| Entry |
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| Name |
2-epi-5-epi-valiolone epimerase;
CetB;
EVE
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| Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
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| Sysname |
2-epi-5-epi-valiolone 2-epimerase
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| Reaction(IUBMB) |
2-epi-5-epi-valiolone = 5-epi-valiolone [RN: R11079]
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| Reaction(KEGG) |
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| Substrate |
2-epi-5-epi-valiolone [CPD: C17691]
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| Product |
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| Comment |
The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.
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| History |
EC 5.1.3.33 created 2015
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| Pathway |
| ec00525 | Acarbose and validamycin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K20431 | 2-epi-5-epi-valiolone epimerase |
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| Genes |
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| Reference |
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| Authors |
Wu X, Flatt PM, Xu H, Mahmud T |
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| Title |
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.1.3.33 |
| ExPASy - ENZYME nomenclature database: | 5.1.3.33 |
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