KEGG   ENZYME: 5.1.3.35
Entry
EC 5.1.3.35                 Enzyme                                 
Name
2-epi-5-epi-valiolone 7-phosphate 2-epimerase;
AcbO
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate [RN:R11081]
Reaction(KEGG)
R11081
Substrate
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Product
5-epi-valiolone 7-phosphate [CPD:C17693]
Comment
The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
History
EC 5.1.3.35 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19974  2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Genes
SERASer39006_003970
SERQCWC46_03970
BIZHC231_14635
CVCBKX93_19965
AVMJQX13_08255
VPYHZI73_09265
HASHalsa_0172
MULMUL_0548
MMIMMAR_0583
MMAEMMARE11_05400
NAHF5544_18740
TSMASU32_10290
SALSSLNWT_0593
SVTSVTN_01215
SCZABE83_10140
SRWTUE45_05033
SLEsle_45850(sle_45850)
SLSSLINC_5099
SCYAEJ357_02090 EJ357_14595
SGZC0216_19325
SAUHSU9_022215
AHMTL08_17640
ACTIUA75_21520
ACADUA74_21040
ASEACPL_3679(acbO)
ACTSACWT_3551
 » show all
Reference
1  [PMID:12681481]
  Authors
Zhang CS, Podeschwa M, Altenbach HJ, Piepersberg W, Wehmeier UF
  Title
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
  Journal
FEBS Lett 540:47-52 (2003)
DOI:10.1016/S0014-5793(03)00221-7
  Sequence
[ase:ACPL_3679]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.35
IUBMB Enzyme Nomenclature: 5.1.3.35
ExPASy - ENZYME nomenclature database: 5.1.3.35
BRENDA, the Enzyme Database: 5.1.3.35

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