KEGG ENZYME: 5.1.99.7

ENZYME: 5.1.99.7

Entry

EC 5.1.99.7 Enzyme

Name

dihydroneopterin triphosphate 2'-epimerase;
D-erythro-7,8-dihydroneopterin triphosphate epimerase;
folX (gene name)

Class

Isomerases;
Racemases and epimerases;
Acting on other compounds

Sysname

7,8-dihydroneopterin 3'-triphosphate 2'-epimerase

Reaction(IUBMB)

7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate [RN:R11082]

Reaction(KEGG)

R11082

Substrate

7,8-dihydroneopterin 3'-triphosphate [CPD:C04895]

Product

7,8-dihydromonapterin 3'-triphosphate [CPD:C21094]

Comment

The enzyme, found in gammaproteobacteria, has almost no activity with 7,8-dihydroneopterin [2].

History

EC 5.1.99.7 created 2015

Pathway

ec00790

Folate biosynthesis

Orthology

K07589

D-erythro-7,8-dihydroneopterin triphosphate epimerase

Genes

ECO:	b2303(folX)

ECJ:	JW2300(folX)

ECD:	ECDH10B_2465(folX)

EBW:	BWG_2077(folX)

ECOK:

ECMDS42_1874(folX)

ECE:	Z3565(folX)

ECS:	ECs3187(folX)

ECF:	ECH74115_3443(folX)

ETW:	ECSP_3178(folX)

ELX:	CDCO157_2951(folX)

EOI:	ECO111_3051(folX)

EOJ:	ECO26_3291(folX)

EOH:	ECO103_2767(folX)

ECOO:

ECRM13514_3060(folX)

ECOH:

ECRM13516_3004(folX)

ESL:	O3K_07980(folX)

ESO:	O3O_17655(folX)

ESM:	O3M_07930(folX)

ECK:	EC55989_2547(folX)

ECG:	E2348C_2443(folX)

EOK:	G2583_2840(folX)

ELR:	ECO55CA74_14075(folX)

ELH:

ETEC_2438

ECW:	EcE24377A_2597(folX)

EUN:	UMNK88_2854

ECP:

ECP_2342

ENA:	ECNA114_2394(folX)

ECOS:

EC958_2639(folX)

ECV:	APECO1_4261(folX)

ECOA:

APECO78_15335

ECX:	EcHS_A2453(folX)

ECM:	EcSMS35_2459(folX)

ECY:

ECSE_2561

ECR:	ECIAI1_2379(folX)

ECQ:	ECED1_2767(folX)

EUM:	ECUMN_2643(folX)

ECT:	ECIAI39_2450(folX)

EOC:	CE10_2686(folX)

EBR:	ECB_02228(folX)

EBL:	ECD_02228(folX)

EBE:	B21_02188(folX)

EBD:

ECBD_1356

ECI:	UTI89_C2587(folX)

EIH:	ECOK1_2536(folX)

ECZ:	ECS88_2450(folX)

ECC:	c2846(folX)

ELO:	EC042_2544(folX)

ELN:	NRG857_11665(folX)

ESE:

ECSF_2180

ECL:	EcolC_1349

EKO:	EKO11_1462

EKF:	KO11_11180(folX)

EAB:	ECABU_c26360(folX)

EDH:	EcDH1_1353

EDJ:	ECDH1ME8569_2241(folX)

ELU:	UM146_05295(folX)

ELW:	ECW_m2492(folX)

ELL:	WFL_12200(folX)

ELC:	i14_2644(folX)

ELD:	i02_2644(folX)

ELP:	P12B_c2396(folX)

ELF:	LF82_0729(folX)

ECOL:

LY180_11935(folX)

ECOI:

ECOPMV1_02462(folX)

ECOJ:

P423_12855(folX)

EFE:	EFER_0860(folX)

EAL:	EAKF1_ch3670c(folX)

EMA:	C1192_00350

ESZ:	FEM44_01695(folX)

SFL:	SF2379(folX)

SFX:	S2514(folX)

SFV:	SFV_2370(folX)

SFE:	SFxv_2624(folX)

SFN:

SFy_3384

SFS:

SFyv_3458

SFT:	NCTC1_02614(folX)

SSN:	SSON_2360(folX)

SBO:	SBO_2338(folX)

SBC:	SbBS512_E2679(folX)

SDY:	SDY_2500(folX)

SDZ:	Asd1617_03367

SHQ:	A0259_15335(folX)

ENC:

ECL_03652

ENL:	A3UG_16145

ECLG:

EC036_31390

ECLE:

ECNIH2_16115(folX)

ECLN:

ECNIH4_07070(folX)

ECLI:

ECNIH5_15055(folX)

ECLX:

LI66_15455(folX)

ECLY:

LI62_16955(folX)

ECLZ:

LI64_14890(folX)

ECLO:

ENC_39050

EHM:	AB284_09965(folX)

EXF:	BFV63_15275(folX)

ECLA:

ECNIH3_15150(folX)

ECLC:

ECR091_15085(folX)

EAU:	DI57_03630(folX)

EKB:	BFV64_15800(folX)

ENO:	ECENHK_15580

EEC:	EcWSU1_03182(folX)

ELG:	BH714_11950

ECAN:

CWI88_06670

ERN:	BFV67_15445(folX)

ECLS:

LI67_016700(folX)

ECHG:

FY206_17260(folX)

ESH:	C1N69_15955

ENT:	Ent638_2852

EAS:	Entas_3024

ENX:	NI40_015685(folX)

EBG:	FAI37_13520(folX)

END:	A4308_20255(folX)

CCON:

AFK62_13510(folX)

KPN:	KPN_02693(folX)

KPU:	KP1_3939(folX)

KPM:	KPHS_37600

KPP:

A79E_1409

KPH:	KPNIH24_09860(folX)

KPZ:	KPNIH27_17970(folX)

KPV:	KPNIH29_18770(folX)

KPW:	KPNIH30_18990(folX)

KPY:	KPNIH31_17920(folX)

KPG:	KPNIH32_19320(folX)

KPC:	KPNIH10_18350(folX)

KPQ:	KPR0928_18370(folX)

KPT:	VK055_4822(folX)

KPO:	KPN2242_16560(folX)

KPR:	KPR_2013(folX)

KPJ:

N559_1560

KPI:	D364_13720(folX)

KPA:	KPNJ1_01648

KPS:	KPNJ2_01617

KPX:	PMK1_00190(folX)

KPB:	FH42_09580(folX)

KPNE:

KU54_007605(folX)

KPNU:

LI86_07610(folX)

KPNK:

BN49_3910(folX)

KVA:

Kvar_1361

KPE:	KPK_1454(folX)

KPK:	A593_03325(folX)

KVD:	KR75_00985(folX)

KVQ:	SP68_07515(folX)

KOX:	KOX_26495(folX)

KOE:

A225_4200

KOY:	J415_11130(folX)

KOM:	HR38_24625(folX)

KMI:	VW41_15725(folX)

KOK:	KONIH1_20705(folX)

KOC:	AB185_15620(folX)

KQU:	AVR78_22760

EAE:	EAE_24500(folX)

EAR:

CCG28919

KQV:	B8P98_08305

KLL:	BJF97_20670

KLW:	DA718_08340

CRO:	ROD_27111(folX)

CKO:

CKO_00484

CFD:	CFNIH1_23065(folX)

CBRA:

A6J81_24705

CWE:	CO701_06400

CYO:	CD187_07645

CPOT:

FOB25_18775(folX)

CFQ:	C2U38_17010

CAMA:

F384_12320(folX)

CAF:	AL524_10605

CIF:	AL515_15960

CFAR:

CI104_17655

CIR:	C2U53_27475

CIE:	AN232_12300

CPAR:

CUC49_12010

EBT:	EBL_c12420(folX)

ROR:	RORB6_01045(folX)

RON:	TE10_20370(folX)

RPLN:

B1209_07190

RAO:	DSD31_07415

RTG:	NCTC13098_01955(folX)

REE:	electrica_01448(folX)

CNT:	JT31_19370(folX)

CEM:	LH23_21725(folX)

CEN:	LH86_20300(folX)

CLAP:

NCTC11466_01285(folX)

PGE:	LG71_11765(folX)

ESC:	Entcl_1421

KLE:	AO703_14760(folX)

KGO:	CEW81_07545

KIE:	NCTC12125_00374(folX)

KAS:	KATP_13690

LAX:	APT61_06760(folX)

LEI:	C2U54_20870

LEH:	C3F35_18895

LEE:	DVA44_06885

LER:	GNG29_15875(folX)

LEA:	GNG26_15725(folX)

LAZ:	A8A57_14830

LEF:	LJPFL01_2925

LNI:	CWR52_19445

LEW:	DAI21_11815

BUF:	D8682_22530

BAGE:

BADSM9389_12420

METY:

MRY16398_16010(folX)

AHN:	NCTC12129_01509(folX)

YRE:	HEC60_10895(folX)

SGOE:

A8O29_006990(folX)

KIN:	AB182_06860(folX)

PDZ:	HHA33_09925(folX)

EBF:

D782_1369

EBC:	C2U52_17390

EBU:	CUC76_22905

SMAR:

SM39_2923(folX)

SMAC:

SMDB11_2721(folX)

SMW:	SMWW4_v1c34360(folX)

SPE:

Spro_3321

SRR:	SerAS9_3519

SRL:	SOD_c32370(folX)

SRY:	M621_17610(folX)

SPLY:

Q5A_017575(folX)

SRS:	SerAS12_3520

SRA:	SerAS13_3521

SMAF:

D781_3118

SLQ:	M495_17065(folX)

SERF:

L085_11500

SERS:

SERRSCBI_16670(folX)

SFW:	WN53_25845(folX)

SFG:	AV650_21650(folX)

SRZ:	AXX16_1955

SERA:

Ser39006_010370

SERQ:

CWC46_10365

SERM:

CLM71_16480

SQU:	E4343_24160(folX)

SFJ:	SAMEA4384070_3446(folX)

SOF:	NCTC11214_03350(folX)

SSUR:

ATE40_013805(folX)

SFO:	Z042_03440(folX)

GQU:	AWC35_19645(folX)

ECA:	ECA3045(folX)

PATR:

EV46_15045(folX)

PATO:

GZ59_30500

PCT:

PC1_2785

PCC:	PCC21_028550

PCV:	BCS7_14225(folX)

PWA:	Pecwa_1478

PPAR:

A8F97_11370(folX)

PEC:

W5S_1362

PWS:	A7983_00965(folX)

PPOA:

BJK05_09160

PBRA:

B5S52_07570

PPUJ:

E2566_14555(folX)

BGJ:	AWC36_03105(folX)

BRB:	EH207_11900

BNG:	EH206_06890

EIC:	NT01EI_2710

ETR:	ETAE_2404(folX)

ETD:

ETAF_2175

ETE:

ETEE_0431

ETC:	ETAC_11385(folX)

EDL:	AAZ33_12545(folX)

EHO:	A9798_05170(folX)

HAV:	AT03_14855(folX)

HPAR:

AL518_11380

OPO:	DSM2777_18195(folX)

PSHI:

SAMEA2665130_1054(folX)

GAN:	UMN179_00060

VSP:

VS_1749

VCY:	IX92_10465(folX)

VCT:	JV59_28000(folX)

VCC:	FAZ90_17095(folX)

VAS:	GT360_15905(folX)

VAQ:	FIV01_17040(folX)

GHO:	AL542_01715

SALY:

E8E00_16720(folX)

SKS:	FCN78_15645(folX)

PAE:	PA3439(folX)

PAEV:

N297_3561(folX)

PAEI:

N296_3561(folX)

PAU:	PA14_19620(folX)

PAP:	PSPA7_1689(folX)

PAG:	PLES_16221(folX)

PAF:	PAM18_1527(folX)

PNC:	NCGM2_4576(folX)

PAEB:

NCGM1900_2832(folX)

PDK:	PADK2_07070(folX)

PSG:	G655_07525(folX)

PRP:	M062_18345(folX)

PAEP:

PA1S_08125(folX)

PAER:

PA1R_gp1279

PAEM:

U769_07600(folX)

PAEL:

T223_08110(folX)

PAES:

SCV20265_1606

PAEU:

BN889_03819(folX)

PAEG:

AI22_25770(folX)

PAEC:

M802_3560(folX)

PAEO:

M801_3426(folX)

PMY:

Pmen_3290

PMK:

MDS_3592

PRE:	PCA10_27810(folX) PCA10_47630(folX)

PPSE:

BN5_1170(folX)

PALC:

A0T30_16590(folX)

PCQ:	PcP3B5_51140(folX)

PFV:	Psefu_1345

PST:	PSPTO_1181(folB-2)

PSB:	Psyr_1019(folX)

PSYR:

N018_20590(folX)

PSP:	PSPPH_1070(folB2)

PAMG:

BKM19_007810

PAVL:

BKM03_06750

PVD:	CFBP1590__4337

PFL:	PFL_0948(folB_1)

PPRC:

PFLCHA0_c09630(folX)

PPRO:

PPC_0982(folX)

PFO:	Pfl01_0890

PFS:

PFLU_5159

PFE:	PSF113_4879

PFC:	PflA506_4451(folB_1)

PFN:	HZ99_22995(folX)

PPZ:	H045_16475(folX)

PFB:

VO64_1999

PMAN:

OU5_2510

PTV:	AA957_19205(folX)

PCG:	AXG94_19965(folX)

PVR:	PverR02_26285

PAZO:

AYR47_01665(folX)

POI:	BOP93_21700

PFW:	PF1751_v1c46080(folX)

PFF:	PFLUOLIPICF712975(folX)

PFX:	A7318_21545(folX)

PSA:	PST_1135 PST_1974

PSZ:	PSTAB_1039(folB) PSTAB_1870(folB)

PSR:	PSTAA_1096(folX-1) PSTAA_2002(folX-2)

PSC:	A458_10945(folX) A458_16080(folX)

PSJ:	PSJM300_15015(folX)

PSH:	Psest_2387 Psest_3205

PSTU:

UIB01_12130(folX) UIB01_16485(folX)

PSTT:

CH92_05015(folX)

PBM:	CL52_09880(folX) CL52_15725(folX)

PBA:	PSEBR_a4713

PBC:	CD58_04780(folX)

PPUU:

PputUW4_00809(folX)

PDR:	H681_19965(folX)

PSK:	U771_26660(folX)

PKC:	PKB_4624(folX)

PCH:	EY04_04140(folX)

PCZ:	PCL1606_51450

PCP:	JM49_25545(folX)

PFZ:	AV641_18750(folX)

PLQ:	AA042_14895

PRH:	LT40_20385(folX)

PSES:

PSCI_0768(folX)

PSEM:

TO66_04855(folX)

PPSY:

AOC04_15970(folX)

PSOS:

POS17_0953(folX)

PKR:	AYO71_07240(folX)

PFK:	PFAS1_06680

PANR:

A7J50_4903

PSET:

THL1_4766

PSIL:

PMA3_24880(folX)

PYM:	AK972_4993

PSED:

DM292_13600

PKE:	DLD99_04845

PALL:

UYA_17300(folX)

PUM:	HGP31_04635(folX)

POJ:	PtoMrB4_46840(folX)

PGG:	FX982_00729

AVN:	Avin_10260(folB)

AVL:	AvCA_10260(folX)

AVD:	AvCA6_10260(folX)

ACX:	Achr_31850(folX)

EMO:	DM558_09585

SON:	SO_2921(folX)

SDN:

Sden_2361

SFR:	Sfri_2558 Sfri_3163

SAZ:

Sama_1489

SBL:

Sbal_2682

SBM:	Shew185_2703

SBN:	Sbal195_2779

SBP:	Sbal223_1684

SBT:	Sbal678_2784

SBS:	Sbal117_2814

SBB:	Sbal175_1666

SLO:

Shew_2399

SPC:	Sputcn32_2387

SHP:	Sput200_2414

SPL:

Spea_1664

SHE:	Shewmr4_1484

SHM:	Shewmr7_1549

SHN:	Shewana3_1543

SHW:	Sputw3181_1621

SHL:

Shal_2601

SWD:

Swoo_2892

SWP:

swp_0146

SVO:	SVI_1613(folX)

SHF:	CEQ32_01850

SJA:	SJ2017_0785

SPSW:

Sps_03573

SBJ:	CF168_13045

SMAV:

CFF01_07310

SHEW:

CKQ84_16855

SALG:

BS332_15665

SLJ:	EGC82_05115 EGC82_08340

SMAI:

EXU30_02720

SPOL:

FH971_03490(folX) FH971_07045(folX)

SBK:	SHEWBE_3388(folX)

SKH:	STH12_01130(folX)

SAES:

HBH39_03535(folX) HBH39_10425(folX)

CPS:	CPS_2676(folX)

LSD:	EMK97_16875

THT:	E2K93_04295(folX)

THAP:

FNC98_03210(folX)

PHA:	PSHAa0072(folX)

PTN:	PTRA_a0085(folX)

PAT:

Patl_2910

PSM:	PSM_A0073(folX)

PSEO:

OM33_02955(folX)

PIA:	PI2015_0069

PPHE:

PP2015_38

PBW:	D172_000635(folX)

PRR:	AT705_12505(folX)

PLZ:	S4054249_20265(folX)

PALN:

B0W48_08630

PPIS:

B1L02_00305

PEA:	PESP_a0086(folX)

PSPO:

PSPO_a3219(folX)

PART:

PARC_a3862(folX)

PTU:	PTUN_a3959(folX)

PNG:	PNIG_a0085(folX)

PTD:	PTET_a0078(folX)

PSEN:

PNC201_00305(folX)

PDJ:	D0907_00655

PAGA:

PAGA_a0092(folX)

PCAR:

PC2016_3095

PMAA:

CPA52_00450

MAQ:

Maqu_3783

MHC:	MARHY3688(folX)

MAD:

HP15_3530

MSX:	AU14_18195(folX)

MARI:

ACP86_08180(folX)

MSQ:	BKP64_16170

MARA:

D0851_13170

AMC:	MADE_1006840(folX)

AMH:	I633_07290(folX)

AMAA:

amad1_07300(folX)

AMAL:

I607_06545(folX)

AMAE:

I876_06835(folX)

AMAO:

I634_06955(folX)

AMAD:

I636_07375(folX)

AMAI:

I635_07285(folX)

AMAG:

I533_06865(folX)

AMAC:

MASE_06420(folX)

AMB:	AMBAS45_06725(folX)

AMG:	AMEC673_06485(folX)

AMK:	AMBLS11_06480(folX)

ALT:	ambt_11705(folX)

AAL:	EP13_07225(folX)

AAUS:

EP12_07325(folX)

ASP:	AOR13_2130

ASQ:	AVL57_09355(folX)

AAW:	AVL56_08245(folX)

ALR:	DS731_08375(folX)

ALE:	AV939_08370(folX)

ALZ:	AV940_08190(folX)

APEL:

CA267_002645(folX)

GAG:	Glaag_1416

GNI:

GNIT_1421

GPS:

C427_4002

PMES:

FX988_04013

LAL:	AT746_11300(folX)

CATE:

C2869_17530

SALH:

HMF8227_01222(folX)

SALM:

D0Y50_06370

SALK:

FBQ74_11195(folX)

FBL:

Fbal_2566

FES:	HER31_02485(folX)

RHH:	E0Z06_08710

AEH:

Mlg_1300

SSAL:

SPISAL_08010(folX)

SPIU:

SPICUR_08995

SROS:

BBH56_08160(folX)

SPIZ:

GJ672_08830(folX)

CSA:

Csal_2293

HEL:	HELO_2174(folX)

HHU:	AR456_11930(folX)

HCO:	LOKO_01212(folX)

HSI:	BOX17_13740

HALO:

BWR19_07570

HBE:	BEI_2229(folX)

HAF:	C8233_07095

CMAI:

BFX80_13155(folX)

MMW:	Mmwyl1_1710

MME:	Marme_2591

MPC:	Mar181_2100

MPRI:

MP3633_2362(folX)

MARD:

IBG28_13035(folX)

MARS:

A8C75_19475(folX)

NCU:	F0U83_05570(folX)

NIK:	F5I99_09320(folX)

BMAR:

HF888_13990(folX)

GSN:	YC6258_04578

RFO:	REIFOR_02906(folX)

OME:	OLMES_0416

TBN:

TBH_C1932

SECH:

B18_00245

SPYG:

YGS_C2P1137

ANH:	A6F65_00142

SYP:	SYNPCC7002_A0307(folB)

SYV:	AWQ23_01690

SYL:	AWQ21_01575

LEP:	Lepto7376_1118

CAP:	CLDAP_28290(folB)

PLS:	VT03_08380(folX)

GMR:	GmarT_28510(folX)

GIM:	F1728_00630(folB)

PLON:

Pla110_07110(folX)

KST:	KSMBR1_1773(folB)

VBL:	L21SP4_00861(folX)

OCK:	EXM22_07230

DORI:

FH5T_08700(folX)

DRC:	G0Q07_00695

ASX:	CDL62_00790(folX)

MBAS:

ALGA_3592

NAX:	HC341_15580(folX)

» show all

Reference

1 [PMID:9182560]

Authors

Ahn C, Byun J, Yim J

Title

Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli.

Journal

J Biol Chem 272:15323-8 (1997)
DOI:10.1074/jbc.272.24.15323

Sequence

[eco:b2303]

Reference

2 [PMID:9651328]

Authors

Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G

Title

Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.

Journal

J Biol Chem 273:17418-24 (1998)
DOI:10.1074/jbc.273.28.17418

Sequence

[eco:b2303]

Other DBs

ExplorEnz - The Enzyme Database:

5.1.99.7

IUBMB Enzyme Nomenclature:

5.1.99.7

ExPASy - ENZYME nomenclature database:

5.1.99.7

BRENDA, the Enzyme Database:

5.1.99.7

DBGET integrated database retrieval system