KEGG ENZYME: 5.1.3.28

ENZYME: 5.1.3.28

Entry

EC 5.1.3.28 Enzyme

Name

UDP-N-acetyl-L-fucosamine synthase;
WbjD;
Cap5G

Class

Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives

Sysname

UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase

Reaction(IUBMB)

UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine [RN:R10676]

Reaction(KEGG)

R10676

Substrate

UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD:C20768]

Product

UDP-N-acetyl-beta-L-fucosamine [CPD:C20774]

Comment

Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Involved in bacterial polysaccharide biosynthesis.

History

EC 5.1.3.28 created 2014

Reference

1 [PMID:12464616]

Authors

Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS

Title

Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.

Journal

J Biol Chem 278:3615-27 (2003)
DOI:10.1074/jbc.M203867200

Reference

2 [PMID:15778500]

Authors

Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS

Title

Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11.

Journal

J Biol Chem 280:19535-42 (2005)
DOI:10.1074/jbc.M500612200

Other DBs

ExplorEnz - The Enzyme Database:

5.1.3.28

IUBMB Enzyme Nomenclature:

5.1.3.28

ExPASy - ENZYME nomenclature database:

5.1.3.28

BRENDA, the Enzyme Database:

5.1.3.28

All links

Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (9)   
   UniProt (9)   
DNA sequence (24)   
   GenBank (12)   
   EMBL (12)   
All databases (37)   

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