KEGG   ENZYME: 5.1.3.26Help
Entry
EC 5.1.3.26                 Enzyme                                 

Name
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase;
GlcNAc-P-P-Und epimerase;
GlcNAc-P-P-Und 4-epimerase;
gne (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase
Reaction(IUBMB)
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R10554]
Reaction(KEGG)
Substrate
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C20620]
Comment
The enzyme is involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen produced by some Gram-negative bacteria.
History
EC 5.1.3.26 created 2013
Orthology
K19997  GlcNAc-P-P-Und epimerase
Genes
ECE: Z3206
ECS: ECs2847
ECF: ECH74115_2976(gne)
ETW: ECSP_2797(gne)
ELX: CDCO157_2627
ESL: O3K_09215
ESO: O3O_16405
ESM: O3M_09180
ECK: EC55989_2298(gne)
ECG: E2348C_2184(gne)
EOK: G2583_2565(gne)
ECM: EcSMS35_1020(gne)
ECR: ECIAI1_2117(gne)
ECQ: ECED1_2388(gne)
SBG: SBG_1917
SBC: SbBS512_E1190(gne)
ESA: ESA_01176
CSK: ES15_1414
HDE: HDEF_0179(galE_1)
YPY: YPK_3179
SPE: Spro_2896
SRL: SOD_c27230(gne)
SPLY: Q5A_015045(gnu)
SMAF: D781_2683
SMAR: SM39_2357(gne)
SMAC: SMDB11_2153(gne)
SERF: L085_14300
MINT: C7M51_01871(gnu)
PRG: RB151_044070(galE_3)
ANS: ArsFIN_07600(gnu)
LRI: NCTC12151_01024(galE_1)
PCQ: PcP3B5_48010(galE_1)
RHT: NT26_1041
XAU: Xaut_3561
PHL: KKY_3120
BVR: BVIR_903
CAK: Caul_0135
RCP: RCAP_rcc01936(gne)
GAK: X907_1850
PGV: SL003B_3042(gne)
BCV: Bcav_1168
PRC: EW14_1482
CAA: Caka_1981
MFF: MFFC18_01490(galE_1)
TDE: TDE1439
FSC: FSU_1441
GBA: J421_2491
BTH: BT_2887
BFR: BF3647
BXY: BXY_37990
SMIZ: 4412673_02365(galE_2)
EAO: BD94_3329
ELB: VO54_03300(galE_3)
CLI: Clim_1879
PVI: Cvib_0649
PAA: Paes_1748
CACI: CLOAM1566
 » show all
Taxonomy
Reference
1  [PMID:19923219]
  Authors
Rush JS, Alaimo C, Robbiani R, Wacker M, Waechter CJ
  Title
A novel epimerase that converts GlcNAc-P-P-undecaprenol to GalNAc-P-P-undecaprenol in Escherichia coli O157.
  Journal
J Biol Chem 285:1671-80 (2010)
DOI:10.1074/jbc.M109.061630
  Sequence
[ece:Z3206]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.26
IUBMB Enzyme Nomenclature: 5.1.3.26
ExPASy - ENZYME nomenclature database: 5.1.3.26
BRENDA, the Enzyme Database: 5.1.3.26

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