KEGG   ENZYME: 5.1.3.23Help
Entry
EC 5.1.3.23                 Enzyme                                 

Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase;
UDP-GlcNAc3NAcA 2-epimerase;
UDP-alpha-D-GlcNAc3NAcA 2-epimerase;
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase;
WbpI;
WlbD
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [RN:R09600]
Reaction(KEGG)
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Product
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [CPD:C19745]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].
History
EC 5.1.3.23 created 2007
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K13019  UDP-GlcNAc3NAcA epimerase
Genes
PLU: plu4804(wblH)
PLUM: A4R40_23895
PAY: PAU_04319(wblH)
PTT: VY86_07555
PAE: PA3148(wbpI)
PAEV: N297_3260
PAEI: N296_3260
PAEC: M802_3258
PAEO: M801_3125
PDR: H681_23245
PSES: PSCI_2869
SSE: Ssed_2967
PPIS: B1L02_14620
MARI: ACP86_02290
MARA: D0851_05390
MARJ: MARI_04700(wbpI)
AAUS: EP12_05170
LAL: AT746_12790
CATE: C2869_15630
CEY: CleRT_10730
FRX: F7310_06795
CYY: CPC19_11130
TNI: TVNIR_0699(wecB_[C])
TTI: THITH_05805
MMW: Mmwyl1_0835
TOR: R615_06315
OME: OLMES_5518
LHK: LHK_02802
PPNO: DA70_17285
LMIR: NCTC12852_00313(mnaA_2)
BPE: BP0090(bplD)
BPC: BPTD_0086(bplD)
BPER: BN118_0159(wlbD)
BPET: B1917_0093(bplD)
BPEU: Q425_2030(bplD)
BPA: BPP0152(bplD)
BPAR: BN117_0150(wlbD)
BBR: BB0152(bplD)
BBM: BN115_0141(wlbD)
BBH: BN112_3259(wlbD)
BBX: BBS798_0151(bplD)
BPT: Bpet4819(wlbD)
BHO: D560_1331
BHM: D558_1320
BHZ: ACR54_00107(wbpI)
BTRM: SAMEA390648701339(wlbD)
BPDZ: BBN53_20155
TEQ: TEQUI_1017
TEA: KUI_0418
TEG: KUK_0136
AAV: Aave_0953
ACK: C380_07320
HYL: LPB072_07130
MASW: AM586_10875
HMS: HMU06640
HBI: HBZC1_15210
HET: BBW65_04710
WSU: WS2189(WBPI)
TDN: Suden_1418
CCO: CCC13826_0521
ABU: Abu_0692
GLO: Glov_1505
GSB: GSUB_15300
PEF: A7E78_01570
DDN: DND132_2429
DEO: CAY53_06115
DSF: UWK_02413
DOL: Dole_1828
DWD: DSCW_06940
DAO: Desac_2653
BDC: DOE51_07915
SBF: JCM31447_25060
EAA: I862_07330
MESP: C1M53_01175
RBS: RHODOSMS8_00383(wbpI)
AGC: BSY240_4586
BRK: CWS35_31810
MIV: C4E04_13610 C4E04_13650
MICO: GDR74_06705
HNI: W911_00410
CMB: CSW64_01275
PZH: CX676_22395
HBC: AEM38_13070 AEM38_13090
SPHO: C3E99_07045
SPHU: SPPYR_1658(wbpI)
ERR: DVR09_11335
MAI: MICA_1024
MAN: A11S_979
BACI: B1NLA3E_20895
BMET: BMMGA3_15100
BON: A361_24855
GKA: GK3162
GTE: GTCCBUS3UF5_35310
GTK: GT3570_15435
GTM: GT3921_03270
GYC: GYMC61_3253
GYA: GYMC52_3284
GCT: GC56T3_3173
GGH: GHH_c32370(mnaA)
GEL: IB49_07975
GSE: GT50_07665
AAMY: GFC30_485
VNE: CFK40_05105
LAO: AOX59_11995
AQT: FN924_03245
PSYH: D0S48_07325
PSYO: PB01_04645
RUE: DT065_00075
POD: PODO_28510
PNP: IJ22_38280
LFB: C1X05_15860
TVU: AB849_005655
CBO: CBO3100
CBA: CLB_3129
CBH: CLC_3002
CBY: CLM_3506
CBL: CLK_2494
CBK: CLL_A3182
CBB: CLD_1440
CBI: CLJ_B3366
CBT: CLH_2927
CBF: CLI_3159
CBM: CBF_3148
CBJ: H04402_03177
CBE: Cbei_4627
CBZ: Cbs_4627
CBEI: LF65_05170
CKL: CKL_3166
CKR: CKR_2804
CLJ: CLJU_c34070
CCB: Clocel_3137
CSR: Cspa_c53520
CSB: CLSA_c41270
CAH: CAETHG_1305
CSQ: CSCA_4791
CLD: CLSPO_c18630 CLSPO_c31990
CCK: Ccar_17245
CBUT: ATN24_15745
CTYK: CTK_C08720
CEU: A7L45_12065
CTAE: BGI42_12630
CDRK: B9W14_20915
CDY: F3K33_23555
HHW: NCTC503_01993(wecB)
CCEL: CCDG5_0710
RBP: B6259_08160
CAPR: EQM14_12865
DFG: B0537_15540
DKU: Desku_0874
DOR: Desor_5330
DAI: Desaci_4441
DMI: Desmer_4332
ELM: ELI_2561
SAY: TPY_3671(wecB)
SAP: Sulac_3370
STHR: BXT84_14970
MDV: C5Q96_07715
TTE: TTE0661(WecB2)
MAS: Mahau_0358
EUZ: DVS28_a1719
HHG: XM38_017570(wbpI)
GLP: Glo7428_3721
GEI: GEI7407_2308
GLJ: GKIL_0481(wecB)
CALH: IJ00_16800
RRS: RoseRS_4430
RCA: Rcas_0784
CAG: Cagg_1972
PSUB: Pelsub_P0628
CAP: CLDAP_36180
DSW: QR90_12670
TTH: TT_C0285
PUV: PUV_00130
PBS: Plabr_1618
TPED: TPE_0207
TRM: JO41_03110
SPER: EW093_13210 EW093_13440
TPX: Turpa_0308
GMA: AciX8_3530
TRS: Terro_1265
TALB: FTW19_11825
TLI: Tlie_1813
AMO: Anamo_1187
PPN: Palpr_1323
TFO: BFO_2566
TOH: BCB71_09295
OSP: Odosp_0942
BACC: BRDCF_p1451(wecB)
DORI: FH5T_09075
RMG: Rhom172_0568
CPI: Cpin_4757
NIA: A8C56_08555
FLA: SY85_01715
PGIN: FRZ67_02945
SBX: CA265_19270
RUN: DR864_23725
CAPH: CGC49_04830
ZGA: ZOBELLIA_1741(wecB)
CARH: EGY05_16490
TDI: AUW17_08820
TEN: LPB136_00970
TMP: F9Y86_02255 F9Y86_04655
LUT: Lupro_12975
LUL: LPB138_15100
WFU: AXE80_02790
SALT: AO058_00370
SPON: HME9304_01541(wbpI)
EMAR: D1013_01185
PSYN: E9099_06875
FBE: FF125_16525
FTE: Fluta_2189
FLU: CHH17_06355
OHO: Oweho_1403
BBAU: AEM51_07985
MRO: MROS_2673
CNI: Calni_1804
DTH: DICTH_0427
DTU: Dtur_0574
BIH: BIP78_0584
METT: CIT01_00335
NDV: NDEV_0205(wecB2)
 » show all
Taxonomy
Reference
1  [PMID:17346239]
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:123-30 (2007)
DOI:10.1042/BJ20070017
  Sequence
[pae:PA3148] [bpe:BP0090]
Reference
2
  Authors
Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S.
  Title
Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:625 (2007)
Reference
3  [PMID:11526328]
  Authors
Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH.
  Title
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1310-2 (2001)
DOI:10.1107/S0907444901010885
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.23
IUBMB Enzyme Nomenclature: 5.1.3.23
ExPASy - ENZYME nomenclature database: 5.1.3.23
BRENDA, the Enzyme Database: 5.1.3.23

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (7449)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (226)   
   KEGG MGENES (5387)   
   RefGene (1835)   
Protein sequence (420)   
   UniProt (419)   
   SWISS-PROT (1)   
DNA sequence (261)   
   GenBank (129)   
   EMBL (132)   
All databases (8138)   

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