| Entry |
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| Name |
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
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| Class |
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
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| Sysname |
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
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| Reaction(IUBMB) |
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN: R09655]
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| Reaction(KEGG) |
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| Substrate |
9,15,9'-tricis-zeta-carotene [CPD: C19764]
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| Product |
9,9'-dicis-zeta-carotene [CPD: C15857]
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| Comment |
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
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| History |
EC 5.2.1.12 created 2011
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15744 | zeta-carotene isomerase |
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| Genes |
» show all
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| Reference |
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| Authors |
Chen Y, Li F, Wurtzel ET |
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| Title |
Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Li F, Murillo C, Wurtzel ET |
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| Title |
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET |
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| Title |
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.2.1.12 |
| ExPASy - ENZYME nomenclature database: | 5.2.1.12 |
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