Kole_1631
ASAC: ATHSA_0040
FCI: I6I83_02405(wecB)
BIH: BIP78_0584
MMP: MMP0357
MVN: Mevan_0198
MVO: Mvol_0232
MFI: DSM1535_0247
METT: CIT01_00335
PFU: PF0794
PFI: PFC_03140
PYC: TQ32_02915
TSI: TSIB_2024
THM: CL1_0830
THS: TES1_1887
TTD: A3L14_00440
THY: A3L12_02955
THEI: K1720_03030(wecB)
MBA: Mbar_A0052 Mbar_A2140
MBY: MSBRM_0005 MSBRM_0792
MBW: MSBRW_0943 MSBRW_2602
MBAR: MSBR2_0018
MBAK: MSBR3_1166 MSBR3_1605
MMAC: MSMAC_1844
MVC: MSVAZ_0005
MEK: MSKOL_0025
MLS: MSLAZ_1033 MSLAZ_1853 MSLAZ_1949
METM: MSMTP_0932
MEF: MSWH1_0729
MEQ: MSWHS_0769 MSWHS_0879
MSJ: MSSAC_1840 MSSAC_3566
MSZ: MSSIH_3108 MSSIH_3704
MSW: MSSIT_2437 MSSIT_3165 MSSIT_3783
MBU: Mbur_2022
MELO: J7W08_11300(wecB)
MHZ: Metho_1732
MTP: Mthe_1235
MCJ: MCON_2577(wecB)
MHU: Mhun_0382
MRTJ: KHC33_15080(wecB)
MEM: Memar_1605
MBG: BN140_0822(wecB1) BN140_2091(wecB3)
MEMA: MMAB1_1080 MMAB1_2721
MCHK: MchiMG62_18100
MSUM: OH143_02235(wecB)
MRC: R6Y96_07515(wecB)
MAQE: RJ40_10725
MOU: OU421_12420(wecB)
MANQ: L1994_03180
MFO: Metfor_1414
RCI: RCIX1930(wecB)
ACF: AciM339_0818
TPE: Tpen_1715
THB: N186_08030
MVJ: ACO0C9_03705(wecB)
NIP: NsoK4_08535(wecB)
NVN: NVIE_008910
NEV: NTE_02143
NFN: NFRAN_0194
NDV: NDEV_0205(wecB2)
BARB: AOA66_0912
WAR: HYS32_02725(wecB)
AGW: QT03_C0001G0650
 » show all
Reference
1  [PMID:17346239]
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:123-30 (2007)
DOI:10.1042/BJ20070017
  Sequence
[pae:PA3148] [bpe:BP0090]
Reference
2
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:625 (2007)
Reference
3  [PMID:11526328]
  Authors
Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH.
  Title
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1310-2 (2001)
DOI:10.1107/S0907444901010885
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.23
IUBMB Enzyme Nomenclature: 5.1.3.23
ExPASy - ENZYME nomenclature database: 5.1.3.23
BRENDA, the Enzyme Database: 5.1.3.23

  All links  
Gene (7707)   
   MGENES (5872)   
   RefGene (1835)   
Protein sequence (509)   
   UniProt (508)   
   SWISS-PROT (1)   
DNA sequence (558)   
   GenBank (286)   
   EMBL (272)   
Protein domain (2)   
   InterPro (2)   
All databases (8776)   

Download RDF
DBGET integrated database retrieval system