KEGG   ENZYME: 5.2.1.12
Entry
EC 5.2.1.12                 Enzyme                                 
Name
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
Sysname
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
Reaction(IUBMB)
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN:R09655]
Reaction(KEGG)
R09655
Substrate
9,15,9'-tricis-zeta-carotene [CPD:C19764]
Product
9,9'-dicis-zeta-carotene [CPD:C15857]
Comment
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
History
EC 5.2.1.12 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15744  zeta-carotene isomerase
Genes
ATH: AT1G10830(Z-ISO)
ALY: 9328664
CRB: 17899102
CSAT: 104739709 104755305 104769441
EUS: EUTSA_v10007996mg
BRP: 103871859
BNA: 106350180 106357937
BOE: 106343736
RSZ: 108860687 130510407
THJ: 104823658
CPAP: 110821616
CIT: 102630760
CIC: CICLE_v10020648mg
PVY: 116112785 116129121
MINC: 123219946
TCC: 18592559
GRA: 105797062
GHI: 107910439 107951527
GAB: 108474590
HSYR: 120191105 120218540
DZI: 111298953
EGR: 104438291
RARG: 115749093
GMX: 100793910 100820507
GSJ: 114382309 114394693
PVU: 137815268
VRA: 106778251
VAR: 108318983
VUN: 114195875
VUM: 124841671
CCAJ: 109795797
APRC: 113849302
MTR: 11436315 11437558
TPRA: 123909631 123914250
CAM: 101501611 101502677
PSAT: 127083136 127108130
VVO: 131603465 131607947 131661549 131661564
LJA: 130711503
ADU: 107482417
AIP: 107638274
AHF: 112740913 112795633
LANG: 109326097 109344119
PCIN: 129309465
QSA: O6P43_002563
FVE: 101302159
AANS: 126791093
RCN: 112201141
PPER: 18790341
PMUM: 103342570
PAVI: 110745375
MDM: 103400646
MSYL: 126618825
PXB: 103960405
PCOX: 137723032
MNT: 21395241
CSAV: 115722937
CSV: 101211624
CMO: 103494534
BHJ: 120073753
MCHA: 111014723
CMAX: 111470740
CMOS: 111439180
CPEP: 111800986
RCU: 8262245
MEAN: 126654048
JCU: 105636165
HBR: 110632161
MESC: 110627983
POP: 7466321
PEU: 105107708
PALZ: 118040880
PNZ: 133683157
JRE: 108996307
CILL: 122303331
CAVE: 132177001
AGLU: 133871080
QSU: 111994182
QLO: 115965695
TWL: 120014460
VVI: 100258367
VRI: 117913886 117913929
SLY: 101253762(Z-ISO)
SPEN: 107007592
SOT: 102600257
SSTN: 125862454
SDUL: 129883218
CANN: 107850257
LBB: 132604442
NTA: 107798230
NSY: 104238890
NTO: 104121634
NAU: 109214175
INI: 109167937
ITR: 116017865
SIND: 105158676
OEU: 111374624 111376575
EGT: 105963175
SSPL: 121802201 121808397
SMIL: 130997813 130997979
SHIS: 125223593
APAN: 127242650 127264297
PEBU: 140827730
HAN: 110885023
ECAD: 122603563
LSV: 111887957
CCAV: 112513118
DCR: 108196139
CSIN: 114282658
RVL: 131318212
AEW: 130767200
DLT: 127800686
BVG: 104889684
SOE: 110800142
CQI: 110711540 110714736
ATRI: 130806995 130811322
SLAF: 141657385
MOF: 131151932
NNU: 104589367
MING: 122072059
TSS: 122659998
PSOM: 113283997 113315667
OSA: 4352042
DOSA: Os12g0405200
OBR: 102721697
OGL: 127756214
BDI: 100842276
ATS: 109740170
TDC: 119298937 119307233
TAES: 123102131 123110269 123119310
TUA: 125507720
LPER: 127345546
LRD: 124662880 124665892
SBI: 110429871
ZMA: 100194203
MFLO: 136504846 136504911
SITA: 101783502
SVS: 117848203
PVIR: 120666062 120699317
PHAI: 112887978
PAUA: 133905296 133905931
TANG: 140766001
PDA: 103722002
EGU: 105038852
MUS: 103968483 135614719
ZOF: 122020335 122023750
DCT: 110105626
PEQ: 110018946
AOF: 109823824
MSIN: 131239583
ACAK: 137962434
NCOL: 116251278
ATR: 18438214
CJF: 131075870
SMO: SELMODRAFT_13999 SELMODRAFT_157819
PPP: 112288753 112294069
CRE: CHLRE_19g750247v5
MNG: MNEG_11647
CSL: COCSUDRAFT_53522
CVR: CHLNCDRAFT_59823
APRO: F751_1881
GSL: Gasu_38400
CCP: CHC_T00001067001
PTI: PHATRDRAFT_16955
FCY: FRACYDRAFT_291550(Z-ISO)
TPS: THAPSDRAFT_33312
AAF: AURANDRAFT_3442
EHX: EMIHUDRAFT_458464 EMIHUDRAFT_463302(AMT17)
GTT: GUITHDRAFT_63717
SYN: slr1599
SYZ: MYO_14320
SYY: SYNGTS_0427(slr1599)
SYT: SYNGTI_0427(slr1599)
SYS: SYNPCCN_0427(slr1599)
SYQ: SYNPCCP_0427(slr1599)
SYJ: D082_25400
SYO: C7I86_02220
SYNH: HTZ78_07430
SYNS: OLK001_10920
SYC: syc2117_d
SYU: M744_06525
SYF: Synpcc7942_1979
SYD: Syncc9605_2399
SYE: Syncc9902_0294
SYG: sync_2612
SYR: SynRCC307_0234
SYX: SynWH7803_2277
CYA: CYA_2799
CYB: CYB_0962
SYNE: Syn6312_3404
SYNP: Syn7502_00043
SYNK: KR100_14840
SYNR: KR49_07585
SYND: KR52_04095
SYH: Syncc8109_2508
SYNW: SynWH8103_02598(Z-ISO)
SYNC: CB0101_14700
SYNY: BM449_04440
SYNZ: H8F24_02570
SYNL: KJJ24_13325
SYNO: LY254_09765
SYNU: SynWH8101_2606
SYW: SYNW2261
CGC: Cyagr_2886
CYI: CBM981_3157
PMA: Pro_0171
PMM: PMM0148
PMT: PMT_2008
PMN: PMN2A_1514
PMI: PMT9312_0150
PMB: A9601_01651
PMC: P9515_01761
PMF: P9303_26691
PMG: P9301_01671
PMH: P9215_01651
PMJ: P9211_01631
PME: NATL1_02201
PRC: EW14_0190
PRM: EW15_0235
WNA: KA717_15970
CMP: Cha6605_5260
CYN: Cyan7425_3165
CEP: Cri9333_2093
TVN: NIES2134_123860
SLW: BRW62_09130
TEL: tll0146
THN: NK55_09945(nnrU)
THEC: FFX45_07600
THEY: JW907_11685
TSQ: D3A95_11360
AMR: AM1_2494
ACAM: HRE53_09985
TSZ: OOK60_11435
LEN: LEP3755_38020
LET: O77CONTIG1_00156
LBO: LBWT_43550
LEPI: EDM05_027295
KOV: K9N68_00720
LSC: KIK02_09165
LSK: J5X98_06940
SFRI: RBJ76_08870
HHG: XM38_050570
DSL: Dacsa_0119
PSEU: Pse7367_1968
PSER: ABRG53_0976(nnrU)
PGX: OA858_03770
THEU: HPC62_14125
TOG: HNI00_15630
TSIN: OXH18_15885
CHON: NIES4102_37840
GDU: P0S91_15790
GEN: GM3709_518
GEE: GM3708_2770
CAN: Cyan10605_0836
CSN: Cyast_1185
CYL: AA637_03275
CYR: A5482_006910
CYD: Dongsha4_12645
SYP: SYNPCC7002_A1197
SYV: AWQ23_06140
SYL: AWQ21_06685
LEP: Lepto7376_2047
SYNN: NIES970_12870
PIP: FEK30_10105
MAR: MAE_42990
MPK: VL20_2690
MIQ: B5D77_19790
MVZ: myaer102_17390
HAO: PCC7418_2737
ENN: FRE64_14845
CYU: UCYN_08290
CYT: cce_2781
CWA: CwatDRAFT_0283
CYP: PCC8801_0470
CYH: Cyan8802_0483
CYC: PCC7424_0460
CYJ: Cyan7822_2383
TER: Tery_2010
PAGH: NIES204_43020
PPSU: NO713_00448(Z-ISO)
PRUN: PCC7821_04416
MVAG: D0A34_07755
LFS: HFV01_22730
LIX: H2674_04455
ARP: NIES39_D06110
CSAU: ACL6C3_31005
OXY: HCG48_23510
OAC: Oscil6304_4207
PHOR: JWS08_21275
PYH: NEA10_10980
ONI: Osc7112_1004
MIC: Mic7113_0529
MPRO: BJP34_29500
GEI: GEI7407_2956
ANA: alr3954
NPU: Npun_R6187
NOS: Nos7107_3611
NOP: Nos7524_0813
NON: NOS3756_11560
NFL: COO91_07443
NOE: CLI64_04270
NSH: GXM_01188
NED: HUN01_31110
NPZ: ACX27_05340
NLK: NIES25_23490
NCW: NIES2107_52300
NCF: ANSO36C_49350
NOST: GJB62_09080
NOSU: JYQ62_34685
NOSQ: PQG02_12085
AVA: Ava_1748
NAZ: Aazo_0147
ANB: ANA_C13213
ACY: Anacy_2780
AWA: AA650_15905
ANN: EH233_08975
CSG: Cylst_3760
RSIN: B6N60_04002
HBQ: QI031_12795
NSP: BMF81_01983
NSPH: BDGGKGIB_02204
AEE: IM676_09075
CALO: Cal7507_1931
CALT: Cal6303_1772
CALH: IJ00_21195
CALN: NIES2098_55780
RIV: Riv7116_1190
MDP: NIES3275_61180
FIS: FIS3754_00470
DOU: BMF77_03309
DFS: HGD76_21005
DHT: NG743_08595
DCM: NIES806_23360
DOT: EZY12_03980
DOZ: HEP80_12615
DOC: HEQ26_14205
CCUR: IAR63_11940
CRK: L3I90_01395
AFLO: HEQ12_15375
STOQ: K2F26_10300
SKV: NIES73_31810
RCS: NIES932_03120
OCF: WJM97_08145
TOQ: HCG51_15015
TTQ: NIES37_05830
ALAX: NIES50_14010
SCYT: SAMD_34680
SCYS: NIES4073_68350
BSEN: DP114_10040
BOX: DP113_09990
NCN: BZZ01_28910
CTHE: Chro_5441
PLP: Ple7327_0195
SCS: Sta7437_0113
STAN: STA3757_36790
GLT: GlitD10_2018
GCY: LQF76_13525
CEO: ETSB_1488
CER: RGRSB_1527
CEEC: P3F56_07565
 » show all
Reference
1  [PMID:20335404]
  Authors
Chen Y, Li F, Wurtzel ET
  Title
Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants.
  Journal
Plant Physiol 153:66-79 (2010)
DOI:10.1104/pp.110.153916
  Sequence
[ath:AT1G10830] [zma:100194203]
Reference
2  [PMID:17434985]
  Authors
Li F, Murillo C, Wurtzel ET
  Title
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization.
  Journal
Plant Physiol 144:1181-9 (2007)
DOI:10.1104/pp.107.098996
  Sequence
[zma:100194203]
Reference
3  [PMID:26075523]
  Authors
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET
  Title
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.
  Journal
Nat Chem Biol 11:598-605 (2015)
DOI:10.1038/nchembio.1840
Other DBs
ExplorEnz - The Enzyme Database: 5.2.1.12
IUBMB Enzyme Nomenclature: 5.2.1.12
ExPASy - ENZYME nomenclature database: 5.2.1.12
BRENDA, the Enzyme Database: 5.2.1.12

  All links  
Gene (1641)   
   MGENES (1349)   
   RefGene (292)   
Protein sequence (30)   
   UniProt (26)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
DNA sequence (68)   
   RefSeq(nuc) (2)   
   GenBank (43)   
   EMBL (23)   
Protein domain (1)   
   InterPro (1)   
All databases (1740)   

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