Entry |
|
Name |
2-epi-5-epi-valiolone epimerase;
CetB;
EVE
|
Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
|
Sysname |
2-epi-5-epi-valiolone 2-epimerase
|
Reaction(IUBMB) |
2-epi-5-epi-valiolone = 5-epi-valiolone [RN: R11079]
|
Reaction(KEGG) |
|
Substrate |
2-epi-5-epi-valiolone [CPD: C17691]
|
Product |
|
Comment |
The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.
|
History |
EC 5.1.3.33 created 2015
|
Pathway |
ec00525 | Acarbose and validamycin biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K20431 | 2-epi-5-epi-valiolone epimerase |
|
Genes |
|
Reference |
|
Authors |
Wu X, Flatt PM, Xu H, Mahmud T |
Title |
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 5.1.3.33 |
ExPASy - ENZYME nomenclature database: | 5.1.3.33 |
|