KEGG   ENZYME: 5.1.3.24
Entry
EC 5.1.3.24                 Enzyme                                 

Name
N-acetylneuraminate epimerase;
sialic acid epimerase;
N-acetylneuraminate mutarotase;
NanM;
NanQ
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
N-acetyl-alpha-neuraminate 2-epimerase
Reaction(IUBMB)
N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate (oveall reaction) [RN:R09797];
(1a) N-acetyl-alpha-neuraminate = aceneuramate [RN:R12769];
(1b) aceneuramate = N-acetyl-beta-neuraminate [RN:R12770]
Reaction(KEGG)
Substrate
N-acetyl-alpha-neuraminate [CPD:C19909];
aceneuramate [CPD:C22382]
Product
N-acetyl-beta-neuraminate [CPD:C19910];
aceneuramate [CPD:C22382]
Comment
Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.
History
EC 5.1.3.24 created 2011, modified 2021
Orthology
K17948  N-acetylneuraminate epimerase
Genes
ECO: b4310(nanM)
ECJ: JW5777(yjhT)
ECD: ECDH10B_4513(yjhT)
EBW: BWG_4008(nanM)
ECE: Z5906(yjhT)
ECS: ECs5269
ECF: ECH74115_5814
ETW: ECSP_5392(yjhT)
ELX: CDCO157_4954
EOI: ECO111_5164(nanM)
EOJ: ECO26_5507(nanM)
EOH: ECO103_5091(nanM)
ECOO: ECRM13514_5553(yjhT)
ECOH: ECRM13516_5268(yjhT)
ECG: E2348C_4617(yjhT)
EOK: G2583_5111(yjhT)
ELH: ETEC_4622
ECP: ECP_4643
ENA: ECNA114_4554(yjhT)
ECV: APECO1_2121(yjhT)
ECY: ECSE_4582
ECR: ECIAI1_4523(yjhT)
ECT: ECIAI39_4781(yjhT)
EOC: CE10_5054(nanM)
EBR: ECB_04177(yjhT)
EBL: ECD_04177(nanM)
EBE: B21_04139(nanM)
EBD: ECBD_3727
ECZ: ECS88_4927(yjhT)
ECC: c3634 c5388
ESE: ECSF_4250
EKF: KO11_23175(nanM)
EDJ: ECDH1ME8569_4169(yjhT)
ELW: ECW_m4667(nanM)
ELL: WFL_22730(nanM)
ELF: LF82_3478(yjhT)
ECOI: ECOPMV1_04756(nanM)
STY: STY1167
STT: t1790
STM: STM1130
SENI: CY43_05765
SEI: SPC_2619
SEC: SCH_1080(yjhT)
SHB: SU5_01759
SED: SeD_A1205
SEL: SPUL_1927
SET: SEN0991
SENA: AU38_05120
SENO: AU37_05110
SENV: AU39_05110
SENQ: AU40_05745
SENL: IY59_05215
SEEP: I137_08760
SENE: IA1_05560
SFL: SF4212(yjhT)
SFX: S4469(yjhT)
SFV: SFV_4217(yjhT)
SFE: SFxv_4595
SFN: SFy_6049
SFS: SFyv_6119
SFT: NCTC1_04579(yjhT)
SSN: SSON_4472(yjhT)
SBO: SBO_4360(yjhT)
YPE: YPO1858
YPK: y2448
YPH: YPC_2405
YPA: YPA_1237
YPN: YPN_2265
YPM: YP_1535
YPZ: YPZ3_1871
YPD: YPD4_1647
YPX: YPD8_1903
YPW: CH59_3308(nanM)
YPJ: CH55_817(nanM)
YPV: BZ15_1692(nanM)
YPL: CH46_3265(nanM)
YPS: YPTB1729
YPO: BZ17_771(nanM)
YPY: YPK_2362
YPB: YPTS_1861
YPQ: DJ40_491(nanM)
YPU: BZ21_1083(nanM)
YPR: BZ20_245(nanM)
YPC: BZ23_1364(nanM)
YPF: BZ19_1157(nanM)
YEN: YE1943
YEY: Y11_13781
YEW: CH47_1375(nanM)
YET: CH48_3365(nanM)
YFR: AW19_918(nanM)
YKR: CH54_744
YRO: CH64_268(nanM)
YRU: BD65_2428(nanM)
MMK: MU9_1237
ETR: ETAE_0932
ETD: ETAF_0868(nanM)
ETE: ETEE_2873
HIN: HI_0148
HIT: NTHI0235
HIU: HIB_02010
HIE: R2846_0489(nanM)
HIZ: R2866_0439(nanM)
HIK: HifGL_000825(nanM)
HIA: H733_0032(nanM)
HIW: NTHI477_01181(nanM)
HIC: NTHIC486_00883(nanM)
HIX: NTHI723_01555(nanM)
HPIT: NCTC13334_00443(nanM)
HHZ: NCTC10839_01822(nanM)
HAEG: NCTC8502_01090(nanM)
PMU: PM1707
PMV: PMCN06_2150(nanM)
PMP: Pmu_20710(nanM)
PMUL: DR93_654(nanM)
AAT: D11S_1586
AAN: D7S_00408
AACN: AANUM_1474
ASEG: NCTC10977_01728(nanM)
AVT: NCTC3438_00937(nanM)
RPNE: NCTC8284_03406(nanM_2)
VCH: VC_1774
VCS: MS6_1547
VCI: O3Y_08590
VVU: VV2_0726
SPL: Spea_1514
CHJ: NCTC10426_00703(nanM)
SCL: sce5357
BME: BMEII0856
BMEL: DK63_2392
BMEE: DK62_3015
BMF: BAB2_0809
BABO: DK55_2765
BABR: DO74_3181
BABT: DK49_2474
BABB: DK48_3032
BABU: DK53_2768
BABS: DK51_2252
BABC: DO78_2289
BSZ: DK67_2419
BOV: BOV_A0355
BCAR: DK60_2139
BCAS: DA85_12455
BMR: BMI_II409
BPP: BPI_II394
BPV: DK65_2091
GMO: NCTC11323_00012(nanM)
GHA: NCTC10459_00013(nanM)
MHG: MHY_00950
KFL: Kfla_0128
DFC: DFI_16055
AGL: PYTT_1911
PSL: Psta_1238
PIR: VN12_17085(nanM_1)
ROL: CA51_38050(nanM_1)
PLS: VT03_21000(nanM_2)
ULI: ETAA1_10650(nanM_1)
PBU: L21SP3_00912(nanM)
BRM: Bmur_2467
BPW: WESB_2249
BIP: Bint_0697
SMF: Smon_1051
BXY: BXY_44770
BOA: Bovatus_01545(nanM_1)
BVU: BVU_4137
PMUC: ING2E5A_0814(nanM)
PSAC: PSM36_2234
PDI: BDI_2949
TFO: BFO_2210
POC: NCTC13071_00094(nanM)
DORI: FH5T_13875
SMIZ: 4412673_03728(nanM_2)
SDJ: NCTC13534_05183(nanM_2)
STHA: NCTC11429_02641(nanM_1) NCTC11429_04305(nanM_2)
SLI: Slin_2624
COC: Coch_2065
 » show all
Reference
1  [PMID:18063573]
  Authors
Severi E, Muller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH
  Title
Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT.
  Journal
J Biol Chem 283:4841-9 (2008)
DOI:10.1074/jbc.M707822200
  Sequence
[eco:b4310]
Reference
2  [PMID:33895133]
  Authors
Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.
  Title
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
  Journal
J Biol Chem 296:100699 (2021)
DOI:10.1016/j.jbc.2021.100699
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.24
IUBMB Enzyme Nomenclature: 5.1.3.24
ExPASy - ENZYME nomenclature database: 5.1.3.24
BRENDA, the Enzyme Database: 5.1.3.24

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