KEGG ENZYME: 5.2.1.12

ENZYME: 5.2.1.12

Entry

EC 5.2.1.12 Enzyme

Name

zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase

Class

Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)

Sysname

9,15,9'-tricis-zeta-carotene cis-trans-isomerase

Reaction(IUBMB)

9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN:R09655]

Reaction(KEGG)

R09655

Substrate

9,15,9'-tricis-zeta-carotene [CPD:C19764]

Product

9,9'-dicis-zeta-carotene [CPD:C15857]

Comment

The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.

History

EC 5.2.1.12 created 2011

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15744

zeta-carotene isomerase

Genes

ATH:	AT1G10830(Z-ISO)

ALY:

9328664

CRB:

17899102

CSAT:

104739709 104755305 104769441

EUS:	EUTSA_v10007996mg

BRP:

103871859

BNA:	106350180 106357937

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10020648mg

TCC:

18592559

GRA:

105797062

GHI:	107910439 107951527

GAB:

108474590

DZI:

111298953

EGR:

104438291

GMX:	100793910 100820507

GSJ:	114382309 114394693

PVU:	PHAVU_001G263600g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_3g084950 MTR_8g097190

CAM:	101501611 101502677

LJA:	Lj4g3v2573870.1(Lj4g3v2573870.1) Lj4g3v2573880.1(Lj4g3v2573880.1)

ADU:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:

PXB:

ZJU:	107422221 107422224 107422240

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

JRE:

QSU:

VVI:

SLY:	101253762(Z-ISO)

SPEN:

SOT:

CANN:

NTA:

NSY:

NTO:

NAU:

INI:

SIND:

OEU:	111374624 111376575

HAN:

LSV:

CCAV:

DCR:

BVG:

SOE:

CQI:	110711540 110714736

NNU:

104589367

PSOM:

113283997 113315667

OSA:

4352042

DOSA:

Os12t0405200-01(Os12g0405200)

OBR:

102721697

BDI:

100842276

ATS:	109740170(LOC109740170)

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:	103968483 103987601

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_13999 SELMODRAFT_157819

PPP:	112288753 112294069

MNG:	MNEG_11647

CSL:	COCSUDRAFT_53522

CVR:	CHLNCDRAFT_59823

APRO:

F751_1881

GSL:	Gasu_38400

CCP:	CHC_T00001067001

FCY:	FRACYDRAFT_291550(Z-ISO)

AAF:	AURANDRAFT_3442

EHX:	EMIHUDRAFT_458464 EMIHUDRAFT_463302(AMT17)

GTT:	GUITHDRAFT_63717

» show all

Reference

1 [PMID:20335404]

Authors

Chen Y, Li F, Wurtzel ET

Title

Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants.

Journal

Plant Physiol 153:66-79 (2010)
DOI:10.1104/pp.110.153916

Sequence

[ath:AT1G10830] [zma:100194203]

Reference

2 [PMID:17434985]

Authors

Li F, Murillo C, Wurtzel ET

Title

Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization.

Journal

Plant Physiol 144:1181-9 (2007)
DOI:10.1104/pp.107.098996

Sequence

[zma:100194203]

Reference

3 [PMID:26075523]

Authors

Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET

Title

Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.

Journal

Nat Chem Biol 11:598-605 (2015)
DOI:10.1038/nchembio.1840

Other DBs

ExplorEnz - The Enzyme Database:

5.2.1.12

IUBMB Enzyme Nomenclature:

5.2.1.12

ExPASy - ENZYME nomenclature database:

5.2.1.12

BRENDA, the Enzyme Database:

5.2.1.12

DBGET integrated database retrieval system